Abstract:
:The Microsealed Drug Delivery (MDD) system was developed to achieve several objectives: to maximize the bioavailability of a therapeutic agent in a target tissue; to minimize the adverse side effects of a therapeutic agent or its metabolites; to optimize the onset, rate, and duration of drug delivery; to maintain the steady-state plasma drug level within a therapeutic range for as long as required for effective treatment; and to improve the patient compliance to a therapeutic regimen. This drug delivery system is fabricated from a biocompatible elastomer by microdispersion of the drug reservoir, as immobilized microscopic spheres, in the cross-linked polymer matrix. The release of drugs is controlled at a programmed rate for a prolonged time period. Several physical shapes and sizes of controlled-release drug delivery devices can be fabricated from this MDD system for various biomedical applications. For subcutaneous controlled drug administration, a cylinder-shaped subdermal implant was fabricated from the MDD system for easy subcutaneous implantation and the controlled release of deoxycorticosterone acetate in rats at zero-order rates for a duration of up to 129 days for cardiovascular pharmacology studies. This is 1 example of the many controlled-release drug delivery devices that can be fabricated from the patented MDD system. A bandage-type transdermal MDD device was developed to release an androgen, testosterone, at a constant rate. Topical application of this testosterone-releasing transdermal patch over the skin in the umbilical area of monkeys was observed to achieve a relatively constant plasma level of testosterone for a duration of up to 31 days. The encouraging results laid the foundation for the recent development and marketing of Nitrodisc system. A donut-shaped vaginal device can be fabricated from the MDD system for the intravaginal controlled administration of an orally active contraceptive progestin, such as norethindrone, or of a combination of 1 progestin with 1 estrogen. A 7-shaped IUD can be fabricated from the MDD system for intrauterine controlled administration of an estrogen, such as estriol, or a progestin to achieve a localized contraceptive action.
journal_name
Methods Enzymoljournal_title
Methods in enzymologyauthors
Chien YWdoi
10.1016/s0076-6879(85)12036-7subject
Has Abstractpub_date
1985-01-01 00:00:00pages
461-70eissn
0076-6879issn
1557-7988journal_volume
112pub_type
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