Abstract:
:Early detection of subjects at high risk of developing dementia is essential. By dealing with censoring and competing risk of death, we developed a score for predicting 10-year dementia risk by combining cognitive tests, and we assessed whether inclusion of cognitive change over the previous year increased its discrimination. Data came from the French prospective cohort study Personnes Agées QUID (PAQUID) and included 3,777 subjects aged 65 years or older (1988-1998). The combined prediction score was estimated by means of an illness-death model handling interval censoring and competing risk of death. Its predictive ability was measured using the receiver operating characteristic (ROC) curve, with 2 different definitions depending on the way subjects who died without a dementia diagnosis were considered. To account for right-censoring and interval censoring, we estimated the ROC curves by means of a weighting approach and a model-based imputation estimator. The combined score exhibited an area under the ROC curve (AUROC) of 0.81 for discriminating future demented subjects from subjects alive and nondemented 10 years later and an AUROC of 0.75 for discriminating future demented subjects from all other subjects (including deceased persons). Adjustment for cognitive change over the previous year did not improve prediction.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Jacqmin-Gadda H,Blanche P,Chary E,Loubère L,Amieva H,Dartigues JFdoi
10.1093/aje/kwu202subject
Has Abstractpub_date
2014-10-15 00:00:00pages
790-8issue
8eissn
0002-9262issn
1476-6256pii
kwu202journal_volume
180pub_type
杂志文章abstract::Trends in sexual behavior associated with incident infection with human immunodeficiency virus (HIV) type 1 are described and a case-control study was conducted to examine risk factors for HIV seroconversion in homosexual men who became infected with HIV between 1982 and 1994 from four geographic sites: Amsterdam, the...
journal_title:American journal of epidemiology
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journal_title:American journal of epidemiology
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更新日期:2009-08-15 00:00:00
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更新日期:2002-09-01 00:00:00
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更新日期:1991-10-15 00:00:00
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更新日期:2006-12-15 00:00:00
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journal_title:American journal of epidemiology
pub_type: 杂志文章
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更新日期:1995-03-01 00:00:00
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更新日期:1992-03-15 00:00:00
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更新日期:1998-07-15 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2006-09-15 00:00:00
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更新日期:1980-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113566
更新日期:1983-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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doi:10.1093/oxfordjournals.aje.a112965
更新日期:1980-07-01 00:00:00
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journal_title:American journal of epidemiology
pub_type: 杂志文章
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更新日期:1987-12-01 00:00:00
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更新日期:2004-05-15 00:00:00
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更新日期:2005-06-15 00:00:00
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更新日期:1990-07-01 00:00:00
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journal_title:American journal of epidemiology
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更新日期:1985-02-01 00:00:00