Abstract：
:Spontaneous preterm birth is a syndrome with many causes and thus unresponsive to a single intervention. It logically follows that patients with a prior spontaneous preterm birth are a heterogeneous group unlikely to respond equally to a single preventive intervention such as 17-α hydroxyprogesterone caproate. Further confounding this issue is our fundamental lack of knowledge about the mechanism(s) by which 17-α hydroxyprogesterone caproate reduces preterm birth. Recently, studies demonstrating that responders and nonresponders can be identified based on obstetric history, genotype, physical characteristics, and behavioral factors have begun to provide clues into both 17-α hydroxyprogesterone caproate's mechanism and the pathophysiology of recurrent preterm birth and may allow for more targeted therapy. These studies lend support to speculation that inflammation or nitric oxide metabolism may be common threads between 17-α hydroxyprogesterone caproate's mechanism and preterm birth prevention. It will remain critically important to avoid the temptation to regard prior spontaneous preterm birth as a single disease entity amenable to a single treatment.
journal_name
Obstet Gynecoljournal_title
Obstetrics and gynecologyauthors
Heyborne KDdoi
10.1097/AOG.0000000000001618subject
Has Abstractpub_date
2016-10-01 00:00:00pages
899-903issue
4eissn
0029-7844issn
1873-233Xpii
00006250-201610000-00029journal_volume
128pub_type
杂志文章abstract：:Seventeen cases of fetal cystic hygroma detected during ultrasound examination are reported. In nine instances, associated abnormalities were recognized, such as fetal hydrops and a two-vessel cord. All diagnoses were confirmed at autopsy. Karyotyping revealed normal findings in six cases, Turner's syndrome in eight c...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：
更新日期：1988-08-01 00:00:00
abstract：:Hemostatic and platelet function studies were performed prospectively on 61 preeclamptic patients and 24 healthy pregnant control patients to delineate possible causes of thrombocytopenia in preeclampsia. Thrombocytopenia occurred in 50% of the preeclamptic patients, and was accompanied by qualitative platelet defects...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：OBJECTIVE:To estimate rates of postpartum glucose tolerance testing in women diagnosed with gestational diabetes mellitus (GDM) and to assess factors associated with testing. METHODS:This was a retrospective cohort study of 344 women with GDM who received prenatal care in a maternal diabetes clinic during 2001-2004. R...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000245446.85868.73
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVE:To describe a second-stage partogram based on a system of scoring the descent and position of the fetal head and to use this system for studying progress in the second stage of labor and predicting mode of delivery and obstetric outcome. METHODS:A prospective observational study of 1413 women at term with a ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(00)00981-9
更新日期：2000-11-01 00:00:00
abstract：OBJECTIVE:To compare the effectiveness of orally administered nifedipine and intravenously administered labetalol for acute blood pressure control in hypertensive emergency of pregnancy. METHODS:In this double-blind, randomized, controlled trial, pregnant women with sustained increase in systolic blood pressure of 160...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,随机对照试验
doi：10.1097/AOG.0b013e3182a9ea68
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:To evaluate fetal outcome and long-term impact of very early preterm premature rupture of membranes (PROM). METHODS:In a retrospective cohort study, 78 women with singleton pregnancies who delivered at the Oulu University Central Hospital between 1990 and 1996 and who had early PROM, between the 17th and 30t...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(98)00213-0
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:Selective embolization is an effective and reputedly safe method of managing pregnancy-related bleeding. However, we report an ischemic uterine necrosis after arterial embolization. CASE:The patient had heavy postpartum bleeding treated by embolization of the uterine arteries using polyvinyl alcohol particl...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(02)02050-1
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND:Urinothorax is defined as the presence of urine in the pleural cavity. This condition is due to the leakage of urine from the peritoneal and retroperitoneal space into the pleural space. We report a case of urinothorax after total abdominal hysterectomy. CASE:A premenopausal woman underwent total abdominal ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e31819bda90
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:Adult-onset Still disease is a rare febrile disorder that can present for the first time during pregnancy. It is a diagnosis of exclusion with nonspecific laboratory results. Good maternal and fetal outcomes can be expected after initial diagnosis and treatment. CASE:A 21-year-old (gravida 2, para 1) at 20 ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(03)00065-6
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVE:To systematically review studies examining the relationship between hyperemesis gravidarum and Helicobacter pylori (H pylori) infection. DATA SOURCES:A 1966 to January 2007 search using MEDLINE/PubMed, EMBASE, and Web of Science included MeSH terms: "Helicobacter pylori," "Helicobacter infections," "hypereme...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1097/01.AOG.0000278571.93861.26
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:To estimate the frequency of mismatch repair deficiencies associated with hereditary nonpolyposis colorectal cancer, or Lynch syndrome, in women less than age 50 with endometrial cancer. METHODS:Consecutive patients less than age 50 diagnosed with endometrial adenocarcinoma were identified. Available patholo...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0b013e31817051d9
更新日期：2008-05-01 00:00:00
abstract：:The incidence of spontaneously occurring premature labor in insulin-dependent diabetic pregnancies is unclear, because previous studies have been confounded by a high rate of iatrogenic prematurity. The purpose of this study was to determine, in a large population of insulin-dependent diabetic pregnant women, the rate...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：OBJECTIVE:To assess the effect of maternal involvement in motor vehicle crashes on the likelihood of adverse pregnancy outcomes and to estimate the effect of seatbelt use in reducing the occurrence of those outcomes. METHODS:Statewide motor vehicle crash, birth, and fetal death records from 1992 to 1999 were probabili...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0029-7844(03)00518-0
更新日期：2003-08-01 00:00:00
abstract：:Cortisol concentrations in umbilical cord plasma at birth were determined in association with pregnancy complications which may affect the time of pulmonary maturation of the fetus or otherwise influence its survival. No statistically significant change in these cortisol levels was observed in either term or premature...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1977-09-01 00:00:00
abstract：:This project was designed to determine if the presence of fibrin degradation products (FDP) in the blood are of value in the preoperative evaluation of patients with pelvic masses. This study comprised 120 consecutive patients who were evaluated for a diagnosis of pelvic mass, ovarian cyst, or ovarian carcinoma. A blo...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1978-11-01 00:00:00
abstract：:For certain medical conditions, available data and expert opinion support optimal timing of delivery in the late-preterm or early-term period for improved neonatal and infant outcomes. However, for nonmedically indicated early-term deliveries such an improvement has not been demonstrated. Morbidity and mortality rates...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000428649.57622.a7
更新日期：2013-04-01 00:00:00
abstract：OBJECTIVE:To study the relation between the timing of the postpartum examination and the postpartum Papanicolaou smear. METHODS:One hundred eighty-four women in labor at Arlington Community Hospital were randomized to receive their postpartum Papanicolaou smear at 4, 6, or 8 weeks after delivery. Samples from the exoc...
journal_title：Obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:Cervical varices are an extremely rare complication of pregnancy; they can result in significant maternal morbidity secondary to acute hemorrhage. There is limited evidence to guide the management of cervical varices during termination of pregnancy. CASE:A 37-year-old woman presented with recurrent vaginal ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/01.AOG.0000435449.01356.99
更新日期：2014-02-01 00:00:00
abstract：:A case of meconium peritonitis that was diagnosed ultrasonographically in the early third trimester in a patient with acute polyhydramnios is presented. The pathophysiologic progression of this condition is demonstrated by serial ultrasound examinations. Neonatal radiologic confirmation of the diagnosis is also presen...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：:A retrospective study of 29 patients with invasive carcinoma of the vagina was completed at The Milton S. Hershey Medical Center, Pennsylvania State University, for a ten-year period from 1976-1986. The overall incidence was 1.3% of all gynecologic malignancies. Twenty-four patients (83%) had squamous cell carcinoma a...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:Two cases of unusual postpartum fever in foreign nationals are presented. Prolonged work-up led to the diagnosis of pulmonary tuberculosis as a cause of postpartum fever that responded well to antituberculous drugs. The signs and symptoms illustrated by these cases should alert physicians to consider tuberculosis in t...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：:The presence of diffuse abdominal calcification in patients with known carcinoma is usually a sign of metastatic involvement. This finding in some patients who have been treated with high dosage radiation therapy may represent areas of tumor necrosis and subsequent healing without evidence of active malignancy. ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：BACKGROUND:Extensive bowel resection may lead to a state of inadequate nutrient absorption and malnutrition known as short bowel syndrome. Deficiencies in fat-soluble vitamins may occur from this condition, with sequelae such as a bleeding diathesis. Maternal vitamin deficiencies also have been associated with fetal an...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/aog.0b013e31827e5ab3
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Pessaries are a treatment option for pelvic organ prolapse, stress urinary incontinence (SUI), and cervical incompetence. An effective pessary is comfortable, corrects the presenting problem, does not cause adverse effects, and is easy to remove. Discomfort and poor fit limit the usefulness of pessaries for ...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1097/AOG.0000000000002461
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:To describe the technique and complications of vaginal repair of advanced pelvic organ prolapse using intravenous sedation, pudendal nerve block, and local anesthesia. METHODS:A retrospective review of the gynecologic surgical records of 20 patients was performed. Patient demographics, surgical procedure, su...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0029-7844(95)00331-k
更新日期：1995-12-01 00:00:00
abstract：:The relationship of three different fetal ponderal indexes was studied in 116 normal pregnancies between 20 and 41 weeks. All three fetal ponderal indexes were found to be independent of gestational age. Throughout normal gestation, the femur length to abdominal circumference ratio X 100 was found to be 22.3 +/- 2.4 (...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：:Six girls with suspected Rokitansky syndrome underwent magnetic resonance imaging (MRI) and then sonography and laparoscopy to confirm the clinical diagnosis and define the precise characteristics of the malformation. The uterus was missing in all; four had müllerian rudiments in place of the uterus, which were cavita...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：BACKGROUND:Burkitt lymphoma during pregnancy is a rare event, and outcomes have been poor. However, few patients were treated by current standards, with nearly half receiving single-agent cyclophosphamide or no chemotherapy. CASE:A patient with Burkitt lymphoma presenting at 11 6/7 weeks' gestation was treated with su...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1016/s0029-7844(98)00282-8
更新日期：1998-10-01 00:00:00
abstract：:In 21 pregnant women (seven in the first trimester and 14 in the second trimester), laminaria tents inserted for induction of elective abortion were removed after dilatation had been achieved, but upon the patient's request, the abortion was not carried out. Four patients again changed their minds and had uncomplicate...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:The pregnancy of a woman with Friedreich ataxia was complicated by the onset of preterm labor and preeclampsia. Administration of magnesium sulfate (MgSO4.7H2O) in the usual intravenous dosage resulted in the dramatic development of profound motor weakness and respiratory distress. Magnesium acts to antagonize the act...
journal_title：Obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
