Too many trees to see the forest: performance, event-related potential, and functional magnetic resonance imaging manifestations of integrative congenital prosopagnosia.

Abstract:

:Neuropsychological, event-related potential (ERP), and functional magnetic resonance imaging (fMRI) methods were combined to provide a comprehensive description of performance and neurobiological profiles for K.W., a case of congenital prosopagnosia. We demonstrate that K.W.'s visual perception is characterized by almost unprecedented inability to identify faces, a large bias toward local features, and an extreme deficit in global/configural processing that is not confined to faces. This pattern could be appropriately labeled congenital integrative prosopagnosia, and accounts for some, albeit not all, cases of face recognition impairments without identifiable brain lesions. Absence of face selectivity is evident in both biological markers of face processing, fMRI (the fusiform face area [FFA]), and ERPs (N170). Nevertheless, these two neural signatures probably manifest different perceptual mechanisms. Whereas the N170 is triggered by the occurrence of physiognomic stimuli in the visual field, the deficient face-selective fMRI activation in the caudal brain correlates with the severity of global processing deficits. This correlation suggests that the FFA might be associated with global/configural computation, a crucial part of face identification.

journal_name

J Cogn Neurosci

authors

Bentin S,Degutis JM,D'Esposito M,Robertson LC

doi

10.1162/jocn.2007.19.1.132

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

132-46

issue

1

eissn

0898-929X

issn

1530-8898

journal_volume

19

pub_type

杂志文章
  • The neural correlates of cognitive control: successful remembering and intentional forgetting.

    abstract::The ability to control how we process information by remembering that which is important and forgetting that which is irrelevant is essential to maintain accurate, up-to-date memories. As such, memory success is predicated on both successful intentional encoding and successful intentional forgetting. The current study...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn_a_00310

    authors: Rizio AA,Dennis NA

    更新日期:2013-02-01 00:00:00

  • Eye movements and orienting of attention in patients with visual neglect.

    abstract::The aim of the present study was to assess the relationship between overt and covert orienting of attention in visual neglect patients with parietal and fronto-parietal lesions. Two stimuli were presented at eccentricities of 8° or 20° to the left (LVF) or right (RVF) visual fields and the patient was required to main...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn.1997.9.1.67

    authors: Làdavas E,Zeloni G,Zaccara G,Gangemi P

    更新日期:1997-01-01 00:00:00

  • Feature-selective Attention in Frontoparietal Cortex: Multivoxel Codes Adjust to Prioritize Task-relevant Information.

    abstract::Human cognition is characterized by astounding flexibility, enabling us to select appropriate information according to the objectives of our current task. A circuit of frontal and parietal brain regions, often referred to as the frontoparietal attention network or multiple-demand (MD) regions, are believed to play a f...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn_a_01039

    authors: Jackson J,Rich AN,Williams MA,Woolgar A

    更新日期:2017-02-01 00:00:00

  • Limits of event-related potential differences in tracking object processing speed.

    abstract::We report results from two experiments in which subjects had to categorize briefly presented upright or inverted natural scenes. In the first experiment, subjects decided whether images contained animals or human faces presented at different scales. Behavioral results showed virtually identical processing speed betwee...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn.2007.19.8.1241

    authors: Rousselet GA,Macé MJ,Thorpe SJ,Fabre-Thorpe M

    更新日期:2007-08-01 00:00:00

  • Cross-modal interactions between audition, touch, and vision in endogenous spatial attention: ERP evidence on preparatory states and sensory modulations.

    abstract::Recent behavioral and event-related brain potential (ERP) studies have revealed cross-modal interactions in endogenous spatial attention between vision and audition, plus vision and touch. The present ERP study investigated whether these interactions reflect supramodal attentional control mechanisms, and whether simil...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/089892902317236885

    authors: Eimer M,van Velzen J,Driver J

    更新日期:2002-02-15 00:00:00

  • Combining Multiple Functional Connectivity Methods to Improve Causal Inferences.

    abstract::Cognition and behavior emerge from brain network interactions, suggesting that causal interactions should be central to the study of brain function. Yet, approaches that characterize relationships among neural time series-functional connectivity (FC) methods-are dominated by methods that assess bivariate statistical a...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn_a_01580

    authors: Sanchez-Romero R,Cole MW

    更新日期:2021-02-01 00:00:00

  • Transcranial Cerebellar Direct Current Stimulation Enhances Verb Generation but Not Verb Naming in Poststroke Aphasia.

    abstract::Although the role of the cerebellum in motor function is well recognized, its involvement in the lexical domain remains to be further elucidated. Indeed, it has not yet been clarified whether the cerebellum is a language structure per se or whether it contributes to language processing when other cognitive components ...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1162/jocn_a_01201

    authors: Marangolo P,Fiori V,Caltagirone C,Pisano F,Priori A

    更新日期:2018-02-01 00:00:00

  • The context of uncertainty modulates the subcortical response to predictability.

    abstract::Implicit motor learning tasks typically involve comparisons of subject responses during a sequence versus a random condition. In neuroimaging, brain regions that are correlated with a sequence are described, but the temporal relationship of sequence versus nonsequence conditions is often not explored. We present a fun...

    journal_title:Journal of cognitive neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1162/089892901753165881

    authors: Bischoff-Grethe A,Martin M,Mao H,Berns GS

    更新日期:2001-10-01 00:00:00

  • Rule Perseveration during Task-Switching in Brain Tumor: A Severe Form of Task-Setting Impairment.

    abstract::It has been proposed that at least two distinct processes are engaged during task-switching: reconfiguration of the currently relevant task-set and interference resolution arising from the competing task-set. Whereas in healthy individuals the two are difficult to disentangle, their disruption is thought to cause diff...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn_a_01674

    authors: Arbula S,Della Puppa A,De Pellegrin S,Denaro L,D'Avella D,Semenza C,Corbetta M,Vallesi A

    更新日期:2021-01-21 00:00:00

  • The role of Broca's area in sentence comprehension.

    abstract::The role of Broca's area in sentence processing has been debated for the last 30 years. A central and still unresolved issue is whether Broca's area plays a specific role in some aspect of syntactic processing (e.g., syntactic movement, hierarchical structure building) or whether it serves a more general function on w...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章,评审

    doi:10.1162/jocn.2010.21530

    authors: Rogalsky C,Hickok G

    更新日期:2011-07-01 00:00:00

  • The face of negative affect: trial-by-trial corrugator responses to negative pictures are positively associated with amygdala and negatively associated with ventromedial prefrontal cortex activity.

    abstract::The ability to simultaneously acquire objective physiological measures of emotion concurrent with fMRI holds the promise to enhance our understanding of the biological bases of affect and thus improve our knowledge of the neural circuitry underlying psychiatric disorders. However, the vast majority of neuroimaging stu...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn_a_00622

    authors: Heller AS,Lapate RC,Mayer KE,Davidson RJ

    更新日期:2014-09-01 00:00:00

  • Computer-based training of stimulus detection improves color and simple pattern recognition in the defective field of hemianopic subjects.

    abstract::In a previously conducted randomized placebo-controlled trial, we were able to demonstrate significant visual field enlargement induced by restitution therapy in patients with cerebral lesions [Kasten, E., Wuest, S., Behrens-Bamann, W., & Sabel, B. A. (1998c). Computer-based training for the treatment of partial blind...

    journal_title:Journal of cognitive neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1162/08989290051137530

    authors: Kasten E,Poggel DA,Sabel BA

    更新日期:2000-11-01 00:00:00

  • Behavioral and electrophysiological evidence of a right hemisphere bias for the influence of negative emotion on higher cognition.

    abstract::We examined how responses to aversive pictures affected performance and stimulus-locked event-related potentials (ERPs) recorded during a demanding cognitive task. Numeric Stroop stimuli were brief ly presented to either left or right visual hemifield (LVF and RVF, respectively) after a centrally presented aversive or...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/0898929053279504

    authors: Simon-Thomas ER,Role KO,Knight RT

    更新日期:2005-03-01 00:00:00

  • Large-scale Functional Integration, Rather than Functional Dissociation along Dorsal and Ventral Streams, Underlies Visual Perception and Action.

    abstract::Visual dual-stream theory posits that two distinct neural pathways of specific functional significance originate from primary visual areas and reach the inferior temporal (ventral) and posterior parietal areas (dorsal). However, there are several unresolved questions concerning the fundamental aspects of this theory. ...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn_a_01527

    authors: Ray D,Hajare N,Roy D,Banerjee A

    更新日期:2020-05-01 00:00:00

  • Functionally Separable Font-invariant and Font-sensitive Neural Populations in Occipitotemporal Cortex.

    abstract::Reading relies on the rapid visual recognition of words viewed in a wide variety of fonts. We used fMRI to identify neural populations showing reduced fMRI responses to repeated words displayed in different fonts ("font-invariant" repetition suppression). We also identified neural populations showing greater fMRI resp...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn_a_01408

    authors: Zhou Z,Vilis T,Strother L

    更新日期:2019-07-01 00:00:00

  • Cerebellar transcranial direct current stimulation impairs the practice-dependent proficiency increase in working memory.

    abstract::How the cerebellum is involved in the practice and proficiency of non-motor functions is still unclear. We tested whether transcranial direct current stimulation (tDCS) over the cerebellum (cerebellar tDCS) induces after-effects on the practice-dependent increase in the proficiency of a working memory (WM) task (Stern...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn.2008.20112

    authors: Ferrucci R,Marceglia S,Vergari M,Cogiamanian F,Mrakic-Sposta S,Mameli F,Zago S,Barbieri S,Priori A

    更新日期:2008-09-01 00:00:00

  • Temporal Expectations Prepare Visual Working Memory for Behavior.

    abstract::Working memory enables us to retain past sensations in service of anticipated task demands. How we prepare for anticipated task demands during working memory retention remains poorly understood. Here, we focused on the role of time-asking how temporal expectations help prepare for ensuing memory-guided behavior. We ma...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn_a_01626

    authors: Jin W,Nobre AC,van Ede F

    更新日期:2020-12-01 00:00:00

  • Spatial attention determines the nature of nonverbal number representation.

    abstract::Coordinated studies of adults, infants, and nonhuman animals provide evidence for two systems of nonverbal number representation: a "parallel individuation" system that represents individual items and a "numerical magnitude" system that represents the approximate cardinal value of a group. However, there is considerab...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn.2010.21581

    authors: Hyde DC,Wood JN

    更新日期:2011-09-01 00:00:00

  • A model of saccade initiation based on the competitive integration of exogenous and endogenous signals in the superior colliculus.

    abstract::Significant advances in cognitive neuroscience can be achieved by combining techniques used to measure behavior and brain activity with neural modeling. Here we apply this approach to the initiation of rapid eye movements (saccades), which are used to redirect the visual axis to targets of interest. It is well known t...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/089892901564306

    authors: Trappenberg TP,Dorris MC,Munoz DP,Klein RM

    更新日期:2001-02-15 00:00:00

  • Prescription Stimulants' Effects on Healthy Inhibitory Control, Working Memory, and Episodic Memory: A Meta-analysis.

    abstract::The use of prescription stimulants to enhance healthy cognition has significant social, ethical, and public health implications. The large number of enhancement users across various ages and occupations emphasizes the importance of examining these drugs' efficacy in a nonclinical sample. The present meta-analysis was ...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章,meta分析

    doi:10.1162/jocn_a_00776

    authors: Ilieva IP,Hook CJ,Farah MJ

    更新日期:2015-06-01 00:00:00

  • Processing graded feedback: electrophysiological correlates of learning from small and large errors.

    abstract::Feedback processing is important for learning and therefore may affect the consolidation of skills. Considerable research demonstrates electrophysiological differences between correct and incorrect feedback, but how we learn from small versus large errors is usually overlooked. This study investigated electrophysiolog...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1162/jocn_a_00543

    authors: Luft CD,Takase E,Bhattacharya J

    更新日期:2014-05-01 00:00:00

  • Predictive Pre-updating and Working Memory Capacity: Evidence from Event-related Potentials.

    abstract::It was recently proposed that lexical prediction in sentence context encompasses two qualitatively distinct prediction mechanisms: "pre-activation," namely, activating representations stored in long-term memory, and "pre-updating," namely, updating the sentence's representation, built online in working memory (WM), to...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn_a_01322

    authors: Ness T,Meltzer-Asscher A

    更新日期:2018-12-01 00:00:00

  • A model of prefrontal cortical mechanisms for goal-directed behavior.

    abstract::Many behavioral tasks require goal-directed actions to obtain delayed reward. The prefrontal cortex appears to mediate many aspects of goal-directed decision making. This article presents a model of prefrontal cortex function emphasizing the influence of goal-related activity on the choice of the next motor output. Th...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/0898929054475190

    authors: Hasselmo ME

    更新日期:2005-07-01 00:00:00

  • Developmental trajectory of face processing revealed by integrative dynamics.

    abstract::Given their unique connectivity, a primary function of brain networks must be to transfer and integrate information. Therefore, the way in which information is integrated by individual nodes of the network may be an informative aspect of cognitive processing. Here we present a method inspired by telecommunications res...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn_a_00640

    authors: Mišić B,Mills T,Vakorin VA,Taylor MJ,McIntosh AR

    更新日期:2014-10-01 00:00:00

  • The effects of frontal lobe lesions on goal achievement in the water jug task.

    abstract::Patients with prefrontal cortex lesions are impaired on a variety of planning and problem-solving tasks. We examined the problem-solving performance of 27 patients with focal frontal lobe damage on the Water Jug task. The Water Jug task has never been used to assess problem-solving ability in neurologically impaired p...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/089892901753294419

    authors: Colvin MK,Dunbar K,Grafman J

    更新日期:2001-11-15 00:00:00

  • Electrophysiological evidence of semantic interference in visual search.

    abstract::Visual evoked responses were monitored while participants searched for a target (e.g., bird) in a four-object display that could include a semantically related distractor (e.g., fish). The occurrence of both the target and the semantically related distractor modulated the N2pc response to the search display: The N2pc ...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn.2009.21348

    authors: Telling AL,Kumar S,Meyer AS,Humphreys GW

    更新日期:2010-10-01 00:00:00

  • The neural correlates of object familiarity and domain specificity in the human visual cortex: an FMRI study.

    abstract::Ventral occipito-temporal cortex is known to play a major role in visual object recognition. Still unknown is whether object familiarity and semantic domain are critical factors in its functional organization. Most models assume a functional locus where exemplars of familiar categories are represented: the structural ...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn.2011.21629

    authors: Zannino GD,Barban F,Macaluso E,Caltagirone C,Carlesimo GA

    更新日期:2011-10-01 00:00:00

  • An event-related neuroimaging study distinguishing form and content in sentence processing.

    abstract::Two coordinated experiments using functional Magnetic Resonance Imaging (fMRI) investigated whether the brain represents language form (grammatical structure) separately from its meaning content (semantics). While in the scanner, 14 young, unimpaired adults listened to simple sentences that were either nonanomalous or...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/08989290051137648

    authors: Ni W,Constable RT,Mencl WE,Pugh KR,Fulbright RK,Shaywitz SE,Shaywitz BA,Gore JC,Shankweiler D

    更新日期:2000-01-01 00:00:00

  • Comparisons between Active Properties of Distal Dendritic Branches and Spines: Implications for Neuronal Computations.

    abstract::The specific contributions of distal dendrites to the computational properties of cortical neurons are little understood and are completely ignored in most network simulations of higher brain functions. Compartmental models, based on realistic estimates of morphology and physiology, provide a means for exploring these...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn.1989.1.3.273

    authors: Shepherd GM,Woolf TB,Carnevale NT

    更新日期:1989-07-01 00:00:00

  • Hippocampal Contribution to Ordinal Psychological Time in the Human Brain.

    abstract::The chronology of events in time-space is naturally available to the senses, and the spatial and temporal dimensions of events entangle in episodic memory when navigating the real world. The mapping of time-space during navigation in both animals and humans implicates the hippocampal formation. Yet, one arguably uniqu...

    journal_title:Journal of cognitive neuroscience

    pub_type: 杂志文章

    doi:10.1162/jocn_a_01586

    authors: Gauthier B,Prabhu P,Kotegar KA,van Wassenhove V

    更新日期:2020-11-01 00:00:00