Circulating reticulated platelets over time in patients with myocardial infarction treated with prasugrel or ticagrelor.

abstract：:Pregnancy due to its physiological changes is a procoagulant state. The rate of cardiac valve prosthesis thrombosis, deep venous thrombosis and pulmonary embolism are all increased. Thrombolytic therapy with tissue plasminogen activator (rt-PA) is an approved therapy for ischemic stroke, myocardial infarction, pulmona...

journal_title：Journal of thrombosis and thrombolysis

authors： Leonhardt G,Gaul C,Nietsch HH,Buerke M,Schleussner E

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Oxidative stress play an important role triggering platelet/endothelial activation. AGI-1067 is a novel, phenolic antioxidant, and vascular protectant which dose-dependently inhibits PEA biomarkers in vitro. Whether treatment with AGI-1067 alters platelets in vivo is not known. We serially assessed release o...

journal_title：Journal of thrombosis and thrombolysis

authors： Serebruany V,Malinin A,Qiu FH,Xu XC,Kunsch C,Scott R,ALPS Study Group.

更新日期：2009-05-01 00:00:00

abstract：:Moderate use of alcohol has shown protective effects in coronary artery disease, while excessive use has been associated with cardiomyopathy and hypertension. Since alcohol is a vasodilator, we postulated that it might have protective effects when administered acutely in the setting of ischemia/reperfusion. Therefore,...

journal_title：Journal of thrombosis and thrombolysis

authors： Bellows SD,Hale SL,Kloner RA

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Radiographic contrast agents inhibit fibrinolysis, although by poorly defined pathways. The purpose of this study was to define specific mechanisms by which contrast agents inhibit clot lysis. METHODS AND RESULTS:Diatrizoate (high osmolar ionic agent), ioxaglate (low osmolar ionic), and ioversol (nonionic) ...

journal_title：Journal of thrombosis and thrombolysis

authors： Farrehi PM,Zhu Y,Fay WP

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Sulfonylurea compounds may impair ischemic preconditioning and endogenous fibrinolysis. Increased mortality has been reported in diabetics receiving these drugs prior to admission for acute myocardial infarction when treated by direct angioplasty. Although thrombolytics are currently employed far more freque...

journal_title：Journal of thrombosis and thrombolysis

authors： Halkin A,Roth A,Jonas M,Behar S

更新日期：2001-10-01 00:00:00

abstract：:Unfractionated heparin (UFH) plasma protein binding and elimination might be impaired in patients with chronic kidney disease (CKD-defined as creatinine clearance <60 ml/min). It is currently unknown at which UFH bolus dose persistent prolongation of activated partial thromboplastin time (aPTT) occurs in ST-segment el...

journal_title：Journal of thrombosis and thrombolysis

authors： Kikkert WJ,van Brussel PM,Damman P,Claessen BE,van Straalen JP,Vis MM,Baan J Jr,Koch KT,Peters RJ,de Winter RJ,Piek JJ,Tijssen JG,Henriques JP

更新日期：2016-04-01 00:00:00

abstract：:On stimulation of platelets with agonists, for example, thrombin, a rapid rise in intracellular pH is observed. This alkalinization is mediated by an increase in transport activity of the Na(+)/H(+) exchanger isoform NHE1. In addition to this Na(+)/H(+) exchange mechanism, platelets express bicarbonate/chloride exchan...

journal_title：Journal of thrombosis and thrombolysis

authors： Rosskopf D

更新日期：1999-07-01 00:00:00

abstract：:Fibrinogen depletion via catalysis by snake venom enzymes as a therapeutic strategy to prevent or treat thrombotic disorders was utilized for over four decades, with ancrod being the quintessential agent. However, ancrod eventually was found to not be of clinical utility in large scale stroke trial, resulting in the e...

journal_title：Journal of thrombosis and thrombolysis

authors： Nielsen VG

更新日期：2016-08-01 00:00:00

abstract：:Data regarding possible mechanisms of aspirin (ASA) resistance in patients with recurrent myocardial infarction (MI) or vascular ischemia are limited. Five major possible mechanisms of ASA resistance are documented in the primary literature and are discussed in this paper. These mechanisms include: (1) inadequate bloc...

journal_title：Journal of thrombosis and thrombolysis

authors： Cambria-Kiely JA,Gandhi PJ

更新日期：2002-02-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) is a prothrombotic condition and it is associated with increased in vivo thrombin generation that needs to be treated with non-heparin anticoagulants such as direct thrombin inhibitors (DTIs). DTIs require parenteral administration and are associated with a non negligible risk of...

journal_title：Journal of thrombosis and thrombolysis

authors： Sartori M,Favaretto E,Cini M,Legnani C,Cosmi B

更新日期：2015-10-01 00:00:00

abstract：:The benefit of intravenous thrombolysis (IVT) has been questioned for patients with diabetes mellitus (DM) in cases of acute ischemic stroke (IS). Our objective was to analyze the differences in outcome according to prior diagnosis of DM and the use or not of IVT. Observational study with inclusion of consecutive IS p...

journal_title：Journal of thrombosis and thrombolysis

authors： Fuentes B,Cruz-Herranz A,Martínez-Sánchez P,Rodríguez-Sanz A,Ruiz Ares G,Prefasi D,Sanz-Cuesta BE,Lara-Lara M,Díez-Tejedor E

更新日期：2014-11-01 00:00:00

abstract：:The occurrence of an inhibitor against coagulation factor V (FV) is a rare but challenging condition, which may span from asymptomatic laboratory abnormalities to potentially life-threatening bleeding. The onset of FV inhibitors has been associated most frequently in the past with the patients' exposure to topical bov...

journal_title：Journal of thrombosis and thrombolysis

authors： Franchini M,Lippi G

更新日期：2011-05-01 00:00:00

abstract：:We have applied the low molecular weight heparin dalteparin as once-daily subcutaneous injections to the treatment of deep vein thrombosis (DVT) on an outpatient basis since 1994. Until today, 377 consecutive patients with DVT below the inguinal ligament have been treated at home with dalteparin. The patients administ...

journal_title：Journal of thrombosis and thrombolysis

authors： Stockelberg D,Hansson E,Jonson T

更新日期：1998-09-01 00:00:00

abstract：:Pulmonary embolism (PE) is a leading cause of cardiovascular mortality. We intended to evaluate the awareness and management status of PE among Chinese physicians and provide the basis for establishing Chinese clinical guidelines on PE. We designed a nationwide survey to collect data on physicians' awareness of diagno...

journal_title：Journal of thrombosis and thrombolysis

authors： Zhang M,Zhang YX,Zhang Z,Wang J,Shao X,Xie WM,Wan J,Zhai ZG,Wang C

更新日期：2019-04-01 00:00:00

abstract：:Gastrointestinal bleeding is the most common bleeding complication during anticoagulant therapy. A reliable bleeding risk score can help the clinician assess risk of bleeding in individual patients and select the anticoagulant regimen. This study retrospectively analyzed the data of patients with atrial fibrillation w...

journal_title：Journal of thrombosis and thrombolysis

authors： Lv MN,Zheng XC,Zhang HQ,Xu FD,Wu TT,Chen WJ,Xia XT,Fu JL,Jiang SJ,Zhang JH

更新日期：2021-01-01 00:00:00

abstract：:Amniotic fluid embolism (AFE) is a catastrophic condition in the peripartum period and still remains as a leading cause of maternal death. Although over 80% of cases of AFE cases are accompanied by coagulopathy, the pathology of disseminated intravascular coagulation is not well understood not only because of its rari...

journal_title：Journal of thrombosis and thrombolysis

authors： Fudaba M,Tachibana D,Misugi T,Nakano A,Koyama M

更新日期：2020-07-29 00:00:00

abstract：:We describe the results of a novel complete care package using point-of-care INR testing and computerized decision support for the management of oral anticoagulation by nurse-led primary care clinics in the United Kingdom. We found such therapy to be as safe and effective as traditional hospital-based care for oral an...

journal_title：Journal of thrombosis and thrombolysis

authors： Fitzmaurice DA

更新日期：2006-02-01 00:00:00

abstract：:To investigate the relationship between circulating microRNA 223 (miR-223) levels and clopidogrel responsiveness in patients with coronary heart disease. A total of 62 consecutive patients with troponin-negative non-ST elevation acute coronary syndrome (NSTE-ACS) scheduled for elective percutaneous coronary interventi...

journal_title：Journal of thrombosis and thrombolysis

authors： Zhang YY,Zhou X,Ji WJ,Shi R,Lu RY,Li JL,Yang GH,Luo T,Zhang JQ,Zhao JH,Jiang TM,Li YM

更新日期：2014-07-01 00:00:00

abstract：:The aim of this study was to assess the association between "aspirin non responsiveness" in patients with coronary artery diseases (CAD) and the risk of major adverse cardiovascular events (MACE). 204 patients with CAD receiving aspirin (250 mg/d) were included. Both Collagen/Epinephrine Closure Time (CEPI-CT) and uri...

journal_title：Journal of thrombosis and thrombolysis

authors： Addad F,Chakroun T,Abderazek F,Ben-Farhat M,Hamdi S,Dridi Z,Gamra H,Hassine M,Samama MM,Elalamy I

更新日期：2010-01-01 00:00:00

abstract：:The exact relationship between primary percutaneous coronary intervention (PCI) volume and mortality remains unclear. No data are available on how this relationship could be affected by time-to-presentation. The primary aim of this study was to evaluate the impact of hospital primary PCI volume on in-hospital mortalit...

journal_title：Journal of thrombosis and thrombolysis

authors： Navarese EP,De Servi S,Politi A,Martinoni A,Musumeci G,Boschetti E,Belli G,D'Urbano M,Piccaluga E,Lettieri C,Klugmann S

更新日期：2011-08-01 00:00:00

abstract：:Half of patients with atrial fibrillation (AF) and elevated stroke risk do not receive anticoagulation (AC). Explanations for undertreatment may relate to provider lack of confidence with or knowledge of the CHA2DS2-VASc stroke calculator, unfamiliarity with direct oral anticoagulants (DOACs), or uncertainty about use...

journal_title：Journal of thrombosis and thrombolysis

authors： Amroze A,Mazor K,Crawford S,O'Day K,McManus DD,Kapoor A

更新日期：2019-11-01 00:00:00

abstract：:The home prothrombin time/international normalized ratio (PT/INR) self-management could be convenient for patients, enhancing treatment compliance and improving the quality of the oral anticoagulation. However, patient self-management (PSM) of oral anticoagulation may not be feasible for up to half of the patients due...

journal_title：Journal of thrombosis and thrombolysis

authors： da Silva Saraiva S,Orsi FA,Santos MP,Machado T,Montalvão S,Costa-Lima C,de Paula EV,Colella MP,Annichino-Bizzacchi J

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Abciximab reduces the thrombotic complications of angioplasty. It is also used, as a 'bail out' treatment when angioplasty is complicated by thrombus but its speed of action is not known. This study sought to establish how quickly abciximab blocks the aggregation of both quiescent and activated platelets to ...

journal_title：Journal of thrombosis and thrombolysis

authors： Dalby MC,Davidson SJ,Burman JF,Sigwart U,Davies SW

更新日期：2002-06-01 00:00:00

abstract：:In vascular access practices, the internal vessel size is considered important, and a catheter to vessel ratio (CVR) is recommended to assist clinicians in selecting the most appropriate-sized device for the vessel. In 2016, new practice recommendations stated that the CVR can increase from 33 to 45% of the vessels di...

journal_title：Journal of thrombosis and thrombolysis

authors： Spencer TR,Mahoney KJ

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The role of alpha2-antiplasmin (alpha2-AP) on platelet aggregation was investigated using mice deficient in alpha2-AP (alpha2-AP(-/-)) or using wild type mice (alpha2-AP(+/+)). METHODS:Blood samples were taken from each mouse under anesthesia with ether and platelet rich plasma (PRP) was prepared. Platelet ...

journal_title：Journal of thrombosis and thrombolysis

authors： Takei M,Matsuno H,Okada K,Ueshima S,Matsuo O,Kozawa O

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE) is a significant cause of mortality and morbidity in medical patients. Although thromboprophylaxis with enoxaparin reduces the risk of VTE in these patients, the optimal duration of therapy is not currently known. The EXCLAIM (EXtended CLinical prophylaxis in Acutely Ill Medical ...

journal_title：Journal of thrombosis and thrombolysis

authors： Hull RD,Schellong SM,Tapson VF,Monreal M,Samama MM,Turpie AG,Wildgoose P,Yusen RD

更新日期：2006-08-01 00:00:00

abstract：:Arterial thrombosis is the leading causes of morbidity and mortality worldwide, whereas venous thrombosis is the most common preventable cause of hospital death. In either case, venous and arterial thrombosis should be considered autonomous entities, with only minor overlaps in terms of risk factors, predisposing cond...

journal_title：Journal of thrombosis and thrombolysis

authors： Lippi G,Favaloro EJ,Franchini M

更新日期：2012-10-01 00:00:00

abstract：:Increased level of soluble cell adhesion molecules may be a marker for atherosclerosis and/or reflect complication of the atherosclerotic plaque. To test whether expression of cell adhesion molecules is more pronounced in unstable versus stable coronary plaques, we measured the serum level of soluble E-selectin (sE-se...

journal_title：Journal of thrombosis and thrombolysis

authors： Galvani M,Ferrini D,Ottani F,Nanni C,Ramberti A,Amboni P,Iamele L,Vernocchi A,Nicolini FA

更新日期：2000-01-01 00:00:00

abstract：:Tumour necrosis factor alpha (TNF-alpha) and interlekin-6 (IL-6) are key inflammatory cytokines in the pathogenesis of rheumatoid arthritis (RA), a disease also associated with endothelial perturbation and increased serum levels of adhesion molecules. As relationships between these processes and molecules are unclear,...

journal_title：Journal of thrombosis and thrombolysis

authors： Foster W,Carruthers D,Lip GY,Blann AD

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:We studied whether 2 MHz transcranial color-coded duplex ultrasound (TCCD), combined with a second generation ECA, accelerate IV rtPA-thrombolysis in the acute phase of MCA stroke more than TCCD monitoring alone. METHODS:Non-randomized acute MCA stroke patients undergoing IV rtPA-thrombolysis and 2 MHZ-TCCD...

journal_title：Journal of thrombosis and thrombolysis

authors： Perren F,Loulidi J,Poglia D,Landis T,Sztajzel R

更新日期：2008-04-01 00:00:00