Genetics of Acquired Antibiotic Resistance Genes in Proteus spp.

Abstract:

:Proteus spp. are commensal Enterobacterales of the human digestive tract. At the same time, P. mirabilis is commonly involved in urinary tract infections (UTI). P. mirabilis is naturally resistant to several antibiotics including colistin and shows reduced susceptibility to imipenem. However higher levels of resistance to imipenem commonly occur in P. mirabilis isolates consecutively to the loss of porins, reduced expression of penicillin binding proteins (PBPs) PBP1a, PBP2, or acquisition of several antibiotic resistance genes, including carbapenemase genes. In addition, resistance to non-β-lactams is also frequently reported including molecules used for treating UTI infections (e.g., fluoroquinolones, nitrofurans). Emergence and spread of multidrug resistant P. mirabilis isolates, including those producing ESBLs, AmpC cephalosporinases and carbapenemases, are being more and more frequently reported. This review covers Proteus spp. with a focus on the different genetic mechanisms involved in the acquisition of resistance genes to multiple antibiotic classes turning P. mirabilis into a dreadful pandrug resistant bacteria and resulting in difficult to treat infections.

journal_name

Front Microbiol

authors

Girlich D,Bonnin RA,Dortet L,Naas T

doi

10.3389/fmicb.2020.00256

subject

Has Abstract

pub_date

2020-02-21 00:00:00

pages

256

issn

1664-302X

journal_volume

11

pub_type

杂志文章,评审
  • The GC Content as a Main Factor Shaping the Amino Acid Usage During Bacterial Evolution Process.

    abstract::Understanding how proteins evolve is important, and the order of amino acids being recruited into the genetic codons was found to be an important factor shaping the amino acid composition of proteins. The latest work about the last universal common ancestor (LUCA) makes it possible to determine the potential factors s...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02948

    authors: Du MZ,Zhang C,Wang H,Liu S,Wei W,Guo FB

    更新日期:2018-12-07 00:00:00

  • Fluorescent Reporter Signals, EGFP, and DsRed, Encoded in HIV-1 Facilitate the Detection of Productively Infected Cells and Cell-Associated Viral Replication Levels.

    abstract::Flow cytometric analysis is a reliable and convenient method for investigating molecules at the single cell level. Previously, recombinant human immunodeficiency virus type 1 (HIV-1) strains were constructed that express a fluorescent reporter, either enhanced green fluorescent protein, or DsRed, which allow the monit...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2011.00280

    authors: Terahara K,Yamamoto T,Mitsuki YY,Shibusawa K,Ishige M,Mizukoshi F,Kobayashi K,Tsunetsugu-Yokota Y

    更新日期:2012-01-10 00:00:00

  • Antibacterial Effect of Copaifera duckei Dwyer Oleoresin and Its Main Diterpenes against Oral Pathogens and Their Cytotoxic Effect.

    abstract::This study evaluates the antibacterial activity of the Copaifera duckei Dwyer oleoresin and two isolated compounds [eperu-8(20)-15,18-dioic acid and polyalthic acid] against bacteria involved in primary endodontic infections and dental caries and assesses the cytotoxic effect of these substances against a normal cell ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.00201

    authors: Abrão F,Alves JA,Andrade G,de Oliveira PF,Ambrósio SR,Veneziani RCS,Tavares DC,Bastos JK,Martins CHG

    更新日期:2018-02-21 00:00:00

  • Natural Killer Cell Functions during the Innate Immune Response to Pathogenic Streptococci.

    abstract::Dendritic cells (DCs) and NK cells play a crucial role in the first phase of host defense against infections. Group B Streptococcus (GBS) and Streptococcus suis are encapsulated streptococci causing severe systemic inflammation, leading to septicemia and meningitis. Yet, the involvement of NK cells in the innate immun...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.01196

    authors: Lemire P,Galbas T,Thibodeau J,Segura M

    更新日期:2017-06-29 00:00:00

  • Does Mucosal B1 Activation Result in the Accumulation of Peak IgM During Chronic Intrarectal SIVmac239 Exposure to Protect Chinese-Origin Rhesus Macaques From Disease Progression?

    abstract::Human immunodeficiency virus (HIV) infection is characterized by a dynamic process and highly variable progression. Although extensive comparisons have been reported between the minority of non-progressors (NPGs) and the majority of progressors (PGs), the underlying mechanism is still unclear. One reason for this is t...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00357

    authors: Cong Z,Tong L,Wang Y,Su A,Chen T,Wei Q,Xue J,Qin C

    更新日期:2020-03-19 00:00:00

  • The Strengths of Scanning Electron Microscopy in Deciphering SARS-CoV-2 Infectious Cycle.

    abstract::Electron microscopy is a powerful tool in the field of microbiology. It has played a key role in the rapid diagnosis of viruses in patient samples and has contributed significantly to the clarification of virus structure and function, helping to guide the public health response to emerging viral infections. In the pre...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.02014

    authors: Brahim Belhaouari D,Fontanini A,Baudoin JP,Haddad G,Le Bideau M,Bou Khalil JY,Raoult D,La Scola B

    更新日期:2020-08-19 00:00:00

  • The Capacity of the Fecal Microbiota From Malawian Infants to Ferment Resistant Starch.

    abstract::In Low and Middle-Income Countries (LMIC), weaning is associated with environmentally acquired and inflammation-associated enteric disorders. Dietary intake of high amylose maize starch (HAMS) can promote commensal fermentative bacteria and drive the production of short chain fatty acids (SCFAs). By stabilizing commen...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01459

    authors: Wang Y,Mortimer EK,Katundu KGH,Kalanga N,Leong LEX,Gopalsamy GL,Christophersen CT,Richard AC,Shivasami A,Abell GCJ,Young GP,Rogers GB

    更新日期:2019-06-26 00:00:00

  • Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Isolates Belonging to Major Endemic Clones in South America.

    abstract::Carbapenem-resistant Acinetobacter baumannii (CRAB) are emerging worldwide. In South America, clinical isolates presenting such a phenotype usually do not belong to the globally distributed international clone 2 (IC2). The majority of these isolates are also resistant to multiple other antimicrobials and are often des...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.584603

    authors: Nodari CS,Cayô R,Streling AP,Lei F,Wille J,Almeida MS,de Paula AI,Pignatari ACC,Seifert H,Higgins PG,Gales AC

    更新日期:2020-11-30 00:00:00

  • Evolutionary Implications of Anoxygenic Phototrophy in the Bacterial Phylum Candidatus Eremiobacterota (WPS-2).

    abstract::Genome-resolved environmental metagenomic sequencing has uncovered substantial previously unrecognized microbial diversity relevant for understanding the ecology and evolution of the biosphere, providing a more nuanced view of the distribution and ecological significance of traits including phototrophy across diverse ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01658

    authors: Ward LM,Cardona T,Holland-Moritz H

    更新日期:2019-07-23 00:00:00

  • Modeling Multispecies Gene Flow Dynamics Reveals the Unique Roles of Different Horizontal Gene Transfer Mechanisms.

    abstract::Horizontal gene transfer within diverse bacterial populations occurs through multiple mechanisms of exchange. The most established routes of gene transfer, transduction, transformation, and conjugation, have been characterized in detail, revealing the advantages and limitations of each mechanism. More recently, inters...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02978

    authors: Nazarian P,Tran F,Boedicker JQ

    更新日期:2018-12-04 00:00:00

  • Corrigendum: Integrating DNA Methylation and Gene Expression Data in the Development of the Soybean-Bradyrhizobium N2-Fixing Symbiosis.

    abstract::[This corrects the article on p. 518 in vol. 7, PMID: 27148207.]. ...

    journal_title:Frontiers in microbiology

    pub_type: 已发布勘误

    doi:10.3389/fmicb.2016.00952

    authors: Davis-Richardson AG,Russell JT,Dias R,McKinlay AJ,Canepa R,Fagen JR,Rusoff KT,Drew JC,Kolaczkowski B,Emerich DW,Triplett EW

    更新日期:2016-06-15 00:00:00

  • SNORD126 Promotes Hepatitis C Virus Infection by Upregulating Claudin-1 via Activation of PI3K-AKT Signaling Pathway.

    abstract::Hepatitis C virus (HCV) infection involves a variety of viral and host factors, some of which promote the infection process. A small nucleolar RNA, C/D box 126 (SNORD126), was previously shown to be associated with hepatocellular carcinoma (HCC). However, the role of SNORD126 in HCV infection, which is one of the prim...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.565590

    authors: Qian X,Xu C,Wu B,Tang H,Zhao P,Qi Z

    更新日期:2020-09-15 00:00:00

  • Detection of Shigella in Milk and Clinical Samples by Magnetic Immunocaptured-Loop-Mediated Isothermal Amplification Assay.

    abstract::Shigella is an important human food-borne zoonosis bacterial pathogen, and can cause clinically severe diarrhea. There is an urgent need to develop a specific, sensitive, and rapid methodology for detection of this pathogen. In this study, loop-mediated isothermal amplification (LAMP) combined with magnetic immunocapt...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.00094

    authors: Zhang L,Wei Q,Han Q,Chen Q,Tai W,Zhang J,Song Y,Xia X

    更新日期:2018-02-06 00:00:00

  • Lactobacillus gasseri APC 678 Reduces Shedding of the Pathogen Clostridium difficile in a Murine Model.

    abstract::Clostridium difficile is a common cause of health-care acquired diarrhea, resulting in a spectrum of disease from mild diarrhea to life-threatening illness. Sixty Lactobacillus strains were screened for anti-C. difficile activity using a co-culture method. Based on their ability to inhibit C. difficile, L. gasseri APC...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00273

    authors: Quigley L,Coakley M,Alemayehu D,Rea MC,Casey PG,O'Sullivan Ó,Murphy E,Kiely B,Cotter PD,Hill C,Ross RP

    更新日期:2019-02-20 00:00:00

  • Responses to Hydric Stress in the Seed-Borne Necrotrophic Fungus Alternaria brassicicola.

    abstract::Alternaria brassicicola is a necrotrophic fungus causing black spot disease and is an economically important seed-borne pathogen of cultivated brassicas. Seed transmission is a crucial component of its parasitic cycle as it promotes long-term survival and dispersal. Recent studies, conducted with the Arabidopsis thali...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.01969

    authors: N'Guyen GQ,Raulo R,Marchi M,Agustí-Brisach C,Iacomi B,Pelletier S,Renou JP,Bataillé-Simoneau N,Campion C,Bastide F,Hamon B,Mouchès C,Porcheron B,Lemoine R,Kwasiborski A,Simoneau P,Guillemette T

    更新日期:2019-08-30 00:00:00

  • First Report on the Plasmidome From a High-Altitude Lake of the Andean Puna.

    abstract::Mobile genetic elements, including plasmids, drive the evolution of prokaryotic genomes through the horizontal transfer of genes allowing genetic exchange between bacteria. Moreover, plasmids carry accessory genes, which encode functions that may offer an advantage to the host. Thus, it is expected that in a certain e...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.01343

    authors: Perez MF,Kurth D,Farías ME,Soria MN,Castillo Villamizar GA,Poehlein A,Daniel R,Dib JR

    更新日期:2020-06-23 00:00:00

  • Bacterial Survival under Extreme UV Radiation: A Comparative Proteomics Study of Rhodobacter sp., Isolated from High Altitude Wetlands in Chile.

    abstract::Salar de Huasco, defined as a polyextreme environment, is a high altitude saline wetland in the Chilean Altiplano (3800 m.a.s.l.), permanently exposed to the highest solar radiation doses registered in the world. We present here the first comparative proteomics study of a photoheterotrophic bacterium, Rhodobacter sp.,...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.01173

    authors: Pérez V,Hengst M,Kurte L,Dorador C,Jeffrey WH,Wattiez R,Molina V,Matallana-Surget S

    更新日期:2017-06-26 00:00:00

  • First Report of Vibrio tubiashii Associated with a Massive Larval Mortality Event in a Commercial Hatchery of Scallop Argopecten purpuratus in Chile.

    abstract::The VPAP30 strain was isolated as the highly predominant bacteria from an episode of massive larval mortality occurring in a commercial culture of the Chilean scallop Argopecten purpuratus. The main aims of this study were, to characterize and identify the pathogenic strain using biochemical and molecular methods to d...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,收录出版

    doi:10.3389/fmicb.2016.01473

    authors: Rojas R,Miranda CD,Santander J,Romero J

    更新日期:2016-09-20 00:00:00

  • Use of a Neonatal-Mouse Model to Characterize Vaccines and Strategies for Overcoming the High Susceptibility and Severity of Pertussis in Early Life.

    abstract::Newborns and unvaccinated infants, compared to other age groups, are more susceptible to pertussis infection, manifesting severe symptoms leading to a higher mortality. The recent increase in pertussis cases demands more effective strategies to overcome this major health problem. In parallel with maternal-immunization...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00723

    authors: Martin Aispuro P,Ambrosis N,Zurita ME,Gaillard ME,Bottero D,Hozbor DF

    更新日期:2020-04-17 00:00:00

  • Response to Trypanosoma cruzi by Human Blood Cells Enriched with Dentritic Cells Is Controlled by Cyclooxygenase-2 Pathway.

    abstract::Chagas disease (Cd) or American human trypanosomiasis is caused by Trypanosoma cruzi and affects ~7 million people, mostly in Latin America. The infective trypomastigote forms of the parasite can invade several human blood cell populations, including monocytes and dendritic cells (DC). Although these cells display a w...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.02020

    authors: Lonien SCH,Malvezi AD,Suzukawa HT,Yamauchi LM,Yamada-Ogatta SF,Rizzo LV,Bordignon J,Pinge-Filho P

    更新日期:2017-10-25 00:00:00

  • Functional Analysis of the Citrate Activator CitO from Enterococcus faecalis Implicates a Divalent Metal in Ligand Binding.

    abstract::The regulator of citrate metabolism, CitO, from Enterococcus faecalis belongs to the FCD family within the GntR superfamily. In the presence of citrate, CitO binds to cis-acting sequences located upstream of the cit promoters inducing the expression of genes involved in citrate utilization. The quantification of the m...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00101

    authors: Blancato VS,Pagliai FA,Magni C,Gonzalez CF,Lorca GL

    更新日期:2016-02-09 00:00:00

  • An Integrative Genomic Island Affects the Adaptations of the Piezophilic Hyperthermophilic Archaeon Pyrococcus yayanosii to High Temperature and High Hydrostatic Pressure.

    abstract::Deep-sea hydrothermal vent environments are characterized by high hydrostatic pressure and sharp temperature and chemical gradients. Horizontal gene transfer is thought to play an important role in the microbial adaptation to such an extreme environment. In this study, a 21.4-kb DNA fragment was identified as a genomi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01927

    authors: Li Z,Li X,Xiao X,Xu J

    更新日期:2016-11-29 00:00:00

  • Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by an Escherichia coli S2P Peptidase RseP.

    abstract::Intramembrane proteases (IMPs) are a unique class of proteases that catalyze the proteolysis within the membrane and regulate diverse cellular processes in various organisms. RseP, an Escherichia coli site-2 protease (S2P) family IMP, is involved in the regulation of an extracytoplasmic stress response through the cle...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.607381

    authors: Miyake T,Hizukuri Y,Akiyama Y

    更新日期:2020-11-27 00:00:00

  • Determining the Distribution of Fluorescent Organic Matter in the Indian Ocean Using in situ Fluorometry.

    abstract::In order to determine the dynamics of marine fluorescent organic matter (FOM) using high-resolution spatial data, in situ fluorometers have been used in the open ocean. In this study, we measured FOM during the Global Ocean Ship-based Hydrographic Investigations Program (GO-SHIP) expedition from early December 2019 to...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.589262

    authors: Shigemitsu M,Uchida H,Yokokawa T,Arulananthan K,Murata A

    更新日期:2020-12-23 00:00:00

  • HIV-1 Tat and Viral Latency: What We Can Learn from Naturally Occurring Sequence Variations.

    abstract::Despite the effective use of antiretroviral therapy, the remainder of a latently HIV-1-infected reservoir mainly in the resting memory CD4+ T lymphocyte subset has provided a great setback toward viral eradication. While host transcriptional silencing machinery is thought to play a dominant role in HIV-1 latency, HIV-...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2017.00080

    authors: Kamori D,Ueno T

    更新日期:2017-01-30 00:00:00

  • Variant Signal Peptides of Vaccine Antigen, FHbp, Impair Processing Affecting Surface Localization and Antibody-Mediated Killing in Most Meningococcal Isolates.

    abstract::Meningococcal lipoprotein, Factor H binding protein (FHbp), is the sole antigen of the Trumenba vaccine (Pfizer) and one of four antigens of the Bexsero vaccine (GSK) targeting Neisseria meningitidis serogroup B isolates. Lipidation of FHbp is assumed to occur for all isolates. We show in the majority of a collection ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.02847

    authors: da Silva RAG,Karlyshev AV,Oldfield NJ,Wooldridge KG,Bayliss CD,Ryan A,Griffin R

    更新日期:2019-12-19 00:00:00

  • Comprehensive Transcriptome and Proteome Analyses Reveal the Modulation of Aflatoxin Production by Aspergillus flavus on Different Crop Substrates.

    abstract::As a natural severe contaminant of stored grains and other crops worldwide, Aspergillus flavus can produce aflatoxins (AFs), the most powerful naturally producing toxic and hepatocarcinogenic compounds. AFs production is regulated by diverse factors including AFs cluster genes, transcription factors, regulators, and e...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.01497

    authors: Li X,Jiang Y,Ma L,Ma X,Liu Y,Shan J,Ma K,Xing F

    更新日期:2020-07-14 00:00:00

  • Co-occurrence Analysis of Microbial Taxa in the Atlantic Ocean Reveals High Connectivity in the Free-Living Bacterioplankton.

    abstract::We determined the taxonomic composition of the bacterioplankton of the epipelagic zone of the Atlantic Ocean along a latitudinal transect (51°S-47°N) using Illumina sequencing of the V5-V6 region of the 16S rRNA gene and inferred co-occurrence networks. Bacterioplankon community composition was distinct for Longhursti...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00649

    authors: Milici M,Deng ZL,Tomasch J,Decelle J,Wos-Oxley ML,Wang H,Jáuregui R,Plumeier I,Giebel HA,Badewien TH,Wurst M,Pieper DH,Simon M,Wagner-Döbler I

    更新日期:2016-05-06 00:00:00

  • New Bio-Indicators for Long Term Natural Attenuation of Monoaromatic Compounds in Deep Terrestrial Aquifers.

    abstract::Deep subsurface aquifers despite difficult access, represent important water resources and, at the same time, are key locations for subsurface engineering activities for the oil and gas industries, geothermal energy, and CO2 or energy storage. Formation water originating from a 760 m-deep geological gas storage aquife...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00122

    authors: Aüllo T,Berlendis S,Lascourrèges JF,Dessort D,Duclerc D,Saint-Laurent S,Schraauwers B,Mas J,Patriarche D,Boesinger C,Magot M,Ranchou-Peyruse A

    更新日期:2016-02-09 00:00:00

  • Exploration of the Regulatory Mechanism of Secondary Metabolism by Comparative Transcriptomics in Aspergillus flavus.

    abstract::Mycotoxins cause a huge threaten to agriculture, food safety, and human and animal life. Among them, aflatoxins (AFs) have always been considered the most potent carcinogens, and filamentous fungi from Aspergillus genus are their major producers, especially A. flavus. Although the biosynthesis path of these chemicals ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.01568

    authors: Yao G,Yue Y,Fu Y,Fang Z,Xu Z,Ma G,Wang S

    更新日期:2018-08-07 00:00:00