Complex genome evolution in Anopheles coluzzii associated with increased insecticide usage in Mali.

Abstract:

:In certain cases, a species may have access to important genetic variation present in a related species via adaptive introgression. These novel alleles may interact with their new genetic background, resulting in unexpected phenotypes. In this study, we describe a selective sweep on standing variation on the X chromosome in the mosquito Anopheles coluzzii, a principal malaria vector in West Africa. This event may have been influenced by the recent adaptive introgression of the insecticide resistance gene known as kdr from the sister species Anopheles gambiae. Individuals carrying both kdr and a nearly fixed X-linked haplotype, encompassing at least four genes including the P450 gene CYP9K1 and the cuticular protein CPR125, have rapidly increased in relative frequency. In parallel, a reproductively isolated insecticide-susceptible A. gambiae population (Bamako form) has been driven to local extinction, likely due to strong selection from increased insecticide-treated bed net usage.

journal_name

Mol Ecol

journal_title

Molecular ecology

authors

Main BJ,Lee Y,Collier TC,Norris LC,Brisco K,Fofana A,Cornel AJ,Lanzaro GC

doi

10.1111/mec.13382

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

5145-57

issue

20

eissn

0962-1083

issn

1365-294X

journal_volume

24

pub_type

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