Computerized tomographic and pathologic studies of the untreated, quiescent, and recurrent glioblastoma multiforme.

Abstract:

:Pathological findings in 20 cases of glioblastoma multiforme were correlated with clinical histories and computerized tomographic (CT) scans. This was done to define the neoplasm in three stages: before treatment, during remission, and during recurrence. The untreated lesions were markedly cellular neoplasms composed predominantly of small anaplastic cells. The radiographic central region of low density was necrosis, the enhancing rim was a cellular zone of viable neoplasm, and the perilesional low-density area was edema with infiltrating tumor. In these 20 cases, all of the identifiable neoplasms lay within the zone of peritumoral edema or contrast enhancement, although small anaplastic cells may have been present in more distant regions. The lesions in remission were remarkable for their minimal mass effect, discrete nature, extensive necrosis, and content of large bizarre glia. The large cells were confined to the original tumor bed and were consistent with neoplastic cells inactivated and immobilized by radio- and chemotherapy. These lesions were accurately localized by CT scanning. The recurrent lesions were heterogeneous, but most were formed of widely disseminated small anaplastic cells. The highly cellular regions of such lesions could be localized by CT scanning, but CT could not detect less cellular foci in the cerebrum, cerebellum, or brain stem. In one patient, the contrast-enhancing lesions of "recurrence," were foci of radionecrosis, underscoring the difficulty in distinguishing this entity from recurrent neoplasm.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Burger PC,Dubois PJ,Schold SC Jr,Smith KR Jr,Odom GL,Crafts DC,Giangaspero F

doi

10.3171/jns.1983.58.2.0159

subject

Has Abstract

pub_date

1983-02-01 00:00:00

pages

159-69

issue

2

eissn

0022-3085

issn

1933-0693

journal_volume

58

pub_type

杂志文章
  • Abscess formation within a parasagittal meningioma. Case report.

    abstract::The authors present the case of a 78-year-old woman who developed right lower-extremity paralysis after a focal seizure. Neuroradiological studies revealed a small parasagittal meningioma, which at the time of resection was found to contain a bacterial intratumoral abscess secondary to Proteus mirabilis. This is only ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1998.88.5.0895

    authors: Eisenberg MB,Lopez R,Stanek AE

    更新日期:1998-05-01 00:00:00

  • Long-term survival of patients treated with BCNU for brain tumors.

    abstract::The authors present three patients who, after excision and irradiation of their brain tumors, were treated with BCNU for recurrence. All three patients responded well and now are without evidence of tumor, 37, 30, and 36 months after BCNU was stopped. Although these patients represent only a small fraction of those tr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1975.43.2.0191

    authors: Calogero J,Crafts DC,Wilson CB,Boldrey EB,Rosenberg A,Enot KJ

    更新日期:1975-08-01 00:00:00

  • The effects of ischemia on long-tract neural conduction in the spinal cord.

    abstract::In this experiment, the effects of ischemia on neural conduction in the monkey spinal cord were studied. In six monkeys generalized ischemia of the spinal cord was created by bleeding the animals to a hypotensive level below the lower limits of autoregulation in the spinal cord. The progressive development of spinal c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1979.50.5.0639

    authors: Kobrine AI,Evans DE,Rizzoli HV

    更新日期:1979-05-01 00:00:00

  • Extradural lipomatosis simulating an acute herniated nucleus pulposus. Case report.

    abstract::A 48-year-old laborer presented with a 1-year history of low-back pain radiating into the posterior aspects of both thighs. Two weeks before admission, acute exacerbation resulted in signs and symptoms of compressive radiculopathy at L-5. Myelography revealed concentric constriction of the lower thecal sac due to abun...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1982.57.4.0559

    authors: Archer CR,Smith KR Jr

    更新日期:1982-10-01 00:00:00

  • Intraoperative electromyographic assessment of recurrent laryngeal nerve stress and pharyngeal injury during anterior cervical spine surgery with Caspar instrumentation.

    abstract:OBJECT:Recurrent laryngeal nerve (RLN) injury occurs after anterior cervical spine procedures. In this study the authors used intraoperative electromyographic (EMG) monitoring of the posterior pharynx as a surrogate for RLN function and monitored endotracheal tube (ET) cuff pressure to determine if there was an associa...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.1999.91.2.0170

    authors: Jellish WS,Jensen RL,Anderson DE,Shea JF

    更新日期:1999-10-01 00:00:00

  • Hemorrhage associated with ventriculoperitoneal shunt placement in aneurysmal subarachnoid hemorrhage patients on a regimen of dual antiplatelet therapy: a retrospective analysis.

    abstract:OBJECTIVE:Intracranial stenting and flow diversion require the use of dual antiplatelet therapy (DAPT) to prevent in-stent thrombosis. DAPT may significantly increase the risk of hemorrhagic complications in patients who require subsequent surgical interventions. In this study, the authors sought to investigate whether...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2017.5.JNS17642

    authors: Hudson JS,Nagahama Y,Nakagawa D,Starke RM,Dlouhy BJ,Torner JC,Jabbour P,Allan L,Derdeyn CP,Greenlee JDW,Hasan D

    更新日期:2018-10-01 00:00:00

  • Does adjuvant external-beam radiotherapy improve outcomes for nonbenign meningiomas? A Surveillance, Epidemiology, and End Results (SEER)-based analysis.

    abstract:OBJECT:The aim of this study was to examine the effect of postoperative external-beam radiation therapy (EBRT) on disease-specific survival in patients with nonbenign meningiomas. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2007 was queried for cases of resected Grades II (atyp...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2012.7.JNS111439

    authors: Stessin AM,Schwartz A,Judanin G,Pannullo SC,Boockvar JA,Schwartz TH,Stieg PE,Wernicke AG

    更新日期:2012-10-01 00:00:00

  • Malignant glioma-induced neuronal cell death in an organotypic glioma invasion model. Technical note.

    abstract::Rapid growth and diffuse brain infiltration are hallmarks of malignant gliomas. The underlying molecular pathomechanisms of these tumors, however, remain to be determined. The authors present a novel glioma invasion model that allows researchers to monitor consecutively tumor cell proliferation and migration in an org...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.102.4.0738

    authors: Eyüpoglu IY,Hahnen E,Heckel A,Siebzehnrübl FA,Buslei R,Fahlbusch R,Blümcke I

    更新日期:2005-04-01 00:00:00

  • Punctate midline myelotomy for the relief of visceral cancer pain.

    abstract:OBJECT:This study offers clinical support for the concept that neurosurgical interruption of a midline posterior column pathway by performing a punctate midline myelotomy (PMM) provides significant pain relief without causing adverse neurological sequelae in cancer patients with visceral pain refractory to other therap...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2000.92.2.0125

    authors: Nauta HJ,Soukup VM,Fabian RH,Lin JT,Grady JJ,Williams CG,Campbell GA,Westlund KN,Willis WD Jr

    更新日期:2000-04-01 00:00:00

  • Combined surgical and endovascular treatment of a spontaneous diploic arteriovenous fistula. Case report.

    abstract::The authors report on the case of a 28-year-old woman presenting with an intraosseous arteriovenous fistula (AVF) located in the left parietal bone. The fistula was formed by direct arteriovenous shunts connecting branches of the left middle meningeal and superficial temporal arteries with a parietal diploic vein. Dra...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.103.1.0179

    authors: Burger IM,Tamargo RJ,Broussard J,Gailloud P

    更新日期:2005-07-01 00:00:00

  • Biphasic ventricular dilatation following posterior fossa subdural hematoma in the full-term neonate.

    abstract::Five full-term neonates with a posterior fossa subdural hematoma caused by birth injury are reported. All of the patients were successfully treated with surgery. They all presented with biphasic ventricular dilatation as demonstrated by serial computerized tomography (CT) scanning. The initial dilatation due to obstru...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.68.2.0211

    authors: Tanaka Y,Sakamoto K,Kobayashi S,Kobayashi N,Muraoka S

    更新日期:1988-02-01 00:00:00

  • Cortical calculation localization using electrostimulation.

    abstract:OBJECT:A naming task has been used to spare cortical areas involved in language. In the present study, a calculation task was combined with electrostimulation mapping (awake surgery) to spare cortical areas involved in calculation in patients undergoing surgery for brain lesions. The organization of language and calcul...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2008.8.JNS17649

    authors: Roux FE,Boukhatem L,Draper L,Sacko O,Démonet JF

    更新日期:2009-06-01 00:00:00

  • Dural involvement in primary extradural meningiomas of the cranial vault.

    abstract:OBJECT:The authors retrospectively analyzed a consecutive series of patients with cranial vault primary extradural meningioma (PEM), with particular regard to the tumor's dural involvement. The pertinent literature was reviewed. METHODS:Clinical data were retrospectively obtained in a consecutive series of 16 patients...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2006.105.1.51

    authors: Bassiouni H,Asgari S,Hübschen U,König HJ,Stolke D

    更新日期:2006-07-01 00:00:00

  • Cerebrovascular effects of hypocapnia during adenosine-induced arterial hypotension.

    abstract::Profound arterial hypotension is a commonly used adjunct in surgery for aneurysms and arteriovenous malformations. Hyperventilation with hypocapnia is also used in these patients to increase brain slackness. Both measures reduce cerebral blood flow (CBF). Of concern is whether CBF is reduced below ischemic thresholds ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.63.6.0937

    authors: Boarini DJ,Kassell NF,Sprowell JA,Olin JJ,Coester HC

    更新日期:1985-12-01 00:00:00

  • Bleeding risk of cerebral cavernous malformations in patients on β-blocker medication: a cohort study.

    abstract::OBJECTIVECerebral cavernous malformations (CCMs) are frequently diagnosed vascular malformations of the brain. Although most CCMs are asymptomatic, some can be responsible for intracerebral hemorrhage or seizures. In selected cases, microsurgical resection is the preferred treatment option. Treatment with the unselect...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2017.12.JNS172404

    authors: Goldberg J,Jaeggi C,Schoeni D,Mordasini P,Raabe A,Bervini D

    更新日期:2018-06-15 00:00:00

  • Reduction of hemorrhage risk after stereotactic radiosurgery for cavernous malformations.

    abstract::The benefits of radiosurgery for cavernous malformations are difficult to assess because of the unclear natural history of this vascular lesion, the inability to image malformation vessels, and the lack of an imaging technique that defines "cure." The authors selected for radiosurgery 47 patients who harbored a hemorr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.83.5.0825

    authors: Kondziolka D,Lunsford LD,Flickinger JC,Kestle JR

    更新日期:1995-11-01 00:00:00

  • Distribution of genes for bone morphogenetic protein-4, -6, growth differentiation factor-5, and bone morphogenetic protein receptors in the process of experimental spondylosis in mice.

    abstract:OBJECT:Because little is known about the molecular mechanisms underlying the process of spondylosis, the authors examined the extent of genetic localization of several members of bone morphogenetic protein (BMP) and BMP receptors in chondrogenesis during the process of inducing spondylosis in their previously establish...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2001.94.1.0068

    authors: Nakase T,Ariga K,Miyamoto S,Okuda S,Tomita T,Iwasaki M,Yonenobu K,Yoshikawa H

    更新日期:2001-01-01 00:00:00

  • Malignant triton tumor of the acoustic nerve. Case report.

    abstract::The authors present the clinical, radiological, pathological features, and autopsy findings of a patient with malignant triton tumor of the acoustic nerve, which probably arose from a pre-existing acoustic schwannoma. The term "malignant triton tumor" is applied to malignant schwannomas with rhabdomyoblastic different...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1992.76.5.0874

    authors: Han DH,Kim DG,Chi JG,Park SH,Jung HW,Kim YG

    更新日期:1992-05-01 00:00:00

  • Painful supernumerary phantom arm following motor cortex stimulation for central poststroke pain. Case report.

    abstract::In this report, the authors describe a case in which the patient began to experience a supernumerary phantom arm after she received motor cortex stimulation for central pain. The patient had a history of right thalamocapsular stroke. It is speculated that the motor cortex activation triggered a response in the patient...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.91.1.0121

    authors: Canavero S,Bonicalzi V,Castellano G,Perozzo P,Massa-Micon B

    更新日期:1999-07-01 00:00:00

  • Giant-cell tumor of the sphenoid bone. Review of 10 cases.

    abstract::Giant-cell tumor rarely affects the sphenoid bone. Ten cases of this tumor seen at the Mayo Clinic are reviewed, bringing the number of cases in the world literature to 31. These tumors, which present in the second and third decades of life and are slightly more frequent in women than in men, may present with various ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1983.59.2.0322

    authors: Wolfe JT 3rd,Scheithauer BW,Dahlin DC

    更新日期:1983-08-01 00:00:00

  • Thoracic myelopathy secondary to ossified ligamentum flavum.

    abstract::The authors report a case of ossification of the ligamentum flavum at T-10 and T-11 associated with compressive myelopathy. Metrizamide myelography with computerized tomography allowed precise preoperative diagnosis and anatomic localization of the lesion. The patient had satisfactory and prompt improvement after surg...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1982.56.3.0448

    authors: Omojola MF,Cardoso ER,Fox AJ,Drake CG,Durward QJ

    更新日期:1982-03-01 00:00:00

  • Reflex variability in selective dorsal rhizotomy.

    abstract::The variability of reflex responses during selective dorsal rhizotomy was studied in eight children between the ages of 3 and 7 years. For a given dorsal root or rootlet, the electrical reflex threshold and response varied considerably when observed over several minutes. Changes in electrode pressure, mechanical disse...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1993.79.3.0346

    authors: Weiss IP,Schiff SJ

    更新日期:1993-09-01 00:00:00

  • Reduced expression of the transporter associated with antigen processing 1 molecule in malignant glioma cells, and its restoration by interferon-gamma and -beta.

    abstract:OBJECT:It remains unclear whether malignant glioma cells can deliver tumor antigens efficiently to major histocompatibility complex (MHC) Class I molecules. To elucidate the mechanism of antigen presentation in malignant gliomas, the authors examined the expression of the transporter associated with antigen processing ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2006.104.2.264

    authors: Satoh E,Mabuchi T,Satoh H,Asahara T,Nukui H,Naganuma H

    更新日期:2006-02-01 00:00:00

  • Vertebral artery aneurysms and the risk of cord infarction following spinal artery coverage during flow diversion.

    abstract:OBJECTIVE:Coverage of the anterior spinal artery (ASA) ostia is a source of considerable consternation regarding flow diversion (FD) in vertebral artery (VA) aneurysms due to cord supply. The authors sought to assess the association between coverage of the ASA, posterior spinal artery (PSA), or lateral spinal artery (L...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2020.1.JNS193293

    authors: Dmytriw AA,Kapadia A,Enriquez-Marulanda A,Parra-Fariñas C,Kühn AL,Nicholson PJ,Waqas M,Renieri L,Michelozzi C,Foreman PM,Phan K,Yang IH,Tutino VM,Ogilvy CS,Radovanovic I,Harrigan MR,Siddiqui AH,Levy EI,Limbucci N,Co

    更新日期:2020-03-27 00:00:00

  • Sex differences in outcome following sports-related concussion.

    abstract:OBJECT:Females comprise an increasing percentage of the athlete population across all age groups, and analysis of recent literature reveals that they sustain more concussions in collegiate sports. Results of human and animal studies indicate that females may have poorer outcomes after traumatic brain injury; however, n...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.102.5.0856

    authors: Broshek DK,Kaushik T,Freeman JR,Erlanger D,Webbe F,Barth JT

    更新日期:2005-05-01 00:00:00

  • Effects of experimental fluid-percussion injury of the brain on cerebrovascular reactivity of hypoxia and to hypercapnia.

    abstract::To test the hypothesis that concussive brain injury interferes with the normal vasodilator response of the cerebral circulation to hypoxemia, 30 cats were subjected to mild (PaO2 50 mm Hg) and severe (PaO2 30 mm Hg) hypoxemia while measurements were made of arterial and intracranial pressure, regional cerebral blood f...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1982.56.3.0332

    authors: Lewelt W,Jenkins LW,Miller JD

    更新日期:1982-03-01 00:00:00

  • Modified stereotactic insertion of the Ommaya reservoir. Technical note.

    abstract::Ommaya reservoirs are used primarily for the repeated injection of intrathecal chemotherapy for leptomeningeal metastasis from hematopoietic and solid malignancies. Insertion of this device in a relatively large nondisplaced ventricle is not a difficult task, but challenges arise when the ventricle is small and/or dis...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.92.6.1050

    authors: Al-Anazi A,Bernstein M

    更新日期:2000-06-01 00:00:00

  • Observer reliability in histological grading of astrocytoma stereotactic biopsies.

    abstract::This study provides an objective assessment of the reliability of histological grading of astrocytoma specimens obtained using stereotactic biopsy. Pathological diagnosis of brain tumors provides an index of disease severity and guides clinical practice in their treatment. It also functions as the gold standard in ass...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.85.6.1091

    authors: Mittler MA,Walters BC,Stopa EG

    更新日期:1996-12-01 00:00:00

  • Longitudinal survey of cranial case log entries during neurological surgery residency training.

    abstract::OBJECTIVEThe purpose of this study was to analyze national trends in adult cranial cases performed by neurological surgery residents as logged into the Accreditation Council for Graduate Medical Education (ACGME) system.METHODSThe ACGME resident case logs were retrospectively reviewed for the years 2009-2017. In these...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.2.JNS172734

    authors: Agarwal N,White MD,Cohen J,Lunsford LD,Hamilton DK

    更新日期:2018-07-01 00:00:00

  • Gamma Knife surgery for the management of glomus tumors: a multicenter study.

    abstract:OBJECT:Glomus tumors are rare skull base neoplasms that frequently involve critical cerebrovascular structures and lower cranial nerves. Complete resection is often difficult and may increase cranial nerve deficits. Stereotactic radiosurgery has gained an increasing role in the management of glomus tumors. The authors ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.3171/2012.4.JNS11214

    authors: Sheehan JP,Tanaka S,Link MJ,Pollock BE,Kondziolka D,Mathieu D,Duma C,Young AB,Kaufmann AM,McBride H,Weisskopf PA,Xu Z,Kano H,Yang HC,Lunsford LD

    更新日期:2012-08-01 00:00:00