Chemotherapy or liver transplantation for nonresectable liver metastases from colorectal cancer?

Abstract:

OBJECTIVE:The primary objective was to compare overall survival (OS) in patients with colorectal cancer (CRC) with nonresectable liver-only metastases treated by liver transplantation or chemotherapy. BACKGROUND:CRC is the third most common cancer worldwide. About 50% of patients will develop metastatic disease primarily to the liver and the lung. The majority of patients with liver metastases receive palliative chemotherapy, with a median OS of trial patients of about 2 years, and less than 10% are alive at 5 years. METHODS:Patients with nonresectable liver-only CRC metastases underwent liver transplantation in the SECA study (n = 21). Disease-free survival (DFS) and OS of patients included in the SECA study were compared with progression-free survival (PFS) and OS in a similar cohort of CRC patients with liver-only disease included in a first-line chemotherapy study, the NORDIC VII study (n = 47). PFS/DFS and OS were estimated by the Kaplan-Meier method. RESULTS:DFS/PFS in both groups were 8 to 10 months. However, a dramatic difference in OS was observed. The 5-year OS rate was 56% in patients undergoing liver transplantation compared with 9% in patients starting first-line chemotherapy. The reason for the large difference in OS despite similar DFS/PFS is likely different metastatic patterns at relapse/progression. Relapse in the liver transplantation group was often detected as small, slowly growing lung metastases, whereas progression of nonresectable liver metastases was observed in the chemotherapy group. CONCLUSIONS:Compared with chemotherapy, liver transplantation resulted in a marked increased OS in CRC patients with nonresectable liver-only metastases.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Dueland S,Guren TK,Hagness M,Glimelius B,Line PD,Pfeiffer P,Foss A,Tveit KM

doi

10.1097/SLA.0000000000000786

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

956-60

issue

5

eissn

0003-4932

issn

1528-1140

journal_volume

261

pub_type

杂志文章,多中心研究,随机对照试验
  • Surgical management of Menetrier's disease with protein-losing gastropathy.

    abstract::Three patients with Menetrier's disease and protein-losing gastropathy who were studied during a 12 year period have been presented. The characteristic findings which differentiate them from patients with hypertrophic hypersecretory gastropathy, including the Zollinger-Ellison syndrome, are: 1) hypertrophy of gastric ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197505000-00036

    authors: Scott HW Jr,Shull HJ,Law DH 4th,Burko H,Page DL

    更新日期:1975-05-01 00:00:00

  • Recurrent versus residual carotid stenosis. Incidence detected by Doppler ultrasound.

    abstract::A sterile Doppler probe was used for intraoperative monitoring of the integrity of carotid endarterectomy of 125 vessels of 107 patients. Our objective was to reduce the contribution of residual carotid lesions to recurrent stenosis, which was evaluated by Doppler spectrum analysis in the early (less than 3 months, 66...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198606000-00010

    authors: Barnes RW,Nix ML,Wingo JP,Nichols BT

    更新日期:1986-06-01 00:00:00

  • Incorporation of Procedure-specific Risk Into the ACS-NSQIP Surgical Risk Calculator Improves the Prediction of Morbidity and Mortality After Pancreatoduodenectomy.

    abstract:OBJECTIVE:This multicenter study sought to evaluate the accuracy of the American College of Surgeons National Surgical Quality Improvement Program's (ACS-NSQIP) surgical risk calculator for predicting outcomes after pancreatoduodenectomy (PD) and to determine whether incorporating other factors improves its predictive ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001796

    authors: McMillan MT,Allegrini V,Asbun HJ,Ball CG,Bassi C,Beane JD,Behrman SW,Berger AC,Bloomston M,Callery MP,Christein JD,Dickson E,Dixon E,Drebin JA,Fernandez-Del Castillo C,Fisher WE,Fong ZV,Haverick E,Hollis RH,House MG

    更新日期:2017-05-01 00:00:00

  • An Economic Evaluation of the National Surgical Quality Improvement Program (NSQIP) in Alberta, Canada.

    abstract:OBJECTIVE:The aim of this study was to analyze the health care costs and savings associated with quality improvement (QI) interventions initiated and implemented utilizing NSQIP. BACKGROUND:Five acute care facilities of Alberta Health Services (AHS) adopted NSQIP in 2015 for a pilot project. METHODS:The cost-savings ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002708

    authors: Thanh NX,Baron T,Litvinchuk S

    更新日期:2019-05-01 00:00:00

  • An 11 year evolution of coronary arterial surgery (1968-1978).

    abstract::All patients who underwent isolated myocardial revascularization procedures from 1967-70 (n = 741) were compared with the first 1,000 patients who received similar elective operations each year from 1971 through 1978. Data from these eight years were processed through a computerized cardiovascular information registry...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197910000-00004

    authors: Loop FD,Cosgrove DM,Lytle BW,Thurer RL,Simpfendorfer C,Taylor PC,Proudfit WL

    更新日期:1979-10-01 00:00:00

  • A multivariate analysis of preoperative risk factors in patients with common bile duct stones. Implications for treatment.

    abstract::A multivariate analysis of 30 preoperative risk factors was undertaken in 248 patients who underwent surgery alone for common bile duct (CBD) stones and in 190 patients who had endoscopic sphincterotomy (ES), 77 of whom subsequently also had surgery. Independently significant risk factors in those undergoing surgery w...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198902000-00004

    authors: Neoptolemos JP,Shaw DE,Carr-Locke DL

    更新日期:1989-02-01 00:00:00

  • Noncirrhotic portal vein thrombosis. Physiology before and after shunts.

    abstract::Controversy exists concerning the proper therapy for bleeding gastroesophageal varices secondary to noncirrhotic portal vein thrombosis. Disparity of opinion exists regarding the significance of hepatic portal blood flow and the consequences of total portal-systemic shunts in this condition. One patient is presented w...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198009000-00009

    authors: Warren WD,Millikan WJ Jr,Smith RB 3rd,Rypins EB,Henderson JM,Salam AA,Hersh T,Galambos JT,Faraj BA

    更新日期:1980-09-01 00:00:00

  • Administration of balanced or BCAA-enriched amino acid solution in septic rats. Effects on protein synthesis in the liver.

    abstract::Total hepatic protein synthesis was measured in vivo with a flooding-dose technique, and the production of total secreted proteins, albumin, complement component C3, and seromucoid fraction was measured in perfused livers of septic rats that received one of three different solutions infused intravenously; Group 1 rece...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198812000-00007

    authors: Pedersen P,Li SJ,Hasselgren PO,LaFrance R,Fischer JE

    更新日期:1988-12-01 00:00:00

  • Bilateral breast cancer. Risk reduction by contralateral biopsy.

    abstract::Although survival from primary breast cancer has improved with earlier diagnosis and treatment, the management of the opposite breast is still in question. The risk factors for bilaterality are known, and preoperative mammography is occasionally helpful, but identification of early second breast cancer is very limited...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198506000-00001

    authors: Wanebo HJ,Senofsky GM,Fechner RE,Kaiser D,Lynn S,Paradies J

    更新日期:1985-06-01 00:00:00

  • Individualized Metabolic Surgery Score: Procedure Selection Based on Diabetes Severity.

    abstract:OBJECTIVE:To construct and validate a scoring system for evidence-based selection of bariatric and metabolic surgery procedures according to severity of type 2 diabetes (T2DM). BACKGROUND:Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) account for >95% of bariatric procedures in United States in patients w...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002407

    authors: Aminian A,Brethauer SA,Andalib A,Nowacki AS,Jimenez A,Corcelles R,Hanipah ZN,Punchai S,Bhatt DL,Kashyap SR,Burguera B,Lacy AM,Vidal J,Schauer PR

    更新日期:2017-10-01 00:00:00

  • Increasing operating room efficiency through parallel processing.

    abstract:OBJECTIVE:Because of rising costs and shrinking reimbursements, hospitals must continually find ways to improve efficiency and productivity. This study attempts to increase caseloads in ambulatory surgery operating rooms while maintaining patient satisfaction and safety. SUMMARY BACKGROUND DATA:In most hospitals, pati...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000193600.97748.b1

    authors: Friedman DM,Sokal SM,Chang Y,Berger DL

    更新日期:2006-01-01 00:00:00

  • Higher Recurrence Rate After Endoscopic Totally Extraperitoneal (TEP) Inguinal Hernia Repair With Ultrapro Lightweight Mesh: 5-Year Results of a Randomized Controlled Trial (TULP-trial).

    abstract:OBJECTIVE:The aim of this study was to determine inguinal hernia recurrence rates 5 years after endoscopic totally extraperitoneal (TEP) inguinal hernia repair when either lightweight or heavyweight mesh was used. BACKGROUND:Recurrence is an important complication of inguinal hernia surgery. Higher recurrence rates of...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000002649

    authors: Roos MM,Bakker WJ,Schouten N,Voorbrood CEH,Clevers GJ,Verleisdonk EJ,Davids PH,Burgmans JP

    更新日期:2018-08-01 00:00:00

  • Aortoenteric fistula. Incidence, presentation recognition, and management.

    abstract::Twenty-two patients developed one or more aortoenteric fistulae following aortic reconstruction with a dacron graft. Endoscopy was performed on 11 of these patients on 17 occasions and a preoperative diagnosis was made in eight patients. Fistulous communication was most common between the aorta and duodenum (60%), and...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198203000-00011

    authors: Champion MC,Sullivan SN,Coles JC,Goldbach M,Watson WC

    更新日期:1982-03-01 00:00:00

  • Variceal recurrence, rebleeding, and survival after endoscopic injection sclerotherapy in 287 alcoholic cirrhotic patients with bleeding esophageal varices.

    abstract:OBJECTIVE:This study tested the validity of the hypothesis that eradication of esophageal varices by repeated injection sclerotherapy would reduce recurrent variceal bleeding and death from bleeding varices in a high-risk cohort of alcoholic patients with cirrhosis. SUMMARY BACKGROUND DATA:Although banding of esophage...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000231704.45005.4e

    authors: Krige JE,Kotze UK,Bornman PC,Shaw JM,Klipin M

    更新日期:2006-11-01 00:00:00

  • Oncological Outcomes After Robotic Proctectomy for Rectal Cancer: Analysis of a Prospective Database.

    abstract:OBJECTIVE:The aim of this study is to evaluate the oncological outcomes of robotic total mesorectal excision (TME) at an NCI designated cancer center. SUMMARY BACKGROUND DATA:The effectiveness of laparoscopic TME could not be established, but the robotic-assisted approach may hold some promise, with improved visualiza...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002112

    authors: Sammour T,Malakorn S,Bednarski BK,Kaur H,Shin US,Messick C,You YN,Chang GJ

    更新日期:2018-03-01 00:00:00

  • Suppression of gastrin release and gastric secretion by gastric inhibitory polypeptide (GIP) and vasoactive intestinal polypeptide (VIP).

    abstract::Five dogs prepared with Heidenhain pouches received infusions of saline, GIP and VIP before and after a standard meat meal. Blood samples were obtained under basal conditions and at subsequent intervals for measurement of gastrin, insulin, GIP and VIP by radioimmunoassay. GIP and VIP infusions had no effect on basal l...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197607000-00016

    authors: Villar HV,Fender HR,Rayford PL,Bloom SR,Ramus NI,Thompson JC

    更新日期:1976-07-01 00:00:00

  • Hyperparathyroidism associated with the enlargement of two or three parathyroid glands.

    abstract::Eighty-five (23%) of 375 patients undergoing surgery for primary hyperparathyroidism were found to have enlargement (greater than 50 mg) of two or three parathyroid glands. Of 76 patients followed from 12 to 140 months after surgery, eight (10.5%) developed hypercalcemia at 1, 4, 45, 64, 74, 79, 84, and 133 months. In...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198511000-00001

    authors: Wells SA Jr,Leight GS,Hensley M,Dilley WG

    更新日期:1985-11-01 00:00:00

  • Management of nonpalpable breast abnormalities.

    abstract::From January 1982 to June 1986, 444 patients had localization of 500 nonpalpable mammographically suspicious lesions using the Kopans hook wire technique. Four hundred ninety-nine biopsies were performed in 443 patients. Cancer was identified in 12% of the biopsies performed for a suspicious mass or density and in 20%...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198705000-00010

    authors: Symmonds RE Jr,Roberts JW

    更新日期:1987-05-01 00:00:00

  • Surgeon-related factors and outcome in rectal cancer.

    abstract:OBJECTIVE:To determine whether surgical subspecialty training in colorectal surgery or frequency of rectal cancer resection by the surgeon are independent prognostic factors for local recurrence (LR) and survival. SUMMARY BACKGROUND DATA:Variation in patient outcome in rectal cancer has been shown among centers and am...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00000658-199802000-00001

    authors: Porter GA,Soskolne CL,Yakimets WW,Newman SC

    更新日期:1998-02-01 00:00:00

  • Fontan operation in the current era: a 15-year single institution experience.

    abstract:OBJECTIVE:Evaluate current risk factors for mortality and morbidity in patients undergoing the Fontan procedure at a single institution in the current era. SUMMARY BACKGROUND DATA:An emphasis on early relief of volume and pressure overload culminating in the Fontan procedure has improved patient outcomes for patients ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181858286

    authors: Hirsch JC,Goldberg C,Bove EL,Salehian S,Lee T,Ohye RG,Devaney EJ

    更新日期:2008-09-01 00:00:00

  • Maintenance of cardiodynamics with aspirin during abdominal aortic aneurysmectomy (AAA).

    abstract::The importance of prostacyclin (PGI2) and thromboxane (Tx) medication of depressed cardiac performance during abdominal aortic aneurysm operative surgery was studied by contrasting the effects of 650 mg aspirin administered 12 hours before operation to that of a placebo. In 11 patients who received a placebo, the stab...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1097/00000658-198111000-00008

    authors: Utsunomiya T,Krausz MM,Dunham B,Mannick JA,Allen PD,Shepro D,Hechtman HB

    更新日期:1981-11-01 00:00:00

  • Inhibition of tumor angiogenesis and melanoma growth by targeting vascular E-selectin.

    abstract:OBJECTIVES:Aggressive human melanomas express, C-X-C chemokine receptor 4 (CXCR4), the receptor for the chemokine, stromal cell-derived factor-1alpha (SDF-1α). The CXCR4-SDF-1α axis has been postulated to increase melanoma invasiveness. We discovered that SDF-1α specifically upregulates E-selectin on endothelial cells,...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31822a72dc

    authors: Liu ZJ,Tian R,Li Y,An W,Zhuge Y,Livingstone AS,Velazquez OC

    更新日期:2011-09-01 00:00:00

  • The physiologic effects of pneumoperitoneum in the morbidly obese.

    abstract:OBJECTIVE:To review the physiologic effects of carbon dioxide (CO2) pneumoperitoneum in the morbidly obese. SUMMARY BACKGROUND DATA:The number of laparoscopic bariatric operations performed in the United States has increased dramatically over the past several years. Laparoscopic bariatric surgery requires abdominal in...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/01.sla.0000151791.93571.70

    authors: Nguyen NT,Wolfe BM

    更新日期:2005-02-01 00:00:00

  • Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients.

    abstract:OBJECTIVES:Recent data from Iraq supporting early aggressive use of fresh frozen plasma (FFP) in a 1:1 ratio to packed red blood cells (PRBCs) has led many civilian trauma centers to adopt this resource intensive strategy. METHODS:Prospective data were collected on 806 consecutive trauma patients admitted to the inten...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31818990ed

    authors: Scalea TM,Bochicchio KM,Lumpkins K,Hess JR,Dutton R,Pyle A,Bochicchio GV

    更新日期:2008-10-01 00:00:00

  • Current concepts in the mediastinal lymph node staging of nonsmall cell lung cancer.

    abstract:OBJECTIVE:To review the current concepts in the mediastinal staging of nonsmall cell lung cancer (NSCLC), evaluating traditional and modern staging modalities. SUMMARY BACKGROUND DATA:Staging of NSCLC includes the assessment of mediastinal lymph nodes. Traditionally, computed tomography (CT) and mediastinoscopy are us...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/01.SLA.0000081086.37779.1a

    authors: Kramer H,Groen HJ

    更新日期:2003-08-01 00:00:00

  • Survival in Locally Advanced Pancreatic Cancer After Neoadjuvant Therapy and Surgical Resection.

    abstract:OBJECTIVE:The aim of the study was to identify the survival of patients with locally advanced pancreatic cancer (LAPC) and assess the effect of surgical resection after neoadjuvant therapy on patient outcomes. BACKGROUND:An increasing number of LAPC patients who respond favorably to neoadjuvant therapy undergo surgica...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002753

    authors: Gemenetzis G,Groot VP,Blair AB,Laheru DA,Zheng L,Narang AK,Fishman EK,Hruban RH,Yu J,Burkhart RA,Cameron JL,Weiss MJ,Wolfgang CL,He J

    更新日期:2019-08-01 00:00:00

  • Evolution of the modified Rossetti fundoplication in children: surgical technique and results.

    abstract:OBJECTIVE:To compare the modified Rossetti fundoplication with the classic Nissen. SUMMARY BACKGROUND DATA:The traditional surgical treatment of gastroesophageal reflux in children has been the classic Nissen fundoplication, defined by liver mobilization, crural repair, takedown of short gastric vessels, and floppy wr...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199906000-00003

    authors: Levy MS,Sorrels CW,Wagner CW,Jackson RJ,Barnes RW,Smith SD

    更新日期:1999-06-01 00:00:00

  • Enhanced Recovery After Surgery (ERAS) Pathway in Esophagectomy: Is a Reasonable Prediction of Hospital Stay Possible?

    abstract:OBJECTIVE:To assess whether perioperative variables or deviation from enhanced recovery after surgery (ERAS) items could be associated with delayed discharge after esophagectomy, and to convert them into a scoring system to predict it. SUMMARY BACKGROUND DATA:ERAS perioperative pathways have been recently applied to e...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002775

    authors: Parise P,Ferrari C,Cossu A,Puccetti F,Elmore U,De Pascale S,Garutti L,Fumagalli UR,Di Serio MS,Rosati R

    更新日期:2019-07-01 00:00:00

  • The impact of gastric distension on the lower esophageal sphincter and its exposure to acid gastric juice.

    abstract:BACKGROUND AND AIMS:The lower esophageal sphincter (LES) in patients with gastroesophageal reflux disease often has a low resting pressure and a short abdominal length. The mechanism by which this occurs is unknown. We hypothesize that gastric distension causes progressive effacement of the abdominal portion of the LES...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181e3e411

    authors: Ayazi S,Tamhankar A,DeMeester SR,Zehetner J,Wu C,Lipham JC,Hagen JA,DeMeester TR

    更新日期:2010-07-01 00:00:00

  • Prolonged Air Leak After Pulmonary Resection Increases Risk of Noncardiac Complications, Readmission, and Delayed Hospital Discharge: A Propensity Score-adjusted Analysis.

    abstract:OBJECTIVE:The aim of the study was to determine whether prolonged air leak (PAL) is associated with postoperative morbidity and mortality following pulmonary resection after adjusting for differences in baseline characteristics using propensity score analysis. SUMMARY BACKGROUND DATA:Patients with PAL after lung resec...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003191

    authors: Attaar A,Luketich JD,Schuchert MJ,Winger DG,Sarkaria IS,Nason KS

    更新日期:2021-01-01 00:00:00