The Relationship Between Tumor Necrosis Factor-Alpha (-308G/A, +488G/A, -857C/T, and -1031T/C) Gene Polymorphisms and Risk of Intracerebral Hemorrhage in the North Indian Population: A Hospital-Based Case-Control Study.

Abstract:

Introduction:Genetic factors may play a role in the susceptibility of intracerebral hemorrhage (ICH). The present case-control study hypothesized that genetic polymorphisms in tumor necrosis factor- α (TNF-α) gene may affect the risk of ICH. Materials and Methods:In this study, we investigated the association of four single nucleotide polymorphisms (-308G/A, +488G/A, -857C/T, and -1031T/C) within TNF-α gene promoter and their haplotypes with the risk of ICH in a North Indian population. Genotyping was determined by using the SNaPshot method for 100 ICH patients and 100 age and sex-matched ICH-free controls. Conditional logistic regression analysis with adjusting multiple demographic and risk factor variables was used to calculate the strength of association between TNF-α gene polymorphisms and risk of ICH. Haplotypes were reconstructed using PHASE 2.0, and patterns of linkage disequilibrium (LD) analysis were performed using Haploview version 4.2 software. Results:TNF-α +488G/A gene polymorphism was found to be independently associated with the risk of ICH under dominant [GG + GA vs. AA] (OR = 3.1; 95% CI = 1.2-8.2; P = 0.001) and allelic [G vs. A] (OR = 2.2; 95% CI = 1.2-4.2; P = 0.007) models. However, no significant association between -308G/A, -857C/T, and -1031T/C gene polymorphisms and risk of ICH was observed. Haplotype analysis showed that 308A-488G-857C-1031T and 308G-488A-857T-1031T haplotypes were significantly associated with an increased risk of ICH. Strong LD was observed for + 488G/A and -857C/T TNF-α polymorphisms (D' = 0.72, r2= 0.01). Conclusion:Our findings suggest that the TNF-α +488G/A polymorphism may be an important risk factor for ICH, whereas -308G/A, -857C/T, and -1031T/C gene polymorphisms may not be associated with risk of ICH in North Indian population.

journal_name

Neurol India

journal_title

Neurology India

authors

Kumar P,Misra S,Kumar A,Faruq M,Vivekanandhan S,Srivastava AK,Prasad K

doi

10.4103/0028-3886.279665

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

78-83

issue

1

eissn

0028-3886

issn

1998-4022

pii

ni_2020_68_1_78_279665

journal_volume

68

pub_type

杂志文章
  • Vasculitic neuropathy : clinical electrophysiological and histopathological characterstics.

    abstract::The clinical, electrophysiological and pathological features of 16 patients with vasculitic neuropathy were evaluated. Vasculitic neuropathy accounted for 5.3 of biopsy proven cases of various neuropathies. They included 7 cases of systemic vasculitic neuropathy (SVN) and 9 cases of nonsystemic vasculitic neuropathy (...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Murthy J,Sundram C,Meena AK,Sundaram C

    更新日期:1998-01-01 00:00:00

  • Approach to diagnosis and management of optic neuropathy.

    abstract::Visual loss consequent to anterior visual pathway involvement can occur in a variety of clinical settings. In a tropical country like India, apart from the usual suspects, nutritional, infective, and toxic amblyopia have to be considered in the differential diagnosis. The mode of onset (acute/chronic), unilateral vers...

    journal_title:Neurology India

    pub_type: 杂志文章,评审

    doi:10.4103/0028-3886.149370

    authors: Mustafa S,Pandit L

    更新日期:2014-11-01 00:00:00

  • Description of coma and coma arousal therapy in Caraka Saṁhitā and its corollary in modern medicine.

    abstract::The description of coma and coma arousal therapy in Caraka Saṁhitā is described in sṁtra 24, verses 42-53. It describes the definition of coma, differential diagnosis of coma from other disorders of consciousness, signs of coma, etiology of coma, coma arousal therapy, and emergence from coma. The similarities and diff...

    journal_title:Neurology India

    pub_type: 历史文章,杂志文章

    doi:10.4103/neuroindia.NI_1110_16

    authors: Shukla D

    更新日期:2017-03-01 00:00:00

  • Two eminently treatable genetic metabolic myopathies.

    abstract::Treatment of the genetic metabolic myopathies remains generally unsatisfactory with the exception of a select few. Multiple Acyl Co-A Dehydrogenase Deficiency (Glutaric Aciduria type II), in particular, has been shown to respond well to riboflavin supplementation. Recently, studies have also confirmed the effectivenes...

    journal_title:Neurology India

    pub_type: 杂志文章,评审

    doi:10.4103/0028-3886.43452

    authors: Yee WC

    更新日期:2008-07-01 00:00:00

  • Endolymphatic sac tumor: a rare cerebellopontine angle tumor.

    abstract::Endolymphatic sac tumors (ELST) are rare papillary tumors of the temporal bone. Previously named as aggressive papillary middle ear tumors, they have recently been shown to arise from the endolymphatic sac. They are a rare in cerebello-pontine angle (CPA). We present a case of an ELST who presented as a CPA tumor with...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Joseph BV,Chacko G,Raghuram L,Rajshekhar V

    更新日期:2002-12-01 00:00:00

  • Postoperative Hormonal Outcomes in Patients with Large and Giant Non-functioning Pituitary Adenomas.

    abstract:Objective and Aims:To study hormonal axis (HA) dysfunction pre-operatively and at three months after surgery in patients with large (>3 cms) (Hardy's grade C) and giant (>4 cms) nonfunctioning pituitary adenomas (NFPA). Methods:One hundred thirty nine patients operated between 2006 and 2017, with 3 months post-operati...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.287670

    authors: Baldia M,Rajaratnam S,Rajshekhar V

    更新日期:2020-05-01 00:00:00

  • Suction Pressure Control Valve for Microneurosurgery.

    abstract::A suction pressure control valve (SPCV) for microneurosurgery is designed to place control of safe suction pressure in the hands of an operating neurosurgeon. Tumor tissue needs more negative suction pressure as compared to normal brain tissue, cranial nerves, and vessels in the neurosurgical operating field. The auth...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.288977

    authors: Barath AS,Thakur OP,Garg M,Bhaskar S,Jha DK

    更新日期:2020-05-01 00:00:00

  • Evolution of Pituitary Surgery.

    abstract::Pituitary tumors may well be the most common brain tumors with a mean incidence of 16.7%. Even small tumors become symptomatic when they arise from functioning cells and produce devastating effects on the body. The nonfunctioning tumors may become quite large before producing symptoms due to raised intracranial pressu...

    journal_title:Neurology India

    pub_type: 杂志文章,评审

    doi:10.4103/0028-3886.287673

    authors: Deopujari CE,Shaikh ST

    更新日期:2020-05-01 00:00:00

  • Prevalence of neuropathy in patients with impaired glucose tolerance using various electrophysiological tests.

    abstract:BACKGROUND:Neuropathy is often an associated feature woth long-standing type II diabetes mellitus. Neuropathy may occur even in subjects with impaired glucose tolerance. OBJECTIVE:To study the prevalence of neuropathy using different electrophysiological techniques in subjects with impaired glucose tolerance (IGT) and...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.149393

    authors: Kannan MA,Sarva S,Kandadai RM,Paturi VR,Jabeen SA,Borgohain R

    更新日期:2014-11-01 00:00:00

  • Integrated Genome-Wide DNA Methylation and RNAseq Analysis of Hippocampal Specimens Identifies Potential Candidate Genes and Aberrant Signalling Pathways in Patients with Hippocampal Sclerosis.

    abstract:Background and Aims:DNA methylation and demethylation play a crucial role in the regulation of gene expression, though their interplay during pathogenesis of hippocampal scelerosis (HS) remains elusive. The present study was designed to investigate the DNA methylation regulated changes in expression of HS patients. Me...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.280649

    authors: Dixit AB,Srivastava A,Sharma D,Tripathi M,Paul D,Lalwani S,Doddamani R,Sharma MC,Banerjee J,Chandra PS

    更新日期:2020-03-01 00:00:00

  • Development of neuropsychological evaluation screening tool: An education-free cognitive screening instrument.

    abstract:Background:Due to the paucity of quick, cognitive screening tools available in India that are independent of cultural and educational influences, a 6-item paper and pencil test, covering areas of memory, executive functioning, attention, and visuospatial ability domains - the Neuropsychological Evaluation Screening Too...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.227304

    authors: Chopra S,Kaur H,Pandey RM,Nehra A

    更新日期:2018-03-01 00:00:00

  • Hirayama disease/cervical flexion-induced myelopathy progressing to spastic paraparesis: A report on three cases with literature review.

    abstract::Hirayama disease (HD)/cervical flexion-induced myelopathy (CFIM) is a lower motor neuron disease conventionally affecting a single upper extremity. We describe three men progressing after a long stable period to develop severe spastic paraparesis and bladder disturbances as a protracted implication of HD. The age at o...

    journal_title:Neurology India

    pub_type: 杂志文章,评审

    doi:10.4103/0028-3886.236966

    authors: Preethish-Kumar V,Polavarapu K,Nashi S,Bhattacharya K,Saini J,Vengalil S,Pruthi N,Bhat DI,Nalini A

    更新日期:2018-07-01 00:00:00

  • Prognostic value of magnetic resonance imaging in patients with clinically isolated syndrome conversion to multiple sclerosis: a meta-analysis.

    abstract:BACKGROUND:Numerous studies have investigated the associations of brain or spinal cord MRI with the risk of developing Multiple Sclerosis (MS) in people with Clinically Isolated Syndrome (CIS), however, the findings are uncertain. Therefore, we performed a meta-analysis based on 24 publications to comprehensively evalu...

    journal_title:Neurology India

    pub_type: 杂志文章,meta分析

    doi:10.4103/0028-3886.115058

    authors: Zhang WY,Hou YL

    更新日期:2013-05-01 00:00:00

  • Multidrug-resistant tuberculous subdural empyema with secondary methicillin-resistant Staphylococcus aureus infection: an unusual presentation of cranial tuberculosis in an infant.

    abstract::Despite tuberculosis (TB) being endemic in many parts of the world, its prevalence in infancy is low. Neurotuberculosis in this age is even rarer and presents either as meningitis or intracranial tuberculoma on the background of exposure to the disease. We report occurrence of multidrug-resistant tuberculous subdural ...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.96412

    authors: Turel MK,Moorthy RK,Rajshekhar V

    更新日期:2012-03-01 00:00:00

  • Aberrant activation of Hedgehog/Gli1 pathway on angiogenesis in gliomas.

    abstract:BACKGROUND:Hedgehog/Gli1 (HH/Gli1) pathway plays an important role in the patterning and development of the central nervous system during embryogenesis. Recent data have shown its potential involvement in a subset of human gliomas and inhibition of the pathway resulted in tumor suppression in both in vitro and in vivo ...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.105192

    authors: Cui D,Chen X,Yin J,Wang W,Lou M,Gu S

    更新日期:2012-11-01 00:00:00

  • Parkinsonism with newly diagnosed flare-up rheumatoid arthritis mimicking progressive supranuclear palsy.

    abstract::In order to make a correct diagnosis of idiopathic Parkinson's disease (PD), it is essential to exclude atypical parkinsonian features, such as early dementia, fall, and autonomic dysfunction. Rheumatoid arthritis (RA), which is a systemic inflammatory disorder, although most patients present in a polyarticular manner...

    journal_title:Neurology India

    pub_type:

    doi:10.4103/0028-3886.284382

    authors: Lee KW,Chien CF,Wu MN,Lai CL,Liou LM

    更新日期:2020-03-01 00:00:00

  • Neurology of renal disorders.

    abstract::Chronic kidney disease (CKD) is a critical and rapidly growing global health problem. Neurological complications occur in almost all patients with severe CKD, potentially affecting all levels of the nervous system, from the central nervous system (CNS) through to the peripheral nervous system (PNS). Patients with CKD ...

    journal_title:Neurology India

    pub_type: 杂志文章,评审

    doi:10.4103/0028-3886.222815

    authors: Renjen PN,Chaudhari D,Sagar G,Jasuja S

    更新日期:2018-01-01 00:00:00

  • Neuropathological complications of infective endocarditis : study of autopsy material.

    abstract::78 autopsy proven cases of infective endocarditis (IE) seen during 1983 to 1995 were retrospectively reviewed. The brain was available for examination in 44 cases. In the remaining cases, brain was not examined because examination of it was not requested due to lack of neurological findings. Brain lesions were observe...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Patel FM,Das A,Banerjee AK

    更新日期:2001-03-01 00:00:00

  • Diagnostic accuracy of Magnetic Resonance Parkinsonism Index in differentiating progressive supranuclear palsy from Parkinson's disease and controls in Indian patients.

    abstract:AIMS AND OBJECTIVES:An assessment of the sensitivity and specificity of magnetic resonance (MR) imaging measurements of midbrain, pons, middle cerebellar peduncles (MCPs), and superior cerebellar peduncles (SCPs) and MR Parkinsonism Index (MRPI) in differentiating progressive supranuclear palsy (PSP) from Parkinson's d...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.177611

    authors: Sankhla CS,Patil KB,Sawant N,Gupta S

    更新日期:2016-03-01 00:00:00

  • Role of Aspirin in Tuberculous Meningitis: A Systematic Review and Meta-analysis.

    abstract:Objectives:Aspirin is a drug that has been found to be useful in reducing the incidence of infarctions. This systemic is aimed at review evaluating the benefits of aspirin in the management of tuberculous meningitis. Methods:A systematic literature search was performed using PubMed, Cochrane Central Register of Contro...

    journal_title:Neurology India

    pub_type: 杂志文章,meta分析

    doi:10.4103/0028-3886.266232

    authors: Rizvi I,Garg RK,Malhotra HS,Kumar N,Uniyal R

    更新日期:2019-07-01 00:00:00

  • Calvarial tuberculosis: A report of eleven patients.

    abstract:BACKGROUND:Tuberculosis is endemic in developing countries. However, calvarial tuberculosis is rare, even in areas where tuberculosis is endemic. In the literature, only few case series of calvarial tuberculosis have been reported. AIM:To report a case series of 11 patients with calvarial tuberculosis, and discuss the...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.57814

    authors: Diyora B,Kumar R,Modgi R,Sharma A

    更新日期:2009-09-01 00:00:00

  • An incidentally detected third ventricle chordoid glioma.

    abstract::Chordoid glioma is a rare low-grade tumor located in the third ventricle-hypothalamic region. Since its first report, 37 cases have been described in the literature. We report on an additional case that we considered significant because of its incidental detection and its uneventful surgical removal. ...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.33301

    authors: Gallina P,Pansini G,Mouchaty H,Mura R,Buccoliero AM,Di Lorenzo N

    更新日期:2007-10-01 00:00:00

  • Isolated intracranial Rosai Dorfman disease.

    abstract::Rosai Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a benign histiocytic proliferative disorder mainly affecting the lymph nodes. Although several cases of extra-nodal involvement have been reported previously, central nervous system involvement, particularly in the absence ...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.82770

    authors: Krishnamoorthy V,Parmar CF,Panikar D

    更新日期:2011-05-01 00:00:00

  • Video game epilepsy.

    abstract::Reflex epilepsy is the commonest form of epilepsy in which seizures are provoked by specific external stimulus. Photosensitive reflex epilepsy is provoked by environmental flicker stimuli. Video game epilepsy is considered to be its variant or a pattern sensitive epilepsy. The mean age of onset is around puberty and b...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Singh R,Bhalla A,Lehl SS,Sachdev A

    更新日期:2001-12-01 00:00:00

  • Feasibility and safety of remote radiology interpretation with telephone consultation for acute stroke in Thailand.

    abstract::"Telestroke" is emerging as a potential timesaving, efficient means for evaluating patients experiencing acute ischemic stroke. It provides an opportunity for administration of thrombolytic drugs within the short therapeutic time window associated with AIS. We describe our experiences of the feasibility and safety of ...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.72162

    authors: Muengtaweepongsa S,Dharmasaroja PA,Maungboon P,Wattanaruangkowit P

    更新日期:2010-09-01 00:00:00

  • Quality of life in stroke patients.

    abstract:BACKGROUND AND AIM:To determine the quality of life and its relationship with socio-demographic and medical factors in patients with stroke. SETTING AND DESIGN:Seventy patients with stroke seen in the neurology clinic on a follow-up visit; at least a period of 3 months of follow-up was included. MATERIALS AND METHODS...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.72165

    authors: Dayapoglu N,Tan M

    更新日期:2010-09-01 00:00:00

  • Bilateral optic nerve injury.

    abstract::Bilateral optic nerve injury is a rare condition and is reported in 5-6 percent of all optic nerve injuries. However, there is no published series on bilateral optic nerve injury. Analysis of 31 cases of bilateral optic nerve involvement seen amongst 275 patients with optic nerve injury (11.5 percent) is discussed. Ro...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:

    authors: Mahapatra AK

    更新日期:1999-06-01 00:00:00

  • Traumatic distal anterior cerebral artery aneurysm in a child: a case report.

    abstract::Traumatic intracranial aneurysms constitute less than 1% of all intracranial aneurysms. A case of traumatic distal anterior cerebral artery aneurysm in 18 months old child, treated successfully by microsurgical excision of aneurysm is being reported, along with review of the literature. ...

    journal_title:Neurology India

    pub_type: 杂志文章,评审

    doi:

    authors: Raju BS,Purohit AK,Murthy SR,Sundaram C,Sanjay T

    更新日期:2001-09-01 00:00:00

  • Management outcome of the transcallosal, transforaminal approach to colloid cysts of the anterior third ventricle: an analysis of 78 cases.

    abstract:BACKGROUND:Colloid cysts are not common brain lesions and account for 0.2-2.0% of all brain lesions. Transcallosal, transforaminal approach is a safe route and the most direct path to excise third ventricular colloid cyst, without dependence on hydrocephalus. AIM:To assess the surgical outcome of patients with colloid...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.84334

    authors: Symss NP,Ramamurthi R,Rao SM,Vasudevan MC,Jain PK,Pande A

    更新日期:2011-07-01 00:00:00

  • Gliomatosis cerebri: diagnostic considerations in three cases.

    abstract::Clinical symptoms and radiologic characteristics of gliomatosis cerebri (GC) are non-specific and the condition may be confused with other central nervous system diseases. We report three patients with GC; all the three patients had involvement of more than three lobes and the deep white matter, as well as bilateral i...

    journal_title:Neurology India

    pub_type: 杂志文章

    doi:10.4103/0028-3886.76892

    authors: Brandão RA,de Carvalho GT,de Azeredo Coutinho CA,Christo PP,Santiago CF,Santos Mdo C,de Sousa AA

    更新日期:2011-01-01 00:00:00