Abstract:
:Glucose transporters, such as GLUT-1, mediate the important mechanisms involved in cellular glucose influx, allowing cells to proliferate and survive. The significance of GLUT-1 expression in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) has been less explored, and no study has investigated it in relation to verrucous carcinoma (VC). We evaluated 30 cases each of OED, OSCC, and VC, graded further on the basis of their differentiation, immunohistochemically for GLUT-1 expression, along with 10 specimens of normal oral mucosa (NOM) as controls. In OSCC, GLUT-1 expression increased with the degree of dysplasia and increasing grade (P < 0.001). The expression in VC was predominantly membranous and intense, resembling well differentiated OSCC. This increase of GLUT-1 expression in OSCC along with the degree of dysplasia and the histologic grade reflects the expanding glycolytic response to hypoxia. This is the first study to have revealed prominent GLUT-1 expression in VC, highlighting its inherent metabolic capacity.
journal_name
J Oral Scijournal_title
Journal of oral scienceauthors
Angadi VC,Angadi PVdoi
10.2334/josnusd.57.115subject
Has Abstractpub_date
2015-06-01 00:00:00pages
115-22issue
2eissn
1343-4934issn
1880-4926journal_volume
57pub_type
杂志文章abstract::When a tooth is avulsed and replanted following traumatic dental injury, complications such as replacement and inflammatory resorption may occur. Ultimately, resorption may result in loss of the tooth. This case report describes a traumatic injury to a permanent tooth resulting in complete root resorption within a sho...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.49.341
更新日期:2007-12-01 00:00:00
abstract::Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent thrombosis, other associated autoimmune disease, and/or obstetrical morbidity along with persistent production of antiphospholipid antibodies. Because of the nature of this systemic disease, most patients are medicated with an...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.18-0164
更新日期:2019-08-28 00:00:00
abstract::Accurate diagnosis and exact treatment planning are very important for successful implant treatment. Pretreatment examination and simulations using CT can be especially effective information sources, and diagnosis by CT imaging before treatment substantially enhances the security and safety of the treatment plan. New ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.41.157
更新日期:1999-12-01 00:00:00
abstract::This study investigated the effects of indirect composite polymerization on the postcuring mechanical properties of a fiber-reinforced composite. An indirect composite seated on glass fibers preimpregnated with polymerized monomer was polymerized by 1) photoirradiation using a halogen-fluorescent polymerizing unit for...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.16-0117
更新日期:2017-03-31 00:00:00
abstract::The aim of this study was to investigate the relationship between dental clinic credibility and patient satisfaction with regular dental check-ups, to compare the level of satisfaction of patients who had regular check-ups with those who did not, and to identify factors associated with regular dental checkups. Thirty-...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.47.97
更新日期:2005-06-01 00:00:00
abstract::This pilot study evaluated, by culture testing, the effectiveness of lethal photosensitization for the microbiological treatment of peri-implantitis in dogs. Experimental peri-implantitis was induced by ligature placement for 2 months. Following ligature removal, plaque control was instituted by scrubbing with 0.12% c...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.45.17
更新日期:2003-03-01 00:00:00
abstract::Naso-oral fistula, as the name suggests, is an abnormal communication between the nasal and oral cavities. It is an extremely rare clinical entity encountered in routine rhinology clinics across the world. The occurrence of this fistula due to rhinolithiasis is much rarer. We present one such case in a 40-year-old man...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.51.481
更新日期:2009-09-01 00:00:00
abstract::High mobility group box 1 (HMGB1) was originally defined as a nuclear protein. However, later studies showed that HMGB1 was released from damaged cells into the extracellular milieu and functioned as a danger signaling molecule. HMGB1 has also been shown to exert proliferative and chemoattractant effects on many cell ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.55.45
更新日期:2013-03-01 00:00:00
abstract::The aim of the present study was to evaluate the association of single nucleotide polymorphisms (SNPs) in toll-like receptor 4 (TLR4) with chronic obstructive pulmonary disease (COPD) in Han Chinese patients with chronic periodontitis (CP). Six candidate SNPs of TLR4-rs10759930, rs10983755, rs11536879, rs1927907, rs11...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.16-0187
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:The present study was conducted to determine oxidative stress and cell viability after contact with resin composites polymerized for different times. METHODS:Disk-shaped specimens of Admira Fusion, Ceram X One Universal, Solare x and Filtek Z550 (n = 12) were prepared, and two subgroups with polymerization tim...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.20-0034
更新日期:2020-12-23 00:00:00
abstract::The purpose of the present study was to evaluate the radiopacity of currently available dental luting materials. Five conventional cements, six resin-modified glass ionomers (RMGIs), two methyl methacrylate (MMA)-based acrylic resins (eight shades), and nine composite luting materials were evaluated. Radiographs of th...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.51.223
更新日期:2009-06-01 00:00:00
abstract::The aim of this study was to evaluate the subcutaneous biocompatibility of three root canal sealers in rats. Thirty Wistar rats were divided into three groups according to three time periods (15, 30 and 60 days). Sterilized polyethylene tubes filled with root canal sealers (AH Plus, Epiphany & Grossman), and one empty...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.15
更新日期:2011-03-01 00:00:00
abstract::Previously, we showed that recombinant human bone morphogenetic protein-2 (rhBMP-2) increased bone augmentation beyond the skeletal envelope within a titanium cap in a rabbit calvarium; many cuboidal osteoblastic cells were observed histologically. These results suggested that the new osteoblastic cells might have dif...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.50.427
更新日期:2008-12-01 00:00:00
abstract::This report describes the bonding technique and clinical course of porcelain laminate veneer restorations applied to discolored maxillary incisors and canines. The patient was an 18-year-old woman, and tooth reduction was limited to the enamel. Laminate veneer restorations were made with a feldspathic porcelain materi...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.56.227
更新日期:2014-09-01 00:00:00
abstract::This study, employing an exercise versus control crossover design, was conducted to investigate the influence of acute high-intensity exercise on salivary nitric oxide (NO) levels. Nine healthy males (aged 23.8 ± 1.4 years) performed ergometer exercise at 80%VO2peak for 60 min, whereas controls sat at rest for 60 min....
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.18-0205
更新日期:2019-01-01 00:00:00
abstract::The purpose of this study was to explore the effects of nicotine on the activity of Streptococcus mutans (S. mutans) in soft drinks. Regular soft drinks contain large proportions of high-fructose corn syrup (HFCS), which increases the activity of S. mutans resulting in high-caries risk compared with sugar-free soft dr...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.20-0073
更新日期:2020-12-23 00:00:00
abstract::Differential expression of members of the connexin (Cx) gap junction multigene family permits formation of gap junctions with the varied physiological properties required by different tissues. The aim of this study was to characterize connexin expression and the influence of all-trans-retinoic acid (RA) in mouse gingi...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.327
更新日期:2011-09-01 00:00:00
abstract::We investigated inhibition of lesion progression in artificial enamel lesions. Lesions were created on primary and permanent anterior teeth (n = 10 each) and were divided randomly into two groups with two windows: Group 1 (window A: resin infiltration; window B: negative control) and Group 2 (window A: resin infiltrat...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.57.177
更新日期:2015-09-01 00:00:00
abstract::One of the objectives of this short communication was to add to the literature on the prevalence of oral recurrent aphthous stomatitis (ORAS). This research is based on a total of 11,697 randomly selected Malaysian subjects with an age range of 25-115 years and a mean age of 44.5 +/- 13.9 years who were examined for o...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.42.15
更新日期:2000-03-01 00:00:00
abstract::Despite its important role in the control of periodontal disease, mechanical plaque control is not properly practiced by most individuals. Therefore, adjunctive chemical plaque control using chlorhexidine and antibiotics has also been suggested as an additional therapeutic strategy to augment mechanical plaque control...
journal_title:Journal of oral science
pub_type: 杂志文章,评审
doi:10.2334/josnusd.54.1
更新日期:2012-03-01 00:00:00
abstract::Once a tooth develops deep caries and the dental pulp tissue is irreversibly infected, the infected dental pulp tissue should be removed, and filling material should be placed in the root canal. Endodontically treated teeth are prone to root fracture or periapical periodontitis; however, dental pulp tissue has the pot...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.17-0456
更新日期:2018-12-29 00:00:00
abstract::Oral malignant melanoma is a rare aggressive neoplasm of melanocytic origin, usually found on the hard palate and gingiva, and representing 0.2-8% of all melanomas. Unfortunately, oral mucosal melanomas have by far the worst prognosis, and therefore early detection is indispensable for improving their prognosis. Histo...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.239
更新日期:2011-06-01 00:00:00
abstract::The purpose of this study was to investigate the antimicrobial efficacy of six groups of antibiotics and calcium hydroxide against Enterococcus faecalis biofilm in a membrane filter model. Two-day-old E. faecalis (ATCC 29212) biofilm was exposed to ampicillin, co-trimoxazole, erythr omycin, oxytetracycline, vancomycin...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.49.161
更新日期:2007-06-01 00:00:00
abstract::There are several benefits in using adhesive technique in removable prosthodontics as well as fixed prosthodontics. Previous studies have examined denture-base surface treatments that improve bond strength between a denture base resin and autopolymerizing repair resin. Dichloromethane and ethyl acetate are organic sol...
journal_title:Journal of oral science
pub_type: 杂志文章,评审
doi:10.2334/josnusd.54.205
更新日期:2012-09-01 00:00:00
abstract::It is reported in the European and American literature that salivary duct cysts constitute about 10% of all cysts of the salivary glands, although they appear to be rare in Japan. Between 1975 and 1999, only 3 (0.5%) of 586 salivary gland cysts were diagnosed as salivary duct cysts at the Division of Clinical Patholog...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.43.9
更新日期:2001-03-01 00:00:00
abstract::External invasive resorption is an uncommon but aggressive type of external resorption. This report outlines the management of an advanced case of external invasive resorption with mineral trioxide aggregate (MTA). The clinical and radiographic follow-up after 60 months revealed a functional tooth with a stable period...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.397
更新日期:2011-09-01 00:00:00
abstract::This study aimed to evaluate superficial defects and the composition of Reciproc R25 and ProTaper Retreatment file systems (Dentsply Maillefer, Ballaigues, Switzerland) used for retreatment. A total of 100 maxillary incisor teeth were randomly divided into the following two groups: Reciproc R25 (n = 25) and ProTaper R...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.15-0725
更新日期:2016-01-01 00:00:00
abstract::This study explored differences in dental biofilm solids and fluid fluoride after ingestion of NaF or Na2FPO3 in milk or non-fluoridated milk. Eighteen volunteers ingested 1 mg fluoride in 200 mL of milk or 200 mL of non-fluoridated milk. Biofilm samples were collected at baseline, 30, 60, and 240 min and biofilm soli...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.55.233
更新日期:2013-09-01 00:00:00
abstract::Temporomandibular joint (TMJ) disease classification and subsequent treatment selection are highly debated subjects within dentistry and medicine. Several suggestions for diagnostic classification and treatment algorithms have been proposed thus far without achieving a clear gold standard. A universally accepted diagn...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.19-0128
更新日期:2020-01-01 00:00:00
abstract::We investigated the temporal association between temporomandibular disorders (TMD)-related symptoms and headache during TMD treatment for patients who fulfilled the diagnostic criteria for headache attributed to TMD (HATMD) specified in the Diagnostic criteria for TMD (DC/TMD) and International classification of heada...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.15-0491
更新日期:2016-01-01 00:00:00