The occurrence of dural invasion in pituitary adenomas.

Abstract:

:This report describes 60 dural specimens from patients with pituitary adenomas treated by transsphenoidal microsurgery, and attempts to define more precisely the clinical and pathological correlation of microscopic dural invasion. Analysis of the adenomas was based on four characteristics; size, surgical invasiveness (based on the surgeon's assessment of involvement by tumor of bone, dura, or cavernous sinus), histological evidence of invasion, and immunohistochemical staining characteristics. The incidence of surgical invasiveness (24 cases, 40%) was greater than previously reported, but most important was the frequent occurrence of microscopic dural invasion (51 cases, 85%). There was a clear progression of microscopic evidence of dural invasion with increasing tumor size: 69%, 88%, and 94% of the dural specimens from microadenomas, macroadenomas, and tumors with suprasellar extension, respectively, showed microscopic dural invasion. A correlation of invasiveness with immunohistochemical classification of tumor type was not evident.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Selman WR,Laws ER Jr,Scheithauer BW,Carpenter SM

doi

10.3171/jns.1986.64.3.0402

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

402-7

issue

3

eissn

0022-3085

issn

1933-0693

journal_volume

64

pub_type

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