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A novel amino cellulose derivative using ATRP method: Preparation, characterization, and investigation of its antibacterial activity.

Abstract：

:In this study, we prepared a novel amino cellulose derivative (benzyl cellulose-g-poly [2-(N,N-Dimethylamino)ethyl methacrylate]) via a homogeneous ATRP method. The successful synthesis of the novel amino cellulose was confirmed by FT-IR and 1H NMR. This study addressed the different characteristics of the prepared polymer including the thermal stability, solubility, and X-ray diffraction pattern. The antibacterial activity of the synthesized cellulose derivative was investigated using the diffusion disk method against both gram-negative (Escherichia coli, Salmonella enterica) and gram-positive (Staphylococcus aureus, Bacillus subtilis) bacteria. Based on the inhibition zone, it was confirmed that the prepared benzyl cellulose-g-PDMAEMA possesses acceptable antibacterial activity against Escherichia coli, Salmonella enterica, and Staphylococcus aureus while Bacillus subtilis is resistant to the prepared polymer. Also according to the inhibition zone, it was shown that benzyl cellulose-g-PDMAEMA has more impact on E. coli and Salmonella enterica than Staphylococcus aureus. Molecular dynamics simulation was also used to study the interaction of the synthesized cellulose derivative with a model membrane which presented atomistic details of the polymer-lipid interactions. According to the results obtained from the molecular dynamics simulation, the polymer was able to destabilize the structure of the membrane and clearly express its signs of degradation.

journal_name

Bioorg Chem

journal_title

Bioorganic chemistry

authors

Shokri M,Moradi S,Amini S,Shahlaei M,Seidi F,Saedi S

doi

10.1016/j.bioorg.2020.104355

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

104355

eissn

0045-2068

issn

1090-2120

pii

S0045-2068(20)31653-9

journal_volume

106

pub_type

杂志文章

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