Acute Ethanol Does Not Protect Against Ischemic/Reperfusion Injury in Rabbit Myocardium.

abstract：UNLABELLED:Platelet P-selectin and activated glycoprotein IIb-IIIa (GPIIb-IIIa) are markers of platelet activation and mediates platelet aggregation. Prasugrel (Pras) 5 mg may be used in very elderly (VE) acute coronary syndrome (ACS) patients undergoing PCI, but its effect on platelet P-selectin and activated GPIIb-II...

journal_title：Journal of thrombosis and thrombolysis

authors： Wagner H,Lood C,Borna C,Gidlöf O,Truedsson L,Brown P,Zhou C,Winters K,Jakubowski JA,Erlinge D

更新日期：2016-10-01 00:00:00

abstract：:The relation of device related thrombosis (DRT) and major bleeding after left atrial appendage closure (LAAC) to laboratory thrombosis and hemostasis markers has not been studied. We performed a prospective case control study to identify clinical characteristics and laboratory markers in patients who developed DRT and...

journal_title：Journal of thrombosis and thrombolysis

authors： Sherwood M,Bliden KP,Ilkhanoff L,Venkataraman G,Strickberger A,Yazdani S,McSwain R,Rashid H,Navarese EP,Plummer T,Batchelor W,Chaudhary R,Tantry US,Gurbel PA

更新日期：2020-10-01 00:00:00

abstract：:The outbreak of 2019 novel coronavirus disease (COVID-19) began since early December 2019, and has been declared as a public health emergency by the World Health Organization. Due to the hypercoagulable state, blood stasis and endothelial injury, severe patients with COVID-19 are at high risk for thrombosis. We report...

journal_title：Journal of thrombosis and thrombolysis

authors： Zhou B,She J,Wang Y,Ma X

更新日期：2020-07-01 00:00:00

abstract：:According to our personal experience and to the study of the literature, 11 cases of venous thrombosis have been described as sporadic reports in patients with severe (homozygous) factor XII (FXII) deficiencies. In every cases but 4, associated risk factors were found to be present (pregnancy, post-partum period, surg...

journal_title：Journal of thrombosis and thrombolysis

authors： Girolami A,Randi ML,Gavasso S,Lombardi AM,Spiezia F

更新日期：2004-04-01 00:00:00

abstract：:This study investigates the association between the treatment with heparin and mortality in patients admitted with Covid-19. Routinely recorded, clinical data, up to the 24th of April 2020, from the 2075 patients with Covid-19, admitted in 17 hospitals in Spain between the 1st of March and the 20th of April 2020 were ...

journal_title：Journal of thrombosis and thrombolysis

authors： Ayerbe L,Risco C,Ayis S

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:The aim of our study was to determine the relation between exercise stress test and aspirin resistance in patients with stable coronary artery disease. BACKGROUND:Clinically aspirin resistance is defined as having thrombotic and embolic cardiovascular events despite regular aspirin therapy. METHODS:We stud...

journal_title：Journal of thrombosis and thrombolysis

authors： Pamukcu B,Oflaz H,Acar RD,Umman S,Koylan N,Umman B,Nisanci Y

更新日期：2005-08-01 00:00:00

abstract：:The risk benefit decision in providing anticoagulation for patients with brain metastases is amongst the most difficult decisions faced by clinicians. The purpose of our study was to evaluate both the risk of intracerebral hemorrhage (ICH) associated with anticoagulation therapy and the effect of anticoagulation on su...

journal_title：Journal of thrombosis and thrombolysis

authors： Hunter BD,Minichiello T,Bent S

更新日期：2017-10-01 00:00:00

abstract：:Data regarding possible mechanisms of aspirin (ASA) resistance in patients with recurrent myocardial infarction (MI) or vascular ischemia are limited. Five major possible mechanisms of ASA resistance are documented in the primary literature and are discussed in this paper. These mechanisms include: (1) inadequate bloc...

journal_title：Journal of thrombosis and thrombolysis

authors： Cambria-Kiely JA,Gandhi PJ

更新日期：2002-02-01 00:00:00

abstract：:Warfarin is dependent on multiple hepatic enzymes for metabolism while apixaban is a substrate for P-glycoprotein (P-gp) transport and hepatic CYP3A4 metabolism. The aim of this analysis was to assess the impact of interacting medication use on the treatment effects of apixaban versus warfarin. Outcomes were compared ...

journal_title：Journal of thrombosis and thrombolysis

authors： Washam JB,Hohnloser SH,Lopes RD,Wojdyla DM,Vinereanu D,Alexander JH,Gersh BJ,Hanna M,Horowitz J,Hylek EM,Xavier D,Verheugt FWA,Wallentin L,Granger CB,ARISTOTLE Committees and Investigators.

更新日期：2019-04-01 00:00:00

abstract：:Heparin and low-molecular weight heparin (LMWH) are complex, heterogeneous polysaccharides used in the treatment of arterial and venous thrombosis. M118 is a novel LMWH with low polydispersity and pronounced anti-Xa and anti-thrombin (IIa) activity as compared to current LMWHs. To determine if M118 is effective in pre...

journal_title：Journal of thrombosis and thrombolysis

authors： Chakrabarti S,Beaulieu LM,Reyelt LA,Iafrati MD,Freedman JE

更新日期：2009-11-01 00:00:00

abstract：:Rivaroxaban is a direct factor Xa inhibitor, which is rapidly absorbed in the upper gastrointestinal (GI) tract. In large trials, it has been shown to be effective and safe in VTE treatment. However, in these trials patients with morbid obesity were not reported and it is unknown if the standard dosage of 20 mg rivaro...

journal_title：Journal of thrombosis and thrombolysis

authors： Mahlmann A,Gehrisch S,Beyer-Westendorf J

更新日期：2013-11-01 00:00:00

abstract：:Amniotic fluid embolism (AFE) is a catastrophic condition in the peripartum period and still remains as a leading cause of maternal death. Although over 80% of cases of AFE cases are accompanied by coagulopathy, the pathology of disseminated intravascular coagulation is not well understood not only because of its rari...

journal_title：Journal of thrombosis and thrombolysis

authors： Fudaba M,Tachibana D,Misugi T,Nakano A,Koyama M

更新日期：2020-07-29 00:00:00

abstract：:Drug-eluting stents (DES) reduce the incidence of in-stent restenosis (ISR) after primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). Whether the use of biomarkers might be of utility to identify patients who remain at risk for DES ISR after primary PCI has never been exami...

journal_title：Journal of thrombosis and thrombolysis

authors： Claessen BE,Stone GW,Mehran R,Witzenbichler B,Brodie BR,Wöhrle J,Witkowski A,Guagliumi G,Zmudka K,Henriques JP,Tijssen JG,Sanidas EA,Chantziara V,Hakim D,Leon S,Xu K,Dangas GD

更新日期：2012-08-01 00:00:00

abstract：:Fibrinogen depletion via catalysis by snake venom enzymes as a therapeutic strategy to prevent or treat thrombotic disorders was utilized for over four decades, with ancrod being the quintessential agent. However, ancrod eventually was found to not be of clinical utility in large scale stroke trial, resulting in the e...

journal_title：Journal of thrombosis and thrombolysis

authors： Nielsen VG

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Apoptosis causes myocardiocyte loss during and after myocardial infarction. Therapeutic approaches designed to arrest apoptosis would be a significant new development in the recovery of acute myocardial infarction (AMI). In order to examine apoptotic markers in the circulation, serum levels of p53 and cytoch...

journal_title：Journal of thrombosis and thrombolysis

authors： Dincer Y,Himmetoglu S,Bozcali E,Vural VA,Akcay T

更新日期：2010-01-01 00:00:00

abstract：:Infarct artery stenting with adjunctive abciximab therapy is widely used treatment for patients with acute myocardial infarction (AMI). However, bleeding complications have been associated with a worse clinical outcome. Randomized trials in elective patients have shown that postprocedural protamine administration is s...

journal_title：Journal of thrombosis and thrombolysis

authors： Parodi G,De Luca G,Moschi G,Bellandi B,Valenti R,Migliorini A,Carrabba N,Antoniucci D

更新日期：2010-11-01 00:00:00

abstract：:One of the major mechanisms of action of chemo-radiation is to induce cellular senescence, which exerts crucial roles in age-related pathology. The concept of senescence is evolved, and the novel understanding of senescence-associated reprogramming/stemness has emerged. This new concept emphasizes senescence as not on...

journal_title：Journal of thrombosis and thrombolysis

authors： Dominic A,Hamilton D,Abe JI

更新日期：2020-10-20 00:00:00

abstract：:Stroke and other thromboembolic events are mainly caused by emboli from heart, aorta and other arteries. In this paper we describe a group of 5 middle-aged patients suffering from emboli caused by large thrombi in the aorta. Since the development of giant thrombi under high flow conditions in the aorta is a pathophysi...

journal_title：Journal of thrombosis and thrombolysis

authors： Stoevesandt D,Klempt C,Scheubel R,Herr W,Hettwer S,Werdan K,Silber RE,Kraya T,Thews O,Schlitt A

更新日期：2013-02-01 00:00:00

abstract：:The relationship between vascular-specific epicardial adipose tissue (vEAT) volume and myocardial ischemia measured by fractional flow reserve (FFR) was not well investigated. Patients with typical and atypical chest pain undergoing coronary computed tomographic angiography scan followed by invasive coronary angiograp...

journal_title：Journal of thrombosis and thrombolysis

authors： Shan D,Wang X,Dou G,Zhang W,Jing J,He B,Li Y,Chen Y,Yang J

更新日期：2020-10-17 00:00:00

abstract：:The role of the A>G polymorphism at position 19911 in the prothrombin gene (factor [F] 2 at rs3136516) as a risk factor for venous thromboembolism [VTE] is still unclear. To evaluate the presence of the F2 polymorphism in VTE patients compared to healthy blood donors and to adjust the results for common inherited thro...

journal_title：Journal of thrombosis and thrombolysis

authors： Limperger V,Kenet G,Kiesau B,Köther M,Schmeiser M,Langer F,Juhl D,Shneyder M,Franke A,Klostermeier UK,Mesters R,Rühle F,Stoll M,Steppat D,Kowalski D,Rocke A,Kuta P,Bajorat T,Torge A,Neuner B,Junker R,Nowak-Göttl

更新日期：2020-06-27 00:00:00

abstract：:On stimulation of platelets with agonists, for example, thrombin, a rapid rise in intracellular pH is observed. This alkalinization is mediated by an increase in transport activity of the Na(+)/H(+) exchanger isoform NHE1. In addition to this Na(+)/H(+) exchange mechanism, platelets express bicarbonate/chloride exchan...

journal_title：Journal of thrombosis and thrombolysis

authors： Rosskopf D

更新日期：1999-07-01 00:00:00

abstract：:Acutely ill medical patients are at significant risk of venous thromboembolism (VTE). Thromboprophylaxis can substantially reduce the incidence of VTE, but to be optimally effective must consist of the correct choice of agent, at an appropriate dose, and for sufficient duration. Increasing evidence suggests that VTE r...

journal_title：Journal of thrombosis and thrombolysis

authors： Stark JE,Smith WJ

更新日期：2011-10-01 00:00:00

abstract：:To investigate the relationship between circulating microRNA 223 (miR-223) levels and clopidogrel responsiveness in patients with coronary heart disease. A total of 62 consecutive patients with troponin-negative non-ST elevation acute coronary syndrome (NSTE-ACS) scheduled for elective percutaneous coronary interventi...

journal_title：Journal of thrombosis and thrombolysis

authors： Zhang YY,Zhou X,Ji WJ,Shi R,Lu RY,Li JL,Yang GH,Luo T,Zhang JQ,Zhao JH,Jiang TM,Li YM

更新日期：2014-07-01 00:00:00

abstract：:The anticoagulant properties of a novel RNA aptamer that binds FIXa depend collectively on the intensity of surface contact activation of human blood plasma, aptamer concentration, and its binding affinity for FIXa. Accordingly, anticoagulation efficiency of plasma containing any particular aptamer concentration is lo...

journal_title：Journal of thrombosis and thrombolysis

authors： Krishnan A,Vogler EA,Sullenger BA,Becker RC

更新日期：2013-01-01 00:00:00

abstract：:A 64-year-old man first developed ligneous conjunctivitis at the age of 58 years after right pulmonary resection because of suspected cancer; otherwise, he had been healthy. Since then, he began to suffer from various forms of chronic pseudomembranous mucositis. Laboratory tests demonstrated that he had 7.8 % of plasm...

journal_title：Journal of thrombosis and thrombolysis

authors： Osaki T,Souri M,Song YS,Izumi N,Law R,Ichinose A

更新日期：2016-08-01 00:00:00

abstract：:Prasugrel has been shown to be superior to clopidogrel in the setting of ACS patients undergoing coronary angioplasty. However, few data have been reported so far on those patients who switch from clopidogrel to prasugrel after coronary angioplasty. Aim of the current study was to evaluate the safety of prasugrel load...

journal_title：Journal of thrombosis and thrombolysis

authors： De Luca G,Verdoia M,Schaffer A,Suryapranata H,Parodi G,Antoniucci D,Marino P

更新日期：2014-10-01 00:00:00

abstract：:Inherited afibrinogenemia and hypofibrinogenemia are rare bleeding disorders characterized by markedly reduced levels of fibrinogen in blood. Thrombotic complications in these disorders have been rarely described. We performed a multicenter retrospective study and reviewed the occurrence of thrombotic complications am...

journal_title：Journal of thrombosis and thrombolysis

authors： Rottenstreich A,Lask A,Schliamser L,Zivelin A,Seligsohn U,Kalish Y

更新日期：2016-08-01 00:00:00

abstract：:This study was intended to evaluate the cost-effectiveness of anticoagulation clinic care and self-testing for the management of patients on chronic warfarin therapy. Using a 5-year Markov model, we evaluated the health and economic outcomes associated with each of three different anticoagulation management approaches...

journal_title：Journal of thrombosis and thrombolysis

authors： Lafata JE,Martin SA,Kaatz S,Ward RE

更新日期：2000-06-01 00:00:00

abstract：:Thromboembolic events are frequent and serious complications of acute lymphoblastic leukaemia treatment. The importance of chemotherapy in the pathogenesis of this increased risk is enhanced by the fact that thrombosis rarely occurs at diagnosis. Our study aims at investigating the effect of chemotherapy on pro-coagul...

journal_title：Journal of thrombosis and thrombolysis

authors： Pluchart C,Poitevin G,Colinart-Thomas M,Guimard G,Audonnet S,Terryn C,Nguyen P

更新日期：2019-08-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a highly prevalent complication of malignancy with emerging changes in incidence, diagnosis and treatment paradigms. This manuscript, initiated by the Anticoagulation Forum, provides clinical guidance based on existing guidelines and consensus expert opinion where guidelines are lacking...

journal_title：Journal of thrombosis and thrombolysis

authors： Khorana AA,Carrier M,Garcia DA,Lee AY

更新日期：2016-01-01 00:00:00