Genetic diversity in human malarial parasites of Khyber Agency Pakistan.

Abstract:

:Malaria is wide spread in poor world and its burden has been assessed by the enumeration of malarial parasites in blood of patients. This study was designed to find a relationship between social structure, and spread of malaria in Khyber agency. The average parasite density was 2050 parasite/μl in Khyber Agency. Due to economic and social setup most of the people have habit of sleeping in open air thus playing role in high malaria prevalence and Plasmodium vivax remains the prevalent species. Genetic study performed on 110 Blood samples showed less genetic diversity for both Plasmodium vivax and Plasmodium falciparum. Eight alleles were distinguished both for Pvmsp 3α and Pvmsp 3β in total of 20 and 39 amplified samples of P. vivax respectively. Out of 17 samples amplified for P. falciparum 11 showed genotype K1 and 10 for MAD at Pfmsp-1 while 14 alleles were identified for 3D7/1C and two for FC27 of corresponding families of Pfmsp-2 gene. This shows that Plasmodium parasites are not genetically diverse in Khyber agency.

journal_name

Acta Parasitol

journal_title

Acta parasitologica

authors

Khatoon L,Jan MI,Khan IU,Ullah F,Malik SA

doi

10.2478/s11686-013-0181-3

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

564-9

issue

4

eissn

1230-2821

issn

1896-1851

journal_volume

58

pub_type

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