Interventional and surgical therapeutic strategies for pulmonary arterial hypertension: Beyond palliative treatments.

Abstract:

:Despite significant advances in pharmacological treatments, pulmonary arterial hypertension remains an incurable disease with an unreasonably high morbidity and mortality. Although specific pharmacotherapies have shifted the survival curves of patients and improved exercise endurance as well as quality of life, it is also true that these pharmacological interventions are not always accessible (particularly in developing countries) and, perhaps most importantly, not all patients respond similarly to these drugs. Furthermore, many patients will continue to deteriorate and will eventually require an additional, non-pharmacological, intervention. In this review we analyze the role of atrial septostomy and Potts anastomosis in the management of patients with pulmonary arterial hypertension, we summarize the current worldwide clinical experience (case reports and case series), and discuss why these interventional/surgical strategies might have a therapeutic role beyond that of a "bridge" to transplantation.

journal_name

J Cardiol

journal_title

Journal of cardiology

authors

Sandoval J,Gomez-Arroyo J,Gaspar J,Pulido-Zamudio T

doi

10.1016/j.jjcc.2015.02.001

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

304-14

issue

4

eissn

0914-5087

issn

1876-4738

pii

S0914-5087(15)00035-0

journal_volume

66

pub_type

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