Abstract：
:Since 1963 there have been 266 patients with cancer of the uterine fundus at the Medical University of South Carolina. Progestational agents were used to treat 54 but 10 received the drugs for less than 1 month. This report relates to the remaining 44. 34 were treated with Depo-Provera (medroxyprogesterone acetate), 9 with Colprone (megestrone acetate), and 1 with Megace (megestrol acetate). Of the 34 patients treated with Depo-Provera 13 showed regression of the tumor; 3 of the 9 treated with Colprone showed regression. In an additional 11 (25%) of cases growth of the tumors was arrested. 7 of these were later found to have abdominal metastases; however, 3 were free of symptoms for over 43 months. A patient on Depo-Provera with lung metastases had recurrence after 62 months when treatment was reduced to every other week but when Colprone was then given, regression again occurred and has continued for almost 10 years. Another patient not responding to Depo-Provera did respond to Colprone. Average duration of regression was 27.7 months, of survival 31.1 months. Arrest of growth was 25 months in some; survival averaged 23.4 months. (The 1 Megace case was in this group.)y Those having progression of tumors lived an average of 9 months with the longest survival 24 months. Of the responders 8 lived from 44 to 111 months and 5 remain alive, 4 now showing no evidence of the cancer. Tumors with well-differentiated, slow-growing lesions were most likely to respond. Site of recurrence did not seem to influence the response. No contraindications were found to use of progestational agents in this type of cancer. Local reactions to the injections were few. Subjective response was frequent even though progression was taking place.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
Rozier JC Jr,Underwood PB Jrsubject
Has Abstractpub_date
1974-07-01 00:00:00pages
60-4issue
1eissn
0029-7844issn
1873-233Xjournal_volume
44pub_type
杂志文章abstract：BACKGROUND:Serious injury can result from improper use of the birthing bar. CASE:A 31-year-old woman delivered a neonate using a birthing bar for her entire second stage of labor. Shortly after delivery, she experienced bilateral upper extremity weakness from compression of the radial nerve. She was treated with physi...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:To identify and estimate prevalence rates of maternal morbidities by pregnancy outcome and selected covariates during the antepartum, intrapartum, and postpartum periods in a defined population of pregnant women. METHODS:We used electronic data systems of a large, vertically integrated, group-model health ma...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e31816c441a
更新日期：2008-05-01 00:00:00
abstract：:The Acyclovir in Pregnancy Registry was established to gather data on prenatal exposure to acyclovir. Exposed pregnancies are tracked prospectively to ascertain exposure, risk factors, and pregnancy outcome. Through June 30, 1990, 312 acyclovir-exposed pregnancies had been reported and followed. Of these, 239 were exp...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The endocrine effects of induction of ovulation with menotropins were studied in 43 patients: 11 with hypothalamic amenorrhea and 32 with the polycystic ovary syndrome. Patients with polycystic ovary syndrome had higher base-line values of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17 beta-est...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1985-02-01 00:00:00
abstract：OBJECTIVE:To estimate the clinical effectiveness, as determined by positive pregnancy test, of letrozole compared with clomiphene citrate for ovarian stimulation in patients with unexplained infertility. DATA SOURCES:We conducted a systematic review and meta-analysis of data from electronic databases including Ovid-ME...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,meta分析
doi：10.1097/AOG.0000000000003105
更新日期：2019-03-01 00:00:00
abstract：:Prospective evaluation of 155 couples with two or more consecutive pregnancy losses disclosed uterine morphologic abnormalities in 27%, chromosomal abnormalities in 21 individuals (7.7%, or 15.4% of the couples), and at least one abnormal diagnostic test suggestive of a cause for recurrent pregnancy losses in 106 (68%...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
abstract：:Hysteroscopic evaluation of 187 patients with abnormal uterine bleeding is reviewed. One hundred fifty-one patients had recent tissue sampling by a blind method. The hysteroscope with selected endometrial sampling was more accurate in 9.1% and less accurate in only 0.5% of patients. The specificity of both techniques ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:To determine if women who have undergone transcervical resection of the endometrium can be treated safely with estrogens alone. METHODS:Sixty-two postmenopausal women who had undergone endometrial resection were recruited into a double-blind, randomized study. Twenty-one had menopausal symptoms at the primar...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0029-7844(96)00308-0
更新日期：1996-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the role of immediate cerclage removal versus retention in patients experiencing premature rupture of the membranes remote from term (PROM). METHODS:Thirty patients with prophylactic cerclage experiencing PROM at 24-32 weeks were managed expectantly after either immediate removal in 20 (67%) or r...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：:Preoperative abdominopelvic computed tomography results and operative findings were compared in 52 patients undergoing second-look laparotomy to confirm tumor status. Seventeen true-negative, 22 false-negative, and 13 true-positive scans were found. The sensitivity was 0.38, specificity was 1.0, and diagnostic accurac...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1985-05-01 00:00:00
abstract：OBJECTIVE:To describe a pilot implementation of couple's human immunodeficiency virus (HIV) testing and counseling in an antenatal care clinic in the United States. METHODS:We used a cross-sectional study design. Couples were recruited from an antenatal care clinic of a large, urban, tertiary medical center, and were ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000003932
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVE:To examine the availability of trial of labor after cesarean delivery (TOLAC) in New Mexico from 1998 to 2012 and maternity care providers' perception of barriers to TOLAC. METHODS:Hospital maternity unit directors were surveyed regarding TOLAC availability from 1998 to 2012. Maternity care providers (obstet...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e31829bd0a0
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVE:To evaluate postpartum blood loss in women with treated intrahepatic cholestasis of pregnancy. METHODS:In a retrospective case-control study, 15,083 deliveries including 348 women with intrahepatic cholestasis of pregnancy (2.3%) were analyzed from 2004 to 2014. To adjust for differences in baseline characte...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000001693
更新日期：2016-11-01 00:00:00
abstract：:Ectopic pregnancy is suspected when a pregnancy test is positive and an Arias-Stella phenomenon with decidua is seen on endometrial curettings in the absence of chorionic villi and trophoblast. We performed immunoperoxidase stains for beta-hCG, hPL, placental alkaline phosphatase, and keratin (AE1/AE3) on endometrial ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
abstract：OBJECTIVE:To compare the Centers for Disease Control and Prevention's (CDC) contraceptive effectiveness poster with a more patient-centered poster on factors affecting the likelihood of using effective contraceptives. METHODS:The posters were tested in a randomized controlled trial. Women were eligible if they were ag...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,随机对照试验
doi：10.1097/AOG.0000000000003012
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Primary vaginal stones in children are extremely rare but important because they are often mistaken for bladder calculi on plain film. CASE:A 13-year-old girl was admitted to the hospital with abdominal pain. Physical and serial radiologic examinations found a hard mass anterior to the rectum. By vaginoscop...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
abstract：OBJECTIVES:To investigate the sensitivity of immunoblotting and enzyme-linked immunosorbent assay (ELISA) to detect autoantibodies to bullous pemphigoid antigen 180 in patients with pemphigoid gestationis and to correlate autoantibody serum levels with disease activity. METHODS:In serum samples obtained from 44 pregna...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/01.AOG.0000115506.76104.ad
更新日期：2004-04-01 00:00:00
abstract：OBJECTIVE:To develop a scoring system to predict the likelihood of vaginal birth in patients undergoing a trial of labor after previous cesarean delivery using factors known at the time of hospital admission. METHODS:Trial of labor was attempted in 5022 patients who were assigned randomly to score derivation and score...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0029-7844(97)00531-0
更新日期：1997-12-01 00:00:00
abstract：OBJECTIVE:To use decision analysis to evaluate whether and under what conditions routine setup of intraoperative cell salvage during cesarean delivery is cost-saving. METHODS:We developed a decision model to compare costs associated with two strategies for cesarean delivery: 1) routine setup of intraoperative cell sal...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000000465
更新日期：2014-10-01 00:00:00
abstract：:A patient undergoing evaluation for primary infertility with regular menses had a normal hysterosalpingogram in the follicular phase and underwent diagnostic laparoscopy the next day, with the finding of a tubal pregnancy. The patient had a negative serum pregnancy test. Although a normal hysterosalpingogram and negat...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：OBJECTIVE:To determine the association of intimate partner violence with maternal cigarette smoking before and during pregnancy. METHODS:Data were obtained for 196,391 U.S. mothers who delivered live neonates from 2004-2008 and completed the Pregnancy Risk Assessment Monitoring System survey 2-9 months postpartum. Int...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000000609
更新日期：2015-02-01 00:00:00
abstract：:Hydramnios and maternal renal compromise are described in a singleton pregnancy with a large fetal abdominal cystic mass. Both the hydramnios and the renal failure resolved after percutaneous drainage of the fetal cyst. Rapid reaccumulation of the mass resulted in redrainage and placement of an indwelling cyst/amnioti...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/00006250-198409001-00007
更新日期：1984-09-01 00:00:00
abstract：OBJECTIVE:To compare the efficacy and safety of routine electronic fetal monitoring (EFM) of labor with intermittent auscultation, using the results of published randomized controlled trials (RCTs). DATA SOURCES:We identified RCTs by searching the MED-LINE data base for the period 1966-1994, contacting experts, and re...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1995-10-01 00:00:00
abstract：OBJECTIVE:To assess the feasibility of using cytologic examination of ovarian cyst fluid for distinguishing between benign and malignant tumors. METHODS:Cyst fluid was aspirated at surgery in 83 women with benign and 35 women with malignant (25 invasive and ten borderline) ovarian tumors and submitted for routine cyto...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
abstract：:Spontaneous preterm birth is a syndrome with many causes and thus unresponsive to a single intervention. It logically follows that patients with a prior spontaneous preterm birth are a heterogeneous group unlikely to respond equally to a single preventive intervention such as 17-α hydroxyprogesterone caproate. Further...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000001618
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVE:To define the strengths and weaknesses of existing research on the natural history of cervical squamous intraepithelial lesions (SIL) and to estimate rates of progression and regression without treatment. DATA SOURCES:Studies of women whose cervical smears showed squamous atypia or worse and who were observe...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,meta分析
doi：10.1016/s0029-7844(98)00245-2
更新日期：1998-10-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of stress, urge, and mixed urinary incontinence and associated risk factors in postmenopausal women. METHODS:Before enrollment in a 4-year, randomized trial of combination hormone therapy to prevent coronary heart disease, 2763 participants completed questionnaires on prevalence a...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0029-7844(99)00263-x
更新日期：1999-07-01 00:00:00
abstract：:The role of Neisseria gonorrhoeae in the etiology and pathogenesis of acute salpingitis and its relationship to nongonococcal salpingitis were investigated. To accomplish this goal, isolated microorganisms obtained from the fallopian tubes and cul-de-sac via laparoscopy were evaluated in relation to the number of epis...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1981-07-01 00:00:00
abstract：:Carrier screening for cystic fibrosis as part of reproductive health care, including prenatal care, is not the standard of practice at this time. However, a recent National Institutes of Health Consensus Development Conference recommended that cystic fibrosis carrier screening should be offered to adults with a family...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Although not all multifetal pregnancies occur after the use of assisted reproductive technology, fertility treatments have contributed significantly to the increase in multifetal pregnancies. In almost all cases, it is preferable to avoid the risk of higher-order multifetal pregnancy by limiting the number of embryos ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,实务指引
doi：10.1097/AOG.0000000000002302
更新日期：2017-09-01 00:00:00
