Abstract:
:A genetic algorithm has been used to optimize the composition of the culture medium for growing the microalga Nannochloropsis gaditana, based on the nutrients composition of the commercial medium ALGAL. This strategy was carried out through the implementation of 270 experiments spread over nine generations, which allowed achieving an eicosapentaenoic acid (EPA) productivity of 17.8 m gL(-1) d(-1) in a continuous culture of N. gaditana, with an increase of 23% compared to the commercial medium. The EPA yield on nitrogen and phosphorous, 0.042 and 1.146 g(EPA) g(s)(-1), respectively, were 40% and 5-fold higher, respectively, than the values obtained with the nitrogen-optimized ALGAL medium. This improvement was obtained with the medium G-8, which also allowed reducing the requirement of several nutrients such as P, Mo, Mn in 74%, 69% and 66%, respectively, as well as the thiamine content a 46%.
journal_name
Bioresour Technoljournal_title
Bioresource technologyauthors
Camacho-Rodríguez J,Cerón-García MC,Fernández-Sevilla JM,Molina-Grima Edoi
10.1016/j.biortech.2014.11.057subject
Has Abstractpub_date
2015-02-01 00:00:00pages
102-9eissn
0960-8524issn
1873-2976pii
S0960-8524(14)01659-9journal_volume
177pub_type
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