Repeat region of Brugia malayi sheath protein (Shp-1) carries Dominant B epitopes recognized in filarial endemic population.

Abstract:

:Transmission of lymphatic filariasis is mediated through microfilariae (L1 stage of the parasite) which is encased in an eggshell called sheath. The sheath protein Shp-1 stabilizes the structure due to the unique repeat region with Met-Pro-Pro-Gln-Gly sequences. Microfilarial proteins could be used as transmission blocking vaccines. Since the repeat region of Shp-1 was predicted to carry putative B epitopes, this region was used to analyze its reactivity with clinical samples towards construction of peptide vaccine. In silico analysis of Shp-1 showed the presence of B epitopes in the region 49-107. The polypeptide epitopic region Shp-149-107 was cloned and expressed in Escherichia coli. Antibody reactivity of the Shp-149-107 construct was evaluated in filarial endemic population by ELISA. Putatively immune endemic normals (EN) showed significantly high reactivity (P < 0.05) when compared to all the other categories. Antibody reactivity of Shp-1 repeat region was similar to that of whole protein proving that this region carries B epitopes responsible for its humoral response in humans. Thus this can be employed for inducing anti-microfilarial immunity in the infected population that may lead to reduction in transmission intensity and also it could be used along with other epitopes from different stages of the parasite in order to manage the disease effectively.

journal_name

Acta Parasitol

journal_title

Acta parasitologica

authors

Jawaharlal JP,Madhumathi J,Prince RP,Kaliraj P

doi

10.2478/s11686-014-0270-y

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

454-8

issue

3

eissn

1230-2821

issn

1896-1851

journal_volume

59

pub_type

杂志文章
  • Genotypes of Giardia duodenalis in Household Dogs and Cats from Poland.

    abstract:BACKGROUND:Giardia duodenalis is a widespread protozoan parasite affecting humans and many species of animals, including dogs and cats. Due to its zoonotic potential, it is important to know the frequency of this parasite in companion animals. The aim of this study was to determine current epidemiological status of G. ...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1007/s11686-020-00292-1

    authors: Piekara-Stępińska A,Piekarska J,Gorczykowski M,Bania J

    更新日期:2020-10-11 00:00:00

  • Oxidative stress and cytotoxicity elicited lipid peroxidation in hemocytes of Bombyx mori larva infested with dipteran parasitoid, Exorista bombycis.

    abstract::Parasitization of silkworm, Bombyx mori by invasive larva of dipteran parasitoid Exorista bombycis caused upto 20% revenue loss in sericulture. The parasitism was successful by suppressing host immune system however mechanism of immune suppression induced by E. bombycis is unknown which is unravelled here. The infesta...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1515/ap-2017-0086

    authors: Pooja M,Pradeep ANR,Hungund SP,Sagar C,Ponnuvel KM,Awasthi AK,Trivedy K

    更新日期:2017-12-20 00:00:00

  • A new species of coccidia (Apicomplexa: Eimeriidae) from Cordillera striped shrew-rat, Chrotomys whiteheadi (Rodentia: Muridae), from the Philippines.

    abstract::During July 2011, a single Cordillera striped shrew-rat (Chrotomys whiteheadi) was collected from the Philippines and its faeces examined for coccidian parasites. It harboured an eimerian that we describe here as new. Oocysts of Eimeria macarthuri sp. n. were spheroidal to subspheroidal with a bi-layered wall and meas...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.2478/s11686-014-0304-5

    authors: McAllister CT,Seville RS,Duszynski DW,Bush SE

    更新日期:2014-10-01 00:00:00

  • The prevalence of helminth parasites in Pelophylax nigromaculatus (Anura: Ranidae) from Shanghai, China.

    abstract::Parasites are ubiquitous members of biotic communities. To investigate the infective status of helminth parasites in Pelophylax nigromaculatus from Shanghai, 90 frogs were collected from July 2013 to July 2014 and examined for the presence of internal parasites. Of these, 86.67% (78/90) of frogs were infected with par...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1515/ap-2016-0111

    authors: Men Q,Han H,Zhao Q,Xia W,Dong H,Zhu S,Wang Z,Li C,Zhu X,Huang B

    更新日期:2016-12-01 00:00:00

  • Prevalence and molecular characterization of Theileria equi and Babesia caballi in jereed horses in Erzurum, Turkey.

    abstract::Equine piroplasmosis (EP) is a hemoprotozoan tick-borne disease with worldwide distribution that is caused by Theileria equi and Babesia caballi. There are studies reporting the presence of equine piroplasmosis in Turkey but the situation in Erzurum is unknown. The aim of the current study was to determine the situati...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1515/ap-2017-0025

    authors: Guven E,Avcioglu H,Deniz A,Balkaya İ,Abay U,Yavuz Ş,Akyüz M

    更新日期:2017-03-01 00:00:00

  • Ultrastructural and Molecular Identification of the sarcocysts of Sarcocystis tenella and Sarcocystis arieticanis Infecting Domestic Sheep (Ovis aries) from Egypt.

    abstract:BACKGROUND:In spite of the global economic significance of sheep production, little is known about the prevalence of various Sarcocystis spp. infecting the domestic sheep (Ovis aries) in Egypt. MATERIALS AND METHODS:Muscle samples were collected from 175 sheep (> 2 years) slaughtered at El-Mahalla El-Kubra abattoir, G...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.2478/s11686-019-00070-8

    authors: El-Morsey A,Abdo W,Sultan K,Elhawary NM,AbouZaid AA

    更新日期:2019-09-01 00:00:00

  • Genetic diversity in human malarial parasites of Khyber Agency Pakistan.

    abstract::Malaria is wide spread in poor world and its burden has been assessed by the enumeration of malarial parasites in blood of patients. This study was designed to find a relationship between social structure, and spread of malaria in Khyber agency. The average parasite density was 2050 parasite/μl in Khyber Agency. Due t...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.2478/s11686-013-0181-3

    authors: Khatoon L,Jan MI,Khan IU,Ullah F,Malik SA

    更新日期:2013-12-01 00:00:00

  • Identification of public areas with potential toxocariasis transmission risk using geographical information systems.

    abstract:UNLABELLED:Geographic information system (GIS) or Health geography is a geographical identification of the spatial variation of contagion disease and zoonosis risk in certain conditions. OBJECTIVE:Comparing the variation of environmental contamination of Toxocara spp. sands of lawns and public areas through the Geogra...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.2478/s11686-013-0142-x

    authors: Marchioro AA,Colli CM,Ferreira ÉC,Tiyo R,Mattia S,de Souza WF,Falavigna-Guilherme AL

    更新日期:2013-09-01 00:00:00

  • Comparison Between Immuno-Clinicopathological Features of Experimental and Human Visceral Leishmaniasis by Leishmania donovani.

    abstract:BACKGROUND:Current understanding of visceral leishmaniasis (VL) depends upon the experimental model. Different species of mouse and hamster have been used as model for VL. It is already evident that the mouse model of VL is not a true reflection of the pathology of human visceral leishmaniasis (HuVL). On the other hand...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.2478/s11686-019-00127-8

    authors: Saini S,Dube A,Sahasrabuddhe AA,Thakur CP,Joshi S,Rawat K,Rai AK

    更新日期:2020-03-01 00:00:00

  • A new isosporoid coccidia (Apicomplexa: Eimeriidae)from the southern house wren Troglodytes musculus Naumann, 1823 (Passeriformes: Troglodytidae) from Brazil.

    abstract::A new isosporoid coccidian species (Protozoa: Apicomplexa: Eimeriidae) is reported from the southern house wren Troglodytes musculus, a very well distributed species in South and Central America. Isospora corruirae sp. nov. oocysts are subspherical to ovoidal, 24.1 × 21.4 μm, with smooth, bilayered wall. Micropyle and...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1515/ap-2016-0057

    authors: doBomfim Lopes B,Rodrigues MB,da Silva LM,Berto BP,Luz HR,Ferreira I,Lopes CW

    更新日期:2016-03-01 00:00:00

  • Nematode Parasites in Baltic Sea Mammals, Grey Seal (Halichoerus grypus (Fabricius, 1791)) and Harbour Porpoise (Phocoena phocoena (L.)), from the German Coast.

    abstract:PURPOSE:Endoparasitic nematodes of six harbour porpoises Phocoena phocoena and four grey seals Halichoerus grypus, stranded at the eastern coast of the Baltic Sea in Germany in winter 2019, were analysed in order to identify nematode parasites and to compare with recent studies from the same area. METHODS:Endoparasiti...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1007/s11686-020-00246-7

    authors: Gabel M,Theisen S,Palm HW,Dähne M,Unger P

    更新日期:2020-07-08 00:00:00

  • The Prevalence of Cyclospora cayetanensis and Cryptosporidium spp. in Turkish patients infected with HIV-1.

    abstract::Opportunistic infections such as cryptosporidiosis and cyclosporiasis are commonly encountered in patients with acquired immunodeficiency syndrome (AIDS). We investigated the existence of opportunistic protozoans that significantly affect the quality of life in HIV-1 infected patients using conventional and molecular ...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1515/ap-2017-0067

    authors: Uysal HK,Adas GT,Atalik K,Altiparmak S,Akgul O,Saribas S,Gurcan M,Yuksel P,Yildirmak T,Kocazeybek B,Ziver T,Oner YA

    更新日期:2017-09-26 00:00:00

  • Investigation of Isolated Blastocystis Subtypes from Cancer Patients in Turkey.

    abstract:PURPOSE:It is not clear that Blastocystis remains without damage to the digestive tract or has a pathogenic effect in relation to subtypes in immunocompromised people, such as cancer patients. The present study aimed to investigate the frequency and subtype distribution of Blastocystis in cancer patients who were follo...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1007/s11686-020-00322-y

    authors: Mülayim S,Aykur M,Dağcı H,Dalkılıç S,Aksoy A,Kaplan M

    更新日期:2021-01-02 00:00:00

  • Larval helminths in the invasive American brine shrimp Artemia franciscana throughout its annual cycle.

    abstract::One of the best examples of rapid displacement of native species by an invader is the eradication of native Artemia salina and A. parthenogenetica in the Mediterranean by the introduced American A. franciscana. Previous studies based on sampling from limited time periods suggest that the success of the American specie...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.2478/s11686-014-0255-x

    authors: Georgiev BB,Angelov A,Vasileva GP,Sánchez MI,Hortas F,Mutafchiev Y,Pankov P,Green AJ

    更新日期:2014-09-01 00:00:00

  • Leishmania infantum is present in vaginal secretions of naturally infected bitches at lower levels in oestrogenized bitches than in non-oestrogenized bitches.

    abstract::Naturally Leishmania infantum infected bitches were divided into oestrogenized (n = 11) and non-oestrogenized (n = 6) groups. Vaginal secretions were collected for polymerase chain reaction (PCR), and vulval, vaginal and uterine tissues were collected for the immunohistochemical (IHQ) identification of L. infantum. Pa...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1515/ap-2017-0076

    authors: Magro AG,Assis VP,Silva LC,Tafuri WL,Silva SO,Melo MN,Valle GR

    更新日期:2017-09-26 00:00:00

  • Diphyllidean cestodes from the bigeye houndshark Iago omanensis (Norman) (Carcharhiniformes: Triakidae) in the Gulf of Oman, with the description of Coronocestus ehsanentezarii sp. nov. (Echinobothriidae).

    abstract::A new species of Coronocestus Caira, Marques, Jensen, Kuchta and Ivanov, 2013 is described from Iago omanensis (Norman) from the Gulf of Oman. Coronocestus ehsanentezarii sp. nov. differs from C. musteli (Pintner, 1889) Caira, Marques, Jensen, Kuchta and Ivanov, 2013 in that its ovary is H- rather than U-shape. The ne...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1515/ap-2015-0043

    authors: Haseli M,Azad S

    更新日期:2015-06-01 00:00:00

  • Topography and ultrastructure of the tegument of Aphallus tubarium (Rodolphi, 1819) Poche, 1926 (Digenea: Cryptogonimidae), intestinal parasite of the common Dentex dentex (Linnaeus 1758) from Valinco Gulf.

    abstract::The tegument ultrastructure of the intestinal fluke Aphallus tubarium was studied for the first time with the use of scanning and transmission electron microscopy. New details on morphology were recorded. The ultrastructural study revealed that the tegument of A. tubarium had a syncytial organization with a distal cyt...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.2478/s11686-014-0281-8

    authors: Antonelli L,Quilichini Y,Foata J,Marchand B

    更新日期:2014-10-01 00:00:00

  • First report of the nematode Leidynema appendiculata from Periplaneta fuliginosa.

    abstract::The smokybrown cockroach Periplaneta fuliginosa has spread all over the world, and is now one of the most undesired invasive alien pests in Japan. Because cockroaches are generally infected by thelastomatid nematodes, they are being distributed around the world with their parasitic nematodes. Nothing is known about pa...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.2478/s11686-014-0230-6

    authors: Ozawa S,Vicente CS,Sato K,Yoshiga T,Kanzaki N,Hasegawa K

    更新日期:2014-06-01 00:00:00

  • Intestinal coccidian parasites as an underestimated cause of travellers' diarrhoea in Polish immunocompetent patients.

    abstract::Intestinal coccidian parasites are intracellular protozoa most frequently transmitted during food-borne and water-borne infections. This group of parasites is responsible for acute diarrhoeal illnesses especially among immunocompromised patients. However, they are more frequently detected in immunocompetent individual...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1515/ap-2017-0077

    authors: Kłudkowska M,Pielok Ł,Frąckowiak K,Paul M

    更新日期:2017-09-26 00:00:00

  • Norway rat (Rattus norvegicus) as a potential reservoir for Echinococcus granulosus: A public health implication.

    abstract::Cystic hydatidosis is a re-emerging parasitic zoonosis with worldwide distribution. The current study was carried out to investigate the possible role of rats in the epidemiology of such disease in urban and suburban areas. For this purpose, a total of 50 feral Norway rats (Rattus norvegicus) were collected from urban...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1515/ap-2016-0113

    authors: Abdel-Moein KA,Hamza DA

    更新日期:2016-12-01 00:00:00

  • New Species of Rhabdosynochus Mizelle and Blatz 1941 (Monogenoidea: Diplectanidae) From the Gills of the Cultured Centropomus viridis (Perciformes) in the Mexican Eastern Tropical Pacific.

    abstract:PURPOSE:There are currently nine monogenoidean species of Rhabdosynochus infecting the gill lamellae of wild and cultured centropomid fishes from tropical and subtropical waters of the western Atlantic and eastern Pacific Oceans. The purpose of the present study was to describe the morphological distinctiveness of two ...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1007/s11686-020-00303-1

    authors: Montero-Rodríguez M,Mendoza-Franco EF,Téllez NAL

    更新日期:2020-11-08 00:00:00

  • Patterns of the parasite communities in a fish assemblage of a river in the Brazilian Amazon region.

    abstract::This paper characterizes the pattern of ectoparasite and endoparasite communities in an assemblage of 35 sympatric fish from different trophic levels in a tributary from the Amazon River system, northern Brazil. In detritivorous, carnivorous, omnivorous and piscivorous hosts, the species richness consisted of 82 ectop...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1515/ap-2018-0035

    authors: Baia RRJ,Florentino AC,Silva LMA,Tavares-Dias M

    更新日期:2018-06-26 00:00:00

  • Pseudo-Tumor of the Epididymis, a Rare Clinical Presentation of Human Dirofilaria repens Infection: a Report of Autochthonous Case of Dirofilariasis in Southwestern Slovakia.

    abstract:PURPOSE:Dirofilariasis caused by the filarial nematode Dirofilaria repens is mainly a disease of dogs and other carnivores. Also, humans can be accidentally infected with this parasite. The infective third-stage filariform larvae are transmitted by various species of mosquitoes. Until this day, a total of 17 human case...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.2478/s11686-020-00170-w

    authors: Boldiš V,Ondriska F,Bošák V,Hajdúk O,Antolová D,Miterpáková M

    更新日期:2020-06-01 00:00:00

  • Ultrastructure of digenean trematode eggs (Platyhelminthes: Neoophora): A review emphasizing new comparative data on four European Microphalloidea.

    abstract::Despite their tremendous diversity and their medical and veterinary importance, details of egg ultrastructure among the digenean trematodes has been studied rather little. The available literature is spread over several decades and several species, but has not been adequately reviewed to reveal patterns of similarity ...

    journal_title:Acta parasitologica

    pub_type: 杂志文章,评审

    doi:10.1515/ap-2018-0001

    authors: Conn DB,Świderski Z,Miquel J

    更新日期:2018-03-26 00:00:00

  • Molecular Assessment of Anaplasma marginale in Bovine and Rhipicephalus (Boophilus) microplus Tick of Endemic Tribal Belt of Coastal South Gujarat, India.

    abstract:BACKGROUND AND METHODS:This study described the detection, prevalence and phylogeny of Anaplasma marginale in the bovine (cattle and buffaloes) and Rhipicephalus (Boophilus) microplus tick belonged to the tribal area of coastal South Gujarat, India, by amplifying 576 bp of major surface protein (msp) 5 gene using custo...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.2478/s11686-019-00041-z

    authors: Kumar N,Solanki JB,Varghese A,Jadav MM,Das B,Patel MD,Patel DC

    更新日期:2019-12-01 00:00:00

  • Epidemiological Study of Canine Babesiosis and Hepatozoonosis in the South of Romania.

    abstract:PURPOSE:The aim of this study was to evaluate the prevalence and distribution of canine babesiosis and hepatozoonosis in the south of Romania as well as to assess if there are differences in the prevalence between regions in that area. METHODS:Blood samples from 300 dogs from the south of Romania were screened for the...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.2478/s11686-020-00199-x

    authors: Cimpan AA,Nachum-Biala Y,Ben-Shitrit B,Miron L,Baneth G

    更新日期:2020-09-01 00:00:00

  • Effects of Schistosoma mansoni infection on lutein and β-carotene concentrations in Biomphalaria glabrata snails as determined by quantitative high performance reversed phase thin-layer chromatography.

    abstract::High performance thin-layer chromatography was used to determine the concentration of β-carotene and lutein in the whole body and digestive gland-gonad complex (DGG) of uninfected Biomphalaria glabrata snails and those infected with Schistosoma mansoni for 6 and 8 weeks. Pigments were extracted from the snails using a...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.2478/s11686-013-0140-z

    authors: Dieterich N,Fried B,Sherma J

    更新日期:2013-09-01 00:00:00

  • A new species of Cosmocerca (Nematoda: Cosmocercidae) and other helminths in Cyrtodactylus gubaot (Squamata: Gekkonidae) from the Philippines.

    abstract::Cosmocerca leytensis sp. nov. (Ascaridida, Cosmocercidae) from the large intestine of Cyrtodactylus gubaot (Squamata: Gekkonidae) collected on Leyte Island, Philippines is described and illustrated. Cosmocerca leytensis sp. nov. is the 30th species assigned to the genus, the 4th from the Oriental region, and the first...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1515/ap-2015-0096

    authors: Bursey CR,Goldberg SR,Siler CD,Brown RM

    更新日期:2015-12-01 00:00:00

  • CIAS detection of Fasciola hepatica/F. gigantica intermediate forms in bovines from Bangladesh.

    abstract::Fascioliasis is an important food-borne parasitic zoonosis caused by two trematode species, Fasciola hepatica and Fasciola gigantica. The characterisation and differentiation of Fasciola populations is crucial to control the disease, given the different transmission, epidemiology and pathology characteristics of the t...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.1515/ap-2016-0037

    authors: Ahasan SA,Valero MA,Chowdhury EH,Islam MT,Islam MR,Hussain Mondal MM,Peixoto RV,Berinde L,Panova M,Mas-Coma S

    更新日期:2016-03-01 00:00:00

  • A Laboratory Strain of Leishmania major: Protective Effects on Experimental Leishmaniasis.

    abstract:PURPOSE:Leishmaniasis, as one of the most important vector-borne and zoonotic diseases, can be seen in different forms and is more prevalent in developing countries worldwide. Due to the absence of effective strategies in its prevention, treatment, and control, investigation of effective control strategies against the ...

    journal_title:Acta parasitologica

    pub_type: 杂志文章

    doi:10.2478/s11686-019-00068-2

    authors: Namavari M,Namazi F,Asadi-Manesh R,Hosseini MH,Nazifi S,Asadpour M

    更新日期:2019-09-01 00:00:00