Altered prolactin bioactivity in amniotic fluid of hypertensive pregnancy.

Abstract:

:The high concentrations of prolactin (hPRL) in human amniotic fluid appear to be derived principally from maternal decidua. The present study evaluated both the biologic and immunologic activity of amniotic fluid hPRL obtained from normal and selected complicated pregnancies. Biologic and immunologic activities of amniotic fluid hPRL were also compared with lecithin:sphingomyelin ratios and phosphatidylglycerol content. No significant correlation existed between amniotic fluid hPRL activities and fetal lung maturation. However, a significant increase in amniotic fluid hPRL concentration as well as specific biologic activity of the hormone was found in pregnancies complicated by hypertension. These findings suggest alterations in the synthesis of decidual hPRL and/or its transport to the amniotic fluid that may influence pregnancy-induced hypertension.

journal_name

Obstet Gynecol

authors

McCoshen JA,Tyson JE

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

24-30

issue

1

eissn

0029-7844

issn

1873-233X

journal_volume

65

pub_type

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