Abstract:
PURPOSE OF THE STUDY:The study of the influenza and ARVI clinical performance, the development of patients with diabetes mellitus, evaluation of the effectiveness and safety application of antiviral therapy, carried out in the framework of routine clinical practice. MATERIALS AND METHODS:126 patients aged from 22 to 83 years (27.8% of men) with ARVI or influenza that occurred with medical care during the first 5 days of the disease (60.3% in the first 48 hours) are included. All patients suffer from diabetes, for the treatment of which oral hypoglycemic agents or insulins were constantly taken. The patients were divided into two groups: the first group received standard symptomatic treatment of ARVI; antiviral drug Kagocel. RESULTS AND CONCLUSION:Diabetes and other acute respiratory viral infections. There is an increase in the incidence of bacterial complications - 2.2 times, an increase in the frequency of systemic antibiotics - 2.3 times. The purpose of the drug prescription led to a more rapid regression of all the symptoms of influenza and ARVI, but the most striking positive dynamics was observed in the symptoms of general weakness and headache. The prescription of Kagocel was accompanied by a 58% reduction in the number of bacterial complications and a 53% reduction in the use of antibiotics, which led to a reduction in the number of cases of the disease and an improvement in initial diseases, with an frequency increase in 1.8 times. The most significant effect achieved with early treatment and early initiation of antiviral therapy (in the first 48 hours of the disease). :Цель исследования. Изучение течения клинической картины гриппа и острых респираторных вирусных инфекций (ОРВИ) у больных сахарным диабетом (СД) с оценкой эффективности и безопасности применяемой противовирусной терапии, проводимой в рамках рутинной клинической практики. Материалы и методы. Включено 126 пациентов в возрасте 22-83 лет (27,8% мужчин) с ОРВИ или гриппом, обратившихся за медицинской помощью в первые 5 дней заболевания (60,3% - в первые 48 ч). У всех пациентов был ранее диагностирован СД, для лечения которого они постоянно принимали пероральные гипогликемические средства либо инсулины. Пациенты были разделены на две группы: первая получала стандартную симптоматическую терапию ОРВИ; вторая в составе комплексного лечения получала противовирусный препарат Кагоцел. Результаты и заключение. СД ухудшает течение и исход гриппа и других ОРВИ. У больных СД наблюдалось повышение частоты бактериальных осложнений по сравнению с общей популяцией - в 2,2 раза, увеличение частоты применения системных антибиотиков - в 2,3 раза. Назначение препарата Кагоцел привело к более быстрому регрессу всех симптомов гриппа и ОРВИ, но наиболее яркая позитивная динамика зарегистрирована по таким симптомам, как общая слабость (частота выявления которой при отсутствии противовирусной терапии отмечалась участниками в 1,24 раза чаще на 2-м визите и в 2,21 - на 3-м визите) и головная боль (участники исследования в группе сравнения предъявляли жалобы на данный симптом чаще в 1,53 раза на 2-м визите и в 3,66 раза на 3-м визите). Назначение Кагоцела сопровождалось сокращением числа бактериальных осложнений на 58% и частоты применения антибиотиков на 53%, что в результате способствовало сокращению сроков выздоровления и улучшению исхода заболевания с повышением в 1,8 раза случаев полного выздоровления в среднем к 7-м суткам. Наиболее значимый эффект достигнут при раннем обращении и раннем начале противовирусной терапии (в первые 48 ч заболевания).
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Sitnikov IG,Fazylov VK,Silina EVdoi
10.26442/00403660.2019.10.000333subject
Has Abstractpub_date
2019-10-15 00:00:00pages
39-47issue
10eissn
0040-3660issn
2309-5342journal_volume
91pub_type
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