Abstract:
:Four patients with radiologically normal pituitary gland were examined with positron emission tomography after the administration of (methyl-11C)-L-methionine. On a following day the examination was repeated with (methyl-11C)-D-methionine. The accumulation rate of L-methionine in the pituitary was measured, giving a value that was about twice that of normal brain tissue. The accumulation rate of D-methionine in the pituitary was almost a factor of 10 lower than that of L-methionine. In the normal brain tissue that ratio was 2.3. The study clearly indicates that the methionine uptake in the pituitary is stereospecific. 11C-D-methionine is freely distributed in the tissue without entrapment, whereas 11C-L-methionine is irreversibly bound. It is concluded that PET with 11C-L-methionine can be used to study amino acid utilization in the pituitary.
journal_name
Neuroradiologyjournal_title
Neuroradiologyauthors
Bergström M,Muhr C,Ericson K,Lundqvist H,Lilja A,Eriksson L,Blomquist G,Långström B,Johnström Pdoi
10.1007/BF00451757subject
Has Abstractpub_date
1987-01-01 00:00:00pages
221-5issue
3eissn
0028-3940issn
1432-1920journal_volume
29pub_type
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