Diagnostic usefulness of the cytological study of the transport buffer in transrectal prostate core biopsies.

Abstract:

BACKGROUND:To evaluate the diagnostic usefulness of the cytological study of the transport buffer in the diagnosis of prostate adenocarcinoma in transrectal core biopsies. METHODS:A total of 256 consecutively biopsied patients have been included in the analysis, 100 of them diagnosed of prostate adenocarcinoma. The procedure included the cytological analysis of the transport buffer and conventional histology. Cytological evaluation was performed in a blind way by the same pathologist. RESULTS:Overall sensitivity, specificity, and positive and negative predictive values to detect malignancy in the cytological slides were 54%, 98%, 94% and 76%, respectively. When restricted the analysis to cases with Gleason score higher than 8, sensitivity and negative predictive value increased to 85% and 97%, respectively. Similarly, when the analysis focused exclusively to cases with more than 5mm of cancer in the biopsy, sensitivity and positive predictive value increased to 66% and 96%, respectively. CONCLUSIONS:This study shows that whilst specificity was maintained in 98%, sensitivity, and positive and negative predictive values significantly improved in high grade and high volume adenocarcinomas. Our findings confirm that the cytological study of the transport buffer may complement the histology in the diagnosis of prostate adenocarcinoma.

journal_name

Actas Urol Esp

authors

López JI,Cáceres F,Pérez A,Caamaño V,Larrinaga G,Lecumberri D,Arruza A

doi

10.1016/j.acuro.2014.01.003

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

566-70

issue

9

eissn

0210-4806

issn

1699-7980

pii

S0210-4806(14)00034-5

journal_volume

38

pub_type

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