Abstract:
:Differential expression of members of the connexin (Cx) gap junction multigene family permits formation of gap junctions with the varied physiological properties required by different tissues. The aim of this study was to characterize connexin expression and the influence of all-trans-retinoic acid (RA) in mouse gingival epithelial cells (GE1). The cells were treated with RA, and expression of Cxs was analyzed by immunofluorescence, reverse transcriptase-polymerase chain reaction (RT-PCR), and real-time PCR. RT-PCR revealed that GE1 cells expressed mRNA for Cx26, Cx30.3, Cx31.1, Cx32, and Cx43. In addition, real-time PCR revealed that RA significantly decreased expression of Cx31.1 as compared with control. These results indicate that GE1 cells are useful in analyzing the expression of connexin molecules in oral keratinocytes from oral mucosal lesions.
journal_name
J Oral Scijournal_title
Journal of oral scienceauthors
Hatakeyama S,Mikami T,Habano W,Takeda Ydoi
10.2334/josnusd.53.327subject
Has Abstractpub_date
2011-09-01 00:00:00pages
327-32issue
3eissn
1343-4934issn
1880-4926pii
JST.JSTAGE/josnusd/53.327journal_volume
53pub_type
杂志文章abstract::Age-related deterioration in physical and oral health reduces healthy life expectancy and is thus an important problem for very elderly people. We investigated the effects of satisfaction with dietary life (SDL) in everyday life on oral health-related quality of life (OHRQoL) and subjective well-being and examined ass...
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