Abstract：
:Nineteen patients with severe or recalcitrant rosacea were treated twice daily with 0.75 percent metronidazole topical gel in an open label study. Sixteen of the patients (84 percent) showed 50 percent or greater reduction in inflammatory lesions, while fifteen (79 percent) demonstrated a reduction in erythema severity and an improvement when evaluated by the investigator global assessment. No positive response was recorded for any patient prior to topical medication, whereas six of nine patients previously treated with tetracycline/minocycline demonstrated improvement. Seven of these nine patients responded to topical metronidazole treatment. One additional patient who did not respond to minocycline or desonide treatment showed a good response to topical metronidazole. Only one patient reported local irritation after using metronidazole. These results demonstrate that topical metronidazole gel is safe and effective for the treatment of severe or recalcitrant rosacea.
journal_name
Cutisjournal_title
Cutisauthors
Lowe NJ,Henderson T,Millikan LE,Smith S,Turk K,Parker Fsubject
Has Abstractpub_date
1989-03-01 00:00:00pages
283-6issue
3eissn
0011-4162issn
2326-6929journal_volume
43pub_type
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