Artifacts in the measurement of pulmonary artery wedge pressure.

abstract：:Calcium chloride is administered frequently to critically ill patients to improve cardiac output and BP. However, Ca has been implicated in the pathophysiology of shock and ischemic disorders. To test the hypothesis that Ca may be deleterious to shock outcome, we studied the effects of CaCl and Ca chelator (EGTA) infu...

journal_title：Critical care medicine

authors： Malcolm DS,Zaloga GP,Holaday JW

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVES:Interventions that reduce the generation or the effects of reactive oxygen species exert controversial effects in animal models of lung injury, and these could be secondary to the pro-oxidant effects of antioxidants generally by their interaction with iron. We here describe the effects of N-acetylcysteine, d...

journal_title：Critical care medicine

authors： Ritter C,da Cunha AA,Echer IC,Andrades M,Reinke A,Lucchiari N,Rocha J,Streck EL,Menna-Barreto S,Moreira JC,Dal-Pizzol F

更新日期：2006-02-01 00:00:00

abstract：:In a prospective 30-month study of nosocomial infections in a pediatric ICU (PICU), the incidence, sites, and causes of infection were determined. Factors associated with increased risk of infection were investigated. In 1,388 patients who remained in the PICU for a minimum of 72 h, 116 infections occurred (6.1 infect...

journal_title：Critical care medicine

authors： Milliken J,Tait GA,Ford-Jones EL,Mindorff CM,Gold R,Mullins G

更新日期：1988-03-01 00:00:00

abstract：:The tradition of clinical ultrasound in the hands of physicians who provide critical care to the most acutely ill patients stretches back into the 1980s and is rich with experiences from surgical, emergency medicine, and other practices. Now, as critical care ultrasound explodes around the world, it is important to re...

journal_title：Critical care medicine

authors： Kendall JL,Hoffenberg SR,Smith RS

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVES:Biomedical ethics has assumed an increasingly important role in medicine over the past 30 yrs, and its development has served the important goal of protecting patients' rights and interests. However, medical ethics has evolved within a Western tradition, and conflict often arises when trying to apply Western...

journal_title：Critical care medicine

authors： Ip M,Gilligan T,Koenig B,Raffin TA

更新日期：1998-03-01 00:00:00

abstract：PURPOSES:To discuss the theoretical relationship of mean alveolar pressure to its most easily measured analog, the mean airway pressure, and to describe the key determinants, measurement considerations, and clinical implications of this index. DATA SOURCES:Relevant articles from the medical and physiologic literature,...

journal_title：Critical care medicine

authors： Marini JJ,Ravenscraft SA

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVES:To determine whether contemporary β-lactam anti-infective dosing recommendations in critically ill children achieve concentrations associated with maximal anti-infective activity. The secondary objective was to describe the microbiological and clinical outcomes associated with β-lactam therapeutic drug manag...

journal_title：Critical care medicine

authors： Cies JJ,Moore WS 2nd,Enache A,Chopra A

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:To systematically investigate the effect of altering release time during airway pressure release ventilation in a neonatal animal model before and after oleic acid-induced acute lung injury. DESIGN:Prospective, nonrandomized, controlled study with repeated measures. SETTING:University research laboratory. ...

journal_title：Critical care medicine

authors： Martin LD,Wetzel RC

更新日期：1994-03-01 00:00:00

abstract：:Pulmonary mechanics were studied in ten anemic preterm infants using an esophageal balloon and mask, before and after transfusion with 10 ml/kg of packed RBC. Their mean birth weight was 1212 +/- 323 g and gestational age was 29.27 +/- 2.4 wk. Transfusions were carried out at a mean postnatal age of 41.9 +/- 21.8 days...

journal_title：Critical care medicine

authors： Sasidharan P,Heimler R

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVES:Pneumothorax is a frequent complication during mechanical ventilation. Electrical impedance tomography (EIT) is a noninvasive tool that allows real-time imaging of regional ventilation. The purpose of this study was to 1) identify characteristic changes in the EIT signals associated with pneumothoraces; 2) d...

journal_title：Critical care medicine

authors： Costa EL,Chaves CN,Gomes S,Beraldo MA,Volpe MS,Tucci MR,Schettino IA,Bohm SH,Carvalho CR,Tanaka H,Lima RG,Amato MB

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVES:To describe the timing of onset of organ system failure, multiple organ system failure diagnosis, and the subsequent death in children admitted to a pediatric intensive care unit (ICU). Second, to identify independent risk markers of death in pediatric patients with multiple organ system failure. DESIGN:Rev...

journal_title：Critical care medicine

authors： Proulx F,Gauthier M,Nadeau D,Lacroix J,Farrell CA

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVES:To define the hemodynamic and gastric intramucosal PCO2 (PiCO2) changes during the first 48 hrs after burn trauma and to analyze their relationship with outcome. DESIGN:Prospective, observational study in a cohort of consecutively admitted critically ill burn patients. SETTING:Intensive care burn unit in a...

journal_title：Critical care medicine

authors： Lorente JA,Ezpeleta A,Esteban A,Gordo F,de la Cal MA,Díaz C,Arévalo JM,Tejedor C,Pascual T

更新日期：2000-06-01 00:00:00

abstract：:The venous-arterial PCO2 gradient may increase in certain low-flow states, such as CPR and canine endotoxemia. To determine whether venous hypercarbia also occurs in hemorrhagic shock, we studied 12 anesthetized, mechanically ventilated dogs. We performed laparotomies on the animals, inserting catheters into their ren...

journal_title：Critical care medicine

authors： Benjamin E,Paluch TA,Berger SR,Premus G,Wu C,Iberti TJ

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:To determine the significance of moderate elevations of serum troponin I in a surgical intensive care unit patient population in terms of its impact on indexes of outcome including mortality, morbidity, and hospital and intensive care unit length of stay. DESIGN:Retrospective chart review and analysis of cli...

journal_title：Critical care medicine

authors： Relos RP,Hasinoff IK,Beilman GJ

更新日期：2003-11-01 00:00:00

abstract：:Medical technology is a two-edged sword, capable of saving and improving life but also of ending and harming life. Finding the right stance toward technology requires great balance and sensitivity. It has seductive powers because of its expected benefits, the social and professional pressures to use it, and a frequent...

journal_title：Critical care medicine

authors： Callahan D

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:Although misperceptions about prognosis by surrogates in ICUs are common and influence treatment decisions, there is no validated, practical way to measure the effectiveness of prognostic communication. Surrogates' subjective ratings of quality of communication have been used in other domains as markers of ef...

journal_title：Critical care medicine

authors： Chiarchiaro J,Buddadhumaruk P,Arnold RM,White DB

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine the prognostic value of sublingual PCO2 (P(SL)CO2), lactate concentration, and mixed venous oxygen saturation (S(MV)O2) in hemodynamically unstable intensive care patients and, additionally, to compare the temporal changes of these variables in response to treatment....

journal_title：Critical care medicine

authors： Marik PE,Bankov A

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:To determine the relationships between plasma L-arginine concentrations and the severity of respiratory distress syndrome (RDS) or systemic blood pressure in premature infants. DESIGN:Prospective, observational study. SETTING:Neonatal intensive care, tertiary referral hospital. SUBJECTS:Fifty-three prematu...

journal_title：Critical care medicine

authors： Zamora SA,Amin HJ,McMillan DD,Fick GH,Butzner JD,Parsons HG,Scott RB

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVES:We aimed to implement our Smart Use of Antibiotics Program to ensure the proper use of antimicrobials, improve patient care and outcomes, and reduce the risks of adverse effects and antimicrobial resistance. DESIGN:We compared the time periods before (baseline) and after (intervention) the implementation of...

journal_title：Critical care medicine

authors： Lu C,Liu Q,Yuan H,Wang L

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:To examine whether niacin attenuates lung inflammation and improves survival during sepsis and to determine whether the beneficial effects of niacin are associated with downregulation of the nuclear factor (NF)-κB pathway. DESIGN:Prospective laboratory study. SETTING:University laboratory. SUBJECTS:Male S...

journal_title：Critical care medicine

authors： Kwon WY,Suh GJ,Kim KS,Kwak YH

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:To examine the relationship between aminoglycoside disposition kinetics and hemodynamic response to sepsis, as well as vital support therapy, in critically ill patients with sepsis. DESIGN:Cross-sectional study of critically ill patients with sepsis undergoing physiologic and aminoglycoside pharmacokinetic m...

journal_title：Critical care medicine

authors： Lugo G,Castañeda-Hernández G

更新日期：1997-05-01 00:00:00

abstract：:The effect of positive end-expiratory pressure (PEEP) on PaO2 during collapse of a single pulmonary lobe was investigated in seven dogs. Increasing PEEP to the ventilated region of lung increased the proportion of cardiac output flowing to the collapsed lobe and decreased PaO2 and pH. PaCO2 increased at the onset of l...

journal_title：Critical care medicine

authors： Sánchez De León R,Orchard C,Sykes K,Brajkovich I

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVE:To assess the feasibility and safety of delivering early goal-directed sedation compared with standard sedation. DESIGN:Pilot prospective, multicenter, randomized, controlled trial. SETTING:Six ICUs. PATIENTS:Critically ill adults mechanically ventilated for greater than 24 hours. INTERVENTIONS:Patients r...

journal_title：Critical care medicine

authors： Shehabi Y,Bellomo R,Reade MC,Bailey M,Bass F,Howe B,McArthur C,Murray L,Seppelt IM,Webb S,Weisbrodt L,Sedation Practice in Intensive Care Evaluation Study Investigators.,Australian and New Zealand Intensive Care Society Clinical

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:Delirium occurs in approximately 30% of critically ill patients, and the risk of dying during admission doubles in those patients. Molecular mechanisms causing delirium are largely unknown. However, critical illness and the ICU environment consistently disrupt circadian rhythms, and circadian disruptions are...

journal_title：Critical care medicine

authors： Gile J,Scott B,Eckle T

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the clinical utility of right ventricular end-diastolic volume index (RVEDVI) and pulmonary artery occlusion pressure (PAOP) as measures of preload status in patients with acute respiratory failure receiving treatment with positive end-expiratory pressure. DESIGN:Prospective, cohort study. SETTI...

journal_title：Critical care medicine

authors： Cheatham ML,Nelson LD,Chang MC,Safcsak K

更新日期：1998-11-01 00:00:00

abstract：:The current investigation describes the morphological and pathophysiological effects of stroma-free hemoglobin solution (SFH) on the liver and kidney. One h after a 75% blood volume exchange in animals receiving 7% SFH, hepatic morphology was normal. Animals whose blood was similarly exchanged with 7% albumin demonstr...

journal_title：Critical care medicine

authors： Friedman HI,DeVenuto F

更新日期：1982-04-01 00:00:00

abstract：OBJECTIVES:To measure total serum nitrite and nitrate concentrations in children with the sepsis syndrome as an indicator of endogenous nitric oxide production. To determine if there is an association between total serum nitrite and nitrate concentrations and vascular responsiveness to norepinephrine. DESIGN:A prospec...

journal_title：Critical care medicine

authors： Wong HR,Carcillo JA,Burckart G,Shah N,Janosky JE

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:To determine the frequency and effects of weaning-related myocardial ischemia on weaning outcomes in patients with coronary artery disease. DESIGN:Prospective cohort study. SETTING:Medical and cardiac intensive care units of a 300-bed teaching community hospital. MEASUREMENTS AND MAIN RESULTS:Three-lead ST...

journal_title：Critical care medicine

authors： Srivastava S,Chatila W,Amoateng-Adjepong Y,Kanagasegar S,Jacob B,Zarich S,Manthous CA

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:To perform an analysis of the quality of life of survivors after ICU discharge. DESIGN:Prospective study. SETTING:Medical-surgical ICU of a Spanish reference hospital. PATIENTS:Patients (n = 606) admitted in a 6-month period. METHOD:A questionnaire regarding quality of life issues was completed at the tim...

journal_title：Critical care medicine

authors： Vazquez Mata G,Rivera Fernandez R,Gonzalez Carmona A,Delgado-Rodriguez M,Torres Ruiz JM,Raya Pugnaire A,Aguayo de Hoyos E

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:The neuroprotective effects of the noble gas xenon are well known. Argon, in contrast to xenon, is abundant, inexpensive, and therefore widely applicable. In this study, we analyzed the possible neuroprotective role of argon in an in vivo rat model of acute focal cerebral ischemia. DESIGN:Controlled laborato...

journal_title：Critical care medicine

authors： Ryang YM,Fahlenkamp AV,Rossaint R,Wesp D,Loetscher PD,Beyer C,Coburn M

更新日期：2011-06-01 00:00:00