Abstract:
AIMS AND OBJECTIVES:An assessment of the sensitivity and specificity of magnetic resonance (MR) imaging measurements of midbrain, pons, middle cerebellar peduncles (MCPs), and superior cerebellar peduncles (SCPs) and MR Parkinsonism Index (MRPI) in differentiating progressive supranuclear palsy (PSP) from Parkinson's disease (PD) and controls was performed. The correlation of these MR imaging measurements with the duration and severity of disease in the Indian patients using the PSP rating scale (PSPRS) was also performed. MATERIALS AND METHODS:Twenty-six consecutive patients were enrolled in this study, satisfying the diagnostic criteria by the National Institute for Neurological Disorders and Stroke, and the Society for PSP (NINDS-SPSP), along with 13 PD and 30 control patients. All PSP patients were assessed using the PSP rating scale and staging system. Radiologists were blinded to the clinical diagnoses. MRPI was calculated by multiplying the pons area/midbrain area ratio by MCP width/SCP width ratio. The midbrain/pons area (M/P) ratio was measured as the ratio of midbrain area to pons area. RESULTS:Mean MRPI in PSP patients (23.48 ± 9.61) was significantly higher than that in PD patients (9.07 ± 2.23) and controls (9.45 ± 1.87). In this study, MRPI was 100% sensitive, specific, and accurate in differentiating PSP from PD and was 96.3% sensitive, 100% specific, and 98.21% accurate in differentiating PSP from controls. No correlation was found between the duration of disease, PSP rating scale, PSP staging system, and MRPI in the present study. MRPI was only marginally superior to the M/P ratio in differentiating between PSP and PD patients on an individual basis. No overlapping values were observed in the PSP and PD patients. CONCLUSION:Magnetic Resonance Parkinsonism Index is more sensitive, specific, and accurate in differentiating PSP from PD in the early stages on an individual basis.
journal_name
Neurol Indiajournal_title
Neurology Indiaauthors
Sankhla CS,Patil KB,Sawant N,Gupta Sdoi
10.4103/0028-3886.177611subject
Has Abstractpub_date
2016-03-01 00:00:00pages
239-45issue
2eissn
0028-3886issn
1998-4022pii
ni_2016_64_2_239_177611journal_volume
64pub_type
杂志文章相关文献
NEUROLOGY INDIA文献大全abstract::Herpes simplex virus (HSV) encephalitis complicated by cerebral hematoma is extremely rare. We report a 54-year-old man with hepes simplex encephalitis complicated by intracerebral hematoma and review the literature and describe the characteristics of HSV encephalitis complicated by intracerebral hematoma. ...
journal_title:Neurology India
pub_type: 杂志文章,评审
doi:10.4103/0028-3886.84344
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Limb girdle muscular dystrophy (LGMD) is a phenotypic expression of a heterogeneous group of diseases and sarcoglycanopathy is one of the causes of LGMD. There is only one study on sarcoglycanopathies in the Indian literature. No data is available from northern India. MATERIALS AND METHODS:All cases of musc...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract:INTRODUCTION:The endovascular modality of treatment is the preferred treatment modality for DAVF. In some circumstances, successful obliteration may not be possible by endovascular means, and such cases may require a direct surgical treatment. The authors report on their experience with the use of cranial base approach...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND/AIMS:To compare the influence of stroke risk factors between different stroke types and age groups in Taiwan. MATERIALS AND METHODS:During the study period, March 2007 to August 2008, 1,161 patients with acute ischemic stroke were admitted to the neurological ward. All the patients had risk factors work up ...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.73747
更新日期:2010-11-01 00:00:00
abstract::Stem cells are self regenerating multipotential cells, found in the human brain which have the potential to differentiate into neurons, astrocytes and oligodendrocytes, and to self renew sufficiently to provide adequate number of cells in the brain. Neural stem cell grafts have been studied in a variety of animal mode...
journal_title:Neurology India
pub_type: 杂志文章,评审
doi:
更新日期:2003-09-01 00:00:00
abstract::Chronic kidney disease (CKD) is a critical and rapidly growing global health problem. Neurological complications occur in almost all patients with severe CKD, potentially affecting all levels of the nervous system, from the central nervous system (CNS) through to the peripheral nervous system (PNS). Patients with CKD ...
journal_title:Neurology India
pub_type: 杂志文章,评审
doi:10.4103/0028-3886.222815
更新日期:2018-01-01 00:00:00
abstract::Opinion is still divided over a standard surgical procedure to decompress lumbar canal stenosis. Both, laminectomy with or without facetectomy and foraminotomy and interlaminar fenestration have been advocated. In the present communication interlaminar decompression in lumbar canal stenosis has been discussed. Sixteen...
journal_title:Neurology India
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::Twenty seven patients with hemifacial spasm (HFS) and sixteen patients with blepharospasm (BS) having mean Jankovic disability rating scale score of 2.56+0.58 SD and 2.81+0.54 SD, respectively, were treated with botulinum toxin A (BTX-A) injections. The total number of injection sessions were ninety one with relief re...
journal_title:Neurology India
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::We report three patients with pyomyositis due to Staphylococcus aureus. Magnetic resonance imaging aided in the accurate diagnosis of the infection and of the extent of involvement. Incision, drainage and antibiotic therapy eradicated the infection in all the patients. We suggest clinical or subclinical bacteraemic se...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Corpus Callosum (CC) abnormalities have been described in schizophrenia. Review of CC measurement methods in schizophrenia reveals inconsistency and lack of neuroanatomical basis. AIMS:The aims of the study are to describe a new CC measurement method with valid a neuroanatomical and cytoarchitectural basis ...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::Seventy cases of primary degenerative cerebellar ataxias in ethnic Bengalees from southern West Bengal, India, were studied by the authors. Of these, 50 cases were of the familial type (hereditary ataxias) encountered in 23 families and the remaining 20 were of sporadic onset. 18 cases (from 11 families) were of "prob...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::Cerebral involvement is rare in polyarteritis nodosa (PAN) and is mostly characterized by ischemic events and intracranial hemorrhages secondary to cerebral aneurysms is extremely rare. We report two patients of PAN with multiple intracranial aneurysms. One patient presented with intracerebral hemorrhage and in the ot...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.65840
更新日期:2010-05-01 00:00:00
abstract::A prospective study was done to evaluate the role of short-term Video EEG (VEEG) recording in assessing the nature of clinical behaviour and in classification of seizures in children with frequent intractable seizure episodes. Forty five children upto 12 years of age with frequent intractable seizure episodes (> or =3...
journal_title:Neurology India
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::A simultaneous odontoid decompression and bilateral posterior atlanto-axial facetal distraction, C1-2 joint spacer/bone graft placement and stabilization may be performed utilizing the 'posterior-only' approach. This procedure may be performed utilizing a single posterior midline incision, a bilateral posterior approa...
journal_title:Neurology India
pub_type:
doi:10.4103/neuroindia.NI_819_17
更新日期:2017-09-01 00:00:00
abstract::Scedosporium apiospermum is a filamentous fungus causing a broad spectrum of clinical diseases especially in those who are immunocompromised. The common sites involved are lungs, skin, sinuses, eyes, bones, joints, and central nervous system (CNS). CNS is involved in invasive Scedosporiosis in the form of a cerebral a...
journal_title:Neurology India
pub_type:
doi:10.4103/0028-3886.293486
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Symptomatic neurosyphilis (NS) can have varied syndromic presentations: Meningitis, meningovascular and parenchymatous involvement. AIMS:To evaluate the different types of clinical syndrome of NS in a tertiary care hospital. MATERIAL AND METHODS:This was a study of clinical profile of 16 patients with NS, ...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.82719
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Colloid cysts are not common brain lesions and account for 0.2-2.0% of all brain lesions. Transcallosal, transforaminal approach is a safe route and the most direct path to excise third ventricular colloid cyst, without dependence on hydrocephalus. AIM:To assess the surgical outcome of patients with colloid...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.84334
更新日期:2011-07-01 00:00:00
abstract::We report two siblings with Allgrove's syndrome and extrapyramidal features. Though various neurological abnormalities have been described in this disorder, we report the first patient of Allgrove's syndrome associated with dystonia and chorea. ...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::Delayed carpal tunnel syndrome is rare. We describe the electrophysiological findings in a patient with Colle's fracture, who developed carpal tunnel syndrome 22 years after a wrist injury. ...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
abstract::The Department of Neurological Sciences at Christian Medical College (CMC), Vellore was the first department to start neurosurgical and neurological services in India. Jacob Chandy started the department in 1949 against several odds. He started a formal training program in neurosurgery in 1958, for the first time in I...
journal_title:Neurology India
pub_type: 历史文章,杂志文章
doi:10.4103/0028-3886.177625
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Pain-related studies have mainly been performed through traditional methods, which lack the rigorous analysis of anatomical locations. Functional magnetic resonance imaging (fMRI) is a noninvasive method detecting neural activity, and has the ability to precisely locate related activations in vivo. Moreover,...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.73748
更新日期:2010-11-01 00:00:00
abstract:Background and Aims:DNA methylation and demethylation play a crucial role in the regulation of gene expression, though their interplay during pathogenesis of hippocampal scelerosis (HS) remains elusive. The present study was designed to investigate the DNA methylation regulated changes in expression of HS patients. Me...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.280649
更新日期:2020-03-01 00:00:00
abstract::Epilepsy surgery currently offers the best treatment for patients with drug-refractory epilepsy (DRE). Resective surgery, in the presence of a well-localized epileptogenic focus, remains the best modality towards achieving seizure freedom. However, localization of the focus may not be possible in all the cases of DRE,...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.302475
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Leprosy is one of the most common causes of peripheral neuropathy, perhaps closely matched by diabetic neuropathy. Patterns of peripheral neuropathy in leprosy can be varied, which may include mononeuropathy, mononeuritis multiplex and symmetric polyneuropathy. Cranial nerves, especially facial and trigemina...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.27154
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Treatment of brain abscess is still a subject of controversy. Simple therapeutic approaches like twist drill/burr hole aspiration with or without insertion of a drain are also quite effective. There are reports of encouraging results following endoscopic treatment. We are reporting our results of endoscopic ...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.39305
更新日期:2008-01-01 00:00:00
abstract::An adult male presenting with acute onset opsoclonus, myoclonus and cerebellar ataxia is being reported. Patient had myoclonus involving limbs and palate. There are only a few reported cases associated with palatal myoclonus. Patient showed gradual spontaneous recovery. Possibility of underlying malignancy was exclude...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Earthquake is one of the most devastating natural disasters that threaten human lives. Worldwide more than 3 million deaths have been caused by earthquakes in recent 20 years. AIM:To analyze clinical features of head injuries after Sichuan earthquake. MATERIALS AND METHODS:From May 12 to June 12, 2008, Dep...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.60406
更新日期:2010-01-01 00:00:00
abstract::Spinal congenital dermal sinus is a rare entity, which supposedly results from the failure of neuroectoderm to separate from the cutaneous ectoderm during the process of neurulation. The present study was undertaken to know the clinical profile of these patients, to study associated anomalies and to assess the results...
journal_title:Neurology India
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract::A "Hot Cross Bun" sign on T2-weighted MRI was described as a result of selective loss of myelinated transverse pontocerebellar fibers and neurons in the pontine raphe with preservation of the pontine tegmentum and corticospinal tracts (CST). However, neuropathologic studies showed contradicting results with no sparing...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.79143
更新日期:2011-03-01 00:00:00
abstract::Recurrence of coiled aneurysm usually due to coil compaction is a known phenomenon. Extent of recurrence and its relation to re-bleeding is not known. The authors report a case of spontaneous asymptomatic extrusion of guglielmi detachable coils from the dome of a previously ruptured anterior communicating artery aneur...
journal_title:Neurology India
pub_type: 杂志文章
doi:10.4103/0028-3886.32787
更新日期:2007-04-01 00:00:00