Abstract:
:Once a tooth develops deep caries and the dental pulp tissue is irreversibly infected, the infected dental pulp tissue should be removed, and filling material should be placed in the root canal. Endodontically treated teeth are prone to root fracture or periapical periodontitis; however, dental pulp tissue has the potential to prevent root fracture or periapical periodontitis. Therefore, dental pulp regeneration after pulpectomy may help prolong tooth life. In this study, a new method of dental pulp regeneration was developed. Vascular endothelial growth factor-adsorbed collagen gel was injected into the root canal of a prepared root canal model, placed into the dorsum of a rat, and cultured for 3 weeks. After retrieving the implant, histological analysis was performed. It was found that rat somatic cells were recruited into the root apex of the transplanted root canal model. These findings suggest a new potential technique for engineering dental pulp tissue.
journal_name
J Oral Scijournal_title
Journal of oral scienceauthors
Matsuura T,Sugimoto K,Kawata-Matsuura VKS,Yanagiguchi K,Yamada S,Hayashi Ydoi
10.2334/josnusd.17-0456subject
Has Abstractpub_date
2018-12-29 00:00:00pages
634-637issue
4eissn
1343-4934issn
1880-4926journal_volume
60pub_type
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