Dosing Recommendations for Pediatric Patients With Renal Impairment.

abstract：:This experiment represents the first time that it has been possible to measure a body fluid compartment by direct means during spaceflight. Based on the results observed in the five crewmen in this study, it is concluded that TBW decreases by 3.4% after 1 to 3 days of exposure to microgravity in the Space Shuttle. Som...

journal_title：Journal of clinical pharmacology

authors： Leach CS,Inners LD,Charles JB

更新日期：1991-10-01 00:00:00

abstract：:The electrocardiographic (ECG) effects of rivastigmine treatment were assessed in mild to moderately severe Alzheimer's disease (AD) by analysis of four 26-week, double-blind, multicenter, placebo-controlled, phase III clinical trials. Of an initial 2791 patients, 77% completed treatment. Seventy-one percent required ...

journal_title：Journal of clinical pharmacology

authors： Morganroth J,Graham S,Hartman R,Anand R

更新日期：2002-05-01 00:00:00

abstract：:Although there are many reports of the short-term effectiveness of antiarrhythmic drugs for suppression of ventricular ectopic depolarizations, there are less data available on the long-term use of these drugs. We treated 122 patients for up to 2 years with antiarrhythmic drugs for suppression of frequent ventricular ...

journal_title：Journal of clinical pharmacology

authors： Salerno DM,Fifield J,Hodges M

更新日期：1990-03-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of ranitidine were studied in 13 term neonates with stable renal and hepatic function who were treated with extracorporeal membrane oxygenation (ECMO). Ranitidine was initially administered as a single 2 mg/kg dose over 10 minutes and intragastric pH was monitored to determine...

journal_title：Journal of clinical pharmacology

authors： Wells TG,Heulitt MJ,Taylor BJ,Fasules JW,Kearns GL

更新日期：1998-05-01 00:00:00

abstract：:The effect of food on the oral bioavailability of sustained-release morphine sulfate tablets (ORAMORPH SR; Roxane Laboratories, Inc., Columbus, OH; OSR) was examined in an open-label, randomized, two-period crossover study. Healthy male volunteers received a 30-mg OSR tablet orally every 12 hours for seven doses durin...

journal_title：Journal of clinical pharmacology

authors： Bass J,Shepard KV,Lee JW,Hulse J

更新日期：1992-11-01 00:00:00

abstract：:The objective of this study was to establish effects of inhaled loxapine on the QTc interval in this randomized, placebo-controlled, double-blind crossover study. Forty-eight healthy volunteers received a single inhaled placebo or 10 mg loxapine. Plasma concentrations of loxapine increased with a median Tmax of 1 minu...

journal_title：Journal of clinical pharmacology

authors： Spyker DA,Voloshko P,Heyman ER,Cassella JV

更新日期：2014-06-01 00:00:00

abstract：:The present study was conducted to determine the absolute bioavailability of fimasartan (FMS; Kanarb(®) ) after the single oral administration of a 60-mg tablet or a single 30-mg intravenous (IV) infusion. This investigation was a randomized, single-dose, open-labeled, two-way crossover study of 16 healthy Korean male...

journal_title：Journal of clinical pharmacology

authors： Ghim JL,Paik SH,Hasanuzzaman M,Chi YH,Choi HK,Kim DH,Shin JG

更新日期：2016-05-01 00:00:00

abstract：:This study was performed to estimate the population pharmacokinetic (PK) parameters of etanercept in pediatric juvenile rheumatoid arthritis (JRA) patients and to compare the steady-state time-concentration profiles between etanercept 0.8-mg/kg once-weekly and 0.4-mg/kg twice-weekly subcutaneous (SC) regimens by clini...

journal_title：Journal of clinical pharmacology

authors： Yim DS,Zhou H,Buckwalter M,Nestorov I,Peck CC,Lee H

更新日期：2005-03-01 00:00:00

abstract：:Antibody-drug conjugates (ADCs) represent an innovative therapeutic approach that provides novel treatment options and hope for patients with cancer. By coupling monoclonal antibodies (mAbs) to cytotoxic small-molecule payloads with a plasma-stable linker, ADCs offer the potential for increased drug specificity and fe...

journal_title：Journal of clinical pharmacology

authors： Vezina HE,Cotreau M,Han TH,Gupta M

更新日期：2017-10-01 00:00:00

abstract：:The primary objective of this phase 1, open-label, multicenter, 3-period, fixed-sequence study was to evaluate the effect of multiple doses of vemurafenib on the pharmacokinetics of a single dose of digoxin, a probe P-glycoprotein (P-gp) substrate, in patients with BRAFV600 mutation-positive metastatic malignancy. Fol...

journal_title：Journal of clinical pharmacology

authors： Zhang W,McIntyre C,Kuhn M,Forbes H,Kim TM,Lee J,Demidov L,Colburn D

更新日期：2018-08-01 00:00:00

abstract：:The safety, antiretroviral activity, and pharmacokinetic profile of nelfinavir, a potent and specific inhibitor of human immunodeficiency virus (HIV) protease, were assessed in a small open-label phase I/II dose-ranging study in protease inhibitor-naive HIV-positive men. A total of 22 patients with baseline plasma HIV...

journal_title：Journal of clinical pharmacology

authors： Moyle GJ,Youle M,Higgs C,Monaghan J,Prince W,Chapman S,Clendeninn N,Nelson MR

更新日期：1998-08-01 00:00:00

abstract：:Aprepitant or its prodrug fosaprepitant, in combination with a corticosteroid and a 5-HT(3) receptor antagonist, are used to prevent chemotherapy-induced nausea and vomiting. This study evaluated the effect of fosaprepitant 150 mg on CYP3A4 metabolism. Fosaprepitant 150 mg has been submitted to regulatory agencies for...

journal_title：Journal of clinical pharmacology

authors： Marbury TC,Ngo PL,Shadle CR,Jin B,Panebianco D,Caro L,Valentine J,Murphy G

更新日期：2011-12-01 00:00:00

abstract：:Taranabant is a novel cannabinoid CB-1 receptor (CB1R) inverse agonist in clinical development for the treatment of obesity. This double-blind, randomized, placebo-controlled, single oral dose study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of taranabant (0.5-600 mg) in 24 healthy male...

journal_title：Journal of clinical pharmacology

authors： Addy C,Li S,Agrawal N,Stone J,Majumdar A,Zhong L,Li H,Yuan J,Maes A,Rothenberg P,Cote J,Rosko K,Cummings C,Warrington S,Boyce M,Gottesdiener K,Stoch A,Wagner J

更新日期：2008-04-01 00:00:00

abstract：:The aim of these two studies was to evaluate the safety and pharmacokinetics of oral nalmefene, a new orally effective opioid antagonist. In the first study, single ascending doses of 50, 100, 200, and 300 mg of nalmefene HCl were administered in double-blind fashion to four groups of healthy men. There were six subje...

journal_title：Journal of clinical pharmacology

authors： Dixon R,Gentile J,Hsu HB,Hsiao J,Howes J,Garg D,Weidler D

更新日期：1987-03-01 00:00:00

abstract：:The antihypertensive effect and safety of hydrochlorothiazide administration as a single drug and together with medroxalol were determined in 20 patients with primary hypertension. Following two biweekly intervals on placebo and hydrochlorothiazide, medroxalol was started at 100 mg three times a day and titrated again...

journal_title：Journal of clinical pharmacology

authors： Vlachakis ND,Valasquez M,Alexander N,Maronde RF

更新日期：1983-10-01 00:00:00

abstract：:The pharmacokinetic actions, bioequivalence, and cardiovascular effects of two verapamil products were studied in a randomized, double-blind, crossover study in eight elderly hypertensive patients (median age, 69.5 years; range, 60-79 years) given brand-name or generic immediate-release verapamil in 120-mg twice-daily...

journal_title：Journal of clinical pharmacology

authors： Saseen JJ,Porter JA,Barnette DJ,Bauman JL,Zajac EJ Jr,Carter BL

更新日期：1997-06-01 00:00:00

abstract：:The relative analgesic potency of oral and intramuscular oxymorphone was evaluated in a double-blind crossover comparison of graded single doses in patients with chronic pain due to cancer. When both duration and intensity of analgesia are considered (total effect), oral oxymorphone was 1/6 as potent as the intramuscu...

journal_title：Journal of clinical pharmacology

authors： Beaver WT,Wallenstein SL,Houde RW,Rogers A

更新日期：1977-04-01 00:00:00

abstract：:The time course, dose frequency schedule, and dose-response relationship of the citraturic response to orally administered potassium citrate was examined in 22 normal volunteers and 21 patients with uric acid or calcium nephrolithiasis. The slow-release (wax matrix) preparation of potassium citrate produced a rapid an...

journal_title：Journal of clinical pharmacology

authors： Pak CY,Skurla C,Brinkley L,Sakhaee K

更新日期：1984-01-01 00:00:00

abstract：:We compared the gastrointestinal (GI) tolerability and assessed for bioequivalent absorption of R-lipoic acid (LA) in people with progressive multiple sclerosis (MS) in a single-center, double-blind, randomized crossover trial. Participants randomly assigned to formulation sequence took 600 mg of R-LA or 1200 mg of a ...

journal_title：Journal of clinical pharmacology

authors： Cameron M,Taylor C,Lapidus J,Ramsey K,Koop D,Spain R

更新日期：2020-08-01 00:00:00

abstract：:A double-blind, crossover study was carried out to compare the antihypertensive efficacy of the long-acting ACE inhibitor trandolapril 1 mg administered once daily and 0.5 mg twice daily in 31 patients with mild to moderate essential hypertension. After randomization, patients entered a single-blind placebo period of ...

journal_title：Journal of clinical pharmacology

authors： Poirier L,Bourgeois J,Lacourcière Y

更新日期：1993-09-01 00:00:00

abstract：:Triamcinolone acetonide (TCA) is a corticosteroid that is frequently used in the treatment of asthma. After inhalation, TCA can become systemically available when the inhaled formulation is swallowed, causing undesirable systemic effects. A clinical study was conducted to determine the systemic side effects of TCA aft...

journal_title：Journal of clinical pharmacology

authors： Rohatagi S,Hochhaus G,Mollmann H,Barth J,Galia E,Erdmann M,Sourgens H,Derendorf H

更新日期：1995-12-01 00:00:00

abstract：:The aim of the study was to investigate the pharmacokinetics and removal of midazolam and unconjugated and glucuronidated 1-hydroxy-midazolam in 4 intensive care patients on continuous venovenous hemodialysis. Plasma midazolam and its metabolites were assessed by HPLC from blood samples collected during continuous inf...

journal_title：Journal of clinical pharmacology

authors： Bolon M,Bastien O,Flamens C,Paulus S,Boulieu R

更新日期：2001-09-01 00:00:00

abstract：:Udenafil, a cyclic guanosine monophosphate-specific phosphodiesterase type 5 inhibitor, has been developed to treat erectile dysfunction. We evaluated the effect of age on the pharmacokinetics and tolerability of udenafil. A single-center, open-label, parallel-group phase 1 study was conducted in healthy adult subject...

journal_title：Journal of clinical pharmacology

authors： Choi HK,Jung JA,Shon J,Bahng MY,Cho DY,Yeo CW,Kim EY,Shin JG

更新日期：2016-11-01 00:00:00

abstract：:The selective T-cell costimulation modulator abatacept is approved for treatment of adult rheumatoid arthritis (RA) and polyarticular juvenile idiopathic arthritis (pJIA; 6-17 years [intravenous] and 2-17 years [subcutaneous]). An extrapolation approach was taken to determine subcutaneous weight-tiered doses of abatac...

journal_title：Journal of clinical pharmacology

authors： Gandhi Y,Passarell JA,Roy A,Murthy B

更新日期：2020-12-07 00:00:00

abstract：:Guanfacine, an alpha 2 adrenoceptor agonist, was compared with prazosin hydrochloride for the treatment of patients with mild to moderate essential hypertension in an 8-week, double-blind, randomized, parallel evaluation to determine efficacy and safety. The study consisted of a 2-week screening/weaning period (phase ...

journal_title：Journal of clinical pharmacology

authors： Lewin A,Alderman MH,Mathur P

更新日期：1990-12-01 00:00:00

abstract：:The pharmacokinetics of codeine, codeine glucuronide, morphine, and morphine glucuronide were assessed after single- (60 mg) and multiple-dose (60 mg every six hours for nine doses) oral administration of codeine sulfate to six normal volunteers. Multiple blood and urine samples were collected after administration of ...

journal_title：Journal of clinical pharmacology

authors： Guay DR,Awni WM,Halstenson CE,Findlay JW,Opsahl JA,Abraham PA,Jones EC,Matzke GR

更新日期：1987-12-01 00:00:00

abstract：:The safety and pharmacokinetics of single and multiple administrations of cefpirome (HR810), a new cephalosporin antibiotic agent with a broad antibacterial spectrum, were studied in healthy male volunteers. The single administration protocols included a 3-minute intravenous injection of 0.5 g or 1 g, and a 1-hour int...

journal_title：Journal of clinical pharmacology

authors： Nakayama I,Akieda Y,Yamaji E,Nitta Y,Ohishi M,Katagiri K,Imamura N,Takase K

更新日期：1992-03-01 00:00:00

abstract：:Reduced bioavailability (F) due to hepatic first-pass extraction of an oral dose (D) is a well-known pharmacokinetic phenomenon. An integrated solution for Michaelis-Menten kinetics of the first-pass effect is derived from the maximal metabolic rate (Vm), volume of distribution (Vd), first order absorption rate consta...

journal_title：Journal of clinical pharmacology

authors： Keller F,Kunzendorf U,Walz G,Haller H,Offermann G

更新日期：1989-03-01 00:00:00

abstract：:Migraine is a common and debilitating disorder of uncertain pathogenesis. Recent research into the pathophysiology of migraine and serotonin receptors has revolutionized the approach to pharmacotherapy. New medications, such as sumatriptan, and new dosage forms of older medications, including dihydroergotamine, NSAIDs...

journal_title：Journal of clinical pharmacology

authors： Solomon GD

更新日期：1993-03-01 00:00:00

abstract：:Microgravity is produced for 20 to 30 seconds in NASA's KC-135 aircraft at the end of a 2 G pullup for each of 40 parabolas per flight. Continuous transcranial Doppler ultrasound, arterial blood pressure, and acceleration levels were recorded for 12 male and 8 female healthy subjects without known cardiovascular or ce...

journal_title：Journal of clinical pharmacology

authors： Bondar RL,Stein F,Kassam MS,Dunphy PT,Bennett BS,Johnston KW

更新日期：1991-10-01 00:00:00