Plasma L-arginine concentration, oxygenation index, and systemic blood pressure in premature infants.


OBJECTIVE:To determine the relationships between plasma L-arginine concentrations and the severity of respiratory distress syndrome (RDS) or systemic blood pressure in premature infants. DESIGN:Prospective, observational study. SETTING:Neonatal intensive care, tertiary referral hospital. SUBJECTS:Fifty-three premature infants. INTERVENTIONS:We measured arginine and nutritional intake, plasma arginine concentration, total amino acid concentrations, and blood pressure on days 3, 7, 14, and 21 of life. In 33 infants who received assisted ventilation, oxygenation index could be calculated to reflect the severity of RDS. The relationships between plasma arginine and oxygenation index or blood pressure were analyzed using multiple linear regression. MEASUREMENTS AND MAIN RESULTS:On day 3, plasma arginine concentrations were decreased compared with normal published values. Arginine concentrations increased with the day of life of measurement (p < .001) and with arginine intake (p < .001). After adjusting for arginine intake and day of life, an inverse relationship was found between oxygenation index and plasma arginine concentrations: (p = .025). No similar relationship was found between oxygenation index and the concentration of total amino acids. A weak positive relationship was found between plasma arginine concentration and systemic blood pressure. CONCLUSIONS:Increments in the oxygenation index, reflective of an increased severity of RDS, are associated with a decrease in plasma arginine concentration. This finding may reflect arginine consumption by the nitric oxide synthase pathway in the lungs of premature infants with RDS, or may be explained by increased arginine catabolism. The lack of a similar relationship between total plasma amino acids and oxygenation index supports the first interpretation.


Crit Care Med


Critical care medicine


Zamora SA,Amin HJ,McMillan DD,Fick GH,Butzner JD,Parsons HG,Scott RB




Has Abstract


1998-07-01 00:00:00












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    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Fathali N,Ostrowski RP,Lekic T,Jadhav V,Tong W,Tang J,Zhang JH

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    abstract::Clonidine may be a source of serious toxicity when ingested by toddlers. We describe 11 cases of clonidine ingestion by toddlers (mean dose 0.15 mg/kg; range 0.01 to 0.57). The source of the clonidine was a grand-parent in six of 11 cases. Symptoms included altered level of consciousness (n = 11), miosis (n = 5), brad...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Fiser DH,Moss MM,Walker W

    更新日期:1990-10-01 00:00:00

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    abstract:OBJECTIVE:Acute lung injury secondary to smoke inhalation is a major source of morbidity and mortality in burn patients. We tested the hypothesis that nebulized epinephrine would ameliorate pulmonary dysfunction secondary to acute lung injury by reducing airway hyperemia and edema formation and mediating bronchodilatat...

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    authors: Lange M,Hamahata A,Traber DL,Cox RA,Kulp GA,Nakano Y,Traber LD,Herndon DN,Enkhbaatar P

    更新日期:2011-04-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2002-01-01 00:00:00

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    abstract::Fifteen patients with septic shock and perfusion failure received a 20-min infusion of glucose-insulin-potassium (GIK, glucose 50%, 1 g/kg body weight; insulin 1.5 U/kg, potassium, 10 mMol) after volume loading and vasoactive medication had failed to eliminate hypotension and lactacidemia. Hemodynamic and oxygen measu...

    journal_title:Critical care medicine

    pub_type: 杂志文章


    authors: Bronsveld W,van den Bos GC,Thijs LG

    更新日期:1985-07-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:1994-09-01 00:00:00

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    更新日期:2009-07-01 00:00:00

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    pub_type: 杂志文章,多中心研究,随机对照试验


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    pub_type: 临床试验,杂志文章,随机对照试验


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    pub_type: 杂志文章,评审


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    journal_title:Critical care medicine

    pub_type: 杂志文章


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    更新日期:2003-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Neviere R,Mathieu D,Riou Y,Guimez P,Renaud N,Chagnon JL,Wattel F

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