当前位置： SCI文献检索 > JOURNAL OF COGNITIVE NEUROSCIENCE期刊下所有文献 > Phonological Processing in Primary Progressive Aphasia.

Phonological Processing in Primary Progressive Aphasia.

Abstract：

:Individuals with primary progressive aphasia (PPA) show selective breakdown in regions within the proposed dorsal (articulatory-phonological) and ventral (lexical-semantic) pathways involved in language processing. Phonological STM impairment, which has been attributed to selective damage to dorsal pathway structures, is considered to be a distinctive feature of the logopenic variant of PPA. By contrast, phonological abilities are considered to be relatively spared in the semantic variant and are largely unexplored in the nonfluent/agrammatic variant. Comprehensive assessment of phonological ability in the three variants of PPA has not been undertaken. We investigated phonological processing skills in a group of participants with PPA as well as healthy controls, with the goal of identifying whether patterns of performance support the dorsal versus ventral functional-anatomical framework and to discern whether phonological ability differs among PPA subtypes. We also explored the neural bases of phonological performance using voxel-based morphometry. Phonological performance was impaired in patients with damage to dorsal pathway structures (nonfluent/agrammatic and logopenic variants), with logopenic participants demonstrating particular difficulty on tasks involving nonwords. Binary logistic regression revealed that select phonological tasks predicted diagnostic group membership in the less fluent variants of PPA with a high degree of accuracy, particularly in conjunction with a motor speech measure. Brain-behavior correlations indicated a significant association between the integrity of gray matter in frontal and temporoparietal regions of the left hemisphere and phonological skill. Findings confirm the critical role of dorsal stream structures in phonological processing and demonstrate unique patterns of impaired phonological processing in logopenic and nonfluent/agrammatic variants of PPA.

journal_name

J Cogn Neurosci

journal_title

Journal of cognitive neuroscience

authors

Henry ML,Wilson SM,Babiak MC,Mandelli ML,Beeson PM,Miller ZA,Gorno-Tempini ML

doi

10.1162/jocn_a_00901

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

210-22

issue

2

eissn

0898-929X

issn

1530-8898

pii

10.1162/jocn_a_00901

journal_volume

28

pub_type

杂志文章

相关文献

JOURNAL OF COGNITIVE NEUROSCIENCE文献大全
  • Development of Network Synchronization Predicts Language Abilities.

    abstract：:Synchronization of oscillations among brain areas is understood to mediate network communication supporting cognition, perception, and language. How task-dependent synchronization during word production develops throughout childhood and adolescence, as well as how such network coherence is related to the development o...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_00879

    authors： Doesburg SM,Tingling K,MacDonald MJ,Pang EW

    更新日期：2016-01-01 00:00:00

  • Medial Orbitofrontal Cortex, Dorsolateral Prefrontal Cortex, and Hippocampus Differentially Represent the Event Saliency.

    abstract：:Two primary functions attributed to the hippocampus and prefrontal cortex (PFC) network are retaining the temporal and spatial associations of events and detecting deviant events. It is unclear, however, how these two functions converge into one mechanism. Here, we tested whether increased activity with perceiving sal...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_01392

    authors： Jafarpour A,Griffin S,Lin JJ,Knight RT

    更新日期：2019-06-01 00:00:00

  • Attention extracts signal in external noise: a BOLD fMRI study.

    abstract：:On the basis of results from behavioral studies that spatial attention improves the exclusion of external noise in the target region, we predicted that attending to a spatial region would reduce the impact of external noise on the BOLD response in corresponding cortical areas, seen as reduced BOLD responses in conditi...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn.2010.21511

    authors： Lu ZL,Li X,Tjan BS,Dosher BA,Chu W

    更新日期：2011-05-01 00:00:00

  • The neural correlates of object familiarity and domain specificity in the human visual cortex: an FMRI study.

    abstract：:Ventral occipito-temporal cortex is known to play a major role in visual object recognition. Still unknown is whether object familiarity and semantic domain are critical factors in its functional organization. Most models assume a functional locus where exemplars of familiar categories are represented: the structural ...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn.2011.21629

    authors： Zannino GD,Barban F,Macaluso E,Caltagirone C,Carlesimo GA

    更新日期：2011-10-01 00:00:00

  • Too many trees to see the forest: performance, event-related potential, and functional magnetic resonance imaging manifestations of integrative congenital prosopagnosia.

    abstract：:Neuropsychological, event-related potential (ERP), and functional magnetic resonance imaging (fMRI) methods were combined to provide a comprehensive description of performance and neurobiological profiles for K.W., a case of congenital prosopagnosia. We demonstrate that K.W.'s visual perception is characterized by alm...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn.2007.19.1.132

    authors： Bentin S,Degutis JM,D'Esposito M,Robertson LC

    更新日期：2007-01-01 00:00:00

  • Temporal dynamics of the attentional spotlight: neuronal correlates of attentional capture and inhibition of return in early visual cortex.

    abstract：:A stimulus that suddenly appears in the corner of the eye inevitably captures our attention, and this in turn leads to faster detection of a second stimulus presented at the same position shortly thereafter. After about 250 msec, however, this effect reverses and the second stimulus is detected faster when it appears ...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn.2007.19.4.587

    authors： Müller NG,Kleinschmidt A

    更新日期：2007-04-01 00:00:00

  • Encoding of Predictable and Unpredictable Stimuli by Inferior Temporal Cortical Neurons.

    abstract：:Animals and humans learn statistical regularities that are embedded in sequences of stimuli. The neural mechanisms of such statistical learning are still poorly understood. Previous work in macaque inferior temporal (IT) cortex demonstrated suppressed spiking activity to visual images of a sequence in which the stimul...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_01135

    authors： Kumar S,Kaposvari P,Vogels R

    更新日期：2017-08-01 00:00:00

  • Top-Down Control of Alpha Phase Adjustment in Anticipation of Temporally Predictable Visual Stimuli.

    abstract：:Alpha oscillations (8-14 Hz) are proposed to represent an active mechanism of functional inhibition of neuronal processing. Specifically, alpha oscillations are associated with pulses of inhibition repeating every ∼100 msec. Whether alpha phase, similar to alpha power, is under top-down control remains unclear. Moreov...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_01280

    authors： Solís-Vivanco R,Jensen O,Bonnefond M

    更新日期：2018-08-01 00:00:00

  • Planning Complexity Registers as a Cost in Metacontrol.

    abstract：:Decision-making algorithms face a basic tradeoff between accuracy and effort (i.e., computational demands). It is widely agreed that humans can choose between multiple decision-making processes that embody different solutions to this tradeoff: Some are computationally cheap but inaccurate, whereas others are computati...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_01263

    authors： Kool W,Gershman SJ,Cushman FA

    更新日期：2018-10-01 00:00:00

  • Rejection sensitivity polarizes striatal-medial prefrontal activity when anticipating social feedback.

    abstract：:As a social species, humans are acutely aware of cues that signal inclusionary status. This study characterizes behavioral and neural responses when individuals anticipate social feedback. Across two fMRI studies, participants (n = 42) made social judgments about supposed peers and then received feedback from those in...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_00446

    authors： Powers KE,Somerville LH,Kelley WM,Heatherton TF

    更新日期：2013-11-01 00:00:00

  • Short- and long-range neural synchrony in grapheme-color synesthesia.

    abstract：:Grapheme-color synesthesia is a perceptual phenomenon where single graphemes (e.g., the letter "E") induce simultaneous sensations of colors (e.g., the color green) that were not objectively shown. Current models disagree as to whether the color sensations arise from increased short-range connectivity between anatomic...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_00374

    authors： Volberg G,Karmann A,Birkner S,Greenlee MW

    更新日期：2013-07-01 00:00:00

  • Rules rule! Brain activity dissociates the representations of stimulus contingencies with varying levels of complexity.

    abstract：:The significance of stimuli is linked not only to their nature but also to the sequential structure in which they are embedded, which gives rise to contingency rules. Humans have an extraordinary ability to extract and exploit these rules, as exemplified by the role of grammar and syntax in language. To study the brai...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_00229

    authors： Tse CY,Low KA,Fabiani M,Gratton G

    更新日期：2012-09-01 00:00:00

  • Perceptual fusion tendency of speech sounds.

    abstract：:To discriminate and to recognize sound sources in a noisy, reverberant environment, listeners need to perceptually integrate the direct wave with the reflections of each sound source. It has been confirmed that perceptual fusion between direct and reflected waves of a speech sound helps listeners recognize this speech...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn.2010.21470

    authors： Huang Y,Li J,Zou X,Qu T,Wu X,Mao L,Wu Y,Li L

    更新日期：2011-04-01 00:00:00

  • Decoding and Reconstructing the Focus of Spatial Attention from the Topography of Alpha-band Oscillations.

    abstract：:Many aspects of perception and cognition are supported by activity in neural populations that are tuned to different stimulus features (e.g., orientation, spatial location, color). Goal-directed behavior, such as sustained attention, requires a mechanism for the selective prioritization of contextually appropriate rep...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_00955

    authors： Samaha J,Sprague TC,Postle BR

    更新日期：2016-08-01 00:00:00

  • Attention and sensory gain control: a peripheral visual process?

    abstract：:Attention-related sensory gain control in human extrastriate cortex is believed to improve the acuity of visual perception. Yet given wide variance in the spatial resolution of vision across the retina, it remains unclear whether sensory gain operates homogenously between foveal and nonfoveal retinotopic locations. To...

    journal_title：Journal of cognitive neuroscience

    pub_type： 临床试验,杂志文章

    doi：10.1162/089892905775008715

    authors： Handy TC,Khoe W

    更新日期：2005-12-01 00:00:00

  • Predictive Pre-updating and Working Memory Capacity: Evidence from Event-related Potentials.

    abstract：:It was recently proposed that lexical prediction in sentence context encompasses two qualitatively distinct prediction mechanisms: "pre-activation," namely, activating representations stored in long-term memory, and "pre-updating," namely, updating the sentence's representation, built online in working memory (WM), to...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_01322

    authors： Ness T,Meltzer-Asscher A

    更新日期：2018-12-01 00:00:00

  • Specificity of the effect of a nicotinic receptor polymorphism on individual differences in visuospatial attention.

    abstract：:Cortical neurotransmitter availability is known to exert domain-specific effects on cognitive performance. Hence, normal variation in genes with a role in neurotransmission may also have specific effects on cognition. We tested this hypothesis by examining associations between polymorphisms in genes affecting choliner...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/089892905774597281

    authors： Greenwood PM,Fossella JA,Parasuraman R

    更新日期：2005-10-01 00:00:00

  • Neural Representations for Sensorimotor Control. III. Learning a Body-Centered Representation of a Three-Dimensional Target Position.

    abstract：:Abstract A neural model is described of how the brain may autonomously learn a body-centered representation of a three-dimensional (3-D) target position by combining information about retinal target position, eye position, and head position in real time. Such a body-centered spatial representation enables accurate mov...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn.1994.6.4.341

    authors： Guenther FH,Bullock D,Greve D,Grossberg S

    更新日期：1994-10-01 00:00:00

  • Task-relevant output signals are sent from monkey dorsolateral prefrontal cortex to the superior colliculus during a visuospatial working memory task.

    abstract：:Visuospatial working memory is one of the most extensively investigated functions of the dorsolateral prefrontal cortex (DLPFC). Theories of prefrontal cortical function have suggested that this area exerts cognitive control by modulating the activity of structures to which it is connected. Here, we used the oculomoto...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn.2009.21067

    authors： Johnston K,Everling S

    更新日期：2009-05-01 00:00:00

  • Division of labor between lateral and ventral extrastriate representations of faces, bodies, and objects.

    abstract：:The occipito-temporal cortex is strongly implicated in carrying out the high-level computations associated with vision. In human neuroimaging studies, focal regions are consistently found within this broad region that respond strongly and selectively to faces, bodies, or objects. A notable feature of these selective r...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章,评审

    doi：10.1162/jocn_a_00091

    authors： Taylor JC,Downing PE

    更新日期：2011-12-01 00:00:00

  • Images of illusory motion in primary visual cortex.

    abstract：:Illusory motion can be generated by successively flashing a stationary visual stimulus in two spatial locations separated by several degrees of visual angle. In appropriate conditions, the apparent motion is indistinguishable from real motion: The observer experiences a luminous object traversing a continuous path fro...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn.2006.18.7.1174

    authors： Larsen A,Madsen KH,Lund TE,Bundesen C

    更新日期：2006-07-01 00:00:00

  • Syntactically based sentence processing classes: evidence from event-related brain potentials.

    abstract：:Theoretical considerations and diverse empirical data from clinical, psycholinguistic, and developmental studies suggest that language comprehension processes are decomposable into separate subsystems, including distinct systems for semantic and grammatical processing. Here we report that event-related potentials (ERP...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn.1991.3.2.151

    authors： Neville H,Nicol JL,Barss A,Forster KI,Garrett MF

    更新日期：1991-04-01 00:00:00

  • Auditory imagery modulates frequency-specific areas in the human auditory cortex.

    abstract：:Neural responses in early sensory areas are influenced by top-down processing. In the visual system, early visual areas have been shown to actively participate in top-down processing based on their topographical properties. Although it has been suggested that the auditory cortex is involved in top-down control, functi...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_00280

    authors： Oh J,Kwon JH,Yang PS,Jeong J

    更新日期：2013-02-01 00:00:00

  • Self-enhancement influences medial frontal cortex alpha power to social rejection feedback.

    abstract：:Although previous research has demonstrated that individuals are motivated to self-enhance, the neurocognitive mechanisms and temporal dynamics of self-enhancement are poorly understood. The current research examined whether self-enhancing motivations affect the perceptual processing of social feedback. Participants w...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_00645

    authors： Leitner JB,Hehman E,Jones JM,Forbes CE

    更新日期：2014-10-01 00:00:00

  • Declarative and nondeclarative memory: multiple brain systems supporting learning and memory.

    abstract：:Abstract The topic of multiple forms of memory is considered from a biological point of view. Fact-and-event (declarative, explicit) memory is contrasted with a collection of non conscious (non-declarative, implicit) memory abilities including skills and habits, priming, and simple conditioning. Recent evidence is rev...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn.1992.4.3.232

    authors： Squire LR

    更新日期：1992-07-01 00:00:00

  • Neural precursors of delayed insight.

    abstract：:The solution of a problem left unresolved in the evening can sometimes pop into mind as a sudden insight after a night of sleep in the following morning. Although favorable effects of sleep on insightful behavior have been experimentally confirmed, the neural mechanisms determining this delayed insight remain unknown....

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn.2010.21550

    authors： Darsaud A,Wagner U,Balteau E,Desseilles M,Sterpenich V,Vandewalle G,Albouy G,Dang-Vu T,Collette F,Boly M,Schabus M,Degueldre C,Luxen A,Maquet P

    更新日期：2011-08-01 00:00:00

  • Temporal Tuning of Word- and Face-selective Cortex.

    abstract：:Sensitivity to temporal change places fundamental limits on object processing in the visual system. An emerging consensus from the behavioral and neuroimaging literature suggests that temporal resolution differs substantially for stimuli of different complexity and for brain areas at different levels of the cortical h...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_01002

    authors： Yeatman JD,Norcia AM

    更新日期：2016-11-01 00:00:00

  • Trade-off between capacity and precision in visuospatial working memory.

    abstract：:Limitations in the performance of working memory (WM) tasks have been characterized in terms of the number of items retained (capacity) and in terms of the precision with which the information is retained. The neural mechanisms behind these limitations are still unclear. Here we used a biological constrained computati...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn_a_00485

    authors： Roggeman C,Klingberg T,Feenstra HE,Compte A,Almeida R

    更新日期：2014-02-01 00:00:00

  • ERP evidence for rapid hedonic evaluation of logos.

    abstract：:We know that human neurocognitive systems rapidly and implicitly evaluate emotionally charged stimuli. But what about more everyday, frequently encountered kinds of objects, such as computer desktop icons and business logos? Do we rapidly and implicitly evaluate these more prosaic visual images, attitude objects that ...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn.2008.21180

    authors： Handy TC,Smilek D,Geiger L,Liu C,Schooler JW

    更新日期：2010-01-01 00:00:00

  • Eye movements and orienting of attention in patients with visual neglect.

    abstract：:The aim of the present study was to assess the relationship between overt and covert orienting of attention in visual neglect patients with parietal and fronto-parietal lesions. Two stimuli were presented at eccentricities of 8° or 20° to the left (LVF) or right (RVF) visual fields and the patient was required to main...

    journal_title：Journal of cognitive neuroscience

    pub_type： 杂志文章

    doi：10.1162/jocn.1997.9.1.67

    authors： Làdavas E,Zeloni G,Zaccara G,Gangemi P

    更新日期：1997-01-01 00:00:00