Nerve graft immunogenicity as a factor determining axonal regeneration in the rat.

Abstract:

:Acellular basal lamina grafts have recently been reported to support axonal regeneration and have been used in peripheral nerve repair. The present study was designed to determine the immunogenicity of such basal lamina allografts (grafts that are genetically different) and their potential as bridging material for nerve gap repair. Inbred strains of Fischer and Buffalo rats with known histocompatibility differences were used. Acellular grafts were prepared by repeated freezing and thawing nerve tissue predegenerated in situ for 6 weeks. Non-frozen predegenerated nerves were used as cellular grafts for comparison. Fischer rats were used as hosts and received cellular or acellular grafts obtained from Fischer (isograft, genetically identical) or Buffalo (allograft) donors. The grafts were evaluated morphologically at 1, 2, 4, and 12 weeks after transplantation. The cellular isografts supported axonal regeneration best. The cellular allografts were invariably rejected and were unsuccessful or only partially successful in supporting regeneration. In contrast, acellular allografts, in spite of their mild immunogenicity were successful in supporting regeneration, as were the acellular isografts. The rate of host axonal regeneration and recovery of target muscle was reduced in acellular allografts and isografts as compared to cellular isografts. It is concluded that acellular allografts are suitable for supporting axonal regeneration and may be used to bridge gaps in injured peripheral nerves.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Gulati AK,Cole GP

doi

10.3171/jns.1990.72.1.0114

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

114-22

issue

1

eissn

0022-3085

issn

1933-0693

journal_volume

72

pub_type

杂志文章
  • Management of accidental minor head injuries in children: a prospective outcomes study.

    abstract:OBJECT:The authors conducted a study to determine clinical, patient/family satisfaction, and financial outcomes following application of a management scheme that involves evaluation of computerized tomography (CT) scans and emergency department observation, rather than overnight admission, for children who have sustain...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2004.101.2.0038

    authors: Dias MS,Lillis KA,Calvo C,Shaha SH,Li V

    更新日期:2004-08-01 00:00:00

  • Cognitive functioning early after surgery of gliomas in eloquent areas.

    abstract:OBJECT:Patients with gliomas frequently have cognitive deficits, and surgery can exacerbate these deficits. Preoperative assessment is therefore crucial in patients undergoing surgery for glioma in eloquent areas, because the proximity of functional areas increases the risk of permanent postoperative cognitive disturba...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2012.7.JNS12263

    authors: Satoer D,Vork J,Visch-Brink E,Smits M,Dirven C,Vincent A

    更新日期:2012-11-01 00:00:00

  • A new microclip for vascular occlusion. Technical note.

    abstract::A new microclip for use on blood vessels 300 mu to 1 mm in diameter is described. This clip is suitable for either temporary or permanent occlusion and has been used in experimental applications. Potential clinical applications are described. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.64.5.0822

    authors: Andrews BT,Lutz A,Bederson JB,Pitts LH

    更新日期:1986-05-01 00:00:00

  • Effect of subthalamic deep brain stimulation on postural abnormality in Parkinson disease.

    abstract:OBJECT:Parkinson disease (PD) is often accompanied by various postural abnormalities such as camptocormia (bent spine) or Pisa syndrome (lateral flexion). The authors studied the effect of subthalamic nucleus deep brain stimulation (STN DBS) on postural abnormality in patients with PD. METHODS:The authors retrospectiv...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2009.10.JNS09917

    authors: Umemura A,Oka Y,Ohkita K,Yamawaki T,Yamada K

    更新日期:2010-06-01 00:00:00

  • Fourth ventriculoceles with extracranial extension.

    abstract::The radiographic features and long-term clinical outcome in three patients who presented at birth with a cystic suboccipital mass in direct communication with the fourth ventricle are reviewed. The pathological findings in a fourth infant who died are also discussed. All surviving infants were treated with cyst excisi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.61.2.0348

    authors: Fenstermaker RA,Roessmann U,Rekate HL

    更新日期:1984-08-01 00:00:00

  • Drowning hazard with deep brain stimulation: case report.

    abstract::The caudal zona incerta target within the posterior subthalamic area is an investigational site for deep brain stimulation (DBS) in Parkinson disease (PD) and tremor. The authors report on a patient with tremor-predominant PD who, despite excellent tremor control and an otherwise normal neurological examination, exhib...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.5.JNS15589

    authors: Bangash OK,Thorburn M,Garcia-Vega J,Walters S,Stell R,Starkstein SE,Lind CR

    更新日期:2016-05-01 00:00:00

  • Leptomeningeal cyst of the posterior fossa. Case report.

    abstract::A patient with a posttraumatic leptomeningeal cyst is described. The cyst simulated an occipital encephalocele and communicated with an epidural cerebrospinal fluid collection in the posterior fossa. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.65.5.0704

    authors: Nemoto S,Hoffman HJ

    更新日期:1986-11-01 00:00:00

  • Invading meningiomas of the sphenoid ridge.

    abstract::The authors report a series of 34 meningiomas of the sphenoid ridge. Eight tumors were totally removed uneventfully: two from the middle sphenoid ridge and six from the pterion or Sylvian point. Five tumors were not operated on because of their extensions or the patient's age. Twenty-one tumors raised serious surgical...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1980.53.5.0587

    authors: Bonnal J,Thibaut A,Brotchi J,Born J

    更新日期:1980-11-01 00:00:00

  • Two examples of ancient skull surgery.

    abstract::The author, while a research illustrator at the Smithsonian Institution National Museum of Natural History, studied two ancient skulls from the Incan period in Peru, both with trephination. Her conclusions and illustrations of the skulls are included in this paper. ...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章

    doi:10.3171/jns.1992.76.3.0550

    authors: Froeschner EH

    更新日期:1992-03-01 00:00:00

  • Experimental chronic subdural hematoma in mice. Gross morphology and light microscopic observations.

    abstract::A new experimental model of chronic subdural hematoma in mice is described. A single intraperitoneal injection of 6-aminonicotinamide (25 mg/kg body weight) on the 5th postnatal day induced hydrocephalus in mice with almost 100% success. Approximately 60% of the mice spontaneously developed intracranial hemorrhage 20 ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.67.5.0710

    authors: Aikawa H,Suzuki K

    更新日期:1987-11-01 00:00:00

  • Resection for solitary brain metastasis. Role of adjuvant radiation and prognostic variables in 229 patients.

    abstract::The authors reviewed 229 consecutive patients treated intramurally by resection of solitary cerebral metastasis. Patients were classified into four groups on the basis of whether a gross total resection or subtotal resection was performed and whether systemic disease was present or absent at the time of craniotomy. Gr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1992.77.4.0531

    authors: Smalley SR,Laws ER Jr,O'Fallon JR,Shaw EG,Schray MF

    更新日期:1992-10-01 00:00:00

  • Normal perfusion pressure breakthrough: the role of capillaries.

    abstract::Excision of human cerebral arteriovenous malformations (AVMs) can be complicated by postoperative edema and hemorrhage in adjacent brain tissue, despite the complete excision of the malformation. Various theories have purported to explain the hemodynamic basis for this predisposition, including disordered autoregulati...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1997.86.3.0519

    authors: Sekhon LH,Morgan MK,Spence I

    更新日期:1997-03-01 00:00:00

  • Evaluation of prognostic factors and clinical outcome in elderly patients in whom expansive laminoplasty is performed for cervical myelopathy due to multisegmental spondylotic canal stenosis. A retrospective comparison with younger patients.

    abstract:OBJECT:It remains unclear whether elderly patients with compressive cervical myelopathy can be expected to experience a promising surgery-related outcome after undergoing expansive laminoplasty. The purposes of this study were to evaluate the efficacy of expansive laminoplasty in elderly patients with cervical myelopat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2002.96.2.0173

    authors: Handa Y,Kubota T,Ishii H,Sato K,Tsuchida A,Arai Y

    更新日期:2002-03-01 00:00:00

  • A vascular malformation mimicking an intracanalicular acoustic neurilemoma. Case report.

    abstract::A patient with an enhancing, completely intracanalicular mass on magnetic resonance imaging was operated on for a presumed acoustic neurilemoma, but was found at surgery to have an intracanalicular vascular malformation. This rare lesion should be distinguished from angiomatous change within an acoustic neurilemoma an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1991.74.3.0516

    authors: Linskey ME,Jannetta PJ,Martinez AJ

    更新日期:1991-03-01 00:00:00

  • Development of experimental meningeal gliomatosis models in rats.

    abstract::Experimental models of meningeal gliomatosis (MG) have been produced by intracisternal inoculation of rat C6 and 9L glioma cells into Wistar and Fischer 344 rats, respectively. Tumor growth was steady and rapid in both MG models when more than 10(6) tumor cells were implanted. The median survival time of the rats inoc...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.65.4.0503

    authors: Yoshida T,Shimizu K,Ushio Y,Hayakawa T,Arita N,Mogami H

    更新日期:1986-10-01 00:00:00

  • Hyperacute measurement of intracranial pressure, cerebral perfusion pressure, jugular venous oxygen saturation, and laser Doppler flowmetry, before and during removal of traumatic acute subdural hematoma.

    abstract:OBJECT:The poor prognosis for traumatic acute subdural hematoma (ASDH) might be due to underlying primary brain damage, ischemia, or both. Ischemia in ASDH is likely caused by increased intracranial pressure (ICP) leading to decreased cerebral perfusion pressure (CPP), but the degree to which these phenomena occur is u...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2001.95.4.0569

    authors: Verweij BH,Muizelaar JP,Vinas FC

    更新日期:2001-10-01 00:00:00

  • Microsurgical resection of extensive craniopharyngiomas using a frontolateral approach: operative technique and outcome.

    abstract:OBJECT:An extensive craniopharyngioma is a tumor that extends into multiple compartments (subarachnoid spaces) and attains a size larger than 4 cm. A wide spectrum of approaches and strategies has been used for resection of such craniopharyngiomas. In this report the authors focused on the feasibility and efficacy of m...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2013.9.JNS122133

    authors: Gerganov V,Metwali H,Samii A,Fahlbusch R,Samii M

    更新日期:2014-02-01 00:00:00

  • Control of growth of vestibular schwannomas with low-dose Gamma Knife surgery.

    abstract:OBJECT:The treatment of solitary vestibular schwannomas by performing Gamma Knife surgery is well established. It has been reported that decreasing the surface dose reduces patient morbidity, especially facial weakness and numbness. The authors of this retrospective study examine patient data from a single center to de...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/sup.2006.105.7.154

    authors: Hudgins WR,Antes KJ,Herbert MA,Weiner RL,DeSaloms JM,Stamos D,Barker JL,Echt GA,Nichols TD,Schwarz DE

    更新日期:2006-12-01 00:00:00

  • Short-term preoperative treatment of macroprolactinomas by dopamine agonists.

    abstract::During a period of 3 years, 25 patients with intra- and extrasellar macroprolactinomas were pretreated with dopamine agonists for a period of 2 to 6 1/2 weeks prior to transsphenoidal microsurgical tumor resection. Dopamine agonists were administered orally to 17 patients, intramuscularly to three patients, and both o...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.67.6.0807

    authors: Fahlbusch R,Buchfelder M,Schrell U

    更新日期:1987-12-01 00:00:00

  • Improvement in intensive care unit outcomes in patients with subarachnoid hemorrhage after initiation of neurointensivist co-management.

    abstract:OBJECT:Neurointensivists are specialists trained to manage all aspects of the intensive care unit (ICU) stay of neurologically ill patients. No study to date has examined the role of neurointensivists specifically in subarachnoid hemorrhage (SAH) management. This study examined the use of a team-based neurointensivist ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2009.8.JNS09441

    authors: Josephson SA,Douglas VC,Lawton MT,English JD,Smith WS,Ko NU

    更新日期:2010-03-01 00:00:00

  • Development of neurosurgery in Greece: past, present, and future.

    abstract::In this study the authors examine the historical tradition as well as current features of neurosurgery in Greece and compare the available data with international standards. In particular, they describe the organizational structure of neurosurgery with reference to manpower, unit distribution, training, and qualificat...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章

    doi:10.3171/jns.1998.88.4.0782

    authors: Stranjalis G,Singounas E

    更新日期:1998-04-01 00:00:00

  • Low flow velocity in the middle cerebral artery predicting infarction after bypass surgery in adult moyamoya disease.

    abstract::OBJECTIVE Direct and indirect bypass surgeries are recognized as the most effective treatments for preventing further stroke in adults with moyamoya disease (MMD). However, the risk factors for postoperative infarction after bypass surgery for MMD are not well established. Therefore, the objective of this study was to...

    journal_title:Journal of neurosurgery

    pub_type: 评论,杂志文章

    doi:10.3171/2016.3.JNS152256

    authors: Cho H,Jo KI,Yu J,Yeon JY,Hong SC,Kim JS

    更新日期:2017-05-01 00:00:00

  • Individual variations in the sulcal anatomy of the basal temporal lobe and its relevance for epilepsy surgery: an anatomical study performed using magnetic resonance imaging.

    abstract:OBJECT:The concept of selective amygdalohippocampectomy is based on pathophysiological insights into the epileptogenicity of the hippocampal region and the definition of the clinical syndrome of mesial temporal lobe epilepsy (TLE). High-resolution magnetic resonance (MR) imaging allows correlation of the site of histol...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2002.96.3.0464

    authors: Novak K,Czech T,Prayer D,Dietrich W,Serles W,Lehr S,Baumgartner C

    更新日期:2002-03-01 00:00:00

  • Survival following gunshot wound of the pons: neuroanatomic considerations. Case report.

    abstract::The successful treatment of a civilian gunshot wound of the vermis and pons is described. A large missile fragment was removed from a depth of 2 cm within the pons at the level of the facial colliculus. Despite initial coma and subsequent irregular respiration with sleep apnea, the patient survived. Neurological, radi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1971.35.3.0342

    authors: Kline DG,LeBlanc HJ

    更新日期:1971-09-01 00:00:00

  • Combined treatment of advanced stages of recurrent skin cancer of the head.

    abstract:OBJECT:The authors investigated whether skull base resection and primary free-flap reconstruction in a single-stage surgery is oncologically effective for treating advanced stages of recurrent skin cancer (RSC) of the head. METHODS:Eighteen consecutive patients were surgically treated. Twelve of them underwent an ante...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.3171/jns.2004.100.4.0652

    authors: Pompucci A,Rea G,Farallo E,Salgarello M,Campanella A,Fernandez E

    更新日期:2004-04-01 00:00:00

  • Cerebral protection.

    abstract::Cerebral protection from an ischemic/hypoxic insult implies that tissue injury can be controlled or even prevented by certain therapeutic maneuvers. For example, physiological thresholds may be altered so that tissue vulnerability to the insult is reduced, or the intensity of an insult may be blunted by enhancing brai...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.1986.65.5.0579

    authors: Hoff JT

    更新日期:1986-11-01 00:00:00

  • Surgical considerations regarding giant dilations of the perivascular spaces.

    abstract:OBJECT:Dilations of brain perivascular spaces (PVSs), also known as Virchow-Robin spaces, are routinely identified on magnetic resonance imaging studies of the brain and recognized as benign normal variants. Giant dilations occur only rarely and can be easily misdiagnosed as central nervous system tumors. The relevant ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2004.100.5.0820

    authors: House P,Salzman KL,Osborn AG,MacDonald JD,Jensen RL,Couldwell WT

    更新日期:2004-05-01 00:00:00

  • Aneurysmal bone cyst of the skull. Case report.

    abstract::A case of giant aneurysmal bone cyst of the skull is reported. Treatment was by total excision in three-staged surgery. The patient made a good recovery. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1977.47.4.0633

    authors: Chalapati Rao KV,Rao BS,Reddy CP,Sundareshwar B,Reddy CR

    更新日期:1977-10-01 00:00:00

  • A leap forward in the endovascular management of acute basilar artery occlusion since the appearance of stent retrievers: a single-center comparative study.

    abstract::OBJECTIVE Contrary to acute ischemic stroke involving the anterior circulation, no randomized trial has yet demonstrated the safety and effectiveness of endovascular management in acute basilar artery occlusion (BAO). Recently developed thrombectomy devices, such as stentrievers and aspiration systems, have helped in ...

    journal_title:Journal of neurosurgery

    pub_type: 评论,杂志文章

    doi:10.3171/2016.2.JNS151983

    authors: Fahed R,Di Maria F,Rosso C,Sourour N,Degos V,Deltour S,Baronnet-Chauvet F,Léger A,Crozier S,Gabrieli J,Samson Y,Chiras J,Clarençon F

    更新日期:2017-05-01 00:00:00

  • Is there an inherited anatomical conformation favoring aneurysmal formation of the anterior communicating artery?

    abstract::OBJECTIVE The pathophysiological mechanisms responsible for the formation of intracranial aneurysms (IAs) remain only partially elucidated. However, current evidence suggests a genetic component. The purpose of this study was to investigate the specific anatomical variations in the arterial complex that are associated...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.3171/2016.4.JNS153032

    authors: Bourcier R,Lenoble C,Guyomarch-Delasalle B,Daumas-Duport B,Papagiannaki C,Redon R,Desal H

    更新日期:2017-05-01 00:00:00