Natriuretic peptides, heart, and adipose tissue: new findings and future developments for diabetes research.

Abstract:

:Natriuretic peptides (NPs) play a key role in cardiovascular homeostasis, counteracting the deleterious effects of volume and pressure overload and activating antibrotic and antihypertrophic pathways in the heart. N-terminal B-type NP (NT-proBNP) also is a promising biomarker of global cardiovascular risk in the general population, and there is increasing interest on its potential use in diabetic patients for screening of silent cardiovascular abnormalities, cardiovascular risk stratification, and guided intervention. Recently, both atrial NP (ANP) and B-type NP (BNP) have emerged as key mediators in the control of metabolic processes including the heart in the network of organs that regulate energy usage and metabolism. Epidemiological studies have shown that ANP and BNP are reduced in people with obesity, insulin resistance, and diabetes, and this deficiency may contribute to enhance their global cardiovascular risk. Moreover, ANP and BNP have receptors in the adipose tissue, enhance lipolysis and energy expenditure, and modulate adipokine release and food intake. Therefore, low ANP and BNP levels may be not only a consequence but also a cause of obesity, and recent prospective studies have shown that low levels of NT-proBNP and midregional proANP (MR-proANP) are a strong predictor of type 2 diabetes onset. Whether ANP and BNP supplementation may result in either cardiovascular or metabolic benefits in humans remains, however, to be established.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Gruden G,Landi A,Bruno G

doi

10.2337/dc14-0669

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

2899-908

issue

11

eissn

0149-5992

issn

1935-5548

pii

37/11/2899

journal_volume

37

pub_type

杂志文章,评审
  • Interaction between plastic catheter tubings and regular insulin preparations used for continuous subcutaneous insulin-infusion therapy.

    abstract::In search of possible interactions between plastic tubings used for insulin-pump treatment and commercial regular insulin preparations, various catheter sets made from polyvinyl chloride (PVC), polyethylene (PE), and nylon plastics were perfused at 30 degrees C in a laboratory setting for up to 72 h. The perfused insu...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.10.3.348

    authors: Chantelau E,Lange G,Gasthaus M,Boxberger M,Berger M

    更新日期:1987-05-01 00:00:00

  • Detection of microalbuminuria. Receiver operating characteristic curve analysis favors albumin-to-creatinine ratio over albumin concentration.

    abstract:OBJECTIVE:To compare albumin-to-creatinine ratio (ACR) and albumin concentration (ALB) for detection of microalbuminuria using precise data on CIs for sensitivity and specificity and to determine sex- and age-specific discriminator values for ACR. RESEARCH DESIGN AND METHODS:All consecutive patients investigated for t...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.2.307

    authors: Bakker AJ

    更新日期:1999-02-01 00:00:00

  • Continuous subcutaneous insulin infusion. American Diabetes Association.

    abstract::Use of continuous subcutaneous insulin infusion requires continuing available care by skilled professionals, careful selection of patients, meticulous patient monitoring, and provisions for recording and reporting experiences. Insulin pumps prescribed by a physician within these guidelines are a part of treatment and ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.8.5.516

    authors:

    更新日期:1985-09-01 00:00:00

  • Cross-sectional analysis of renal function in black Americans with NIDDM.

    abstract::Our objective was to define glomerular filtration rate (GFR) and renal plasma flow (RPF) in Black Americans with non-insulin-dependent diabetes mellitus (NIDDM). This was a cross-sectional study of 71 Black NIDDM patients with diagnosed diabetes duration from 1 mo to 21 yr. Hyperglycemia was regulated and stabilized b...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.13.11.1186

    authors: Lebovitz HE,Palmisano J

    更新日期:1990-11-01 00:00:00

  • Intensive insulin therapy for treatment of type I diabetes.

    abstract::Intensive insulin therapy is best defined as a comprehensive system of diabetes management with the patient and management team as partners. The system is directed at improvement of glycemia and patient well-being. Glycemic targets should be individually defined. Frequent self-monitoring of blood glucose, probably at ...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.13.12.1265

    authors: Hirsch IB,Farkas-Hirsch R,Skyler JS

    更新日期:1990-12-01 00:00:00

  • Association of ACE gene polymorphism with arterial stiffness in patients with type 2 diabetes.

    abstract:OBJECTIVE:To assess the relationship between the insertion (I)/deletion (D) polymorphism of the ACE gene and arterial distensibility in patients with type 2 diabetes and healthy control subjects. RESEARCH DESIGN AND METHODS:Aortic and carotid arterial distensibility were evaluated by measuring aortic pulse-wave veloci...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.22.11.1858

    authors: Taniwaki H,Kawagishi T,Emoto M,Shoji T,Hosoi M,Kogawa K,Nishizawa Y,Morii H

    更新日期:1999-11-01 00:00:00

  • Neuronal Food Reward Activity in Patients With Type 2 Diabetes With Improved Glycemic Control After Bariatric Surgery.

    abstract:OBJECTIVE:Obesity and type 2 diabetes mellitus (T2DM) are associated with altered food-related neuronal functions. Besides weight loss, substantial improvement of glucose metabolism in patients with T2DM can be achieved by bariatric surgery. We aimed to target the neuronal and behavioral correlates of improved glycemic...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc16-0094

    authors: Frank S,Heinze JM,Fritsche A,Linder K,von Feilitzsch M,Königsrainer A,Häring HU,Veit R,Preissl H

    更新日期:2016-08-01 00:00:00

  • Pharmacist interventions to improve cardiovascular disease risk factors in diabetes: a systematic review and meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE:This systematic review and meta-analysis of randomized controlled trials (RCTs) assesses the effect of pharmacist care on cardiovascular disease (CVD) risk factors among outpatients with diabetes. RESEARCH DESIGN AND METHODS:MEDLINE, EMBASE, CINAHL, and the Cochrane Central Register of Controlled Trials were...

    journal_title:Diabetes care

    pub_type: 杂志文章,meta分析,评审

    doi:10.2337/dc12-0369

    authors: Santschi V,Chiolero A,Paradis G,Colosimo AL,Burnand B

    更新日期:2012-12-01 00:00:00

  • Factors determining the blood pressure response to enalapril and nifedipine in hypertension associated with NIDDM.

    abstract:OBJECTIVE:To examine the factors that determine the blood pressure response to enalapril and nifedipine monotherapy in the treatment of hypertension associated with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:After a 6-week placebo baseline period, 102 hypertensive NIDDM patients were ...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.18.7.1001

    authors: Chan JC,Nicholls MG,Cheung CK,Law LK,Swaminathan R,Cockram CS

    更新日期:1995-07-01 00:00:00

  • Screening for abnormalities of carbohydrate metabolism in pregnancy 1966-1977: the Belfast experience.

    abstract::Of the 30,300 mothers who attended consecutively at the antenatal clinic during an 11-yr period, 3063 mothers screened positive using clinical criteria for potential diabetes in pregnancy. These 3063 mothers had a glucose tolerance test (GTT), of which 661 were judged abnormal. At different times an oral GTT, cortison...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.3.3.440

    authors: Hadden DR

    更新日期:1980-05-01 00:00:00

  • Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes.

    abstract:OBJECTIVE:The recommendations for dietary fats in patients with type 2 diabetes are based largely on the impact of fatty acids on fasting serum lipid and glucose concentrations. How fatty acids affect postprandial insulin, glucose, and triglyceride concentrations, however, remains unclear. The objective of this study w...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc07-1026

    authors: Shah M,Adams-Huet B,Brinkley L,Grundy SM,Garg A

    更新日期:2007-12-01 00:00:00

  • Effect of weight loss with lifestyle intervention on risk of diabetes.

    abstract:OBJECTIVE:Diabetes Prevention Program (DPP) participants randomized to the intensive lifestyle intervention (ILS) had significantly reduced risk of diabetes compared with placebo participants. We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS par...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc06-0560

    authors: Hamman RF,Wing RR,Edelstein SL,Lachin JM,Bray GA,Delahanty L,Hoskin M,Kriska AM,Mayer-Davis EJ,Pi-Sunyer X,Regensteiner J,Venditti B,Wylie-Rosett J

    更新日期:2006-09-01 00:00:00

  • Periodontal infection, systemic inflammation, and insulin resistance: results from the continuous National Health and Nutrition Examination Survey (NHANES) 1999-2004.

    abstract:OBJECTIVE:Adverse microbial exposures might contribute to diabetogenesis. We hypothesized that clinical periodontal disease (a manifestation of microbial exposures in dysbiotic biofilms) would be related to insulin resistance among diabetes-free participants. The roles of inflammatory mediation and effect modification ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc12-0072

    authors: Demmer RT,Squillaro A,Papapanou PN,Rosenbaum M,Friedewald WT,Jacobs DR Jr,Desvarieux M

    更新日期:2012-11-01 00:00:00

  • Smoking and mortality among women with type 2 diabetes: The Nurses' Health Study cohort.

    abstract:OBJECTIVE:To assess the relationship between cigarette smoking and mortality among women with type 2 diabetes in the Nurses' Health Study cohort. RESEARCH DESIGN AND METHODS:The Nurses' Health Study, a prospective cohort of U.S. female registered nurses, included 7,401 women with type 2 diabetes diagnosed at baseline ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.12.2043

    authors: Al-Delaimy WK,Willett WC,Manson JE,Speizer FE,Hu FB

    更新日期:2001-12-01 00:00:00

  • Diet-quality scores and the risk of type 2 diabetes in men.

    abstract:OBJECTIVE:To 1) compare associations of diet-quality scores, which were inversely associated with cardiovascular disease, with incident type 2 diabetes and 2) test for differences in absolute-risk reduction across various strata. RESEARCH DESIGN AND METHODS:Men from the Health Professionals Follow-Up Study, who were i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-2352

    authors: de Koning L,Chiuve SE,Fung TT,Willett WC,Rimm EB,Hu FB

    更新日期:2011-05-01 00:00:00

  • Trends in health care expenditure in U.S. adults with diabetes: 2002-2011.

    abstract:OBJECTIVE:Direct medical cost of diabetes in the U.S. has been estimated to be 2.3 times higher relative to individuals without diabetes. This study examines trends in health care expenditures by expenditure category in U.S. adults with diabetes between 2002 and 2011. RESEARCH DESIGN AND METHODS:We analyzed 10 years o...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc15-0369

    authors: Ozieh MN,Bishu KG,Dismuke CE,Egede LE

    更新日期:2015-10-01 00:00:00

  • Predicting the development of diabetes in older adults: the derivation and validation of a prediction rule.

    abstract:OBJECTIVE:To create a simple prediction rule that could perform as well as the 2-h postchallenge plasma glucose (PCPG) test to predict those at risk for diabetes. We created a prediction rule in one sample and prospectively validated it for incident diabetes in a separate cohort. RESEARCH DESIGN AND METHODS:A cross-se...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.28.2.404

    authors: Kanaya AM,Wassel Fyr CL,de Rekeneire N,Shorr RI,Schwartz AV,Goodpaster BH,Newman AB,Harris T,Barrett-Connor E

    更新日期:2005-02-01 00:00:00

  • Cardiovascular disease risk factors predict the development of type 2 diabetes: the insulin resistance atherosclerosis study.

    abstract:OBJECTIVE:In a few previous studies, cardiovascular disease (CVD) risk factors (RFs) have been shown to predict diabetes. Our objective was to determine whether the presence of CVD RFs predict the eventual development of diabetes after controlling for known RFs, such as directly measured insulin resistance and obesity....

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.27.9.2234

    authors: D'Agostino RB Jr,Hamman RF,Karter AJ,Mykkanen L,Wagenknecht LE,Haffner SM,Insulin Resistance Atherosclerosis Study Investigators.

    更新日期:2004-09-01 00:00:00

  • Disability-Free Life-Years Lost Among Adults Aged ≥50 Years With and Without Diabetes.

    abstract:OBJECTIVE:To quantify the impact of diabetes status on healthy and disabled years of life for older adults in the U.S. and provide a baseline from which to evaluate ongoing national public health efforts to prevent and control diabetes and disability. RESEARCH DESIGN AND METHODS:Adults (n = 20,008) aged 50 years and o...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc15-1095

    authors: Bardenheier BH,Lin J,Zhuo X,Ali MK,Thompson TJ,Cheng YJ,Gregg EW

    更新日期:2016-07-01 00:00:00

  • Reduction in cardiovascular risk factors with intensive diabetes treatment in insulin-dependent diabetes mellitus.

    abstract::We measured plasma lipid and lipoprotein levels at baseline and at 6-mo intervals in 47 normolipidemic patients with classic insulin-dependent diabetes mellitus treated either with a conventional (n = 21) or intensive (n = 26) diabetes-treatment program. Patients were followed for a mean of 3 yr (range 1-4 yr). Intens...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.10.6.729

    authors: Rosenstock J,Strowig S,Cercone S,Raskin P

    更新日期:1987-11-01 00:00:00

  • Cancer arising after pancreas and/or kidney transplantation in a series of 99 diabetic patients.

    abstract:OBJECTIVE:Recipients of solid organ transplants have an increased risk of developing certain types of malignancies as compared with the general population. The majority of the literature has reported on neoplasms in kidney and heart transplant recipients. RESEARCH DESIGN AND METHODS:We describe 9 neoplasms occurring i...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.20.3.272

    authors: Martinenghi S,Dell'Antonio G,Secchi A,Di Carlo V,Pozza G

    更新日期:1997-03-01 00:00:00

  • Aspirin use and counseling about aspirin among patients with diabetes.

    abstract:OBJECTIVE:Despite being a safe, effective therapy for lowering cardiovascular risk, only 20% of diabetic patients were using aspirin in the early 1990s. This study examines current physician practices and the use of aspirin therapy by individuals with diabetes. RESEARCH DESIGN AND METHODS:A random sample of diabetic p...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.25.6.965

    authors: Krein SL,Vijan S,Pogach LM,Hogan MM,Kerr EA

    更新日期:2002-06-01 00:00:00

  • The Impact of Liraglutide on Diabetes-Related Foot Ulceration and Associated Complications in Patients With Type 2 Diabetes at High Risk for Cardiovascular Events: Results From the LEADER Trial.

    abstract:OBJECTIVE:Diabetes-related foot ulcers (DFUs) and their sequelae result in large patient and societal burdens. Long-term data determining the efficacy of individual glucose-lowering agents on DFUs are lacking. Using existing data from the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome R...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc18-1094

    authors: Dhatariya K,Bain SC,Buse JB,Simpson R,Tarnow L,Kaltoft MS,Stellfeld M,Tornøe K,Pratley RE,LEADER Publication Committee on behalf of the LEADER Trial Investigators.

    更新日期:2018-10-01 00:00:00

  • Efficacy and safety of inhaled insulin (exubera) compared with subcutaneous insulin therapy in patients with type 2 diabetes: results of a 6-month, randomized, comparative trial.

    abstract:OBJECTIVE:Glycemic control using inhaled, dry-powder insulin plus a single injection of long-acting insulin was compared with a conventional regimen in patients with type 2 diabetes, which was previously managed with at least two daily insulin injections. RESEARCH DESIGN AND METHODS:Patients were randomized to 6 month...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2337/diacare.27.10.2356

    authors: Hollander PA,Blonde L,Rowe R,Mehta AE,Milburn JL,Hershon KS,Chiasson JL,Levin SR

    更新日期:2004-10-01 00:00:00

  • Can adoption of regular exercise later in life prevent metabolic risk for cardiovascular disease?

    abstract:OBJECTIVE:To determine the impact of chronic exercise training initiated later in life upon development of metabolic markers of cardiovascular disease risk. RESEARCH DESIGN AND METHODS:Two inception cohorts of previously sedentary healthy adults aged 55-75 years at baseline (1989), one initiating regular supervised ph...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.28.3.694

    authors: Petrella RJ,Lattanzio CN,Demeray A,Varallo V,Blore R

    更新日期:2005-03-01 00:00:00

  • Screening for coronary artery disease in patients with diabetes.

    abstract::Coronary artery disease (CAD) accounts for a large fraction of the morbidity, mortality, and cost of diabetes. Recognizing this, nearly 10 years ago the American Diabetes Association published a consensus recommendation that clinicians consider a risk factor-guided screening approach to early diagnosis of CAD in both ...

    journal_title:Diabetes care

    pub_type: 共识发展会议,杂志文章

    doi:10.2337/dc07-9927

    authors: Bax JJ,Young LH,Frye RL,Bonow RO,Steinberg HO,Barrett EJ,ADA.

    更新日期:2007-10-01 00:00:00

  • Skeletal muscle morphology and exercise response in congenital generalized lipodystrophy.

    abstract:OBJECTIVE:Congenital generalized lipodystrophy (CGL) is an autosomal recessive genetic disorder characterized by almost complete absence of adipose tissue, muscular appearance, and severe insulin resistance since birth. We investigated whether insulin resistance in CGL patients is associated with abnormal muscle morpho...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.23.10.1545

    authors: Garg A,Stray-Gundersen J,Parsons D,Bertocci LA

    更新日期:2000-10-01 00:00:00

  • Racial differences in glycemic control in a well-functioning older diabetic population: findings from the Health, Aging and Body Composition Study.

    abstract:OBJECTIVE:To evaluate racial differences and factors associated with worse glycemic control in well-functioning older individuals with type 2 diabetes. Our hypothesis was that glycemic control would be worse among black than white diabetic individuals but that this association would be explained by differences in sever...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/diacare.26.7.1986

    authors: de Rekeneire N,Rooks RN,Simonsick EM,Shorr RI,Kuller LH,Schwartz AV,Harris TB,Health, Aging and Body Composition Study.

    更新日期:2003-07-01 00:00:00

  • Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study).

    abstract:OBJECTIVE:Intrauterine exposure to maternal type 1 diabetes is associated with a less favorable metabolic profile later in life. Nonalcoholic fatty liver disease is the hepatic manifestation of a cluster of metabolic abnormalities linked to insulin resistance. This study aimed to evaluate the effect of maternal pregest...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-0571

    authors: Knorr S,Bytoft B,Lohse Z,Boisen AB,Clausen TD,Jensen RB,Damm P,Beck-Nielsen H,Holst JJ,Hartmann B,Møller HJ,Højlund K,Gravholt CH,Jensen DM

    更新日期:2019-08-01 00:00:00

  • Signs of beta-cell autoimmunity in nondiabetic schoolchildren: a comparison between Russian Karelia with a low incidence of type 1 diabetes and Finland with a high incidence rate.

    abstract:OBJECTIVE:We sought to study the prevalence of autoantibodies to various islet cell antigens in the background population of two neighboring countries with a sixfold difference in the incidence of type 1 diabetes. RESEARCH DESIGN AND METHODS:Serum samples were obtained from 3,652 nondiabetic schoolchildren in Finland ...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究

    doi:10.2337/dc06-0711

    authors: Kondrashova A,Viskari H,Kulmala P,Romanov A,Ilonen J,Hyöty H,Knip M

    更新日期:2007-01-01 00:00:00