Transmission characteristics of variably protease-sensitive prionopathy.

Abstract:

:Variably protease-sensitive prionopathy (VPSPr), a recently identified and seemingly sporadic human prion disease, is distinct from Creutzfeldt-Jakob disease (CJD) but shares features of Gerstmann-Sträussler-Scheinker disease (GSS). However, contrary to exclusively inherited GSS, no prion protein (PrP) gene variations have been detected in VPSPr, suggesting that VPSPr might be the long-sought sporadic form of GSS. The VPSPr atypical features raised the issue of transmissibility, a prototypical property of prion diseases. We inoculated VPSPr brain homogenate into transgenic mice expressing various levels of human PrP (PrPC). On first passage, 54% of challenged mice showed histopathologic lesions, and 34% harbored abnormal PrP similar to that of VPSPr. Surprisingly, no prion disease was detected on second passage. We concluded that VPSPr is transmissible; thus, it is an authentic prion disease. However, we speculate that normal human PrPC is not an efficient conversion substrate (or mouse brain not a favorable environment) and therefore cannot sustain replication beyond the first passage.

journal_name

Emerg Infect Dis

authors

Notari S,Xiao X,Espinosa JC,Cohen Y,Qing L,Aguilar-Calvo P,Kofskey D,Cali I,Cracco L,Kong Q,Torres JM,Zou W,Gambetti P

doi

10.3201/eid2012.140548

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

2006-14

issue

12

eissn

1080-6040

issn

1080-6059

journal_volume

20

pub_type

杂志文章
  • Common reservoirs for Penicillium marneffei infection in humans and rodents, China.

    abstract::Human penicilliosis marneffei is an emerging infectious disease caused by the fungus Penicillium marneffei. High prevalence of infection among bamboo rats of the genera Rhizomys and Cannomys suggest that these rodents are a key facet of the P. marneffei life cycle. We trapped bamboo rats during June 2004-July 2005 acr...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1702.100718

    authors: Cao C,Liang L,Wang W,Luo H,Huang S,Liu D,Xu J,Henk DA,Fisher MC

    更新日期:2011-02-01 00:00:00

  • Kyasanur Forest disease, India, 2011-2012.

    abstract::To determine the cause of the recent upsurge in Kyasanur Forest disease, we investigated the outbreak that occurred during December 2011-March 2012 in India. Male patients >14 years of age were most commonly affected. Although vaccination is the key strategy for preventing disease, vaccine for boosters was unavailable...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1902.120544

    authors: Kasabi GS,Murhekar MV,Yadav PD,Raghunandan R,Kiran SK,Sandhya VK,Channabasappa GH,Mishra AC,Mourya DT,Mehendale SM

    更新日期:2013-02-01 00:00:00

  • Multidrug-resistant Acinetobacter extremity infections in soldiers.

    abstract::War wound infection and osteomyelitis caused by multidrug-resistant (MDR) Acinetobacter species have been prevalent during the 2003-2005 military operations in Iraq. Twenty-three soldiers wounded in Iraq and subsequently admitted to our facility from March 2003 to May 2004 had wound cultures positive for Acinetobacter...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/1108.050103

    authors: Davis KA,Moran KA,McAllister CK,Gray PJ

    更新日期:2005-08-01 00:00:00

  • Atypical avian influenza (H5N1).

    abstract::We report the first case of avian influenza in a patient with fever and diarrhea but no respiratory symptoms. Avian influenza should be included in the differential diagnosis for patients with predominantly gastrointestinal symptoms, particularly if they have a history of exposure to poultry. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1007.040415

    authors: Apisarnthanarak A,Kitphati R,Thongphubeth K,Patoomanunt P,Anthanont P,Auwanit W,Thawatsupha P,Chittaganpitch M,Saeng-Aroon S,Waicharoen S,Apisarnthanarak P,Storch GA,Mundy LM,Fraser VJ

    更新日期:2004-07-01 00:00:00

  • Genome sequence conservation of Hendra virus isolates during spillover to horses, Australia.

    abstract::Bat-to-horse transmission of Hendra virus has occurred at least 14 times. Although clinical signs in horses have differed, genome sequencing has demonstrated little variation among the isolates. Our sequencing of 5 isolates from recent Hendra virus outbreaks in horses found no correlation between sequences and time or...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1611.100501

    authors: Marsh GA,Todd S,Foord A,Hansson E,Davies K,Wright L,Morrissy C,Halpin K,Middleton D,Field HE,Daniels P,Wang LF

    更新日期:2010-11-01 00:00:00

  • Sporadic cryptosporidiosis, North Cumbria, England, 1996-2000.

    abstract::Risk factors for sporadic cryptosporidiosis were determined in 152 patients and 466 unmatched controls who resided in two local government districts in North Cumbria, North West England, from March 1, 1996, to February 29, 2000. Risk was associated with the usual daily volume of cold unboiled tap water drunk (odds rat...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/10.3201/eid1006.030325

    authors: Goh S,Reacher M,Casemore DP,Verlander NQ,Chalmers R,Knowles M,Williams J,Osborn K,Richards S

    更新日期:2004-06-01 00:00:00

  • Outbreak of Vaccinia Virus Infection from Occupational Exposure, China, 2017.

    abstract::Human infections with vaccinia virus (VACV), mostly from laboratory accidents or contact with infected animals, have occurred since smallpox was eradicated in 1980. No recent cases have been reported in China. We report on an outbreak of VACV from occupational exposure to rabbit skins inoculated with VACV. ...

    journal_title:Emerging infectious diseases

    pub_type: 历史文章,杂志文章

    doi:10.3201/eid2506.171306

    authors: Lu B,Cui LB,Gu MH,Shi C,Sun CW,Zhao KC,Bi J,Tan ZM,Guo XL,Huo X,Bao CJ

    更新日期:2019-06-01 00:00:00

  • Enterovirus 68 among children with severe acute respiratory infection, the Philippines.

    abstract::Enterovirus 68 (EV68) is a rare enterovirus associated with respiratory illness that, unlike other enteroviruses, has been identified only from respiratory specimens. We identified EV68 from respiratory specimens of children hospitalized with a diagnosis of severe pneumonia in Leyte, Republic of the Philippines. Twent...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1708.101328

    authors: Imamura T,Fuji N,Suzuki A,Tamaki R,Saito M,Aniceto R,Galang H,Sombrero L,Lupisan S,Oshitani H

    更新日期:2011-08-01 00:00:00

  • Bacteriophages and diffusion of beta-lactamase genes.

    abstract::We evaluated the presence of various Beta-lactamase genes within the bacteriophages in sewage. Results showed the occurrence of phage particles carrying sequences of bla(OXA-2), bla(PSE-1) or bla(PSE-4) and bla(PSE)-type genes. Phages may contribute to the spread of some Beta-lactamase genes. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1006.030472

    authors: Muniesa M,García A,Miró E,Mirelis B,Prats G,Jofre J,Navarro F

    更新日期:2004-06-01 00:00:00

  • Invasive group a streptococcal disease in nursing homes, Minnesota, 1995-2006.

    abstract::Nursing home residents are at high risk for invasive group A streptococcal (GAS) disease, and clusters of cases in nursing homes are common.To characterize the epidemiologic features of invasive GAS disease in nursing homes, we conducted active, statewide, population- and laboratory-based surveillance in Minnesota fro...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1405.070407

    authors: Rainbow J,Jewell B,Danila RN,Boxrud D,Beall B,Van Beneden C,Lynfield R

    更新日期:2008-05-01 00:00:00

  • Rotavirus G5P[6] in child with diarrhea, Vietnam.

    abstract::We detected rotavirus G5P[6] with a long RNA pattern in a Vietnamese child with diarrhea. Viral outer capsid protein VP7 and VP4 genes suggest that it likely originated from porcine rotavirus either by genetic reassortment or as whole virions. To our knowledge, this is the first report of human rotavirus G5 in Asia. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1308.061038

    authors: Ahmed K,Anh DD,Nakagomi O

    更新日期:2007-08-01 00:00:00

  • Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions in Strains from Nigeria, Sudan, and South Sudan.

    abstract::Deletion of histidine-rich protein genes pfhrp2/3 in Plasmodium falciparum causes infections to go undetected by HRP2-based malaria rapid diagnostic tests. We analyzed P. falciparum malaria cases imported to Australia (n = 210, collected 2010-2018) for their pfhrp2/3 status. We detected gene deletions in patients from...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2702.191410

    authors: Prosser C,Gresty K,Ellis J,Meyer W,Anderson K,Lee R,Cheng Q

    更新日期:2021-02-01 00:00:00

  • Sensitive and Specific Detection of Low-Level Antibody Responses in Mild Middle East Respiratory Syndrome Coronavirus Infections.

    abstract::Middle East respiratory syndrome coronavirus (MERS-CoV) infections in humans can cause asymptomatic to fatal lower respiratory lung disease. Despite posing a probable risk for virus transmission, asymptomatic to mild infections can go unnoticed; a lack of seroconversion among some PCR-confirmed cases has been reported...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2510.190051

    authors: Okba NMA,Raj VS,Widjaja I,GeurtsvanKessel CH,de Bruin E,Chandler FD,Park WB,Kim NJ,Farag EABA,Al-Hajri M,Bosch BJ,Oh MD,Koopmans MPG,Reusken CBEM,Haagmans BL

    更新日期:2019-10-01 00:00:00

  • Rat-to-human transmission of Cowpox infection.

    abstract::We isolated Cowpox virus (CPXV) from the ulcerative eyelid lesions of a 14-year-old girl, who had cared for a clinically ill wild rat that later died. CPXV isolated from the rat (Rattus norvegicus) showed complete homology with the girl's virus. Our case is the first proven rat-to-human transmission of cowpox. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0812.020089

    authors: Wolfs TF,Wagenaar JA,Niesters HG,Osterhaus AD

    更新日期:2002-12-01 00:00:00

  • Clinical findings of West Nile virus infection in hospitalized patients, New York and New Jersey, 2000.

    abstract::Outbreaks of West Nile (WN) virus occurred in the New York metropolitan area in 1999 and 2000. Nineteen patients diagnosed with WN infection were hospitalized in New York and New Jersey in 2000 and were included in this review. Eleven patients had encephalitis or meningoencephalitis, and eight had meningitis alone. Ag...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0704.010409

    authors: Weiss D,Carr D,Kellachan J,Tan C,Phillips M,Bresnitz E,Layton M,West Nile Virus Outbreak Response Working Group.

    更新日期:2001-07-01 00:00:00

  • Potential arbovirus emergence and implications for the United Kingdom.

    abstract::Arboviruses have evolved a number of strategies to survive environmental challenges. This review examines the factors that may determine arbovirus emergence, provides examples of arboviruses that have emerged into new habitats, reviews the arbovirus situation in western Europe in detail, discusses potential arthropod ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章,评审

    doi:10.3201/eid1204.051010

    authors: Gould EA,Higgs S,Buckley A,Gritsun TS

    更新日期:2006-04-01 00:00:00

  • European echinococcosis registry: human alveolar echinococcosis, Europe, 1982-2000.

    abstract::Surveillance for alveolar echinococcosis in central Europe was initiated in 1998. On a voluntary basis, 559 patients were reported to the registry. Most cases originated from rural communities in regions from eastern France to western Austria; single cases were reported far away from the disease-"endemic" zone through...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0903.020341

    authors: Kern P,Bardonnet K,Renner E,Auer H,Pawlowski Z,Ammann RW,Vuitton DA,Kern P,European Echinococcosis Registry.

    更新日期:2003-03-01 00:00:00

  • Francisella tularensis in rodents, China.

    abstract::A total of 420 rodents in China were examined for Francisella tularensis by polymerase chain reaction. The infection rates were 4.76% in total, and 11.65%, 10.00%, 6.56%, 1.77%, and 0% in Jilin, Xinjiang, Heilongjiang, Inner Mongolia, and Zhejiang, respectively. Sequence analysis showed that all the detected agents be...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1206.051324

    authors: Zhang F,Liu W,Chu MC,He J,Duan Q,Wu XM,Zhang PH,Zhao QM,Yang H,Xin ZT,Cao WC

    更新日期:2006-06-01 00:00:00

  • Disappearance of SARS-CoV-2 Antibodies in Infants Born to Women with COVID-19, Wuhan, China.

    abstract::We report the detection and decline over time of severe acute respiratory syndrome coronavirus 2 antibodies in infants born to women with coronavirus disease. Among 11 infants tested at birth, all had detectable IgG and 5 had detectable IgM. IgG titers with positive IgM declined more slowly than those without. ...

    journal_title:Emerging infectious diseases

    pub_type: 信件

    doi:10.3201/eid2610.202328

    authors: Gao J,Li W,Hu X,Wei Y,Wu J,Luo X,Chen S,Chen L

    更新日期:2020-10-01 00:00:00

  • Influenza A pandemic (H1N1) 2009 virus infection in domestic cat.

    abstract::Influenza A pandemic (H1N1) 2009 virus continues to rapidly spread worldwide. In 2009, pandemic (H1N1) 2009 infection in a domestic cat from Iowa was diagnosed by a novel PCR assay that distinguishes between Eurasian and North American pandemic (H1N1) 2009 virus matrix genes. Human-to-cat transmission is presumed. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1603.091737

    authors: Sponseller BA,Strait E,Jergens A,Trujillo J,Harmon K,Koster L,Jenkins-Moore M,Killian M,Swenson S,Bender H,Waller K,Miles K,Pearce T,Yoon KJ,Nara P

    更新日期:2010-03-01 00:00:00

  • High prevalence of multidrug-resistant tuberculosis, Swaziland, 2009-2010.

    abstract::In Africa, although emergence of multidrug-resistant (MDR) tuberculosis (TB) represents a serious threat in countries severely affected by the HIV epidemic, most countries lack drug-resistant TB data. This finding was particularly true in the Kingdom of Swaziland, which has the world's highest HIV and TB prevalences. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1801.110850

    authors: Sanchez-Padilla E,Dlamini T,Ascorra A,Rüsch-Gerdes S,Tefera ZD,Calain P,de la Tour R,Jochims F,Richter E,Bonnet M

    更新日期:2012-01-01 00:00:00

  • Infectious causes of chronic inflammatory diseases and cancer.

    abstract::Powerful diagnostic technology, plus the realization that organisms of otherwise unimpressive virulence can produce slowly progressive chronic disease with a wide spectrum of clinical manifestations and disease outcomes, has resulted in the discovery of new infectious agents and new concepts of infectious diseases. Th...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0403.980339

    authors: Cassell GH

    更新日期:1998-07-01 00:00:00

  • Crimean-Congo hemorrhagic fever in Bulgaria.

    abstract::We report the epidemiologic characteristics of Crimean-Congo hemorrhagic fever in Bulgaria, as well as the first genetic characterization of the virus strains circulating in the country in 2002 to 2003 that caused disease in humans. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1008.040162

    authors: Papa A,Christova I,Papadimitriou E,Antoniadis A

    更新日期:2004-08-01 00:00:00

  • Virulence potential of fusogenic orthoreoviruses.

    abstract::Several severe respiratory virus infections that have emerged during the past decade originated in animals, including bats. In Indonesia, exposure to bats has been associated with increased risk of acquiring orthoreovirus infection. Although orthoreovirus infections are mild and self-limiting, we explored their potent...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1806.111688

    authors: Wong AH,Cheng PK,Lai MY,Leung PC,Wong KK,Lee WY,Lim WW

    更新日期:2012-06-01 00:00:00

  • Wild chimpanzees infected with 5 Plasmodium species.

    abstract::Data are missing on the diversity of Plasmodium spp. infecting apes that live in their natural habitat, with limited possibility of human-mosquito-ape exchange. We surveyed Plasmodium spp. diversity in wild chimpanzees living in an undisturbed tropical rainforest habitat and found 5 species: P. malariae, P. vivax, P. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1612.100424

    authors: Kaiser M,Löwa A,Ulrich M,Ellerbrok H,Goffe AS,Blasse A,Zommers Z,Couacy-Hymann E,Babweteera F,Zuberbühler K,Metzger S,Geidel S,Boesch C,Gillespie TR,Leendertz FH

    更新日期:2010-12-01 00:00:00

  • Widespread rotavirus H in commercially raised pigs, United States.

    abstract::We investigated the presence in US pigs of rotavirus H (RVH), identified in pigs in Japan and Brazil. From 204 samples collected during 2006-2009, we identified RVH in 15% of fecal samples from 10 US states, suggesting that RVH has circulated in the United States since 2002, but probably longer. ...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2007.140034

    authors: Marthaler D,Rossow K,Culhane M,Goyal S,Collins J,Matthijnssens J,Nelson M,Ciarlet M

    更新日期:2014-07-01 00:00:00

  • Hantavirus Infection with Renal Failure and Proteinuria, Colorado, USA, 2019.

    abstract::In North America, hantaviruses commonly cause hantavirus pulmonary syndrome (HPS). Clinical descriptions of hantavirus-associated renal disease in the Americas are scarce. Herein, we discuss the case of a 61-year-old man whose predominant manifestations were acute kidney injury and proteinuria. Clinical recognition of...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid2602.191349

    authors: Chand S,Thapa S,Kon S,Johnson SC,Poeschla EM,Franco-Paredes C,Rodríguez-Morales AJ,Mattar S,Henao-Martínez AF

    更新日期:2020-02-01 00:00:00

  • B-virus and free-ranging macaques, Puerto Rico.

    abstract::In Puerto Rico, risk for transmission of B-virus from free-ranging rhesus monkeys to humans has become a serious challenge. An incident with an injured rhesus monkey, seropositive for B-virus, resulted in inappropriate administration of antiviral postexposure prophylaxis. This incident underscores the importance of ed...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1003.030257

    authors: Jensen K,Alvarado-Ramy F,González-Martínez J,Kraiselburd E,Rullán J

    更新日期:2004-03-01 00:00:00

  • Mycobacterium canettii, the smooth variant of M. tuberculosis, isolated from a Swiss patient exposed in Africa.

    abstract::An exceptionally smooth and glossy morphotype of Mycobacterium tuberculosis complex was isolated from a 56-year-old Swiss patient with mesenteric tuberculosis. Direct 16S rRNA sequence analysis of the hypervariable signature gene regions revealed a 100% homology to the specific M. tuberculosis complex sequence. Spolig...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid0404.980414

    authors: Pfyffer GE,Auckenthaler R,van Embden JD,van Soolingen D

    更新日期:1998-10-01 00:00:00

  • Human rickettsialpox, southeastern Mexico.

    abstract::The detection of Rickettsia akari in 2 human patients increased the diversity of rickettsioses affecting the public health in the southeast of Mexico. Rickettsialpox should be considered in the differential diagnosis with other febrile illnesses for the correct diagnosis and accurate treatment of this potential threat...

    journal_title:Emerging infectious diseases

    pub_type: 杂志文章

    doi:10.3201/eid1510.081507

    authors: Zavala-Castro JE,Zavala-Velázquez JE,Peniche-Lara GF,Sulú Uicab JE

    更新日期:2009-10-01 00:00:00