Symbiont strain is the main determinant of variation in Wolbachia-mediated protection against viruses across Drosophila species.

Abstract:

:Wolbachia is a common heritable bacterial symbiont in insects. Its evolutionary success lies in the diverse phenotypic effects it has on its hosts coupled to its propensity to move between host species over evolutionary timescales. In a survey of natural host-symbiont associations in a range of Drosophila species, we found that 10 of 16 Wolbachia strains protected their hosts against viral infection. By moving Wolbachia strains between host species, we found that the symbiont genome had a much greater influence on the level of antiviral protection than the host genome. The reason for this was that the level of protection depended on the density of the symbiont in host tissues, and Wolbachia rather than the host-controlled density. The finding that virus resistance and symbiont density are largely under the control of symbiont genes in this system has important implications both for the evolution of these traits and for public health programmes using Wolbachia to prevent mosquitoes from transmitting disease.

journal_name

Mol Ecol

journal_title

Molecular ecology

authors

Martinez J,Tolosana I,Ok S,Smith S,Snoeck K,Day JP,Jiggins FM

doi

10.1111/mec.14164

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

4072-4084

issue

15

eissn

0962-1083

issn

1365-294X

journal_volume

26

pub_type

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