Abstract:
:The aim of the study was to increase production of (R)-PAC by altering carboligation activity of Pdc in Saccharomyces cerevisiae. Pdc1 activity was modified by over-expression as well as changing the rate of decarboxylation and carboligation by site specific mutation in Pdc1. Over-expression of mutant Pdc1 resulted in 50 ± 2.5% increase in levels of (R)-PAC in wild-type and further 30-40% in pdc null background. The combination of mutant Pdc1 in pdc null background was successfully evaluated for production of (R)-PAC at industrial scale. This is the first report of enhancing (R)-PAC product in yeast by recombinant technology with capability of commercial production.
journal_name
Bioresour Technoljournal_title
Bioresource technologyauthors
Agarwal PK,Uppada V,Swaminathan AG,Noronha SBdoi
10.1016/j.biortech.2015.05.060subject
Has Abstractpub_date
2015-09-01 00:00:00pages
90-6eissn
0960-8524issn
1873-2976pii
S0960-8524(15)00733-6journal_volume
192pub_type
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