Abstract:
AIM:Systemic sclerosis (SSc) is a rare chronic disease characterized by pathologic collagen deposits in the skin and internal organs. Although it is considered to be an autoimmune disease, immunosuppressants have a limited effect on severe SSc. Intravenous immunoglobulins (IVIG) have shown favorable effects in patients with SSc by suppressing the action of profibrotic cytokines, so they could have additional effect on standard treatment such as cyclophosphamide (CYC). This article presents the immunomodulatory effect of low-dose IVIG in addition to CYC in the treatment of severe SSc in this center during the last 9 years. METHODS:This retrospective observational study analyzed the medical documentation of nine patients with SSc treated with low-dose IVIG (0.4 g/kg and month) together with intravenous CYC (600 mg/m2 and month). The therapeutic effect on lung and skin manifestations was assessed. RESULTS:Of the patients one had interstitial lung diseases (ILD), two had progressive skin diseases, and six had a combination of skin and lung involvement. The best results were achieved in skin changes, where complete healing of digital ulcers (DU) was recorded in every reported case. A decrease in the modified Rodnan skin score (mRSS) was noted in three patients and increased diffusion capacity of the lungs for carbon monoxide in another three patients. CONCLUSION:The results of the study suggest that IVIG may be an additional treatment option together with CYC for patients for whom other therapies have failed, but further studies on the exact role of IVIG in the treatment of severe SSc are required.
journal_name
Wien Klin Wochenschrjournal_title
Wiener klinische Wochenschriftauthors
Perković D,Petrić M,Božić I,Borić K,Marasović Krstulović D,Radić M,Martinović Kaliterna Ddoi
10.1007/s00508-020-01669-ysubject
Has Abstractpub_date
2020-05-25 00:00:00eissn
0043-5325issn
1613-7671pii
10.1007/s00508-020-01669-ypub_type
杂志文章abstract::Morphological examination of the fundus has improved considerably over the past decade. By means of identation biomicroscopy, hitherto inaccessible, extremely-peripheral areas of the fundus can be examined by the slit lamp now; this of importance in the study of intraocular inflammation and the judgement of retinal te...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1978-06-23 00:00:00
abstract::Apoptosis of renal tubular epithelial cells plays a major role in acute renal failure. Several external and internal signals can induce apoptosis, which is then effectuated via several pathways. These pathways are either the FAS/FAS-L pathway and downstream MAPK (mitogen-activated protein kinases) and JNK (c-Jun N-ter...
journal_title:Wiener klinische Wochenschrift
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abstract::Prostacyclin is degraded in human plasma in vitro with an average half-life of 10 minutes. The degradation in plasma of patients suffering from type II diabetes mellitus is significantly enhanced. However, the inactivation of prostacyclin in plasma in patients with clinical manifestations of atherosclerosis, such as p...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1985-09-13 00:00:00
abstract:INTRODUCTION:Our purpose was to determine whether diffusion-weighted MR imaging (DWI) could be used in differentiation of benign and malign breast lesions. MATERIALS AND METHODS:41 women patients were included in the study. 45 lesions were diagnosed by biopsy; 25 (55.5%) of these lesions were malignant and 20 (44.5%) ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-011-0053-5
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Because of the difficulty associated with making an accurate diagnosis of gastric heterotopic pancreas (HP) before surgery, surgical resection is usually performed in suspected cases. However, this is an invasive procedure and prone to certain surgical complications. AIMS:This study was designed to evaluate...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-014-0563-z
更新日期:2014-09-01 00:00:00
abstract::We report the case of a 60 year-old woman who developed a slowly progressive retrograde diplegia of the lumbo-sacral plexus with mixed sensomotor losses. This occurred with a delay of 6 years after telecobalt irradiation of a pelvic squamous cell carcinoma. Extensive investigations regarding the possibility of tumour ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1981-04-17 00:00:00
abstract::Primary endoscopic removal of bile duct stones is an established method of treatment. However, the extraction of stones is impossible in about 10% of cases despite successful endoscopic papillotomy and manual lithotripsy. Over a period of two years extracorporeal shock-wave lithotripsy (ESWL) was performed in 32 patie...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1989-09-29 00:00:00
abstract:BACKGROUND:In developed countries high socioeconomic status (SES) is associated with lower body mass index (BMI) and greater height compared with low SES. AIM:To investigate differences in BMI/height in adolescent students from two different school types with divergent SES backgrounds. METHODS:A total of 4579 student...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-019-1479-4
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/BF03040501
更新日期:2003-11-28 00:00:00
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journal_title:Wiener klinische Wochenschrift
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1978-12-08 00:00:00
abstract::Whole blood selenium status of 299 persons, 144 women and 155 men, with a mean age of 62 +/- 10 years, has been determined. The individuals came from all Austrian provinces to Bad Hall to improve their heart and circulation disorders. The mean selenium content was 95 micrograms/l. We found no correlations between sele...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Successful research programs on Tropical diseases are closely linked with access to patients and biological material to conduct relevant basic research and develop new interventions. Therefore, the strategy for establishing true collaborations with the local scientific community working in these affected areas has to ...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-010-1331-3
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::The results obtained by closest cooperation between gynaecologist and andrologist in the treatment of sterile marriages are reported. 127 couples were treated over a period of 20 months. Almost 100% of the males and 60% of the females were sub- or infertile. Treatment of both partners was meticulously coordinated in o...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1980-05-09 00:00:00
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章,评审
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:2002-03-28 00:00:00
abstract:INTRODUCTION:Diagnostic hysteroscopy is the most precise procedure to evaluate diseases involving the uterine cavity. There is, however, only limited data concerning the use of hysteroscopy carried out as an outpatient procedure in patients with postmenopausal bleeding. MATERIALS AND METHODS:In this study we report on...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1999-04-09 00:00:00
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-006-0550-0
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-008-1080-8
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:10.1007/s00508-012-0272-4
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journal_title:Wiener klinische Wochenschrift
pub_type: 历史文章,杂志文章
doi:
更新日期:1976-02-20 00:00:00
abstract::Thirty four children, aged 2 to 15 years, were treated by haemodialysis between 1967 and 1978. Eleven children suffered from acute renal failure. Twenty three children with end-stage chronic renal disease were treated over periods ranging from 1 week to 19 months. All children were dialysed in a renal unit for adult p...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1980-01-18 00:00:00
abstract::Dopamine possesses specific pharmacological actions which distinguish it from the other catecholamines. Apart from its positive inotropic effect, dopamine exerts a favourable influence on renal function with an increase in renal blood flow and alterations in intrarenal haemodynamics. The use of dopamine in the early s...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1976-01-23 00:00:00
abstract::The tocolytic effect of hexoprenaline was determined in 20 women by internal cardiotocography during labour. After 30 minutes of intravenous medication (0.3 microgram/min = dosage for massive tocolysis) the uterine activity decreased on average by 73.6%; the maternal pulse rate increased by 25.0%; the fetal heart rate...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1981-09-18 00:00:00
abstract::2851 radiodiagnostic examinations of the skull made in a psychiatric hospital between 1958 and 1977 were reviewed for enostosis frontalis. Out of 1398 female patients there were 125 cases of enostosis frontalis, whereas out of the 1453 male there were only 5. Hence, in females, this is a frequent condition (9%) and sh...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1979-09-14 00:00:00
abstract::From the 1st of April 1974 till the 30th of September 1979 a consecutive series of 123 couples with a history of recurrent abortion was studied cytogenetically with modern banding techniques. 8 chromosomal aberrations were detected (6.5%); 3 women were found to be balanced reciprocal translocation carriers; the karyot...
journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1980-08-29 00:00:00
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journal_title:Wiener klinische Wochenschrift
pub_type: 杂志文章
doi:
更新日期:1975-04-18 00:00:00