Methionine at the Heart of Anabolism and Signaling: Perspectives From Budding Yeast.

Abstract:

:Studies using a fungal model, Saccharomyces cerevisiae, have been instrumental in advancing our understanding of sulfur metabolism in eukaryotes. Sulfur metabolites, particularly methionine and its derivatives, induce anabolic programs in yeast, and drive various processes integral to metabolism (one-carbon metabolism, nucleotide synthesis, and redox balance). Thereby, methionine also connects these processes with autophagy and epigenetic regulation. The direct involvement of methionine-derived metabolites in diverse chemistries such as transsulfuration and methylation reactions comes from the elegant positioning and safe handling of sulfur through these molecules. In this mini-review, we highlight studies from yeast that reveal how this amino acid holds a unique position in both metabolism and cell signaling, and illustrate cell fate decisions that methionine governs. We further discuss the interconnections between sulfur and NADPH metabolism, and highlight critical nodes around methionine metabolism that are promising for antifungal drug development.

journal_name

Front Microbiol

authors

Walvekar AS,Laxman S

doi

10.3389/fmicb.2019.02624

subject

Has Abstract

pub_date

2019-11-15 00:00:00

pages

2624

issn

1664-302X

journal_volume

10

pub_type

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