Rehabilitation Interventions in the Multidisciplinary Management of Patients With Sclerotic Graft-Versus-Host Disease of the Skin and Fascia.

Abstract:

:Graft-versus-host disease (GVHD) is a multisystemic disorder that affects 30%-80% of patients who undergo allogeneic hematopoietic stem cell transplantation 10%-15% of GVHD patients develop sclerotic features affecting the skin or deeper tissues, leading to functional limitations and poor quality of life. There is limited literature regarding the indications and efficacy of specific rehabilitative interventions in sclerotic GVHD (sclGVHD). In this article, we summarize the current evidence supporting rehabilitation intervention in sclGVHD and offer our approach to the multidisciplinary management of this disease. In addition, we review techniques that have been employed in other sclerotic skin diseases (eg, iontophoresis, extracorporeal shock waves, botulinum toxin A, adipose derived stromal vascular fraction), but that require further validation in the sclGVHD setting. Ultimately, optimal care for this complex disease requires a multidisciplinary approach that includes a rehabilitation and adaptive program tailored to each patient's needs.

journal_name

Arch Phys Med Rehabil

authors

Molés-Poveda P,Comis LE,Joe GO,Mitchell SA,Pichard DC,Rosenstein RK,Solomon B,Pavletic SZ,Cowen EW

doi

10.1016/j.apmr.2020.10.141

subject

Has Abstract

pub_date

2020-12-23 00:00:00

eissn

0003-9993

issn

1532-821X

pii

S0003-9993(20)31264-8

pub_type

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