Developments in urologic oncology "OncoForum": The best of 2017.

Abstract:

OBJECTIVE:To put forth new findings of urologic oncology with impact on clinical practice presented during 2017 in the main annual meetings. METHODS:This document reviews abstracts on prostate, kidney and bladder cancer presented at the congresses of 2016 (EAU, AUA, ASCO, ESMO and ASTRO) and publications with the highest impact in this period valued with the highest scores by the OncoForum committee. RESULTS:Among patients at high risk of recurrent renal cell carcinoma after nephrectomy, adjuvant sunitinib compared to placebo showed a benefit in patients at higher risk of recurrence. In cisplatin-ineligible advanced urothelial cancer, pembrolizumab elicits clinically meaningful, durable responses. Among patients with localized prostate cancer, treatment for disease progression was less frequent (absolute difference, 26.2 percentage pontis) and adverse events was more frequent with surgery than with observation. Among patients with locally advanced or merastatic prostate cancer, androgen-deprivation therapy plus abiraterone and prednisolone resulted in fewer deaths and fewer treatment-failure events (P<.001). Among patients with metastatic castration-resistant prostate cancer previously treated with abiraterone acetate, enzalutamide median radiographic progression free survival was 8,1 months and enzalutamide median overall survival was not reached. CONCLUSIONS:Among patients at high risk of recurrent renal cell carcinoma after nephrectomy, adjuvant sunitinib showed a benefit across subgroups including patients at higher risk of recurrence. Among patients with localized prostate cancer, surgery was not associated with significantly lower all-cause or porstate-cancer mortality than observation. Among patients with locally advanced or merastatic prostate cancer, androgen-deprivation therapy plus abiraterone and prednisolone was associated with significantly higher rates of overall and failure-free survival than androgen-deprivation therapy alone. In patients with metastatic castration-resistant prostate cancer previously treated with abiraterone enzalutamide remained active.

journal_name

Actas Urol Esp

authors

Gómez-Veiga F,Alcaraz-Asensio A,Burgos-Revilla J,Cózar-Olmo J

doi

10.1016/j.acuro.2018.06.001

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

488-498

issue

8

eissn

0210-4806

issn

1699-7980

pii

S0210-4806(18)30110-4

journal_volume

42

pub_type

杂志文章,评审
  • [Human chorionic gonadotropin and carcinoembryonic antigen in small cell carcinoma (oat cell) of the urinary bladder].

    abstract::Patient suffering from vesical carcinoma, which is identified as small cells (oat cells) carcinoma. We carried out a histochemical study with H.C.G. and C.E.A. and analyse the results obtained. ...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:

    authors: Bonet Palau I,Torregrosa Bach MA,Ruiz Romero J,Gotzens García V

    更新日期:1989-11-01 00:00:00

  • [Matrix lithiasis. Apropos a case of staghorn lithiasis].

    abstract::Presentation of one case of soft lithiasis in a child which was treated by pyelolithectomy with good results and which has not relapsed after a 20-year follow-up. A commented revision is made of related literature. ...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章,评审

    doi:

    authors: López Cubillana P,Server Pastor G,Hita Villaplana G,Hita Rosino G,Asensio Egea L,Server Falgas G

    更新日期:1994-05-01 00:00:00

  • [Transperitoneal laparoscopic partial nephrectomy in the renal tumor treatment].

    abstract::Laparoscopic surgery is a surgical technique the urologist should add to his surgical armamentarium. Its performance tries to mimic the surgical phases of open surgery, and also its indications. Laparoscopic partial nephrectomy is a sophisticated technique that requires wide experience in the performance of endoscopic...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:10.1016/s0210-4806(06)73486-6

    authors: Rosales Bordes A,Salvador Bayarri J,de Graeve N,Palou Redorta J,Villavicencio Mavrich H

    更新日期:2006-05-01 00:00:00

  • [Value of a second transurethral resection in the assessment and treatment of patients with bladder tumor].

    abstract:OBJECTIVE:To analyse the value of a second transurethral resection, repeated within 3 to 6 weeks after the initial resection, in the treatment and the classification of patients with bladder tumour. MATERIAL AND METHODS:We analyse the results of 72 repeated transurethral resection in 23 (32%) patients with T1 G1-2 bla...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:10.1016/s0210-4806(01)72596-x

    authors: Ojea Calvo A,Núñez López A,Alonso Rodrigo A,Rodríguez Iglesias B,Benavente Delgado J,Barros Rodríguez JM,Nogueira March JL

    更新日期:2001-03-01 00:00:00

  • Influence of the location and number of metastases in the survival of metastatic prostatic cancer patients.

    abstract:INTRODUCTION:The prognosis of patients diagnosed with metastatic prostate cancer seems to be modulated by factors such as the number and site of metastases. Our objective is to evaluate survival outcomes according to the number and site of metastases in our series of metastatic patients over the last 15 years. MATERIA...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:10.1016/j.acuro.2016.09.004

    authors: Guijarro A,Hernández V,de la Morena JM,Jiménez-Valladolid I,Pérez-Fernández E,de la Peña E,Llorente C

    更新日期:2017-05-01 00:00:00

  • [Study of urinary outflow in pregnancy].

    abstract::Anatomical and physiological changes in the urinary tract develop during pregnancy. These changes may affect the urinary outflow. Urinary symptoms may develop during pregnancy in previously asymptomatic patients. Most of these symptoms will vanish after delivery. Some of them remain and others will become worse in con...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:10.1016/s0210-4806(99)72367-3

    authors: Lubrano Rosales A,Chesa Ponce N

    更新日期:1999-10-01 00:00:00

  • [Metastasis in the glans of prostatic adenocarcinoma. Apropos of a case].

    abstract::Case of an 83 year-old male with metastatic penis cancer located at the glans, secondary to moderately differentiated prostatic adenocarcinoma. There was early metastasis clinically expressed as several painful and ulcerous nodes at the glans corona and paraphimosis. The clinical rareness of metastasis in a porous bod...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章,评审

    doi:

    authors: Romero Pérez P,Amat Cecilia M,Andrada Becerra E

    更新日期:1991-05-01 00:00:00

  • Molecular imaging for prostate cancer: Performance analysis of 68Ga-PSMA PET/CT versus choline PET/CT.

    abstract:INTRODUCTION:There is a need for a precise and reliable imaging to improve the management of prostate cancer. In recent years the PET/CT with choline has changed the handling of prostate cancer in Europe, and it is commonly used for initial stratification or for the diagnosis of a biochemical recurrence, although it do...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章,评审

    doi:10.1016/j.acuro.2016.09.015

    authors: Michaud L,Touijer KA

    更新日期:2017-06-01 00:00:00

  • [Oral tegafur plus mitomycin versus intravesical mitomycin alone in the prevention of recurrence in stage Ta bladder tumors].

    abstract:OBJECTIVE:The aim of this study is to know if the use of oral Tegafur associated to intravesical mitomycin is effective in the prevention of the relapses of Ta bladder tumors. METHOD:This is a prospective study in which we compare the recurrence rate and the disease-free interval of 2 groups of 40 patients each one, t...

    journal_title:Actas urologicas espanolas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0210-4806(03)72950-7

    authors: Server Pastor G,Rigabert Montiel M,Bañón Pérez V,Valdelvira Nadal P,Cao Avellaneda E,García Hernández JA,Pérez Albacete M

    更新日期:2003-06-01 00:00:00

  • [Renal transplantectomy].

    abstract::During the first ten years (1981-1990) of our organ transplantation program a total of 395 Renal Transplants (RTx) have been carried out in our Unit, 90 of which in 88 patients had to be subsequently transplantectomized. In 32 of them the reason was acute rejection (35%) including 7 renal rhexis, and in 30 chronic rej...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:

    authors: Rodríguez García J,García Buitron J,Chantada Abal V,García Freire C,Picallo Sánchez J,González Martín M,Alonso Hernández A

    更新日期:1992-01-01 00:00:00

  • [Incomplete urethral duplication in a male. A case report].

    abstract::Urethral duplication is a rare congenital anomaly affecting mainly males and being usually diagnosed during paedriatric age. We report a 20 year old male complaining of double urethral meatus with double urinary stream. Physical examination confirmed and additional hypospadic meatus below a normally placed urethral me...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:10.1016/s0210-4806(05)73204-6

    authors: Muñoz Vélez D,Riera Marí V,Ozonas Moragues M

    更新日期:2005-01-01 00:00:00

  • [Percutaneous renal surgery].

    abstract:RATIONALE:Analysis of complications resulting from the renal percutaneous approach. METHODS:Between 1990 and 1996, 175 percutaneous surgical procedures were performed by our group. In 69.2% cases, the reason was a lithiasic condition. We also carried out: 35 endopyelotomies, 12 renal cyst resections, 4 stenosis of ure...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:

    authors: Estébanez Zarranz MJ,Amón Sesmero J,Alonso Villalba A,Conde Redondo C,Rodríguez Toves A,Martínez-Sagarra JM

    更新日期:1998-02-01 00:00:00

  • [Stage II non-seminoma cancer of the testis: combined treatment with surgery and chemotherapy].

    abstract::Fifty-one patients with non-seminoma testicular cancer who underwent retroperitoneal ganglion dissection and 3 support cycles of chemotherapy with Cys-Platin, Vinblastine and Bleomycin. Four patients presented relapses (7.8%). Actuarial survival by 8 years was 87%, with a median of 38 months. The median survival was 4...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:

    authors: Orlandi L,Van Cauwelaert R,Orlandi F,Vargas R,San Martín S,Arraztoa J

    更新日期:1989-01-01 00:00:00

  • The role of cognitive training in endourology: a randomised controlled trial.

    abstract:INTRODUCTION:Cognitive training is an important training modality which allows the user to rehearse a procedure without physically carrying it out. This has led to recent interests to incorporate cognitive training within surgical education but research is currently limited. The use of cognitive training in surgery is ...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.acuro.2017.06.008

    authors: Shah M,Aydin A,Moran A,Khan MS,Dasgupta P,Ahmed K

    更新日期:2018-04-01 00:00:00

  • [Influence of renal and hepatic function in the serum concentration of prostate specific antigen].

    abstract::The influence of renal and hepatic functioning on serum levels of prostate specific antigen has been studied by examining its behaviour in a control group (CG) of 178 healthy male, a group of 48 patients with end-stage renal failure (ESRF) 22 of which had pre- and post-dialysis PSA measurements and a group of 48 patie...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:

    authors: Morote Robles J,Encabo G,Lorente JA,Peña JA,Raventos C

    更新日期:1997-10-01 00:00:00

  • Uncontrolled non-heartbeating donors (types i-ii) with normothermic recirculation vs. heartbeating donors: evaluation of functional results and survival.

    abstract:OBJECTIVE:Non-heartbeating donors (NHBD) are an alternative to heartbeating donors (HBD). Our objective was to compare functional results and kidney survival from NHBDs and HBDs. MATERIAL AND METHODS:A retrospective study comparing the results of 236 normothermically preserved kidneys from type i and ii type NHBDs wit...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:10.1016/j.acuro.2015.01.005

    authors: Miranda-Utrera N,Medina-Polo J,Pamplona-Casamayor M,Passas-Martínez JB,Rodríguez-Antolín A,de la Rosa Kehrmann F,Duarte-Ojeda JM,Tejido-Sánchez A,Villacampa Aubá F,Andrés Belmonte A

    更新日期:2015-09-01 00:00:00

  • [Primary adenocarcinoma of the bladder as single tumor. Study of 7 cases and review of the literature].

    abstract::Primary vesical adenocarcinoma is an extremely uncommon tumour, representing 0.5 to 2% of all the urothelial vesical neoplasias. Its behaviour is aggressive and its prognosis poor, especially in the seal ring cell variety. We present our experience in seven cases of vesical adenocarcinoma: one of urachal origin, two o...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章,评审

    doi:

    authors: Fernández Fernández A,Maganto Pavón E,Vallejo Herrador J,Escudero Barrilero A

    更新日期:1990-01-01 00:00:00

  • Methodology of a systematic review.

    abstract:CONTEXT:The objective of evidence-based medicine is to employ the best scientific information available to apply to clinical practice. Understanding and interpreting the scientific evidence involves understanding the available levels of evidence, where systematic reviews and meta-analyses of clinical trials are at the ...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:10.1016/j.acuro.2018.01.010

    authors: Linares-Espinós E,Hernández V,Domínguez-Escrig JL,Fernández-Pello S,Hevia V,Mayor J,Padilla-Fernández B,Ribal MJ

    更新日期:2018-10-01 00:00:00

  • [Impact of cervical cancer treatment on micturition and sexual function].

    abstract:CONTEXT:Cervical cancer is the second most common tumor in women worldwide and due to diagnostic and therapeutic advances, the overall survival rates at 5 years is approaching 70%. Disorders in micturition, defecation, sexuality and quality of life have been described, frequently caused by different treatments. Address...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章,评审

    doi:10.1016/j.acuro.2012.03.008

    authors: Ros C,Espuña M

    更新日期:2013-01-01 00:00:00

  • [Mucinous adenocarcinoma of the urachus synchronic with colorectal adenocarcinoma. Value of immunohistochemistry in the differential diagnosis].

    abstract::The coincidence of an urachal adenocarcinoma with another similar tumour in other location makes necessary to separate a true primary from a metastatic adenocarcinoma. We report the case of a 66-years-old-man with an urachal mucinous adenocarcinoma and two colonic adenocarcinoma excised in the same surgical act, showi...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:

    authors: Alvarez Alvarez C,Sánchez Merino JM,Busto Castañón L,Pombo Felipe F,Arnal Monreal F

    更新日期:1998-06-01 00:00:00

  • Metalloproteinase 11, potential marker and molecular target in advanced and castration-resistant prostate cancer. Culture study of peritumoral fibroblasts.

    abstract:OBJECTIVE:To analyze the expression of metalloprotein 11 (MMP11) in cultured fibroblasts obtained from human prostate tumors with different clinical and pathological characteristics. MATERIAL AND METHODS:For this study we analyzed samples of transrectal prostate biopsies from tumors with different characteristics, tre...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:10.1016/j.acuro.2016.12.001

    authors: Fernandez-Gomez JM,Eiro N,García-Rodríguez JJ,Quintás-Blanco A,Gonzalez-Ruiz de León C,Perez de Haro ML,Vizoso-Piñero F

    更新日期:2017-01-01 00:00:00

  • [Pure primary prostate transitional cell carcinoma. A review of our series].

    abstract::Primary prostate transitional cell carcinoma is a very uncommon tumor, that represents about 1% of all prostate tumours. In our institution, only six patients have been diagnosed with pure transitional cell prostate carcinoma until 2002. Bladder origin of the neplasic was ruled out in all cases. We report a study abou...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:10.1016/s0210-4806(04)73092-2

    authors: Mallén Mateo E,Gil Martínez P,Sancho Serrano C,García de Jalón Martínez A,Pascual Regueiro D,Gil Sanz MJ,Rioja Sanz LA

    更新日期:2004-05-01 00:00:00

  • [Iatrogenic foreign bodies. A complication in urologic practice].

    abstract::Report on the presence in 43 patients of various foreign materials left in the urinary tract following a surgical procedure. The clinical symptoms exhibited by these patients correspond to a urinary syndrome with irritation or lumbar pain when the foreign body blocked the upper urinary tract. In most cases, diagnosis ...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章,评审

    doi:

    authors: Granados EA,Ríos GJ,Salvador J

    更新日期:1991-09-01 00:00:00

  • [Giant inguinoscrotal bladder hernia associated with a bladder tumor].

    abstract::Inguinoscrotal bladder hernias are uncommon clinical facts more predominant in males aged between 50 and 70. This entity has no specific clinical character and diagnosis usually happens in the course of surgical repair of inguinal hernia. In about 3%-10% cases, it appears associated to inguinal hernia. Discussion of t...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:

    authors: Pereira Arias JG,Gutíerrez Díez JM,Ateca-Díaz Obregón R,Berreteaga Gallastegui JR

    更新日期:1998-05-01 00:00:00

  • Laparoendoscopic single-site retroperitoneal lymph node dissection in non-seminomatous germ cell malignancy.

    abstract:INTRODUCTION:Umbilical laparoendoscopic single-site (LESS) surgery represents an excellent alternative to laparoscopic or robotic multiport surgery. LESS surgery offers faster recovery, less postoperative pain and optimal cosmetic results. LESS is possible in virtually any urologic surgery. PATIENT AND METHOD:We prese...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:10.1016/j.acuro.2014.07.004

    authors: Angulo JC,Redondo C,Gimbernat H,Ramón de Fata F,García-Tello A,García-Mediero JM

    更新日期:2015-05-01 00:00:00

  • [Role of electrohydraulic extracorporeal shockwave lithotripsy (Dornier HM 4) in the treatment of caliceal diverticulum lithiasis].

    abstract:UNLABELLED:Caliceal diverticula may be congenital or acquired malformations of the collecting system, normally asymptomatic and discovered during an IVP. Indications for treatment included chronic vague flank pain, acute renal colic, urinary tract infection and hematuria. We present the results of 29 patients with symp...

    journal_title:Actas urologicas espanolas

    pub_type: 临床试验,杂志文章,评审

    doi:

    authors: Torrecilla Ortiz C,Marco Pérez L,Contreras García J,Ponce Campuzano A,Ruíz-Lluch López R,Roig Sanz M,Serrallach Mila N

    更新日期:1998-10-01 00:00:00

  • [Retrorbital metastasis an initial manifestation of prostatic cancer].

    abstract::Orbital metastasis is an unusual localization within tumoral dissemination of prostatic cancer. Similarly, it is rare that orbital metastasis might be responsible for the clinic manifestations that determine the initial diagnosis of neoplasia. We illustrate the case of a patient suffering from prostatic adernocarcinom...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:10.1016/s0210-4806(03)72974-x

    authors: Bonillo García MA,Queipo Zaragozá JA,Palmero Marti JA,Pacheco Bru JJ,Vera Sempere FJ,Jiménez Cruz JF

    更新日期:2003-07-01 00:00:00

  • [Iatrogenic prostatorectal fistula. Use of gracilis muscle pedicled flap for its reparation. Presentation of two cases].

    abstract::We present two cases in which during retropubic prostatectomy for benign prostatic disease a prostatorectal fistula ocurred. We describe its reparation using a pedicled flap of gracilis muscle. We also present cystographic and opaque enema images which shows the before and after of this surgery. Patients had good outc...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:10.1016/s0210-4806(04)73113-7

    authors: Blanco Díez A,Alvarez Castelo L,Fernández Rosado E,Alvarez Jorge A,Ruibal Moldes M,Novás Castro S,Barbagelata López A,González Martín M

    更新日期:2004-06-01 00:00:00

  • [Fournier's gangrene: from urological emergency to plastic surgery].

    abstract::Fournier's gangrene (FG) is a rare and potentially fatal infectious disease characterised by necrotic fasciitis of the perineum and abdominal wall in addition to the scrotum and penis in men and the vulva in women. Skin loss can be very damaging and difficult to repair. This condition must be treated aggressively. Sev...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章

    doi:10.1016/s0210-4806(09)72884-0

    authors: Horta R,Cerqueira M,Marques M,Ferreira P,Reis J,Amarante J

    更新日期:2009-09-01 00:00:00

  • [Diagnostic and therapeutic approach to bilateral germinal tumor. Presentation of a case and review of the literature].

    abstract::The germinal bilateral tumor represents from 1 to 4% of the testicle tumors, and it usually turns to be one of the most difficult ones when talking about diagnosis and treatment. We are attaching a 30 years old patient case, with a diagnosis consisting in a seminoma with yolk sac tumor area from the left testicle, tha...

    journal_title:Actas urologicas espanolas

    pub_type: 杂志文章,评审

    doi:

    authors: Cañís Sánchez D,Conde Santos G,Alonso Gracia N,De León Morales E,Arango Toro O,Gelabert Mas A

    更新日期:2003-02-01 00:00:00