Cerebral amyloid angiopathy with focal presentation-about 3 cases.

Abstract:

:Cerebral amyloid angiopathy (CAA) is a common cerebrovascular disease involved in ischemic and hemorrhagic strokes, and its progression is correlated to cognitive decline. In vivo diagnosis of CAA is guided by the modified Boston criteria, with the presence of multiple intracerebral hemorrhage or cerebral microbleeds (CMB), or single hemorrhage and cortical superficial siderosis. The diagnosis of CAA is highly dependent on the quality of imaging and the advent of susceptibility-weighted imaging (SWI) sequences has improved sensitivity of MRI to detect hemosiderin deposition and CMB, hallmarks of CAA. We report here 3 clinical cases of patients with Alzheimer's disease and a focal form (i.e., not disseminated) of probable CAA, diagnosed with SWI sequences. Focal CAA may require closer attention and could offer keys in the understanding of both Alzheimer's disease and CAA pathogenesis.

journal_name

Neuroradiology

journal_title

Neuroradiology

authors

Garnier-Crussard A,Taki A,Bonnefoy M,Bar JY,Krolak-Salmon P,Cotton F,Gilbert T

doi

10.1007/s00234-020-02450-8

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

1195-1197

issue

9

eissn

0028-3940

issn

1432-1920

pii

10.1007/s00234-020-02450-8

journal_volume

62

pub_type

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