Hypoxia-inducible factor/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation.

abstract：:The mammalian ABL1 gene encodes the ubiquitously expressed nonreceptor tyrosine kinase ABL. In response to growth factors, cytokines, cell adhesion, DNA damage, oxidative stress, and other signals, ABL is activated to stimulate cell proliferation or differentiation, survival or death, retraction, or migration. ABL als...

journal_title：Molecular and cellular biology

authors： Wang JY

更新日期：2014-04-01 00:00:00

abstract：:Although the essential involvement of the progesterone receptor (PR) in female reproductive tissues is firmly established, the coregulators preferentially enlisted by PR to mediate its physiological effects have yet to be fully delineated. To further dissect the roles of members of the steroid receptor coactivator (SR...

journal_title：Molecular and cellular biology

authors： Mukherjee A,Soyal SM,Fernandez-Valdivia R,Gehin M,Chambon P,Demayo FJ,Lydon JP,O'Malley BW

更新日期：2006-09-01 00:00:00

abstract：:The extensive array of basic helix-loop-helix (bHLH) transcription factors and their combinations as dimers underpin the diversity of molecular function required for cell type specification during embryogenesis. The bHLH factor TWIST1 plays pleiotropic roles during development. However, which combinations of TWIST1 di...

journal_title：Molecular and cellular biology

authors： Fan X,Waardenberg AJ,Demuth M,Osteil P,Sun JQJ,Loebel DAF,Graham M,Tam PPL,Fossat N

更新日期：2020-05-14 00:00:00

abstract：:The molecular chaperone HSP90 regulates stability and function of multiple protein kinases. The HSP90-binding drug geldanamycin interferes with this activity and promotes proteasome-dependent degradation of most HSP90 client proteins. Geldanamycin also binds to GRP94, the HSP90 paralog located in the endoplasmic retic...

journal_title：Molecular and cellular biology

authors： Marcu MG,Doyle M,Bertolotti A,Ron D,Hendershot L,Neckers L

更新日期：2002-12-01 00:00:00

abstract：:We have shown previously that perturbation of origin firing in chromosome replication causes DNA lesions and triggers DNA damage checkpoint control, which ensures genomic integrity by stopping cell cycle progression until the lesions are repaired or by inducing cell death if they are not properly repaired. This was ba...

journal_title：Molecular and cellular biology

authors： Ide S,Watanabe K,Watanabe H,Shirahige K,Kobayashi T,Maki H

更新日期：2007-01-01 00:00:00

abstract：:Current amino acid and monosaccharide transport models are based on an assumption which equates the intracellular chemical activity of a solute with its concentration. This assumption was tested for alpha-aminoisobutyric acid and 3-O-methylglucose in a giant cell, the amphibian oocyte, by using recently developed cryo...

journal_title：Molecular and cellular biology

authors： Horowitz SB,Pearson TW

更新日期：1981-09-01 00:00:00

abstract：:Transforming growth factor β1 (TGF-β1) is a master cytokine in many biological processes, including tissue homeostasis, epithelial-to-mesenchymal transition, and wound repair. Here, we report that four and a half LIM-only protein 2 (FHL2) is a critical regulator of TGF-β1 expression. Devoid of a DNA-binding domain, FH...

journal_title：Molecular and cellular biology

authors： Dahan J,Levillayer F,Xia T,Nouët Y,Werts C,Fanton d'Andon M,Adib-Conquy M,Cassard-Doulcier AM,Khanna V,Chen J,Tordjmann T,Buendia MA,Jouvion G,Wei Y

更新日期：2017-05-02 00:00:00

abstract：:Genomic DNAs of the related parasitic nematodes Onchocerca volvulus and Dirofilariae immitis, and a cDNA library of O. volvulus, were examined for the presence of the 22-nucleotide spliced leader (SL) found at the 5' ends of 10 to 15% of the mRNAs in the free-living nematode Caenorhabditis elegans. As in C. elegans, g...

journal_title：Molecular and cellular biology

authors： Zeng WL,Alarcon CM,Donelson JE

更新日期：1990-06-01 00:00:00

abstract：:Although mitogenic and differentiating factors often activate a number of common signaling pathways, the mechanisms leading to their distinct cellular outcomes have not been elucidated. In a previous report, we demonstrated that mitogen-activated protein (MAP) kinase (ERK) activation by the neurogenic agents fibroblas...

journal_title：Molecular and cellular biology

authors： Corbit KC,Soh JW,Yoshida K,Eves EM,Weinstein IB,Rosner MR

更新日期：2000-08-01 00:00:00

abstract：:The PHR1 gene of Saccharomyces cerevisiae encodes a photolyase which repairs specifically and exclusively pyrimidine dimers, the most frequent lesions induced in DNA by far-UV radiation. We have asked whether expression of PHR1 is modulated in response to UV-induced DNA damage and to DNA-damaging agents that induce le...

journal_title：Molecular and cellular biology

authors： Sebastian J,Kraus B,Sancar GB

更新日期：1990-09-01 00:00:00

abstract：:Genomic imprinting results in parent-specific monoallelic expression of a small number of genes in mammals. The identity of imprints is unknown, but much evidence points to a role for DNA methylation. The maternal alleles of the imprinted H19 gene are active and hypomethylated; the paternal alleles are inactive and hy...

journal_title：Molecular and cellular biology

authors： Szabó PE,Pfeifer GP,Mann JR

更新日期：1998-11-01 00:00:00

abstract：:The cellular mechanisms involved in chronic inflammatory processes are poorly understood. This is especially true for the role of macrophages, which figure prominently in the inflammatory response. Two proteins, MRP8 and MRP14, which are expressed in infiltrate macrophages during inflammatory reactions but not in norm...

journal_title：Molecular and cellular biology

authors： Lagasse E,Clerc RG

更新日期：1988-06-01 00:00:00

abstract：:DHCR24/seladin-1, a crucial enzyme in sterol synthesis, is of lower abundance in brain areas affected by Alzheimer's disease. While high levels of DHCR24/seladin-1 exert antiapoptotic function by conferring resistance against oxidative stress, the molecular mechanism for this protective effect is not fully understood....

journal_title：Molecular and cellular biology

authors： Kuehnle K,Crameri A,Kälin RE,Luciani P,Benvenuti S,Peri A,Ratti F,Rodolfo M,Kulic L,Heppner FL,Nitsch RM,Mohajeri MH

更新日期：2008-01-01 00:00:00

abstract：:S-Tubercidinylhomocysteine (STH) is a structural analog of S-adenosylhomocysteine and a potent inhibitor of S-adenosylmethionine-dependent methyltransferase reactions. We investigated the effects of STH on HeLa cell mRNA metabolism. Dual labeling studies reveal that STH dramatically inhibits the methylation of HeLa mR...

journal_title：Molecular and cellular biology

authors： Camper SA,Albers RJ,Coward JK,Rottman FM

更新日期：1984-03-01 00:00:00

abstract：:A set of genes is rapidly inducible when quiescent fibroblasts are stimulated by growth factors or by the activation of temperature-sensitive retroviral protein-tyrosine kinases. Most of these so-called immediate-early genes were cloned by differential cDNA hybridization. DNA sequence analysis identified many of them ...

journal_title：Molecular and cellular biology

authors： Jähner D,Hunter T

更新日期：1991-07-01 00:00:00

abstract：:The repair of DNA single-strand breaks in mammalian cells is mediated by poly(ADP-ribose) polymerase 1 (PARP-1), DNA ligase IIIalpha, and XRCC1. Since these proteins are not found in lower eukaryotes, this DNA repair pathway plays a unique role in maintaining genome stability in more complex organisms. XRCC1 not only ...

journal_title：Molecular and cellular biology

authors： Leppard JB,Dong Z,Mackey ZB,Tomkinson AE

更新日期：2003-08-01 00:00:00

abstract：:The failure to transcribe the phenylalanine hydroxylase (PAH) gene in the liver of hepatocyte nuclear factor 1alpha (HNF1alpha)-deficient mice correlated with DNA hypermethylation and the presence of an inactive chromatin structure (M. Pontoglio, D. M. Faust, A. Doyen, M. Yaniv, and M. C. Weiss, Mol. Cell. Biol. 17:49...

journal_title：Molecular and cellular biology

authors： Viollet B,Yaniv M,Pontoglio M

更新日期：2001-06-01 00:00:00

abstract：:Mating-type genes resident in the silent cassette HML at the left arm of chromosome III are repressed by the action of four SIR gene products, most likely mediated through two cis-acting sites located on opposite sides of the locus. We showed that deletion of either of these two cis-acting sites from the chromosome di...

journal_title：Molecular and cellular biology

authors： Mahoney DJ,Broach JR

更新日期：1989-11-01 00:00:00

abstract：:We have previously described a transcription unit on human chromosome 8, designated as PVT, that is consistently disrupted by the minority forms of translocations [t(2;8) and t(8;22)] in Burkitt's lymphoma. PVT begins 57 kilobase pairs downstream of the proto-oncogene MYC and is more than 200 kilobase pairs in length....

journal_title：Molecular and cellular biology

authors： Shtivelman E,Bishop JM

更新日期：1990-04-01 00:00:00

abstract：:Xenopus in vitro studies have implicated both transforming growth factor beta (TGF-beta) and fibroblast growth factor (FGF) families in mesoderm induction. Although members of both families are present during mouse mesoderm formation, there is little evidence for their functional role in mesoderm induction. We show th...

journal_title：Molecular and cellular biology

authors： Johansson BM,Wiles MV

更新日期：1995-01-01 00:00:00

abstract：:Study of the mechanism(s) of genomic instability induced by the c-myc proto-oncogene has the potential to shed new light on its well-known oncogenic activity. However, an underlying mechanism(s) for this phenotype is largely unknown. In the present study, we investigated the effects of c-Myc overexpression on the DNA ...

journal_title：Molecular and cellular biology

authors： Sheen JH,Dickson RB

更新日期：2002-03-01 00:00:00

abstract：:Cellular differentiation is governed by changes in gene expression, but at the same time, a cell's identity needs to be maintained through multiple cell divisions during maturation. In myeloid cell lines, retinoids induce gene expression and a well-characterized two-step lineage-specific differentiation. To identify m...

journal_title：Molecular and cellular biology

authors： Balint BL,Szanto A,Madi A,Bauer UM,Gabor P,Benko S,Puskás LG,Davies PJ,Nagy L

更新日期：2005-07-01 00:00:00

abstract：:The v-vis gene encodes p28sis, the transforming protein of simian sarcoma virus. This gene resulted from a fusion of the env gene of simian sarcoma-associated virus and the woolly monkey gene for the B chain of platelet-derived growth factor (PDGF). Previous work has shown that the v-sis gene product undergoes signal ...

journal_title：Molecular and cellular biology

authors： Lee BA,Maher DW,Hannink M,Donoghue DJ

更新日期：1987-10-01 00:00:00

abstract：:The expression of Id1, a helix-loop-helix protein which inhibits the activity of basic helix-loop-helix transcription factors, is down-regulated during cellular differentiation and cell cycle withdrawal both in tissue culture models and in mouse embryos. In order to study the mechanism of control of Idl expression, we...

journal_title：Molecular and cellular biology

authors： Tournay O,Benezra R

更新日期：1996-05-01 00:00:00

abstract：:Gamma interferon (IFN-γ) regulates immune defenses against viruses, intracellular pathogens, and tumors by modulating cell proliferation, migration, invasion, and vesicle trafficking processes. The large GTPase guanylate binding protein 1 (GBP-1) is among the cellular proteins that is the most abundantly induced by IF...

journal_title：Molecular and cellular biology

authors： Ostler N,Britzen-Laurent N,Liebl A,Naschberger E,Lochnit G,Ostler M,Forster F,Kunzelmann P,Ince S,Supper V,Praefcke GJ,Schubert DW,Stockinger H,Herrmann C,Stürzl M

更新日期：2014-01-01 00:00:00

abstract：:Nucleocytoplasmic shuttling of class IIa of histone deacetylases (HDACs) is a key mechanism that controls cell fate and animal development. We have identified the filamin B (FLNB) as a novel HDAC7-interacting protein that is required for temporal and spatial regulation of vascular endothelial growth factor (VEGF)-medi...

journal_title：Molecular and cellular biology

authors： Su YT,Gao C,Liu Y,Guo S,Wang A,Wang B,Erdjument-Bromage H,Miyagi M,Tempst P,Kao HY

更新日期：2013-04-01 00:00:00

abstract：:The Saccharomyces cerevisiae PGK (phosphoglycerate kinase) gene encodes one of the most abundant mRNA and protein species in the cell. To identify the promoter sequences required for the efficient expression of PGK, we undertook a detailed internal deletion analysis of the 5' noncoding region of the gene. Our analysis...

journal_title：Molecular and cellular biology

authors： Ogden JE,Stanway C,Kim S,Mellor J,Kingsman AJ,Kingsman SM

更新日期：1986-12-01 00:00:00

abstract：:To investigate the role of myogenin in regulating acetylcholine receptor expression in adult muscle, this muscle-specific basic helix-loop-helix transcription factor was overexpressed in transgenic mice by using regulatory elements conferring strong expression confined to differentiated postmitotic muscle fibers. Many...

journal_title：Molecular and cellular biology

authors： Gundersen K,Rabben I,Klocke BJ,Merlie JP

更新日期：1995-12-01 00:00:00

abstract：:Our previous studies of Saccharomyces cerevisiae described a gene repression mechanism where the transcription of intergenic noncoding DNA (ncDNA) (SRG1) assembles nucleosomes across the promoter of the adjacent SER3 gene that interfere with the binding of transcription factors. To investigate the role of histones in ...

journal_title：Molecular and cellular biology

authors： Hainer SJ,Martens JA

更新日期：2011-09-01 00:00:00

abstract：:Various stresses activate the c-Jun N-terminal kinase (JNK), which is involved in the regulation of many aspects of cellular physiology, including apoptosis. Here we demonstrate that in contrast to UV irradiation, heat shock causes little or no stimulation of the JNK-activating kinase SEK1, while knocking out the SEK1...

journal_title：Molecular and cellular biology

authors： Meriin AB,Yaglom JA,Gabai VL,Zon L,Ganiatsas S,Mosser DD,Zon L,Sherman MY

更新日期：1999-04-01 00:00:00