Abstract:
:The bioavailability of a new sustained-release potassium chloride (KCl) tablet, designed for once-a-day dosing, was compared to a KCl elixir using urinary excretion data. The study utilized 25 male volunteers dosed in a crossover design in a dietary/activity-controlled environment. The regimens consisted of a total of 80 mEq of potassium in three equally divided doses of elixir every 6 hr and a single 80-mEq dose using four 20-mEq sustained-release (SR) tablets. The mean time to maximum rate of potassium urinary excretion was 2.2 hr for the first elixir dose and 5.5 hr after the SR tablet (P less than 0.01), thereby supporting the prolonged-release properties of this formulation. After correction for baseline urinary potassium excretion, the mean total 24-hr urinary potassium excretion was 42.18 mEq for the elixir and 40.41 mEq for the SR tablet. The results indicate that the absorption pattern from the SR tablet is equal to three doses of KCl elixir dosed 6 hr apart.
journal_name
Pharm Resjournal_title
Pharmaceutical researchauthors
Betlach CJ,Arnold JD,Frost RW,Leese PT,Gonzalez MAdoi
10.1023/a:1016438413297subject
Has Abstractpub_date
1987-10-01 00:00:00pages
409-11issue
5eissn
0724-8741issn
1573-904Xjournal_volume
4pub_type
杂志文章abstract::The application of supercritical fluid (SF) processing in pharmaceutical research is increasing particularly in the field of particle formation for drug delivery systems. The SF processes have benefits over the existing particle formation methods in terms of improved control, flexibility and operational ease. This rev...
journal_title:Pharmaceutical research
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更新日期:2003-12-01 00:00:00
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