Depression as a predictor of adherence to adjuvant endocrine therapy (AET) in women with breast cancer: a systematic review and meta-analysis.

abstract：:As the number of women surviving breast cancer increases, with implications for the health system, research into the physical and psychosocial sequelae of the cancer and its treatment is a priority. This research estimated self-reported health-related quality of life (HRQoL) associated with two rehabilitation interven...

journal_title：Breast cancer research and treatment

authors： Gordon LG,Battistutta D,Scuffham P,Tweeddale M,Newman B

更新日期：2005-10-01 00:00:00

abstract：:Beta-blockers (BB) drugs have been used for decades worldwide, mainly to treat hypertension. However, in recent epidemiological studies, BBs were suggested to improve cancer prognosis. In the wake of this evidence, we evaluated the possible therapeutic effect of BBs in triple-negative breast cancer (TNBC) patients. We...

journal_title：Breast cancer research and treatment

authors： Botteri E,Munzone E,Rotmensz N,Cipolla C,De Giorgi V,Santillo B,Zanelotti A,Adamoli L,Colleoni M,Viale G,Goldhirsch A,Gandini S

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:Existing high-risk clinic models focus on patients with known risk factors, potentially missing many high-risk patients. Here we describe our experience implementing universal risk assessment in an ambulatory breast center. METHODS:Since May 2017, all breast center patients completed a customized intake survey...

journal_title：Breast cancer research and treatment

authors： Weiss A,Grossmith S,Cutts D,Mikami SA,Suskin JA,Graichen MK,Rojas NA,Pace LE,Joyce E,Rhei E,Scheib R,Bychkovsky B,Garber JE,Morganstern D,King TA

更新日期：2019-05-01 00:00:00

abstract：:In order to assess the impact of modern combination chemotherapy on overall survival of metastatic breast cancer patients, we retrospectively analysed survival data of those patients who presented with breast cancer and developed metastases at our clinic from 1971-78 inclusive. Our results indicate a trend towards imp...

journal_title：Breast cancer research and treatment

authors： Paterson AH,Szafran O,Cornish F,Lees AW,Hanson J

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:We investigated the associations of adolescent adiposity, changes in adiposity during adulthood, and attained adiposity with volumetric mammographic density measures. METHODS:We recruited 383 premenopausal women who had a routine screening mammogram at the Breast Health Center, Washington University in St. Lou...

journal_title：Breast cancer research and treatment

authors： Alimujiang A,Appleton C,Colditz GA,Toriola AT

更新日期：2017-11-01 00:00:00

abstract：:Monitoring effective antiestrogenic activity of the triphenylethylenes in patients with breast cancer is usually determined by the duration of response. The pharmacokinetics of toremifene and tamoxifen have been shown to be highly variable but patient specific. In the present study, we developed a method to accurately...

journal_title：Breast cancer research and treatment

authors： DeGregorio M,Wurz G,Emshoff V,Koester S,Minor P,Wiebe V

更新日期：1992-01-01 00:00:00

abstract：:The basal-like or basal phenotype (BP) class of breast cancers have recently attracted attention as a poor prognostic form of breast cancer. However, BP appears to encompass biologically and clinically heterogeneous tumours, resulting in a lack of consensus definition of BP. We analysed 48,000 gene transcripts in 132 ...

journal_title：Breast cancer research and treatment

authors： Zhang H,Rakha EA,Ball GR,Spiteri I,Aleskandarany M,Paish EC,Powe DG,Macmillan RD,Caldas C,Ellis IO,Green AR

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Younger women diagnosed with breast cancer have poorer prognoses and higher mortality compared to older women. Young black women have higher incidence rates of breast cancer and more aggressive subtypes than women of other races/ethnicities. In this study, we examined recent trends and variations in breast canc...

journal_title：Breast cancer research and treatment

authors： Shoemaker ML,White MC,Wu M,Weir HK,Romieu I

更新日期：2018-06-01 00:00:00

abstract：:Toremifene is a triphenylethylene derivative structurally and pharmacologically similar to tamoxifen. This Phase I trial assessed the safety, pharmacokinetics, anti-estrogenic, and estrogenic effects of toremifene at six dose levels (10, 20, 40, 60, 200, and 400 mg/day). The most common side-effects associated with th...

journal_title：Breast cancer research and treatment

authors： Kohler PC,Hamm JT,Wiebe VJ,DeGregorio MW,Shemano I,Tormey DC

更新日期：1990-08-01 00:00:00

abstract：:Intraoperative radiotherapy with electrons (ELIOT) after conservative surgery for breast carcinoma was introduced at the IEO in 1999 as a research programme. The results on 1,822 patients treated from January 2000 to December 2008 are reported. Women with unicentric primary breast carcinoma of less than 2.5 cm in the ...

journal_title：Breast cancer research and treatment

authors： Veronesi U,Orecchia R,Luini A,Galimberti V,Zurrida S,Intra M,Veronesi P,Arnone P,Leonardi MC,Ciocca M,Lazzari R,Caldarella P,Rotmensz N,Sangalli C,Sances D,Maisonneuve P

更新日期：2010-11-01 00:00:00

abstract：:Secondary lymphedema often develops after removal of lymph nodes in combination with radiation therapy, in particular in patients with breast cancer, inguinal cancer, cervical cancer and melanoma. No convincing treatment for the prevention and therapy of acquired lymphedema exists so far, therefore we wanted to show t...

journal_title：Breast cancer research and treatment

authors： Blum KS,Hadamitzky C,Gratz KF,Pabst R

更新日期：2010-02-01 00:00:00

abstract：:NF-E2-related factor 2 (Nrf2) is an important transcription factor involved in antioxidant response. Nrf2 binds antioxidant response elements (ARE) within promoters of genes encoding detoxification enzymes (e.g., NAD (P) H-quinone oxidoreductase 1 (NQO1)) leading to their transcriptional activation. Nrf2 function is r...

journal_title：Breast cancer research and treatment

authors： Yang M,Yao Y,Eades G,Zhang Y,Zhou Q

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Dysregulation of HER2 signaling pathway in breast cancer is well documented. Our bioinformatics analysis predicted hsa-miR-512-3p (miR-512-3p) as a bona fide regulator of HER2 as well as HER3, PIK3R2, and AKT1 genes. Then, we intended to examine the effect of miR-512-3p on the predicted target genes that are in...

journal_title：Breast cancer research and treatment

authors： Mohamadzade Z,Mahjoubi F,Soltani BM

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:Alongside the modern trend of delaying childbirth, the high incidence of breast cancer among young women is causing significant pregnancy-related problems in Korea. We estimated the incidence of childbirth for young Korean breast cancer survivors compared with women who did not have breast cancer using a nation...

journal_title：Breast cancer research and treatment

authors： Lee HM,Kim BW,Park S,Park S,Lee JE,Choi YJ,Kim SY,Woo SU,Youn HJ,Lee I

更新日期：2019-07-01 00:00:00

abstract：:Eighty-five breast cancer specimens were processed as part of a program in tumor acquisition, propagation, and preservation for biotherapy. Nine long-term culture cell lines were developed. Four cell lines were from solid tumor metastases, two lines were from pleural fluid specimens, and three were from xenograft tumo...

journal_title：Breast cancer research and treatment

authors： Lewko WM,Vaghmar R,Hubbard D,Moore M,He YJ,Chang L,Husseini S,Wallwork K,Thurman GB,Oldham RK

更新日期：1990-12-01 00:00:00

abstract：:We examined the role of Mcl-1 and Bcl-2 expression in the induction of apoptosis. through blocking protein tyrosine kinase (PTK), protein kinase C (PKC), phosphatidylinositol 3-kinase (P13-K) and mitogen-activated protein kinase (MAPK)/Erk kinase (MEK) signaling pathways by various kinase inhibitors in MCF-7 breast ca...

journal_title：Breast cancer research and treatment

authors： Hu Y,Dragowska WH,Wallis A,Duronio V,Mayer L

更新日期：2001-11-01 00:00:00

abstract：:Approximately 15-20% of all breast cancers are human epidermal growth factor receptor 2 (HER2) positive, with clinical studies having validated the HER2 receptor tyrosine kinase pathway as an important therapeutic target. Presently, two HER2-targeted therapies are approved by the Food and Drug Administration for treat...

journal_title：Breast cancer research and treatment

authors： Ahn ER,Vogel CL

更新日期：2012-01-01 00:00:00

abstract：:It has recently been proposed that a three-gene model (SCMGENE) that measures ESR1, ERBB2, and AURKA identifies the major breast cancer intrinsic subtypes and provides robust discrimination for clinical use in a manner very similar to a 50-gene subtype predictor (PAM50). However, the clinical relevance of both predict...

journal_title：Breast cancer research and treatment

authors： Prat A,Parker JS,Fan C,Perou CM

更新日期：2012-08-01 00:00:00

abstract：:We have measured the levels of tamoxifen and three of its metabolites in the blood of patients receiving tamoxifen alone or combination therapy with tamoxifen and medroxyprogesterone acetate. Our results indicate that addition of the progestogen significantly alters the metabolism of tamoxifen over a six-month period....

journal_title：Breast cancer research and treatment

authors： Reid AD,Horobin JM,Newman EL,Preece PE

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:We have developed a decision analysis model that uses the results of available randomized controlled trials to model the natural history of early breast cancer and assess the potential clinical and financial effects of using adjuvant therapies. PATIENTS AND METHODS:The original model was used to assess the ...

journal_title：Breast cancer research and treatment

authors： Hillner BE,Smith TJ,Desch CE

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To determine if response to endocrine therapy of breast cancer can be predicted by either a metabolic "flare reaction" detected by positron emission tomography (PET) with 2-[(18)F]-fluoro-2-deoxyglucose (FDG), induced by an estradiol challenge, or by estrogen-receptor (ER) status, determined by PET with the est...

journal_title：Breast cancer research and treatment

authors： Dehdashti F,Mortimer JE,Trinkaus K,Naughton MJ,Ellis M,Katzenellenbogen JA,Welch MJ,Siegel BA

更新日期：2009-02-01 00:00:00

abstract：:Although a significant proportion of familial aggregation of breast cancer remains unexplained, many of the currently known breast cancer susceptibility genes, including BRCA1, BRCA2 and TP53, play a role in maintaining genome integrity by engaging in DNA repair. RAD51L1 is one of the five RAD51 paralogs involved in h...

journal_title：Breast cancer research and treatment

authors： Johnson J,Healey S,Khanna KK,kConFab.,Chenevix-Trench G

更新日期：2011-08-01 00:00:00

abstract：:While several risk factors for breast cancer have been identified, studies have not consistently shown whether these factors operate more strongly at certain ages or for just pre- or postmenopausal women. We evaluated whether risk factors for breast cancer differ according to age or menopausal status. Data from five p...

journal_title：Breast cancer research and treatment

authors： Trentham-Dietz A,Sprague BL,Hampton JM,Miglioretti DL,Nelson HD,Titus LJ,Egan KM,Remington PL,Newcomb PA

更新日期：2014-05-01 00:00:00

abstract：:Tamoxifen has been a standard first-line endocrine therapy for post-menopausal women with hormone-responsive advanced breast cancer, but more than half of patients fail to respond and time to progression is less than 12 months in responders. The third-generation aromatase inhibitors were developed to provide more effe...

journal_title：Breast cancer research and treatment

authors： Mouridsen HT

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Germline mutations in BRCA1 and BRCA2 confer a significant increase in risk for cancer, and determining pathogenicity of a BRCA variant can guide the clinical management of the disease. About 1/3 of BRCA1 variants reported in the public databases have uncertain clinical significance due to lack of conclusive ev...

journal_title：Breast cancer research and treatment

authors： Yang C,Jairam S,Amoroso KA,Robson ME,Walsh MF,Zhang L

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Vinorelbine (Navelbin; N) has proven to be active in patients with advanced breast cancer (ABC) and cyclophosphamide (C) and epirubicin (Epiadriamycin: E) are still among the main cytostatic agents against this tumor. On this basis was carried out a study to determine the activity and toxicity of the combina...

journal_title：Breast cancer research and treatment

authors： Esteban E,de Sande G,Puertas J,Fra J,Palacio I,Vieitez JM,Fernández JL,Muñiz I,Modollel A,Carrasco J,Sala M,Lacave AJ

更新日期：2000-07-01 00:00:00

abstract：:The activity of selective estrogen receptor modulators (SERMs) is not fully explained by an estrogen receptor (ER) switch model that simply turns estrogen activity on or off. A better understanding of the mechanisms involved in estrogen signaling and the development of drug resistance could help stratify patients into...

journal_title：Breast cancer research and treatment

authors： McCafferty MP,McNeill RE,Miller N,Kerin MJ

更新日期：2009-08-01 00:00:00

abstract：:Genome-Wide Association Studies have identified several loci associated with breast cancer (BC) in populations of different ethnic origins. One of the strongest associations was found in the FGFR2 gene, and MAP3K1 has been proposed as a low-penetrance BC risk factor. In this study, we evaluated the associations among ...

journal_title：Breast cancer research and treatment

authors： Jara L,Gonzalez-Hormazabal P,Cerceño K,Di Capua GA,Reyes JM,Blanco R,Bravo T,Peralta O,Gomez F,Waugh E,Margarit S,Ibañez G,Romero C,Pakomio J,Roizen G

更新日期：2013-01-01 00:00:00

abstract：:We have compared the effects of the progestin R5020 and the antiprogestin RU486 on the growth of the MCF-7 and T47D breast cancer cell lines. Differences between the two compounds were demonstrated in several parameters. 1. Estradiol was required for the efficient inhibition of cell growth of both lines by R5020 but n...

journal_title：Breast cancer research and treatment

authors： Gill PG,Vignon F,Bardon S,Derocq D,Rochefort H

更新日期：1987-10-01 00:00:00

abstract：:Previous studies showing the presence of antibodies against tumor-associated antigens in healthy individuals suggest that antibody-dependent cell cytotoxicity (ADCC) might play a role in the development of breast cancer. We hypothesized that functional polymorphisms in fragment c gamma receptor (FcgR) genes were assoc...

journal_title：Breast cancer research and treatment

authors： Iwasaki M,Shimada N,Kasuga Y,Yokoyama S,Onuma H,Nishimura H,Kusama R,Hamada GS,Nishimoto IN,Iyeyasu H,Motola J Jr,Laginha FM,Anzai R,Tsugane S

更新日期：2011-04-01 00:00:00