Emergence of West Nile virus lineage 2 in Europe: Characteristics of the first seven cases of West Nile neuroinvasive disease in horses in Austria.

Abstract:

:We report details of the first seven equine cases of confirmed West Nile neuroinvasive disease in Austria. The cases presented during summer and autumn of 2016 (n = 2), 2017 (n = 3) and 2018 (n = 2). All horses showed gait abnormalities and 6 of 7 horses exhibited fasciculations and/or tremors, and we provide video recordings of these. Three horses also showed cranial nerve involvement. Following rapid improvement, three horses were discharged. Four horses were euthanized due to the severity of clinical signs and subjected to neuropathological examination. West Nile virus (WNV) lineage 2 nucleic acid was detected in 5 of 7 horses, and WNV-specific neutralizing antibodies in all 7 horses. In addition, serologic evidence of WNV infection was found in two out of fourteen in-contact horses. Horses may be considered a sentinel species for human WNV infections, integrating human and veterinary medicine and thus contributing to the one health concept.

journal_name

Transbound Emerg Dis

authors

de Heus P,Kolodziejek J,Camp JV,Dimmel K,Bagó Z,Hubálek Z,van den Hoven R,Cavalleri JV,Nowotny N

doi

10.1111/tbed.13452

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

1189-1197

issue

3

eissn

1865-1674

issn

1865-1682

journal_volume

67

pub_type

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