Bone density in premenopausal women and men under 50 years of age with cerebral palsy.

Abstract:

OBJECTIVE:To determine bone mineral density (BMD) z scores in adults with cerebral palsy (CP), an understudied population. DESIGN:Cross-sectional. SETTING:Medical facility. PARTICIPANTS:Adults (N=48; mean age, 34.3±5.8y; range, 25-46y) with CP. INTERVENTIONS:Not applicable. MAIN OUTCOME MEASURES:BMD z scores at the lumbar spine and hip using dual-energy x-ray absorptiometry, Gross Motor Function Classification System (GMFCS), body mass index (BMI), and ambulatory status. RESULTS:Mean BMD z scores were -1.40 for the lumbar spine, -1.36 for the total hip, and -1.02 for the femoral neck. The z scores were significantly lower for the nonambulatory group at all 3 sites (P<.05). Significant differences were found among GMFCS levels for the lumbar spine and total hip z scores (P<.05). For the lumbar spine, the mean z scores for level V (the lowest mobility level) were significantly lower than the mean for levels I/II (P=.001), III (P=.002), and IV (P=.013). For the total hip, the mean z scores for level V were significantly lower than the mean for levels I/II (P=.045). A significant positive relationship between the z scores and age was found for the lumbar spine (Spearman ρ=.40, P=.005). Significant positive relationships between BMI and z scores were found for all sites (P<.05). CONCLUSIONS:This study contributes to the sparse literature about bone health in adults with CP. In contrast with pediatric data, z scores did not decrease as a function of age in this adult cohort. This information is important for clinicians considering treatment options for this population.

journal_name

Arch Phys Med Rehabil

authors

Fowler EG,Rao S,Nattiv A,Heberer K,Oppenheim WL

doi

10.1016/j.apmr.2015.03.012

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

1304-9

issue

7

eissn

0003-9993

issn

1532-821X

pii

S0003-9993(15)00284-1

journal_volume

96

pub_type

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