Abstract:
:Cerebral amyloid angiopathy (CAA) is a common cerebrovascular disease involved in ischemic and hemorrhagic strokes, and its progression is correlated to cognitive decline. In vivo diagnosis of CAA is guided by the modified Boston criteria, with the presence of multiple intracerebral hemorrhage or cerebral microbleeds (CMB), or single hemorrhage and cortical superficial siderosis. The diagnosis of CAA is highly dependent on the quality of imaging and the advent of susceptibility-weighted imaging (SWI) sequences has improved sensitivity of MRI to detect hemosiderin deposition and CMB, hallmarks of CAA. We report here 3 clinical cases of patients with Alzheimer's disease and a focal form (i.e., not disseminated) of probable CAA, diagnosed with SWI sequences. Focal CAA may require closer attention and could offer keys in the understanding of both Alzheimer's disease and CAA pathogenesis.
journal_name
Neuroradiologyjournal_title
Neuroradiologyauthors
Garnier-Crussard A,Taki A,Bonnefoy M,Bar JY,Krolak-Salmon P,Cotton F,Gilbert Tdoi
10.1007/s00234-020-02450-8subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1195-1197issue
9eissn
0028-3940issn
1432-1920pii
10.1007/s00234-020-02450-8journal_volume
62pub_type
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