Abstract：
:Lead (Pb2+) is a major public health hazard for urban children, with profound and well-characterized developmental and behavioral implications across the lifespan. The ability of early Pb2+ exposure to induce epigenetic changes is well-established, suggesting that Pb2+-induced neurobehavioral deficits may be heritable across generations. Understanding the long-term and multigenerational repercussions of lead exposure is crucial for clarifying both the genotypic alterations behind these behavioral outcomes and the potential mechanism of heritability. To study this, zebrafish (Danio rerio) embryos (<2 h post fertilization; EK strain) were exposed for 24 h to waterborne Pb2+ at a concentration of 10 μM. This exposed F0 generation was raised to adulthood and spawned to produce the F1 generation, which was subsequently spawned to produce the F2 generation. Previous avoidance conditioning studies determined that a 10 μM Pb2+ dose resulted in learning impairments persisting through the F2 generation. RNA was extracted from control- and 10 μM Pb2+-lineage F2 brains, (n = 10 for each group), sequenced, and transcript expression was quantified utilizing Quant-Seq. 648 genes were differentially expressed in the brains of F2 lead-lineage fish versus F2 control-lineage fish. Pathway analysis revealed altered genes in processes including synaptic function and plasticity, neurogenesis, endocrine homeostasis, and epigenetic modification, all of which are implicated in lead-induced neurobehavioral deficits and/or their inheritance. These data will inform future investigations to elucidate the mechanism of adult-onset and transgenerational health effects of developmental lead exposure.
journal_name
Chemospherejournal_title
Chemosphereauthors
Meyer DN,Crofts EJ,Akemann C,Gurdziel K,Farr R,Baker BB,Weber D,Baker TRdoi
10.1016/j.chemosphere.2019.125527subject
Has Abstractpub_date
2020-04-01 00:00:00pages
125527eissn
0045-6535issn
1879-1298pii
S0045-6535(19)32767-5journal_volume
244pub_type
杂志文章相关文献
CHEMOSPHERE文献大全abstract：:An advanced oxidation treatment, UV/H2O2, was applied to an azo dye, Hispamin Black CA, widely used in the Peruvian textile industry. Rates of color removal and degradation of the dye have been evaluated. A strongly absorbing solution was completely decolorized after 35 min of treatment, and after 60 min an 82% reduct...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/s0045-6535(02)00117-0
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND:As one of the most common endocrine-disrupting chemicals (EDCs), bisphenol A (BPA) is a threat to aquatic ecosystems. Despite a rich literature addressing the adverse effects of BPA on various systems in fish models, the potential impact of parental BPA exposure on offspring pharyngeal cartilage development ...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2020.126537
更新日期：2020-06-01 00:00:00
abstract：:Nutrient enrichment in water bodies, and its detrimental consequences, are a well known and worldwide environmental problem. Agricultural activities are identified as an important source of diffuse losses of phosphate and nitrate because of the leaching out fertilizers from agricultural fields. This study encompasses ...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2020.129276
更新日期：2021-03-01 00:00:00
abstract：:The acid-base properties of humic acids (HAs) and fulvic acids (FAs) isolated from composted sewage sludge (CS), thermally-dried sewage sludge (TS), soils amended with either CS or TS at a rate of 80 t ha(-1)y(-1) for 3y and the corresponding unamended soil were investigated by use of potentiometric titrations. The no...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2007.02.063
更新日期：2007-09-01 00:00:00
abstract：:In situ bioassays provide valuable information about the environment and offer more realistic results than usual laboratory experiments. The aim of this study was to evaluate the quality of water bodies from the lower Paraná River basin, the second most important in South America, through analysis of physiochemical pa...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2021.129598
更新日期：2021-01-11 00:00:00
abstract：:Gestational Bisphenol A (BPA) exposure is associated with low birth weight. We hypothesized that the low birth weight is the consequence of reduced placental efficiency and a function of BPA-induced inflammatory, oxidative, lipotoxic, angiogenic, steroidal and fibrotic changes involving epigenetic alterations. Placent...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2019.125301
更新日期：2020-03-01 00:00:00
abstract：:Dichloromethane (DCM) is a toxic volatile compound which is found in the ground waters and wastewaters of the pharmaceutical, chemical, textile, metal-working and petroleum industries. DCM inhibits the growth of aquatic organisms, induces cancer in animals and is potentially carcinogenic for humans. This article aims ...
journal_title：Chemosphere
pub_type： 杂志文章,评审
doi：10.1016/j.chemosphere.2013.07.022
更新日期：2013-10-01 00:00:00
abstract：:This paper manifests the potential viability of soil as a cost-free catalyst in photo-Fenton-like processes for treating pharmaceuticals at large scale. Naturally available soil without any cost intensive modification was utilized as a catalyst to degrade pharmaceuticals, specifically ornidazole (ORZ) and ofloxacin (O...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2017.09.016
更新日期：2017-12-01 00:00:00
abstract：:This study investigates the effect of sodium nitroprussiate (SNP), an exogenous NO-donor, on the joint toxicity of binary mixtures of cetyltrimethylammonium chloride (CTAC) and fluoranthene (Flu) (CTAC/Flu), which are representatives for surfactants and polycyclic aromatic hydrocarbons (PAHs) respectively, in a unicel...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2013.07.012
更新日期：2014-02-01 00:00:00
abstract：:As a broad-spectrum preservative, toxic o-phenylphenol (OPP) was frequently detected in aquatic environments. In this study, N-doped mesoporous carbon was prepared by a hard template method using different nitrogen precursors and carbonization temperatures (i.e., 700, 850 and 1000 °C), and was used to activate peroxym...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2018.01.031
更新日期：2018-04-01 00:00:00
abstract：:Despite the rapid, widespread accumulation of polybrominated diphenylethers (PBDEs) in our surroundings, their environmental fate has been largely unknown. In the present study, most common congeners (BDE 47, 99, 100, 138, 153, 154, 183 and 209) were investigated for their dynamics in municipal sewage sludge under mes...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2009.12.057
更新日期：2010-03-01 00:00:00
abstract：:Recent studies have found elevated dioxin levels inside some former US military air bases in Vietnam, known as hotspots. The aim of the present study was to evaluate the association of dioxin exposure and steroid hormone in preschool children in Vietnam. In 2010, 2011, 52 primiparae mother-infant pairs in the hotspot ...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2019.124899
更新日期：2020-02-01 00:00:00
abstract：:The potential toxicity of hexabromocyclododecane (HBCD), its persistence in the environment, and its high bioaccumulation characteristics pose a need to remediate HBCD in the environment. Bacillus cereus and B. subtilis species complexes we isolated from Taiwan soil are capable of degrading HBCD. B. cereus can degrade...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2021.129544
更新日期：2021-01-05 00:00:00
abstract：:Evaluating heavy metal pollution status and ecological risk in river sediments is a complex task, requiring consideration of contaminant pollution levels, as well as effects of biological processes within the river system. There are currently no simple or low-cost approaches to heavy metal assessment in river sediment...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2017.07.059
更新日期：2017-10-01 00:00:00
abstract：:Polyfluoroalkyl phosphate surfactants (PAPS) are used on food contact paper to impart oil/grease resistance and have been shown to be able to migrate into food. The biotransformation of the congeners belonging to this class of compounds is considered to be a potential source of perfluorinated carboxylic acids (PFCAs)....
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2013.02.011
更新日期：2013-05-01 00:00:00
abstract：:Pot-culture experiments were conducted to investigate the potential of microorganism-saponin assisted phytoremediation of cadmium (Cd) and benzo(a)pyrene (B[a]P) co-contaminated soil using Cd-hyperaccumulator Sedum alfredii. Results showed that B[a]P-degrading bacterium (Ochrobactrum intermedium B[a]P-16) inoculation ...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2019.125547
更新日期：2020-04-01 00:00:00
abstract：:While surface morphology is the key parameter affecting membrane performance, its exact roles on membrane fouling have not well unveiled. In this study, effects of membrane surface roughness on fouling caused by alginate adhesion were investigated by thermodynamic techniques of the extended Derjaguin-Landau-Verwey-Ove...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2019.05.262
更新日期：2019-10-01 00:00:00
abstract：:Rooftops are both a source of and a pathway for contaminated runoff in urban environments. To investigate the importance of particle-associated contamination in rooftop runoff, particles washed from asphalt shingle and galvanized metal roofs at sites 12 and 102 m from a major expressway were analyzed for major and tra...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/S0045-6535(03)00454-5
更新日期：2003-09-01 00:00:00
abstract：:Passive samplers are used to measure dissolved nonionic organic contaminants (NOCs) in environmental media. More recently, reverse polyethylene samplers (RePES) have been used with spiked sediments to recreate interstitial water exposure concentrations and observed toxicity. In the present study, RePES were used with ...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2010.12.076
更新日期：2011-04-01 00:00:00
abstract：:Food contamination with cadmium (Cd) is a serious health threat to humans worldwide and Cd accumulation by rice is a major source of Cd entrance to the food chain. Silicon (Si) application decreases the Cd content in rice but the timing of Si application may need further investigation. The present study investigated t...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2019.03.182
更新日期：2019-07-01 00:00:00
abstract：:Polychlorinated dibenzo-p-dioxins (PCDDs) are among the most persistent organic pollutants. Although the total input of PCDDs into the environment has decreased substantially over the past four decades, their input via non-point sources is still increasing, especially in estuarine metropolitan areas. Here we report on...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2016.10.082
更新日期：2017-02-01 00:00:00
abstract：:Hydrogen titanate (H-titanate) nanowires were prepared via a hydrothermal reaction of TiO2 powders (P25) in KOH solutions and then calcined at various temperatures. The phase structure, crystallite size, morphology, specific surface area, and pore structures of the calcined H-titanate nanowires at various temperatures...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2006.09.080
更新日期：2007-02-01 00:00:00
abstract：:Seven typical synthetic musks (SMs) in the samples from the surface water, sediment and fish of the Haihe River were measured. The SM concentrations in the sediment and surface water of the Haihe River were significantly lower than those in the Dagu Drainage River and Chentaizi Drainage River (p<0.05). Along the flow ...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2011.09.002
更新日期：2011-09-01 00:00:00
abstract：:Levofloxacin is a large spectrum antibiotic from fluoroquinolones family, widely used and detected in natural waters. Here, this drug was degraded by a novel heterogeneous electro-Fenton (EF) process, so-called EF-pyrite, in which pyrite powder in suspension regulates the solution pH to 3.0 and supplies 0.2mM Fe(2+) a...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2015.08.003
更新日期：2015-12-01 00:00:00
abstract：:Heavy metal removal from water has been approached by using different technologies. Phytotechnologies, with an increasing development during the last two decades, involve using plants for metal removal. Three autochthonous floating macrophytes, common in pampean shallow lakes (Argentina), Pista stratiotes, Spirodela i...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2004.07.024
更新日期：2004-11-01 00:00:00
abstract：:A simple Ca(OH)(2)-based replacement-precipitation process was applied to the removal of EDTA-chelated copper from wastewaters. The effect of initial pH of the solution, molar ratio of Ca(2+) to Cu(II), the presence of CO(2) on the removal efficiency was investigated. The experimental results showed that the Ca(OH)(2)...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2008.06.010
更新日期：2008-10-01 00:00:00
abstract：:Nickel, massively used in plating industry but detrimental to ecosystem, tends to form stable complexes with organic additives in industrial effluents. Currently, most of the available processes aim at water decontamination from free toxic metal ions and thus, could not effectively remove nickel-carboxyl complexes fro...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2019.06.128
更新日期：2019-11-01 00:00:00
abstract：:In this study, low-temperature catalytic NO oxidation with H2O2 over Na- and H-exchanged Y and ZSM-5 zeolites was investigated at 140 °C which is the average exhaust temperature of coal-fired power plant. Fast catalytic NO oxidation rates were observed over H-zeolites, and catalytic activity was proportional to the am...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2020.126561
更新日期：2020-07-01 00:00:00
abstract：:In this study, an evaluation of physico-chemical properties, cytotoxicity and genotoxicity of candle soot derived carbon nanoparticles (CNPs) was carried out. Several physico-chemical characterizations including scanning electron microscopy, transmission electron microscope, Brunauer-Emmet-Teller surface area and pore...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2018.09.112
更新日期：2019-01-01 00:00:00
abstract：:The presence of the radionuclide (99)Tc in the marine environment is of concern to environmental scientists because of its conservative nature and high concentration factor in commercially valuable species. The brown seaweed Ascophyllum nodosum (Linnaeus) Le Jolis was used to biomonitor the spatial distribution of (99...
journal_title：Chemosphere
pub_type： 杂志文章
doi：10.1016/j.chemosphere.2006.05.014
更新日期：2006-12-01 00:00:00
