Atypical antipsychotics in the treatment of schizophrenia: systematic overview and meta-regression analysis.

Abstract:

OBJECTIVE:To develop an evidence base for recommendations on the use of atypical antipsychotics for patients with schizophrenia. DESIGN:Systematic overview and meta-regression analyses of randomised controlled trials, as a basis for formal development of guidelines. SUBJECTS:12 649 patients in 52 randomised trials comparing atypical antipsychotics (amisulpride, clozapine, olanzapine, quetiapine, risperidone, and sertindole) with conventional antipsychotics (usually haloperidol or chlorpromazine) or alternative atypical antipsychotics. MAIN OUTCOME MEASURES:Overall symptom scores. Rate of drop out (as a proxy for tolerability) and of side effects, notably extrapyramidal side effects. RESULTS:For both symptom reduction and drop out, there was substantial heterogeneity between the results of trials, including those evaluating the same atypical antipsychotic and comparator drugs. Meta-regression suggested that dose of conventional antipsychotic explained the heterogeneity. When the dose was

journal_name

BMJ

authors

Geddes J,Freemantle N,Harrison P,Bebbington P

doi

10.1136/bmj.321.7273.1371

keywords:

subject

Has Abstract

pub_date

2000-12-02 00:00:00

pages

1371-6

issue

7273

eissn

0959-8138

issn

1756-1833

journal_volume

321

pub_type

杂志文章,meta分析,评审
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    更新日期:1989-11-25 00:00:00

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    pub_type: 杂志文章,评审

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