Complete assignments of NMR data and assessment of trypanocidal activity of new eremantholide C derivatives.

Abstract:

:Chemical transformations of eremantholide C (1), a sesquiterpene lactone that was isolated from Lychnophora trichocarpha Spreng. led to five new derivatives: 1',2'- epoxyeremantholide C (2), 5-n-propylamine-4,5-dihydro-1',2'-epoxyeremantholide C (3), 5-n-propylammonium-4,5-dihydro-1',2'-epoxyeremantholide C chloride (4), 5-n-propylammonium-4,5-dihydroeremantolide C chloride (5) and 16-O-ethyleremantholide C (6). The structures of all these derivatives were assigned on the basis of IR, MS, 1H and 13C NMR data by 1D and 2D techniques. Eremantholide C and the derivatives 2, 4 and 5 were evaluated against trypomastigotes Y and CL strains of Trypanosoma cruzi. Eremantholide C completely inhibited the growth of both the parasites strains while all derivatives were partially active against the CL strain and inactive against the Y strain.

journal_name

An Acad Bras Cienc

authors

Saúde-Guimarães DA,Raslan DS,Chiari E,De Oliveira AB

doi

10.1590/0001-3765201420140167

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1563-72

issue

4

eissn

0001-3765

issn

1678-2690

pii

S0001-37652014000401563

journal_volume

86

pub_type

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