Immunogenetic heterogeneity in a widespread ungulate: the European roe deer (Capreolus capreolus).

Abstract:

:Understanding how immune genetic variation is shaped by selective and neutral processes in wild populations is of prime importance in both evolutionary biology and epidemiology. The European roe deer (Capreolus capreolus) has considerably expanded its distribution range these last decades, notably by colonizing agricultural landscapes. This range shift is likely to have led to bottlenecks and increased roe deer exposure to a new range of pathogens that until recently predominantly infected humans and domestic fauna. We therefore investigated the historical and contemporary forces that have shaped variability in a panel of genes involved in innate and acquired immunity in roe deer, including Mhc-Drb and genes encoding cytokines or toll-like receptors (TLRs). Together, our results suggest that genetic drift is the main contemporary evolutionary force shaping immunogenetic variation within populations. However, in contrast to the classical view, we found that some innate immune genes involved in micropathogen recognition (e.g. Tlrs) continue to evolve dynamically in roe deer in response to pathogen-mediated positive selection. Most studied Tlrs (Tlr2, Tlr4 and Tlr5) had similarly high levels of amino acid diversity in the three studied populations including one recently established in southwestern France that showed a clear signature of genetic bottleneck. Tlr2 implicated in the recognition of Gram-positive bacteria in domestic ungulates, showed strong evidence of balancing selection. The high immunogenetic variation revealed here implies that roe deer are able to cope with a wide spectrum of pathogens and to respond rapidly to emerging infectious diseases.

journal_name

Mol Ecol

journal_title

Molecular ecology

authors

Quéméré E,Galan M,Cosson JF,Klein F,Aulagnier S,Gilot-Fromont E,Merlet J,Bonhomme M,Hewison AJ,Charbonnel N

doi

10.1111/mec.13292

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

3873-87

issue

15

eissn

0962-1083

issn

1365-294X

journal_volume

24

pub_type

杂志文章
  • The evolutionary history of Afrocanarian blue tits inferred from genomewide SNPs.

    abstract::A common challenge in phylogenetic reconstruction is to find enough suitable genomic markers to reliably trace splitting events with short internodes. Here, we present phylogenetic analyses based on genomewide single-nucleotide polymorphisms (SNPs) of an enigmatic avian radiation, the subspecies complex of Afrocanaria...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.13008

    authors: Gohli J,Leder EH,Garcia-Del-Rey E,Johannessen LE,Johnsen A,Laskemoen T,Popp M,Lifjeld JT

    更新日期:2015-01-01 00:00:00

  • Do male moor frogs (Rana arvalis) lek with kin?

    abstract::Many amphibian species are known to form leks during breeding season, yet it has seldom been tested which evolutionary forces are likely to act on lek formation in this taxon. We tested the kin selection hypothesis for lek formation by using eight variable microsatellite loci to compare the genetic relationship of 203...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2008.03748.x

    authors: Knopp T,Heimovirta M,Kokko H,Merilä J

    更新日期:2008-05-01 00:00:00

  • Transcriptomic variation and plasticity in rufous-collared sparrows (Zonotrichia capensis) along an altitudinal gradient.

    abstract::As modern genomic tools are developed for ecologically compelling models, field manipulation experiments will become important for establishing the role of functional genomic variation in physiological acclimation and evolutionary adaptation along environmental clines. High-altitude habitats expose individuals to hypo...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2008.03942.x

    authors: Cheviron ZA,Whitehead A,Brumfield RT

    更新日期:2008-10-01 00:00:00

  • Detection of environmental and morphological adaptation despite high landscape genetic connectivity in a pest grasshopper (Phaulacridium vittatum).

    abstract::Widespread species that exhibit both high gene flow and the capacity to occupy heterogeneous environments make excellent models for examining local selection processes along environmental gradients. Here we evaluate the influence of temperature and landscape variables on genetic connectivity and signatures of local ad...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.15146

    authors: Yadav S,Stow AJ,Dudaniec RY

    更新日期:2019-07-01 00:00:00

  • Genetic patterns across an invasion's history: a test of change versus stasis for the Eurasian round goby in North America.

    abstract::Biological invasions comprise accidental evolutionary experiments, whose genetic compositions underlie relative success, spread and persistence in new habitats. However, little is known about whether, or how, their population genetic patterns change temporally and/or spatially across the invasion's history. Theory pre...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.13997

    authors: Snyder MR,Stepien CA

    更新日期:2017-02-01 00:00:00

  • Factors affecting the reproductive success of dominant male meerkats.

    abstract::Identifying traits that affect the reproductive success of individuals is fundamental for our understanding of evolutionary processes. In cooperative breeders, a dominant male typically restricts mating access to the dominant female for extended periods, resulting in pronounced variation in reproductive success among ...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2008.03734.x

    authors: Spong GF,Hodge SJ,Young AJ,Clutton-Brock TH

    更新日期:2008-05-01 00:00:00

  • Asexual genome evolution in the apomictic Ranunculus auricomus complex: examining the effects of hybridization and mutation accumulation.

    abstract::Asexual lineages are thought to be prone to extinction because of deleterious mutation accumulation (Muller's ratchet). Here, we analyse genomic effects of hybridity, polyploidy and allelic divergence in apomictic plants, and identify loci under divergent selection among sexual/apomictic lineages. RNAseq was used to s...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.12533

    authors: Pellino M,Hojsgaard D,Schmutzer T,Scholz U,Hörandl E,Vogel H,Sharbel TF

    更新日期:2013-12-01 00:00:00

  • Major histocompatibility complex heterozygosity enhances reproductive success.

    abstract::We investigated how heterozygosity at the major histocompatibility complex (MHC) affects fitness in wild-derived (F2) house mice (Mus musculus musculus). To compare and control for potential confounding effects from close inbreeding and genome-wide heterozygosity, we used mice that were systematically outbred. We asse...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2011.05009.x

    authors: Thoss M,Ilmonen P,Musolf K,Penn DJ

    更新日期:2011-04-01 00:00:00

  • Independent origins and horizontal transfer of bacterial symbionts of aphids.

    abstract::Many insect groups have obligate associations with primary endosymbionts: mutualistic bacteria that are maternally transmitted and derived from an ancient infection. Often, the same insects are hosts to 'secondary' bacterial symbionts which are maternally transmitted but relatively labile within host lineages. To expl...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2001.01189.x

    authors: Sandström JP,Russell JA,White JP,Moran NA

    更新日期:2001-01-01 00:00:00

  • Polyploid evolution and plastid DNA variation in the Dactylorhiza incarnata/maculata complex (Orchidaceae) in Scandinavia.

    abstract::The Dactylorhiza incarnata/maculata complex (Orchidaceae) was used as a model system to understand genetic differentiation processes in a naturally occurring polyploid complex with much of ongoing diversification and wide distribution in recently glaciated areas in northern Europe. Data were obtained for 12 hypervaria...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2008.03965.x

    authors: Hedrén M,Nordström S,Ståhlberg D

    更新日期:2008-12-01 00:00:00

  • Characterizing dispersal patterns in a threatened seabird with limited genetic structure.

    abstract::Genetic assignment methods provide an appealing approach for characterizing dispersal patterns on ecological time scales, but require sufficient genetic differentiation to accurately identify migrants and a large enough sample size of migrants to, for example, compare dispersal between sexes or age classes. We demonst...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2009.04416.x

    authors: Hall LA,Palsbøll PJ,Beissinger SR,Harvey JT,Bérubé M,Raphael MG,Nelson SK,Golightly RT,McFarlane-Tranquilla L,Newman SH,Peery MZ

    更新日期:2009-12-01 00:00:00

  • Diversity, distribution and exchange of blood parasites meeting at an avian moving contact zone.

    abstract::Research on contact zones has paid relatively little attention to host-parasite interactions, although these situations have important but different implications depending on whether one considers the host or the parasite's perspective. We investigated both the role of a host contact zone in parasite expansion and whe...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2005.02826.x

    authors: Reullier J,Pérez-Tris J,Bensch S,Secondi J

    更新日期:2006-03-01 00:00:00

  • Comparative genetic analyses of historical and contemporary collections highlight contrasting demographic histories for the bumble bees Bombus pensylvanicus and B. impatiens in Illinois.

    abstract::Direct comparison of genetic patterns between museum specimens and contemporary collections can be a powerful approach for detecting recent demographic changes. Using microsatellite markers, we examined historical and contemporary genetic variation from an apparently declining bumble bee species, Bombus pensylvanicus,...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2009.04160.x

    authors: Lozier JD,Cameron SA

    更新日期:2009-05-01 00:00:00

  • Postglacial northward expansion and genetic differentiation between migratory and sedentary populations of the broad-tailed hummingbird (Selasphorus platycercus).

    abstract::Unlike other migratory hummingbirds in North America, the broad-tailed hummingbird (Selasphorus platycercus) exhibits both long-distance migratory behaviour in the USA and sedentary behaviour in Mexico and Guatemala. We examined the evolution of migration linked to its northward expansion using a multiperspective appr...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.12614

    authors: Malpica A,Ornelas JF

    更新日期:2014-02-01 00:00:00

  • Molecular biodiversity and population structure in common ash (Fraxinus excelsior L.) in Britain: implications for conservation.

    abstract::Current forestry policy promotes the use of local seed for new plantings, on the assumption that local material may be better adapted to local conditions. However, landscape-scale genetic studies which are necessary to underpin conservation and breeding strategies are often lacking. We investigated molecular diversity...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2009.04376.x

    authors: Sutherland BG,Belaj A,Nier S,Cottrell JE,P Vaughan S,Hubert J,Russell K

    更新日期:2010-06-01 00:00:00

  • Temporal change in the genetic structure between and within cohorts of a marine fish, Diplodus sargus, induced by a large variance in individual reproductive success.

    abstract::Temporal changes at 16 allozyme loci in the Diplodus sargus population of Banyuls-sur-Mer (Mediterranean Sea, France) were monitored. Temporal genetic variation within a single population was examined over two temporal scales: (i) among three year-classes sampled at the same age, and (ii) within a single year-class sa...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2002.01521.x

    authors: Planes S,Lenfant P

    更新日期:2002-08-01 00:00:00

  • Strong dispersal in a parasitoid wasp overwhelms habitat fragmentation and host population dynamics.

    abstract::The population dynamics of a parasite depend on species traits, host dynamics and the environment. Those dynamics are reflected in the genetic structure of the population. Habitat fragmentation has a greater impact on parasites than on their hosts because resource distribution is increasingly fragmented for species at...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.13696

    authors: Couchoux C,Seppä P,van Nouhuys S

    更新日期:2016-07-01 00:00:00

  • An analysis of genetic variation in natural populations of Sticherus flabellatus [R. Br. (St John)] using amplified fragment length polymorphism (AFLP) markers.

    abstract::Amplified fragment length polymorphisms (AFLPs) were used to characterize the genetic diversity within and among natural populations of Sticherus flabellatus. Eight populations within the Sydney region of New South Wales, Australia were surveyed using 11 primer combinations. A total of 1108 reproducible bands were det...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2000.00901.x

    authors: Keiper FJ,McConchie R

    更新日期:2000-05-01 00:00:00

  • Bottlenecks, drift and differentiation: the population structure and demographic history of sika deer (Cervus nippon) in the Japanese archipelago.

    abstract::We assessed genetic differentiation and diversity in 14 populations of sika deer (Cervus nippon) from Japan and four populations of sika deer introduced to the UK, using nine microsatellite loci. We observed extreme levels of differentiation and significant differences in diversity between populations. Our results do ...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2001.01277.x

    authors: Goodman SJ,Tamate HB,Wilson R,Nagata J,Tatsuzawa S,Swanson GM,Pemberton JM,McCullough DR

    更新日期:2001-06-01 00:00:00

  • A restricted hybrid zone between native and introduced red fox (Vulpes vulpes) populations suggests reproductive barriers and competitive exclusion.

    abstract::Introduced species can threaten native taxa in multiple ways, including competition and hybridization, which can reduce fitness, alter ecological niches or swamp native genomes. Encroachment and hybridization by introduced species also provide opportunities to study the dynamics of invasiveness and hybridization durin...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2010.04943.x

    authors: Sacks BN,Moore M,Statham MJ,Wittmer HU

    更新日期:2011-01-01 00:00:00

  • The genetic architecture of local adaptation and reproductive isolation in sympatry within the Mimulus guttatus species complex.

    abstract::The genetic architecture of local adaptation has been of central interest to evolutionary biologists since the modern synthesis. In addition to classic theory on the effect size of adaptive mutations by Fisher, Kimura and Orr, recent theory addresses the genetic architecture of local adaptation in the face of ongoing ...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.13763

    authors: Ferris KG,Barnett LL,Blackman BK,Willis JH

    更新日期:2017-01-01 00:00:00

  • Combined analyses of kinship and FST suggest potential drivers of chaotic genetic patchiness in high gene-flow populations.

    abstract::We combine kinship estimates with traditional F-statistics to explain contemporary drivers of population genetic differentiation despite high gene flow. We investigate range-wide population genetic structure of the California spiny (or red rock) lobster (Panulirus interruptus) and find slight, but significant global p...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.12341

    authors: Iacchei M,Ben-Horin T,Selkoe KA,Bird CE,García-Rodríguez FJ,Toonen RJ

    更新日期:2013-07-01 00:00:00

  • Plague dynamics and population genetics of the desert locust: can turnover during recession maintain population genetic structure?

    abstract::The desert locust (Schistocerca gregaria) undergoes crowding-induced phase transformation from solitary form to gregarious form. The transformations involves changes in behaviour, colour, development, morphometry, fecundity and endocrine physiology. Recession populations of the desert locust exist primarily in the sol...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2001.01212.x

    authors: Ibrahim KM

    更新日期:2001-03-01 00:00:00

  • Low plant density enhances gene dispersal in the Amazonian understory herb Heliconia acuminata.

    abstract::In theory, conservation genetics predicts that forest fragmentation will reduce gene dispersal, but in practice, genetic and ecological processes are also dependent on other population characteristics. We used Bayesian genetic analyses to characterize parentage and propagule dispersal in Heliconia acuminata L. C. Rich...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.12495

    authors: Côrtes MC,Uriarte M,Lemes MR,Gribel R,Kress WJ,Smouse PE,Bruna EM

    更新日期:2013-11-01 00:00:00

  • Estimation of gene flow in the tropical-rainforest tree Neobalanocarpus heimii (Dipterocarpaceae), inferred from paternity analysis.

    abstract::Pollen flow and population genetic structure among 30 potentially flowering individuals of Neobalanocarpus heimii, a tropical emergent tree, were investigated in a lowland tropical rainforest of Malaysia using microsatellite polymorphism. The 248 offspring in the vicinity of five reproductive trees of the 30 potential...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2000.01081.x

    authors: Konuma A,Tsumura Y,Lee CT,Lee SL,Okuda T

    更新日期:2000-11-01 00:00:00

  • Convergence in organ size but not energy metabolism enzyme activities among wild Lake Whitefish (Coregonus clupeaformis) species pairs.

    abstract::The repeated evolution of similar phenotypes by similar mechanisms can be indicative of local adaptation, constraints or biases in the evolutionary process. Little is known about the incidence of physiological convergence in natural populations, so here we test whether energy metabolism in 'dwarf' and 'normal' Lake Wh...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.13847

    authors: Dalziel AC,Laporte M,Rougeux C,Guderley H,Bernatchez L

    更新日期:2017-01-01 00:00:00

  • No evidence for accumulation of deleterious mutations and fitness degradation in clonal fish hybrids: Abandoning sex without regrets.

    abstract::Despite its inherent costs, sexual reproduction is ubiquitous in nature, and the mechanisms to protect it from a competitive displacement by asexuality remain unclear. Popular mutation-based explanations, like the Muller's ratchet and the Kondrashov's hatchet, assume that purifying selection may not halt the accumulat...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.15539

    authors: Kočí J,Röslein J,Pačes J,Kotusz J,Halačka K,Koščo J,Fedorčák J,Iakovenko N,Janko K

    更新日期:2020-08-01 00:00:00

  • Mixed-stock analysis reveals the migrations of juvenile hawksbill turtles (Eretmochelys imbricata) in the Caribbean Sea.

    abstract::Hawksbill turtles (Eretmochelys imbricata) migrate between nesting beaches and feeding habitats that are often associated with tropical reefs, but it is uncertain which nesting colonies supply which feeding habitats. To address this gap in hawksbill biology, we compile previously published and new mitochondrial DNA (m...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2006.03096.x

    authors: Bowen BW,Grant WS,Hillis-Starr Z,Shaver DJ,Bjorndal KA,Bolten AB,Bass AL

    更新日期:2007-01-01 00:00:00

  • Current geography masks dynamic history of gene flow during speciation in northern Australian birds.

    abstract::Genome divergence is greatly influenced by gene flow during early stages of speciation. As populations differentiate, geographic barriers can constrain gene flow and so affect the dynamics of divergence and speciation. Current geography, specifically disjunction and continuity of ranges, is often used to predict the h...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.14978

    authors: Peñalba JV,Joseph L,Moritz C

    更新日期:2019-02-01 00:00:00

  • Features of DNA fragments obtained by random amplified polymorphic DNA (RAPD) assays

    abstract::Random amplified polymorphic DNA (RAPD) fragments were prepared from samples of Calonectris diomedea (Cory's shearwater, Aves) and Haemonchus contortus (Nematoda) DNA by polymerase chain reaction (PCR) using decamers containing two restriction enzyme sites as primers. Six of 19 studied RAPD fragments probably originat...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.1999.00605.x

    authors: Rabouam C,Comes AM,Bretagnolle V V,Humbert JF,Periquet G,Bigot Y

    更新日期:1999-03-01 00:00:00